homefeedbacksupportlog on 19-Nov-2008 
  About F1000

 What is F1000 Biology?
 Key features
 How it's organized
 FAQs
 Faculties and sections
 Scope of sections
 List of Faculty Members
 The evaluation system
 Citing F1000
 Take a tour of the site
 Accessing fulltexts
 PubMed linkout
 How to subscribe
 Academic subscriptions
 Corporate subscriptions
 Try F1000 for free
 Who we are
 Media information
 Librarian resources
 Press releases
 In the press
 Developing countries
 F1000 Medicine
 Terms and conditions
 Privacy policy
 Contact us


John Proudfoot
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, United States of America

Faculty Member: Pharmacology & Drug Discovery > Drug Discovery & Design [ since 3 April 2007 ]
[ Evaluations ]
to email [Help]
Evaluations

Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding.
Young T, Abel R, …, Berne BJ, Friesner RA
Proc Natl Acad Sci U S A 2007 Jan 16 104(3):808-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Proudfoot
Evaluated 29 Oct 2008

A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery.
Hellerstein MK
Metab Eng 2008 Jan 10(1):1-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Proudfoot
Evaluated 11 Aug 2008


Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit.
Ippolito JA, Kanyo ZF, …, Steitz TA, Duffy EM
J Med Chem 2008 May 22 0 [abstract on PubMed] [related articles] [full text]
Selected by | John Proudfoot
Evaluated 28 May 2008


Combination of Virtual Screening and High Throughput Gene Profiling for Identification of Novel Liver X Receptor Modulators.
Cheng JF, Zapf J, …, Jack R, Xu K
J Med Chem 2008 Mar 7 [abstract on PubMed] [related articles] [full text]
Selected by | John Proudfoot
Evaluated 3 Apr 2008

Predicting Key Example Compounds in Competitors' Patent Applications Using Structural Information Alone.
Hattori K, Wakabayashi H, Tamaki K
J Chem Inf Model 2008 Jan 5 [abstract on PubMed] [related articles] [full text]
Selected by | Jefferson Tilley / John Proudfoot
Evaluated 24 Jan 2008

Sila-Haloperidol, a Silicon Analogue of the Dopamine (D(2)) Receptor Antagonist Haloperidol: Synthesis, Pharmacological Properties, and Metabolic Fate.
Tacke R, Popp F, …, Jurva U, Wellner E
ChemMedChem 2008 Jan 11 3(1):152-164 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Proudfoot
Evaluated 6 Dec 2007

Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells.
Awais M, Sato M, Umezawa Y
Chembiochem 2007 May 7 8(7):737-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Proudfoot
Evaluated 25 Oct 2007

Nicotinic acid receptor agonists differentially activate downstream effectors.
Richman JG, Kanemitsu-Parks M, …, Semple G, Connolly DT
J Biol Chem 2007 Jun 22 282(25):18028-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Proudfoot
Evaluated 17 Aug 2007

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.
Black WC, Bayly CI, …, Tsou N, Zamboni R
Bioorg Med Chem Lett 2005 Nov 1 15(21):4741-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Proudfoot
Evaluated 29 Jun 2007

DrugBank: a comprehensive resource for in silico drug discovery and exploration.
Wishart DS, Knox C, …, Chang Z, Woolsey J
Nucleic Acids Res 2006-01-01 34(Database issue):D668-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Celerino Abad-Zapatero / John Proudfoot
Evaluated 30 Apr 2007

Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc.
Price DA, Armour D, …, Stammen BL, Wood A
Bioorg Med Chem Lett 2006 Sep 1 16(17):4633-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Proudfoot
Evaluated 30 Apr 2007

^Top  Back to Faculty Members


© 1999-2008 Biology Reports Ltd unless otherwise stated. < info@f1000.com >   Terms and conditions   Legal info