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Thomas Nystrom
CMB-Microbiology, Goteborg University, Goteborg, Sweden

Faculty Member: Microbiology > Microbial Growth & Development [ since 4 July 2001 ]
[ Evaluations ]
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Evaluations

A mechanism for asymmetric segregation of age during yeast budding.
Shcheprova Z, Baldi S, …, Gonnet G, Barral Y
Nature 2008 Aug 7 454(7205):728-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yukiko Yamashita / Thomas Nystrom / Audrey Gasch / Karsten Weis / June Kwon-Chung
Evaluated 20 Aug 2008

Asymmetric mitosis: Unequal segregation of proteins destined for degradation.
Fuentealba LC, Eivers E, …, Taelman V, De Robertis EM
Proc Natl Acad Sci U S A 2008 Jun 3 105(22):7732-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 17 Jul 2008

Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants.
Ruan H, Wu CF
Proc Natl Acad Sci U S A 2008 May 27 105(21):7506-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Promislow / Thomas Nystrom
Evaluated 2 Jun 2008

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
Steffen KK, MacKay VL, …, Kennedy BK, Kaeberlein M
Cell 2008 Apr 18 133(2):292-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nektarios Tavernarakis / Thomas Nystrom
Evaluated 28 May 2008

The ATPase SpoIIIE Transports DNA across Fused Septal Membranes during Sporulation in Bacillus subtilis.
Burton BM, Marquis KA, …, Rapoport TA, Rudner DZ
Cell 2007 Dec 28 131(7):1301-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 11 Jan 2008

A common mechanism of cellular death induced by bactericidal antibiotics.
Kohanski MA, Dwyer DJ, …, Lawrence CA, Collins JJ
Cell 2007 Sep 7 130(5):797-810 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom / Marc Fontecave / C. Hal Jones
Evaluated 19 Oct 2007

Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes.
Rujano MA, Bosveld F, …, Sibon OC, Kampinga HH
PLoS Biol 2006 Dec 4(12):e417 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 16 Jul 2007

Regulation of Drosophila life span by olfaction and food-derived odors.
Libert S, Zwiener J, …, Roman G, Pletcher SD
Science 2007 Feb 23 315(5815):1133-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kim Hughes / Thomas Nystrom
Evaluated 4 May 2007

Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.
Umeda-Kameyama Y, Tsuda M, …, Ohuchi Y, Aigaki T
J Biol Chem 2007 Apr 13 282(15):11180-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 2 Mar 2007

Opposing activities protect against age-onset proteotoxicity.
Cohen E, Bieschke J, …, Kelly JW, Dillin A
Science 2006 Sep 15 313(5793):1604-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Pamela Larsen / Thomas Nystrom
Evaluated 15 Jan 2007

Detection and quantification of superoxide formed within the periplasm of Escherichia coli.
Korshunov S, Imlay JA
J Bacteriol 2006 Sep 188(17):6326-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 25 Oct 2006

Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis.
Miyoshi N, Oubrahim H, Chock PB, Stadtman ER
Proc Natl Acad Sci U S A 2006 Feb 7 103(6):1727-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 20 Sep 2006

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Mostoslavsky R, Chua KF, …, Yancopoulos GD, Alt FW
Cell 2006 Jan 27 124(2):315-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 2 Jun 2006

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.
Ford E, Voit R, …, Grummt I, Guarente L
Genes Dev 2006 May 1 20(9):1075-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 2 Jun 2006

Cellular senescence in aging primates.
Herbig U, Ferreira M, …, Carey D, Sedivy JM
Science 2006 Mar 3 311(5765):1257 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jan Hoeijmakers / Thomas Nystrom
Evaluated 5 Apr 2006

Evidence that the SpoIIIE DNA translocase participates in membrane fusion during cytokinesis and engulfment.
Liu NJ, Dutton RJ, Pogliano K
Mol Microbiol 2006 Feb 59(4):1097-113 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 13 Feb 2006

Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae.
Khan MA, Chock PB, Stadtman ER
Proc Natl Acad Sci U S A 2005 Nov 29 102(48):17326-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 12 Jan 2006

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.
Nisoli E, Tonello C, …, Moncada S, Carruba MO
Science 2005 Oct 14 310(5746):314-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 9 Nov 2005


Suppression of aging in mice by the hormone Klotho.
Kurosu H, Yamamoto M, …, Rosenblatt KP, Kuro-o M
Science 2005 Sep 16 309(5742):1829-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthew Breyer / William H. Colledge / Thomas Nystrom
Evaluated 27 Sep 2005

HST2 mediates SIR2-independent life-span extension by calorie restriction.
Lamming DW, Latorre-Esteves M, …, Lin SJ, Sinclair DA
Science 2005 Sep 16 309(5742):1861-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Charles Brenner / Thomas Nystrom
Evaluated 24 Aug 2005

Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation.
Liou GG, Tanny JC, …, Walz T, Moazed D
Cell 2005 May 20 121(4):515-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hiten Madhani / Dieter Wolf / Peter B. Becker / Thomas Nystrom
Evaluated 30 Jun 2005

Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
Domergue R, Castaño I, …, Johnson D, Cormack BP
Science 2005 May 6 308(5723):866-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Hiten Madhani / Charles Brenner / Gloria Rudenko / Thomas Nystrom / Emanuela Handman
Evaluated 25 May 2005

Extension of murine life span by overexpression of catalase targeted to mitochondria.
Schriner SE, Linford NJ, …, Wallace DC, Rabinovitch PS
Science 2005 Jun 24 308(5730):1909-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | M. Flint Beal / Heinz Osiewacz / Thomas Nystrom
Evaluated 25 May 2005

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.
Parker JA, Arango M, …, Catoire H, Néri C
Nat Genet 2005 Apr 37(4):349-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 7 Apr 2005

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
Sauve AA, Moir RD, Schramm VL, Willis IM
Mol Cell 2005 Feb 18 17(4):595-601 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 4 Mar 2005

TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.
Martin DE, Soulard A, Hall MN
Cell 2004 Dec 29 119(7):969-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mike Bevan / Thomas Nystrom / Jurg Bahler / Sergio Moreno
Evaluated 14 Jan 2005

An alternative strategy for bacterial ribosome synthesis: Bacillus subtilis rRNA transcription regulation.
Krásný L, Gourse RL
EMBO J 2004 Nov 10 23(22):4473-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 28 Oct 2004

Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae.
Barros MH, Bandy B, Tahara EB, Kowaltowski AJ
J Biol Chem 2004 Nov 26 279(48):49883-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 21 Oct 2004

Sir2-independent life span extension by calorie restriction in yeast.
Kaeberlein M, Kirkland KT, Fields S, Kennedy BK
PLoS Biol 2004 Sep 2(9):E296 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom / James Stivers / Susan Gasser
Evaluated 7 Sep 2004

Activation of chaperone-mediated autophagy during oxidative stress.
Kiffin R, Christian C, Knecht E, Cuervo AM
Mol Biol Cell 2004 Nov 15(11):4829-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 7 Sep 2004

DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP.
Paul BJ, Barker MM, …, Foster JW, Gourse RL
Cell 2004 Aug 6 118(3):311-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Nystrom
Evaluated 20 Aug 2004

A role for the actin cytoskeleton in cell death and aging in yeast.
Gourlay CW, Carpp LN, …, Winder SJ, Ayscough KR
J Cell Biol 2004 Mar 15 164(6):803-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Thomas Nystrom
Evaluated 11 May 2004

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Brunet A, Sweeney LB, …, Alt FW, Greenberg ME
Science 2004 Mar 26 303(5666):2011-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 11 May 2004

Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study.
Bolon DN, Wah DA, …, Baker TA, Sauer RT
Mol Cell 2004 Feb 13 13(3):443-9 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 3 Mar 2004

Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span.
Stumpferl SW, Stephan O, Osiewacz HD
Eukaryot Cell 2004 Feb 3(1):200-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 3 Mar 2004

The distribution of RNA polymerase in Escherichia coli is dynamic and sensitive to environmental cues.
Cabrera JE, Jin DJ
Mol Microbiol 2003 Dec 50(5):1493-505 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 15 Jan 2004

Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.
Gstaiger M, Luke B, …, Peter M, Krek W
Science 2003 Nov 14 302(5648):1208-12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 27 Nov 2003

An age-induced switch to a hyper-recombinational state.
McMurray MA, Gottschling DE
Science 2003 Sep 26 301(5641):1908-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom / Stephen Jackson / Ernst Hafen / Roy Long / Robin Allshire
Evaluated 7 Oct 2003

Control of rRNA expression by small molecules is dynamic and nonredundant.
Murray HD, Schneider DA, Gourse RL
Mol Cell 2003 Jul 12(1):125-34 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom / Jonathan R. Warner
Evaluated 17 Sep 2003

Plasmid accumulation reduces life span in Saccharomyces cerevisiae.
Falcón AA, Aris JP
J Biol Chem 2003 Oct 24 278(43):41607-17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 1 Sep 2003

RelE toxins from bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA.
Christensen SK, Gerdes K
Mol Microbiol 2003 Jun 48(5):1389-400 [abstract on PubMed] [related articles] [order article]
Selected by | Hiroji Aiba / Thomas Nystrom
Evaluated 16 Jul 2003

Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.
Flynn JM, Neher SB, …, Sauer RT, Baker TA
Mol Cell 2003 Mar 11(3):671-83 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 15 Apr 2003

A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis.
O'Toole R, Smeulders MJ, …, Lougheed K, Williams HD
J Bacteriol 2003 Mar 185(5):1543-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 13 Mar 2003

Contrasting sensitivities of Escherichia coli aconitases A and B to oxidation and iron depletion.
Varghese S, Tang Y, Imlay JA
J Bacteriol 2003 Jan 185(1):221-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 28 Jan 2003

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
Onyango P, Celic I, …, Boeke JD, Feinberg AP
Proc Natl Acad Sci U S A 2002 Oct 15 99(21):13653-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jorge C. Escalante-Semerena / Thomas Nystrom
Evaluated 10 Dec 2002

Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival.
Somerville GA, Chaussee MS, …, Reitzer LJ, Musser JM
Infect Immun 2002 Nov 70(11):6373-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 10 Dec 2002

The cellular level of the recognition factor RssB is rate-limiting for sigmaS proteolysis: implications for RssB regulation and signal transduction in sigmaS turnover in Escherichia coli.
Pruteanu M, Hengge-Aronis R
Mol Microbiol 2002 Sep 45(6):1701-13 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 12 Nov 2002

The sigma(70) subunit of RNA polymerase is contacted by the (lambda)Q antiterminator during early elongation.
Nickels BE, Roberts CW, …, Roberts JW, Hochschild A
Mol Cell 2002 Sep 10(3):611-22 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 8 Nov 2002

Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus.
Pasero P, Bensimon A, Schwob E
Genes Dev 2002 Oct 1 16(19):2479-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 15 Oct 2002

DnaK-sigma 32 interaction is temperature-dependent. Implication for the mechanism of heat shock response.
Chattopadhyay R, Roy S
J Biol Chem 2002 Sep 13 277(37):33641-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 24 Sep 2002

Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae.
Cabiscol E, Bellí G, …, Herrero E, Ros J
J Biol Chem 2002 Nov 15 277(46):44531-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 9 Sep 2002

DksA affects ppGpp induction of RpoS at a translational level.
Brown L, Gentry D, Elliott T, Cashel M
J Bacteriol 2002 Aug 184(16):4455-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom / Jorge C. Escalante-Semerena
Evaluated 23 Aug 2002

Characterization of HscC (Hsc62), homologue of Hsp70 in Escherichia coli: over-expression of HscC modulates the activity of house keeping sigma factor sigma70.
Arifuzzaman M, Oshima T, Nakade S, Mori H
Genes Cells 2002 Jun 7(6):553-66 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 25 Jun 2002

Mitochondria are morphologically and functionally heterogeneous within cells.
Collins TJ, Berridge MJ, Lipp P, Bootman MD
EMBO J 2002 Apr 2 21(7):1616-27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Andrews / Thomas Nystrom
Evaluated 28 May 2002

Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes.
Fratelli M, Demol H, …, Gianazza E, Ghezzi P
Proc Natl Acad Sci U S A 2002 Mar 19 99(6):3505-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 15 Apr 2002

ClpS, a substrate modulator of the ClpAP machine.
Dougan DA, Reid BG, Horwich AL, Bukau B
Mol Cell 2002 Mar 9(3):673-83 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom / Regine Hengge
Evaluated 15 Apr 2002

FtsK Is a DNA motor protein that activates chromosome dimer resolution by switching the catalytic state of the XerC and XerD recombinases.
Aussel L, Barre FX, …, Stasiak AZ, Sherratt D
Cell 2002 Jan 25 108(2):195-205 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom / Piet de Boer
Evaluated 21 Feb 2002

hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.
Merker RJ, Klein HL
Mol Cell Biol 2002 Jan 22(2):421-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 7 Feb 2002

rpoS mutations and loss of general stress resistance in Escherichia coli populations as a consequence of conflict between competing stress responses.
Notley-McRobb L, King T, Ferenci T
J Bacteriol 2002 Feb 184(3):806-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 6 Feb 2002

Isolation and characterization of sigma(70)-retaining transcription elongation complexes from Escherichia coli.
Bar-Nahum G, Nudler E
Cell 2001 Aug 24 106(4):443-51 [abstract on PubMed] [related articles] [order article]
Selected by |
Evaluated 24 Jan 2002

Structure of the universal stress protein of Haemophilus influenzae.
Sousa MC, McKay DB
Structure 2001 Dec 9(12):1135-41 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nystrom
Evaluated 18 Jan 2002

The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species.
Helmerhorst EJ, Troxler RF, Oppenheim FG
Proc Natl Acad Sci U S A 2001 Dec 4 98(25):14637-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 18 Jan 2002

Folding properties of the nucleotide exchange factor GrpE from Thermus thermophilus: GrpE is a thermosensor that mediates heat shock response.
Groemping Y, Reinstein J
J Mol Biol 2001 Nov 16 314(1):167-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Franz Schmid / Thomas Nystrom
Evaluated 18 Jan 2002

Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein.
Ostergaard H, Henriksen A, Hansen FG, Winther JR
EMBO J 2001 Nov 1 20(21):5853-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Phil Mullineaux / Thomas Nystrom / Karin Romisch
Evaluated 18 Dec 2001

Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli.
Seaver LC, Imlay JA
J Bacteriol 2001 Dec 183(24):7173-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Nystrom
Evaluated 18 Dec 2001

Improvement of reading frame maintenance is a common function for several tRNA modifications.
Urbonavicius J, Qian Q, …, Hagervall TG, Björk GR
EMBO J 2001 Sep 3 20(17):4863-73 [