Luciano Adorini, MD, has conducted postdoctoral studies at the University of California at Los Angeles under the supervision of Prof. Eli Sercarz. He has then directed a research unit at the Preclinical Research Center, Sandoz Pharma Ltd., Basel and has been Associate Director of Roche Milano Ricerche, Milano. He is presently Chief Scientific Officer at BioXell in Milano, a spin-off of Hoffmann-La Roche of which he is a co-founder.

Dr. Adorini has studied several aspects of antigen recognition by T cells and has analyzed immunoregulatory mechanisms to develop immunosuppressive strategies applicable to the treatment of autoimmune diseases. He has made significant contributions in the field of antigen presentation, peptide-MHC interactions and in the use of synthetic peptides to selectively modulate immune responses in vivo. His current interests are focused on the role of antigen presenting cells in immunoregulation, and on the pathogenesis and treatment of autoimmune diseases.

http://www.interceptpharma.com

The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. Nchinda G, Kuroiwa J, …, Uberla K, Steinman RM J Clin Invest 2008 Apr 1 118(4):1427-1436 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 21 Apr 2008 Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Denning TL, Wang YC, …, Williams IR, Pulendran B Nat Immunol 2007 Oct 8(10):1086-94 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Eric Denkers / Maria Rescigno / Luciano Adorini / Reina Mebius Evaluated 19 Nov 2007 IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Niedbala W, Wei XQ, …, McInnes IB, Liew FY Eur J Immunol 2007 Nov 37(11):3021-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini / Rachel Caspi Evaluated 9 Oct 2007 Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. Chen S, Sims GP, …, Chen S, Lipsky PE J Immunol 2007 Aug 1 179(3):1634-47 [abstract on PubMed] [related articles] [order article] Selected by | Luciano Adorini Evaluated 19 Sep 2007 Phenotypic and functional features of human Th17 cells. Annunziato F, Cosmi L, …, Maggi E, Romagnani S J Exp Med 2007 Aug 6 204(8):1849-61 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini Evaluated 15 Aug 2007 Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. Schauber J, Dorschner RA, …, Modlin RL, Gallo RL J Clin Invest 2007 Mar 117(3):803-11 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 6 Mar 2007 DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Sigmundsdottir H, Pan J, …, Soler D, Butcher EC Nat Immunol 2007 Mar 8(3):285-93 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini Evaluated 14 Feb 2007 IL-25 regulates Th17 function in autoimmune inflammation. Kleinschek MA, Owyang AM, …, Kastelein RA, Cua DJ J Exp Med 2007 Jan 22 204(1):161-70 [abstract on PubMed] [related articles] [FREE full text] Selected by | Torben Lund / Rachel Caspi / Luciano Adorini Evaluated 26 Jan 2007 Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. Krishnamurthy B, Dudek NL, …, Thomas HE, Kay TW J Clin Invest 2006 Dec 116(12):3258-65 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant Morahan / Luciano Adorini / Matthias von Herrath Evaluated 15 Dec 2006 Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Veldhoen M, Hocking RJ, Flavell RA, Stockinger B Nat Immunol 2006 Nov 7(11):1151-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Torben Lund / Luciano Adorini Evaluated 27 Nov 2006 Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. Fife BT, Griffin MD, …, Locksley RM, Bluestone JA J Clin Invest 2006 Aug 116(8):2252-61 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anne Davidson / Luciano Adorini Evaluated 22 Aug 2006 Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Ochando JC, Homma C, …, Randolph GJ, Bromberg JS Nat Immunol 2006 Jun 7(6):652-62 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini Evaluated 16 Jun 2006 Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Liu PT, Stenger S, …, Bloom BR, Modlin RL Science 2006 Mar 24 311(5768):1770-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini / Jean Pieters / Lieping Chen / Thomas Nutman / David Alpers Evaluated 10 Mar 2006 Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. De Rosa V, Procaccini C, …, Zappacosta S, Matarese G J Clin Invest 2006 Feb 116(2):447-55 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 23 Jan 2006 Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Zenz R, Eferl R, …, Tschachler E, Wagner EF Nature 2005 Sep 15 437(7057):369-75 [abstract on PubMed] [related articles] [full text] [order article] Selected by | David Branch Moody / Luciano Adorini Evaluated 1 Nov 2005 Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo. Accapezzato D, Visco V, …, Torrisi MR, Barnaba V J Exp Med 2005 Sep 19 202(6):817-28 [abstract on PubMed] [related articles] [FREE full text] Selected by | Stephen Philip Schoenberger / Luciano Adorini Evaluated 28 Sep 2005 Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. Bashuda H, Kimikawa M, …, Teraoka S, Okumura K J Clin Invest 2005 Jul 115(7):1896-902 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 19 Jul 2005 Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. Belperio JA, Keane MP, …, Ross DJ, Strieter RM J Clin Invest 2005 May 115(5):1150-62 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Kunkel / Luciano Adorini Evaluated 3 Jun 2005 Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. Katakura K, Lee J, …, Eckmann L, Raz E J Clin Invest 2005 Mar 115(3):695-702 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 30 Mar 2005 Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. Vermi W, Riboldi E, …, Facchetti F, Sozzani S J Exp Med 2005 Feb 21 201(4):509-15 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 25 Feb 2005 Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. Migeotte I, Riboldi E, …, Parmentier M, Communi D J Exp Med 2005 Jan 3 201(1):83-93 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 12 Jan 2005 Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. Zabel BA, Silverio AM, Butcher EC J Immunol 2005 Jan 1 174(1):244-51 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 7 Jan 2005 Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement. Fallarino F, Asselin-Paturel C, …, Grohmann U, Puccetti P J Immunol 2004 Sep 15 173(6):3748-54 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 30 Sep 2004 CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. Herman AE, Freeman GJ, Mathis D, Benoist C J Exp Med 2004 Jun 7 199(11):1479-89 [abstract on PubMed] [related articles] [FREE full text] Selected by | Torben Lund / Kenneth Tung / Luciano Adorini Evaluated 12 Jul 2004 Exacerbated graft-versus-host disease in Pirb-/- mice. Nakamura A, Kobayashi E, Takai T Nat Immunol 2004 Jun 5(6):623-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini / Andrew Scharenberg Evaluated 14 Jun 2004 Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Prakken BJ, Samodal R, …, Billetta R, Albani S Proc Natl Acad Sci U S A 2004 Mar 23 101(12):4228-33 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 6 May 2004 Homeostatic proliferation is a barrier to transplantation tolerance. Wu Z, Bensinger SJ, …, Sayegh MH, Turka LA Nat Med 2004 Jan 10(1):87-92 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini Evaluated 24 Feb 2004 Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. Turley S, Poirot L, …, Benoist C, Mathis D J Exp Med 2003 Nov 17 198(10):1527-37 [abstract on PubMed] [related articles] [FREE full text] Selected by | Andrea Sant / Luciano Adorini / Matthias von Herrath / Torben Lund Evaluated 4 Dec 2003 Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells. Schnurr M, Toy T, …, Cebon J, Maraskovsky E Blood 2004 Feb 15 103(4):1391-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 30 Oct 2003 An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. Lasagni L, Francalanci M, …, Serio M, Romagnani P J Exp Med 2003 Jun 2 197(11):1537-49 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini / Marcus Thelen Evaluated 18 Jun 2003 Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Pluchino S, Quattrini A, …, Vescovi AL, Martino G Nature 2003 Apr 17 422(6933):688-94 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Angela Vincent / Luciano Adorini Evaluated 8 May 2003 Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Fontenot JD, Gavin MA, Rudensky AY Nat Immunol 2003 Apr 4(4):330-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini / Christopher Karp / Arthur Hurwitz Evaluated 14 Mar 2003 Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Ghoreschi K, Thomas P, …, Sander CA, Röcken M Nat Med 2003 Jan 9(1):40-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini Evaluated 4 Feb 2003 CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Belkaid Y, Piccirillo CA, …, Shevach EM, Sacks DL Nature 2002 Dec 5 420(6915):502-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Marie Kosco-Vilbois / Christopher Karp / Stefan Kaufmann / Marsha Wills-Karp / Luciano Adorini Evaluated 17 Jan 2003 Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. Annunziato F, Cosmi L, …, Maggi E, Romagnani S J Exp Med 2002 Aug 5 196(3):379-87 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 6 Sep 2002 Identification of regulatory T cells in tolerated allografts. Graca L, Cobbold SP, Waldmann H J Exp Med 2002 Jun 17 195(12):1641-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 5 Jul 2002 Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Chang CC, Ciubotariu R, …, Dalla-Favera R, Suciu-Foca N Nat Immunol 2002 Mar 3(3):237-43 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini Evaluated 11 Feb 2002 Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts. O'Connell PJ, Li W, …, Logar AJ, Thomson AW J Immunol 2002 Jan 1 168(1):143-54 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini Evaluated 22 Jan 2002 Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells. Albert ML, Jegathesan M, Darnell RB Nat Immunol 2001 Nov 2(11):1010-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Luciano Adorini / William Heath Evaluated 19 Nov 2001 Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. Hawiger D, Inaba K, …, Steinman RM, Nussenzweig MC J Exp Med 2001 Sep 17 194(6):769-79 [abstract on PubMed] [related articles] [FREE full text] Selected by | Paul Gleeson / Luciano Adorini / Jeffrey Bluestone Evaluated 19 Nov 2001 Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. Nakamura K, Kitani A, Strober W J Exp Med 2001 Sep 3 194(5):629-44 [abstract on PubMed] [related articles] [FREE full text] Selected by | Luciano Adorini / Paul Gleeson / W. Evan Secor / Bruce Blazar Evaluated 1 Oct 2001

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