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Elmar Wahle
Department of Biochemistry, Martin-Luther-Unversitat Halle-Wittenberg, Halle, Germany

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 25 July 2001 ]
[ Evaluations ]
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Evaluations

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
Mullen TE, Marzluff WF
Genes Dev 2008 Jan 1 22(1):50-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle / Megerditch Kiledjian
Evaluated 7 Feb 2008

Nonsense-Mediated mRNA Decay in Yeast Does Not Require PAB1 or a Poly(A) Tail.
Meaux S, van Hoof A, Baker KE
Mol Cell 2008 Jan 18 29(1):134-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle
Evaluated 5 Feb 2008

Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs.
Lu JY, Sadri N, Schneider RJ
Genes Dev 2006 Nov 15 20(22):3174-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle
Evaluated 5 Feb 2008

Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis.
Balbo PB, Bohm A
Structure 2007 Sep 15(9):1117-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 19 Dec 2007

RNA channelling by the archaeal exosome.
Lorentzen E, Dziembowski A, …, Seraphin B, Conti E
EMBO Rep 2007 May 8(5):470-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle / Samuel Butcher
Evaluated 19 Jun 2007

Identification of a rapid mammalian deadenylation-dependent decay pathway and its inhibition by a viral RNA element.
Conrad NK, Mili S, …, Shu MD, Steitz JA
Mol Cell 2006 Dec 28 24(6):943-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle
Evaluated 12 Mar 2007

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E
EMBO J 2006 Nov 1 25(21):5117-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 23 Nov 2006

PUF proteins bind Pop2p to regulate messenger RNAs.
Goldstrohm AC, Hook BA, Seay DJ, Wickens M
Nat Struct Mol Biol 2006 Jun 13(6):533-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Caddick / Elmar Wahle / Jeff Coller
Evaluated 2 Jun 2006

ARE-mRNA degradation requires the 5'-3' decay pathway.
Stoecklin G, Mayo T, Anderson P
EMBO Rep 2006 Jan 7(1):72-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 9 Mar 2006

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.
Ferraiuolo MA, Basak S, …, Schoenberg DR, Sonenberg N
J Cell Biol 2005 Sep 12 170(6):913-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 18 Jan 2006

General translational repression by activators of mRNA decapping.
Coller J, Parker R
Cell 2005 Sep 23 122(6):875-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 25 Oct 2005

A new yeast poly(A) polymerase complex involved in RNA quality control.
Vanácová S, Wolf J, …, Keith G, Keller W
PLoS Biol 2005 Jun 3(6):e189 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lionel Minvielle-Sebastia / Ian Willis / Sylvie Doublie / Elmar Wahle
Evaluated 23 Jun 2005

Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo.
Semotok JL, Cooperstock RL, …, Lipshitz HD, Smibert CA
Curr Biol 2005 Feb 22 15(4):284-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle
Evaluated 4 Mar 2005

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.
Dower K, Kuperwasser N, Merrikh H, Rosbash M
RNA 2004 Dec 10(12):1888-99 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 25 Feb 2005

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.
Lykke-Andersen J, Wagner E
Genes Dev 2005 Feb 1 19(3):351-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 16 Feb 2005

Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
Dunn EF, Hammell CM, Hodge CA, Cole CN
Genes Dev 2005 Jan 1 19(1):90-103 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian / Elmar Wahle
Evaluated 26 Jan 2005

Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses.
Mili S, Steitz JA
RNA 2004 Nov 10(11):1692-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elsebet Lund / Elmar Wahle / Michael Kiebler
Evaluated 6 Dec 2004

mRNA deadenylation by PARN is essential for embryogenesis in higher plants.
Reverdatto SV, Dutko JA, …, Hamilton DA, Belostotsky DA
RNA 2004 Aug 10(8):1200-14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 27 Aug 2004

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.
Kadaba S, Krueger A, …, Hinnebusch AG, Anderson J
Genes Dev 2004 Jun 1 18(11):1227-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Maraia / Anita Hopper / Elmar Wahle / Samuel Gunderson
Evaluated 16 Jun 2004

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila.
Gatfield D, Izaurralde E
Nature 2004 Jun 3 429(6991):575-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle / Lynne Maquat / Miles Wilkinson
Evaluated 10 Jun 2004

The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA.
Gilbert W, Guthrie C
Mol Cell 2004 Jan 30 13(2):201-12 [abstract on PubMed] [related articles] [order article]
Selected by | Andrea Barta / Elmar Wahle
Evaluated 15 Mar 2004

Cytoplasmic degradation of splice-defective pre-mRNAs and intermediates.
Hilleren PJ, Parker R
Mol Cell 2003 Dec 12(6):1453-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 18 Feb 2004

The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators.
Aviv T, Lin Z, …, Sicheri F, Smibert CA
Nat Struct Biol 2003 Aug 10(8):614-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle
Evaluated 9 Dec 2003

Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA.
Fortes P, Cuevas Y, …, Rowe D, Gunderson SI
Proc Natl Acad Sci U S A 2003 Jul 8 100(14):8264-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 2 Oct 2003

Purifying mRNAs with a high-affinity eIF4E mutant identifies the short 3' poly(A) end phenotype.
Choi YH, Hagedorn CH
Proc Natl Acad Sci U S A 2003 Jun 10 100(12):7033-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 26 Aug 2003

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.
Chen CY, Shyu AB
Mol Cell Biol 2003 Jul 23(14):4805-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arlen Johnson / Elmar Wahle / Megerditch Kiledjian
Evaluated 25 Jul 2003

Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.
Sheth U, Parker R
Science 2003 May 2 300(5620):805-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle / Roy Long / Arlen Johnson / Daniel Gallie
Evaluated 7 May 2003

VgRBP71 stimulates cleavage at a polyadenylation signal in Vg1 mRNA, resulting in the removal of a cis-acting element that represses translation.
Kolev NG, Huber PW
Mol Cell 2003 Mar 11(3):745-55 [abstract on PubMed] [related articles] [order article]
Selected by | Elmar Wahle
Evaluated 22 Apr 2003

Nocturnin, a deadenylase in Xenopus laevis retina: a mechanism for posttranscriptional control of circadian-related mRNA.
Baggs JE, Green CB
Curr Biol 2003 Feb 4 13(3):189-98 [abstract on PubMed] [related articles] [order article]
Selected by | Elmar Wahle
Evaluated 27 Feb 2003

Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides.
Thoma C, Hasselblatt P, …, von Weizsäcker F, Offensperger WB
Mol Cell 2001 Oct 8(4):865-72 [abstract on PubMed] [related articles] [order article]
Selected by | Elmar Wahle
Evaluated 28 Nov 2002

A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans.
Wang L, Eckmann CR, …, Wickens M, Kimble J
Nature 2002 Sep 19 419(6904):312-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Elmar Wahle / Talila Volk / Anita Hopper / Gabriele Varani / Samuel Gunderson
Evaluated 18 Oct 2002

Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover.
Stoecklin G, Colombi M, …, Kitamura T, Moroni C
EMBO J 2002 Sep 2 21(17):4709-18 [abstract on PubMed] [related articles] [order article]
Selected by | Elmar Wahle
Evaluated 1 Oct 2002

Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation.
Chekanova JA, Shaw RJ, Belostotsky DA
Curr Biol 2001 Aug 7 11(15):1207-14 [abstract on PubMed] [related articles] [order article]
Selected by | Elmar Wahle
Evaluated 16 Jul 2002

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
Saitoh S, Chabes A, …, Yates JR, Russell P
Cell 2002 May 31 109(5):563-73 [abstract on PubMed] [related articles] [order article]
Selected by | Nancy Standart / Elmar Wahle / Antony Carr
Evaluated 11 Jun 2002

Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export.
Hector RE, Nykamp KR, …, Minvielle-Sebastia L, Swanson MS
EMBO J 2002 Apr 2 21(7):1800-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 1 May 2002

Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae.
Tucker M, Staples RR, …, Muhlrad D, Parker R
EMBO J 2002 Mar 15 21(6):1427-36 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 25 Mar 2002

The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.
Friesen WJ, Paushkin S, …, Mann M, Dreyfuss G
Mol Cell Biol 2001 Dec 21(24):8289-300 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Pamela Silver / Elmar Wahle
Evaluated 11 Feb 2002

Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.
Tharun S, Parker R
Mol Cell 2001 Nov 8(5):1075-83 [abstract on PubMed] [related articles] [order article]
Selected by | Arlen Johnson / Elmar Wahle
Evaluated 22 Jan 2002

Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation.
Ali IK, McKendrick L, Morley SJ, Jackson RJ
EMBO J 2001 Aug 1 20(15):4233-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 7 Jan 2002

The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer.
Evdokimova V, Ruzanov P, …, Ovchinnikov LP, Sonenberg N
EMBO J 2001 Oct 1 20(19):5491-502 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elmar Wahle
Evaluated 8 Nov 2001

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