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Len Neckers
Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health (NIH), Rockville, United States of America

Faculty Member: Cell Biology > Control of Gene Expression [ since 24 February 2003 ]
[ Evaluations ]
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Evaluations

Survival of cancer cells is maintained by EGFR independent of its kinase activity.
Weihua Z, Tsan R, …, Fidler IJ, Hung MC
Cancer Cell 2008 May 13(5):385-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Isaac Kohane / Sjur Olsnes / Len Neckers
Evaluated 16 Jun 2008

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.
Zhai RG, Zhang F, …, Haueter CM, Bellen HJ
Nature 2008 Apr 17 452(7189):887-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 24 Apr 2008

The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
Zudaire E, Cuesta N, …, Birrer M, Cuttitta F
J Clin Invest 2008 Jan 2 [abstract on PubMed] [related articles] [full text]
Selected by | Len Neckers
Evaluated 15 Jan 2008

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.
Kang BH, Plescia J, …, Doxsey SJ, Altieri DC
Cell 2007 Oct 19 131(2):257-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Surender Kharbanda / Atan Gross / Robert Abraham / Len Neckers
Evaluated 21 Dec 2007

The Golgi-associated protein GRASP is required for unconventional protein secretion during development.
Kinseth MA, Anjard C, …, Loomis WF, Malhotra V
Cell 2007 Aug 10 130(3):524-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Graham Warren / Len Neckers
Evaluated 13 Sep 2007

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
Julien SG, Dubé N, …, Muller WJ, Tremblay ML
Nat Genet 2007 Mar 39(3):338-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers / Jonathan Chernoff
Evaluated 23 May 2007

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.
Westhoff B, Chapple JP, …, Höhfeld J, Cheetham ME
Curr Biol 2005 Jun 7 15(11):1058-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Douglas Cyr / Len Neckers
Evaluated 25 Apr 2007

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.
Sergina NV, Rausch M, …, Shokat KM, Moasser MM
Nature 2007 Jan 25 445(7126):437-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Abraham / Ruth Roberts / Len Neckers / Karen Anderson
Evaluated 8 Feb 2007


The nuclear receptor LXR is a glucose sensor.
Mitro N, Mak PA, …, Kreusch A, Saez E
Nature 2007 Jan 11 445(7124):219-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Axel Nohturfft / Paul Webb / Len Neckers
Evaluated 8 Feb 2007

HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
Wang SE, Narasanna A, …, Muthuswamy SK, Arteaga CL
Cancer Cell 2006 Jul 10(1):25-38 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 19 Sep 2006


A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.
Shore EM, Xu M, …, Brown MA, Kaplan FS
Nat Genet 2006 May 38(5):525-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Graham / Len Neckers
Evaluated 16 Jun 2006


Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted.
Langbein S, Zerilli M, …, Schubert P, Coy JF
Br J Cancer 2006 Feb 27 94(4):578-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 5 May 2006

Progressive disruption of cellular protein folding in models of polyglutamine diseases.
Gidalevitz T, Ben-Zvi A, …, Brignull HR, Morimoto RI
Science 2006 Mar 10 311(5766):1471-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers / Veronica van Heyningen
Evaluated 22 Feb 2006

The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
Wandinger SK, Suhre MH, Wegele H, Buchner J
EMBO J 2006 Jan 25 25(2):367-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers
Evaluated 20 Jan 2006

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.
Katsuno M, Sang C, …, Doyu M, Sobue G
Proc Natl Acad Sci U S A 2005 Nov 15 102(46):16801-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers
Evaluated 20 Dec 2005

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
Dahia PL, Ross KN, …, Li C, Stiles CD
PLoS Genet 2005 Jul 1(1):72-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers
Evaluated 18 Oct 2005

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Lee S, Nakamura E, …, Kaelin WG, Schlisio S
Cancer Cell 2005 Aug 8(2):155-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle / Len Neckers
Evaluated 2 Sep 2005

Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer.
Ruden DM, Xiao L, Garfinkel MD, Lu X
Hum Mol Genet 2005 Apr 15 14 Spec No 1:R149-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers
Evaluated 13 Jul 2005

Rational design of shepherdin, a novel anticancer agent.
Plescia J, Salz W, …, Colombo G, Altieri DC
Cancer Cell 2005 May 7(5):457-68 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 9 Jun 2005

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.
Kovacs JJ, Murphy PJ, …, Pratt WB, Yao TP
Mol Cell 2005 May 27 18(5):601-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers / Cheng-Ming Chiang
Evaluated 8 Jun 2005

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Selak MA, Armour SM, …, Thompson CB, Gottlieb E
Cancer Cell 2005 Jan 7(1):77-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 21 Jan 2005

Gastric cancer originating from bone marrow-derived cells.
Houghton J, Stoicov C, …, Goldenring JR, Wang TC
Science 2004 Nov 26 306(5701):1568-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers / Charles Coutelle
Evaluated 14 Dec 2004

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
Nakayama K, Frew IJ, …, Bowtell DD, Ronai Z
Cell 2004 Jun 25 117(7):941-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 6 Jul 2004

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.
Meyer P, Prodromou C, …, Piper PW, Pearl LH
EMBO J 2004 Feb 11 23(3):511-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Len Neckers
Evaluated 4 Mar 2004

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.
Kamal A, Thao L, …, Fritz LC, Burrows FJ
Nature 2003 Sep 25 425(6956):407-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolfgang Jahnke / Len Neckers
Evaluated 29 Oct 2003

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