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Iain Hagan
Department of Cell Division, Paterson Institute for Cancer Research, Manchester, United Kingdom

Faculty Member: Cell Biology > Cell Growth & Division [ since 24 August 2001 ]
[ Evaluations ]
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Evaluations

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Macurek L, Lindqvist A, …, Yaffe MB, Medema RH
Nature 2008 Jul 9 [abstract on PubMed] [related articles] [full text]
Selected by | Iain Hagan
Evaluated 13 Aug 2008

Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry.
Seki A, Coppinger JA, …, Yates JR, Fang G
Science 2008 Jun 20 320:1655-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser with Zhao Zhuoshen / Iain Hagan
Evaluated 11 Aug 2008

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.
Yamashiro S, Yamakita Y, …, Hartshorne DJ, Matsumura F
Dev Cell 2008 May 14(5):787-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 14 Jul 2008

The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle.
Xiang Y, Takeo S, …, Jaspersen SL, Hawley RS
PLoS Biol 2007 Dec 5(12):e323 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 11 Jul 2008

Mutations in Drosophila Greatwall/Scant Reveal Its Roles in Mitosis and Meiosis and Interdependence with Polo Kinase.
Archambault V, Zhao X, …, Carpenter AT, Glover DM
PLoS Genet 2007 Nov 9 3(11):e200 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 18 Mar 2008

TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.
Petersen J, Nurse P
Nat Cell Biol 2007 Nov 9(11):1263-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 17 Mar 2008

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling.
Griffith E, Walker S, …, Jackson AP, O'Driscoll M
Nat Genet 2008 Feb 40(2):232-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Doxsey / Iain Hagan
Evaluated 17 Mar 2008

Roles of Greatwall Kinase in the Regulation of Cdc25 Phosphatase.
Zhao Y, Haccard O, …, Jessus C, Goldberg ML
Mol Biol Cell 2008 Jan 16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 17 Mar 2008

Microtubules offset growth site from the cell centre in fission yeast.
Castagnetti S, Novák B, Nurse P
J Cell Sci 2007 Jul 1 120(Pt 13):2205-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 30 Aug 2007

Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.
Rebollo E, Sampaio P, …, Varmark H, González C
Dev Cell 2007 Mar 12(3):467-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan / Yukiko Yamashita / Marcos Gonzalez-Gaitan
Evaluated 3 Apr 2007

Asymmetric inheritance of mother versus daughter centrosome in stem cell division.
Yamashita YM, Mahowald AP, Perlin JR, Fuller MT
Science 2007 Jan 26 315(5811):518-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Doxsey / Sally Temple / Berl R. Oakley / Susan Mango / Iain Hagan
Evaluated 3 Apr 2007

Anaphase inactivation of the spindle checkpoint.
Palframan WJ, Meehl JB, …, Winey M, Murray AW
Science 2006 Aug 4 313(5787):680-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Kevin Hardwick
Evaluated 14 Aug 2006

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, …, Prigent C, Giet R
EMBO Rep 2006 Apr 7(4):418-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael B. Yaffe / Iain Hagan
Evaluated 28 Apr 2006

Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts.
Yu J, Zhao Y, …, Galas S, Goldberg ML
Mol Cell 2006 Apr 7 22(1):83-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathon Pines / Iain Hagan
Evaluated 24 Apr 2006

Cdk1-dependent regulation of the mitotic inhibitor Wee1.
Harvey SL, Charlet A, …, Gygi SP, Kellogg DR
Cell 2005 Aug 12 122(3):407-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Iain Hagan / Linda Huang / Arp Schnittger / Francesc Posas
Evaluated 24 Aug 2005

The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly.
Niepel M, Strambio-de-Castillia C, …, Chait BT, Rout MP
J Cell Biol 2005 Jul 18 170(2):225-35 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Susan Wente
Evaluated 9 Aug 2005

The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.
Jin Y, Mancuso JJ, …, Cronembold D, Cande WZ
Dev Cell 2005 Jul 9(1):63-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 5 Aug 2005

Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe.
Tatebe H, Shimada K, …, Morigasaki S, Shiozaki K
Curr Biol 2005 Jun 7 15(11):1006-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 20 Jun 2005

Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity.
Martin SG, McDonald WH, Yates JR, Chang F
Dev Cell 2005 Apr 8(4):479-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 20 Jun 2005

Adenomatous polyposis coli associates with the microtubule-destabilizing protein XMCAK.
Banks JD, Heald R
Curr Biol 2004 Nov 23 14(22):2033-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 18 Mar 2005

Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres.
Maiato H, Khodjakov A, Rieder CL
Nat Cell Biol 2005 Jan 7(1):42-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Glover / Claire Walczak / Bruce McEwen / Iain Hagan
Evaluated 17 Mar 2005

Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis.
Maiato H, Rieder CL, Khodjakov A
J Cell Biol 2004 Dec 6 167(5):831-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Linda Wordeman / Bruce McEwen / Iain Hagan / William Earnshaw
Evaluated 17 Mar 2005

The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments.
Lampson MA, Kapoor TM
Nat Cell Biol 2005 Jan 7(1):93-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 11 Mar 2005

Genome-wide survey of protein kinases required for cell cycle progression.
Bettencourt-Dias M, Giet R, …, Frenz L, Glover DM
Nature 2004 Dec 23 432(7020):980-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael B. Yaffe / Iain Hagan / Ulf Pettersson / Bodo Lange
Evaluated 14 Jan 2005

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.
Mimori-Kiyosue Y, Grigoriev I, …, Tsukita S, Akhmanova A
J Cell Biol 2005 Jan 3 168(1):141-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Vladimir Rodionov
Evaluated 13 Jan 2005

Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway.
Mikhailov A, Shinohara M, Rieder CL
J Cell Biol 2004 Aug 16 166(4):517-26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chloe Bulinski / Iain Hagan
Evaluated 7 Sep 2004

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.
Dutertre S, Cazales M, …, Prigent C, Ducommun B
J Cell Sci 2004 May 15 117(Pt 12):2523-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 3 Sep 2004

Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells.
Matsusaka T, Pines J
J Cell Biol 2004 Aug 16 166(4):507-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 3 Sep 2004

Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes.
Andersson J, Simpson DM, …, Wang Y, Elion EA
EMBO J 2004 Jul 7 23(13):2564-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 3 Aug 2004

Spatial coordination of cytokinetic events by compartmentalization of the cell cortex.
Dobbelaere J, Barral Y
Science 2004 Jul 16 305(5682):393-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Pekka Lappalainen
Evaluated 2 Aug 2004

Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.
Azzam R, Chen SL, …, Carr SA, Deshaies RJ
Science 2004 Jul 23 305(5683):516-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Angelika Amon
Evaluated 2 Aug 2004

Positioning and elongation of the fission yeast spindle by microtubule-based pushing.
Toli¿-Nørrelykke IM, Sacconi L, Thon G, Pavone FS
Curr Biol 2004 Jul 13 14(13):1181-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 26 Jul 2004

Polo-like kinase-2 is required for centriole duplication in mammalian cells.
Warnke S, Kemmler S, …, Fry AM, Hoffmann I
Curr Biol 2004 Jul 13 14(13):1200-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 22 Jul 2004

Proteomic characterization of the human centrosome by protein correlation profiling.
Andersen JS, Wilkinson CJ, …, Nigg EA, Mann M
Nature 2003 Dec 4 426(6966):570-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Gygi / Iain Hagan
Evaluated 9 Jun 2004

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells.
Lindon C, Pines J
J Cell Biol 2004 Jan 19 164(2):233-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen / Iain Hagan
Evaluated 9 Jun 2004

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase.
Yoo HY, Kumagai A, …, Shevchenko A, Dunphy WG
Cell 2004 May 28 117(5):575-88 [abstract on PubMed] [related articles] [order article]
Selected by | Iain Hagan / Sally Kornbluth
Evaluated 9 Jun 2004

Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast.
Gillett ES, Espelin CW, Sorger PK
J Cell Biol 2004 Feb 16 164(4):535-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Kevin Hardwick
Evaluated 14 Apr 2004

Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB.
Morrell JL, Tomlin GC, …, Balasubramanian MK, Gould KL
Curr Biol 2004 Apr 6 14(7):579-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan
Evaluated 7 Apr 2004

Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles.
Okano-Uchida T, Okumura E, …, Tachibana K, Kishimoto T
EMBO J 2003 Oct 15 22(20):5633-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 20 Nov 2003

SAS-4 is a C. elegans centriolar protein that controls centrosome size.
Kirkham M, Müller-Reichert T, …, Grill S, Hyman AA
Cell 2003 Feb 21 112(4):575-87 [abstract on PubMed] [related articles] [order article]
Selected by | David Greenstein / Bodo Lange / Iain Hagan
Evaluated 18 Nov 2003

Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans.
O'Toole ET, McDonald KL, …, Hyman AA, Müller-Reichert T
J Cell Biol 2003 Nov 10 163(3):451-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Inke Nathke
Evaluated 14 Nov 2003

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.
Neef R, Preisinger C, …, Mayer TU, Barr FA
J Cell Biol 2003 Sep 1 162(5):863-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Viki Allan / Michael B. Yaffe / Iain Hagan
Evaluated 13 Nov 2003

Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication.
Kilmartin JV
J Cell Biol 2003 Sep 29 162(7):1211-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michel Bornens / Iain Hagan / Bodo Lange
Evaluated 13 Nov 2003

Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.
Yamashita YM, Jones DL, Fuller MT
Science 2003 Sep 12 301(5639):1547-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andreas Wodarz / Mariann Bienz / Sally Temple / Mark Van Doren / Jeffrey Axelrod / Iain Hagan / Inke Nathke
Evaluated 13 Nov 2003

Targets of the cyclin-dependent kinase Cdk1.
Ubersax JA, Woodbury EL, …, Shokat KM, Morgan DO
Nature 2003 Oct 23 425(6960):859-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan / Kevin Hardwick / Arp Schnittger
Evaluated 7 Nov 2003

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
Elia AE, Rellos P, …, Smerdon SJ, Yaffe MB
Cell 2003 Oct 3 115(1):83-95 [abstract on PubMed] [related articles] [order article]
Selected by | Iain Hagan / Peter Jackson
Evaluated 4 Nov 2003

Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control.
Harvey SL, Kellogg DR
Curr Biol 2003 Feb 18 13(4):264-75 [abstract on PubMed] [related articles] [order article]
Selected by | Iain Hagan
Evaluated 6 May 2003

Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Wang Y, Shirogane T, …, Harper JW, Elledge SJ
Cell 2003 Mar 7 112(5):697-709 [abstract on PubMed] [related articles] [order article]
Selected by | Iain Hagan
Evaluated 13 Mar 2003

The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.
Schuyler SC, Liu JY, Pellman D
J Cell Biol 2003 Feb 17 160(4):517-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 13 Mar 2003

Active cyclin B1-Cdk1 first appears on centrosomes in prophase.
Jackman M, Lindon C, Nigg EA, Pines J
Nat Cell Biol 2003 Feb 5(2):143-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan / Michael B. Yaffe / Anthony Means / Francis Barr
Evaluated 17 Feb 2003

Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions.
Maekawa H, Usui T, Knop M, Schiebel E
EMBO J 2003 Feb 3 22(3):438-49 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kerry Bloom / Tomoyuki Tanaka / Iain Hagan
Evaluated 13 Feb 2003

Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.
Yoon HJ, Feoktistova A, …, Link AJ, Gould KL
Curr Biol 2002 Dec 10 12(23):2048-54 [abstract on PubMed] [related articles] [order article]
Selected by | Orna Cohen-Fix / Iain Hagan
Evaluated 13 Feb 2003

Identification of a MAD2-binding protein, CMT2, and its role in mitosis.
Habu T, Kim SH, Weinstein J, Matsumoto T
EMBO J 2002 Dec 2 21(23):6419-28 [abstract on PubMed] [related articles] [order article]
Selected by | Iain Hagan / Angelika Amon
Evaluated 13 Feb 2003

The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint.
Iouk T, Kerscher O, …, Basrai MA, Wozniak RW
J Cell Biol 2002 Dec 9 159(5):807-19 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Orna Cohen-Fix / Pamela Silver / Iain Hagan
Evaluated 13 Feb 2003

Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation.
Janke C, Ortíz J, …, Lechner J, Schiebel E
EMBO J 2002 Jan 15 21(1-2):181-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 4 Feb 2002

The mitotic spindle is required for loading of the DASH complex onto the kinetochore.
Li Y, Bachant J, …, Qin J, Elledge SJ
Genes Dev 2002 Jan 15 16(2):183-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 1 Feb 2002

Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex.
Pereira G, Tanaka TU, Nasmyth K, Schiebel E
EMBO J 2001 Nov 15 20(22):6359-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Angelika Amon
Evaluated 29 Jan 2002

S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.
Krapp A, Schmidt S, Cano E, Simanis V
Curr Biol 2001 Oct 16 11(20):1559-68 [abstract on PubMed] [related articles] [order article]
Selected by | Iain Hagan / Kathleen Gould
Evaluated 22 Nov 2001

Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.
Wigge PA, Jensen ON, …, Mann M, Kilmartin JV
J Cell Biol 1998 May 18 141(4):967-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan
Evaluated 29 Oct 2001

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