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Joe Heitman
Program in Genetics, Duke University Medical Center, Durham, United States of America

Faculty Member: MICROBIOLOGY > Microbial growth & development [ since 4 July 2001 ]
[ Sponsorship ] [ Biography ] [ Homepage ] [ Evaluations ]
Sponsorship

Joe Heitman sponsors free access to F1000 for KwaZulu-Natal University, South Africa. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

Joseph Heitman, MD, PhD is James B. Duke professor in the Departments of Molecular Genetics and Microbiology, Pharmacology and Cancer Biology, and Medicine at Duke University, director of the Center for Microbial Pathogenesis, and director of the Duke University Program in Genetics and Genomics. His research focuses on how cells sense extracellular cues via signal transduction cascades, the evolution and molecular basis of fungal virulence, the role of the mating type locus in the establishment of cell type identity, and novel antifungal therapeutic approaches.
He is a recipient of the Burroughs Wellcome Scholar Award in Molecular Pathogenic Mycology, the 2002 ASBMB AMGEN award for significant contributions using molecular biology to our understanding of human disease, and the 2003 Squibb Award from the Infectious Diseases Society of America (IDSA) for outstanding contributions to infectious disease research. Dr. Heitman has been an instructor since 1998 at the Woods Hole Molecular Mycology Course at Woods Hole, MA, is an editor of the ASM journal Eukaryotic Cell, was elected a member of the American Society for Clinical Investigation (ASCI) in 2003, a fellow of the Infectious Diseases Society of America (IDSA) in 2003, a fellow of the American Academy of Microbiology in 2004, and a fellow of the American Association for the Advancement of Science (AAAS) in 2004. Dr. Heitman was also an investigator of the Howard Hughes Medical Institute from 1992 to 2005.


Telephone: 919-684-2824
email: heitm001@duke.edu

Home page

http://mgm.duke.edu/microbial/mycology/heitman/

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Evaluations

The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.
Nakashima A, Maruki Y, …, Yonezawa K, Kamada Y
PLoS ONE 2008 3(5):e2223 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman with Cecelia Shertz and Maria E. Cardenas
Evaluated 23 Jun 2008

Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi.
Corradi N, Akiyoshi DE, …, Tzipori S, Keeling PJ
PLoS ONE 2007 2(12):e1277 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman with Soo Chan Lee
Evaluated 20 Jun 2008

Evidence for karyogamy and exchange of genetic material in the binucleate intestinal parasite Giardia intestinalis.
Poxleitner MK, Carpenter ML, …, Dawson SC, Cande WZ
Science 2008 Mar 14 319(5869):1530-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Upinder Singh / Jacqueline Upcroft / Joe Heitman
Evaluated 20 Jun 2008

Evidence of recombination in mixed-mating-type and alpha-only populations of Cryptococcus gattii sourced from single eucalyptus tree hollows.
Saul N, Krockenberger M, Carter D
Eukaryot Cell 2008 Apr 7(4):727-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 22 May 2008

Long-distance dispersal and recombination in environmental populations of Cryptococcus neoformans var. grubii from India.
Hiremath SS, Chowdhary A, …, Sun S, Xu J
Microbiology 2008 May 154(Pt 5):1513-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 22 May 2008

Unicellular Ca2+ Signaling 'Toolkit' at the Origin of Metazoa.
Cai X
Mol Biol Evol 2008 Apr 2 [abstract on PubMed] [related articles] [full text]
Selected by | Joe Heitman
Evaluated 22 May 2008

A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.
Tsaousis AD, Kunji ER, …, Hirt RP, Embley TM
Nature 2008 Apr 30 [abstract on PubMed] [related articles] [full text]
Selected by | Joe Heitman with Edmond Byrnes
Evaluated 21 May 2008

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
King N, Westbrook MJ, …, Grigoriev IV, Rokhsar D
Nature 2008 Feb 14 451(7180):783-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Max Telford / Rafael Zardoya / Charles Streuli / Laura Landweber / Joe Heitman
Evaluated 19 May 2008

Identification of mating type genes in the bipolar basidiomycetous yeast Rhodosporidium toruloides: first insight into the MAT locus structure of the Sporidiobolales.
Coelho MA, Rosa A, …, Fonseca A, Gonçalves P
Eukaryot Cell 2008 Apr 11 [abstract on PubMed] [related articles] [full text]
Selected by | Joe Heitman
Evaluated 15 May 2008

AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles.
Takahashi F, Yamagata D, …, Wada M, Kataoka H
Proc Natl Acad Sci U S A 2007 Dec 4 104(49):19625-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 11 Jan 2008

Kwoniella mangroviensis gen. nov., sp. nov. (Tremellales, Basidiomycota), a teleomorphic yeast from mangrove habitats in the Florida Everglades and Bahamas.
Statzell-Tallman A, Belloch C, Fell JW
FEMS Yeast Res 2008 Jan 8(1):103-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 20 Dec 2007

Evolution of nematode-trapping cells of predatory fungi of the Orbiliaceae based on evidence from rRNA-encoding DNA and multiprotein sequences.
Yang Y, Yang E, An Z, Liu X
Proc Natl Acad Sci U S A 2007 May 15 104(20):8379-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 19 Dec 2007

Genetic variation in a human odorant receptor alters odour perception.
Keller A, Zhuang H, …, Vosshall LB, Matsunami H
Nature 2007 Sep 27 449(7161):468-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Garrity / Joe Heitman
Evaluated 1 Nov 2007

Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora.
Levy O, Appelbaum L, …, Miller DJ, Hoegh-Guldberg O
Science 2007 Oct 19 318(5849):467-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 1 Nov 2007

Blue-light-activated histidine kinases: two-component sensors in bacteria.
Swartz TE, Tseng TS, …, Briggs WR, Bogomolni RA
Science 2007 Aug 24 317(5841):1090-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Spiro / Emmanuel Liscum / Joe Heitman
Evaluated 1 Nov 2007

DNA sequence characterization and molecular evolution of MAT1 and MAT2 mating-type loci of the self-compatible ascomycete mold Neosartorya fischeri.
Rydholm C, Dyer PS, Lutzoni F
Eukaryot Cell 2007 May 6(5):868-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 5 Sep 2007

Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans.
Paoletti M, Seymour FA, …, Archer DB, Dyer PS
Curr Biol 2007 Aug 21 17(16):1384-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 5 Sep 2007

In vivo and in vitro anaerobic mating in Candida albicans.
Dumitru R, Navarathna DH, …, Atkin AL, Nickerson KW
Eukaryot Cell 2007 Mar 6(3):465-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Juergen Wendland / Joe Heitman
Evaluated 16 Aug 2007

Virulence is positively selected by transmission success between mammalian hosts.
Wickham ME, Brown NF, …, Coombes BK, Finlay BB
Curr Biol 2007 May 1 17(9):783-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | L. David Sibley / Joe Heitman
Evaluated 12 Jun 2007

Population structure and evolutionary origins of Microsporum canis, M. ferrugineum and M. audouinii.
Kaszubiak A, Klein S, de Hoog GS, Gräser Y
Infect Genet Evol 2004 Sep 4(3):179-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 12 Jun 2007

Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species.
Eremeeva ME, Gerns HL, …, Dasch GA, Koehler JE
N Engl J Med 2007 Jun 7 356(23):2381-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.
Asara JM, Schweitzer MH, …, Phillips M, Cantley LC
Science 2007 Apr 13 316(5822):280-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.
Jung WH, Sham A, White R, Kronstad JW
PLoS Biol 2006 Nov 4(12):e410 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Guilhem Janbon / Joe Heitman
Evaluated 7 Jun 2007

Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi.
Dadachova E, Bryan RA, …, Nosanchuk JD, Casadevall A
PLoS ONE 2007 2:e457 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Coates / Joe Heitman / John Perfect
Evaluated 7 Jun 2007

Multiple losses of sex within a single genus of Microsporidia.
Ironside JE
BMC Evol Biol 2007 7:48 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans.
Schoustra SE, Debets AJ, Slakhorst M, Hoekstra RF
PLoS Genet 2007 Apr 27 3(4):e68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Reconstructing the early evolution of Fungi using a six-gene phylogeny.
James TY, Kauff F, …, Spatafora JW, Vilgalys R
Nature 2006 Oct 19 443(7113):818-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Martin / Marcel van der Heijden / Joe Heitman
Evaluated 6 Jun 2007

An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Dong B, Kim S, …, Chow SA, Silverman RH
Proc Natl Acad Sci U S A 2007 Jan 30 104(5):1655-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Bryan Williams
Evaluated 6 Feb 2007

A virus in a fungus in a plant: three-way symbiosis required for thermal tolerance.
Márquez LM, Redman RS, Rodriguez RJ, Roossinck MJ
Science 2007 Jan 26 315(5811):513-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / June Kwon-Chung / Julia Kehr / Daniel Gallie / Marc Knight / Ben Lugtenberg
Evaluated 5 Feb 2007

Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans.
Huang G, Wang H, …, Chen J, Liu H
Proc Natl Acad Sci U S A 2006 Aug 22 103(34):12813-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 5 Feb 2007

Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
Urisman A, Molinaro RJ, …, Silverman RH, DeRisi JL
PLoS Pathog 2006 Mar 2(3):e25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 2 Feb 2007


Methanogenic Archaea and human periodontal disease.
Lepp PW, Brinig MM, …, Armitage GC, Relman DA
Proc Natl Acad Sci U S A 2004 Apr 20 101(16):6176-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arcady Mushegian / Joe Heitman
Evaluated 2 Feb 2007

An obesity-associated gut microbiome with increased capacity for energy harvest.
Turnbaugh PJ, Ley RE, …, Mardis ER, Gordon JI
Nature 2006 Dec 21 444(7122):1027-131 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Robertson / Joel Elmquist / Matthias Maiwald / Liang Tong / Joanna Goldberg / Marc Lecuit / Stefan Kaufmann / Joe Heitman / David Bilder
Evaluated 1 Feb 2007

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
Pan F, Sun L, …, Pardoll DM, Liu JO
Nature 2007 Jan 25 445(7126):433-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / Anthony Means
Evaluated 1 Feb 2007

Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages.
Alvarez M, Casadevall A
Curr Biol 2006 Nov 7 16(21):2161-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / June Kwon-Chung / Carol Munro / Juergen Wendland
Evaluated 23 Nov 2006

Genome-wide genetic analysis of polyploidy in yeast.
Storchová Z, Breneman A, …, O'Toole E, Pellman D
Nature 2006 Oct 5 443(7111):541-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 1 Nov 2006

After the duplication: gene loss and adaptation in Saccharomyces genomes.
Cliften PF, Fulton RS, Wilson RK, Johnston M
Genetics 172(2):863-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 1 Nov 2006

Distinct white collar-1 genes control specific light responses in Mucor circinelloides.
Silva F, Torres-Martínez S, Garre V
Mol Microbiol 2006 Aug 61(4):1023-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Identifying transcription factor functions and targets by phenotypic activation.
Chua G, Morris QD, …, Boone C, Hughes TR
Proc Natl Acad Sci U S A 2006 Aug 8 103(32):12045-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Regulation by blue light and heat shock of gene transcription in the fungus Phycomyces: proteins required for photoinduction and mechanism for adaptation to light.
Rodríguez-Romero J, Corrochano LM
Mol Microbiol 2006 Aug 61(4):1049-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

The calcineurin regulator sra plays an essential role in female meiosis in Drosophila.
Takeo S, Tsuda M, …, Matsuo T, Aigaki T
Curr Biol 2006 Jul 25 16(14):1435-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features.
Derelle E, Ferraz C, …, Van de Peer Y, Moreau H
Proc Natl Acad Sci U S A 2006 Aug 1 103(31):11647-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
Selmecki A, Forche A, Berman J
Science 2006 Jul 21 313(5785):367-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Guilhem Janbon / Carol Munro / Tamara Doering / Paula Sundstrom
Evaluated 9 Aug 2006

A phylogenomic inventory of meiotic genes; evidence for sex in Giardia and an early eukaryotic origin of meiosis.
Ramesh MA, Malik SB, Logsdon JM
Curr Biol 2005 Jan 26 15(2):185-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | C. Graham Clark / Jacqueline Upcroft / Upinder Singh / Joe Heitman
Evaluated 31 Jul 2006

Genomic and experimental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicillium marneffei.
Woo PC, Chong KT, …, Lau SK, Yuen KY
FEBS Lett 2006 Jun 12 580(14):3409-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 31 Jul 2006

The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues.
Little DY, Rao H, …, Krapp A, Malamy JE
Proc Natl Acad Sci U S A 2005 Sep 20 102(38):13693-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Brian Forde / Joe Heitman
Evaluated 31 Jul 2006

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
Cramer RA, Gamcsik MP, …, Abraham SN, Steinbach WJ
Eukaryot Cell 2006 Jun 5(6):972-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 13 Jun 2006

Feedback control of morphogenesis in fungi by aromatic alcohols.
Chen H, Fink GR
Genes Dev 2006 May 1 20(9):1150-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gerhard Braus / Mohan Balasubramanian / Joe Heitman
Evaluated 22 May 2006

Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.
Sanna B, Brandt EB, …, Benoit SC, Molkentin JD
Proc Natl Acad Sci U S A 2006 May 9 103(19):7327-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 22 May 2006

Global control of dimorphism and virulence in fungi.
Nemecek JC, Wüthrich M, Klein BS
Science 2006 Apr 28 312(5773):583-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | June Kwon-Chung / Joe Heitman
Evaluated 22 May 2006

Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function.
James TY, Srivilai P, Kües U, Vilgalys R
Genetics 2006 Mar 172(3):1877-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 21 Feb 2006

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
Belov K, Deakin JE, …, Graves JA, Miller RD
PLoS Biol 2006 Mar 4(3):e46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ted Hansen / Lutz Walter / Joe Heitman / Stephan Beck
Evaluated 15 Feb 2006


Asynchronous nuclear division cycles in multinucleated cells.
Gladfelter AS, Hungerbuehler AK, Philippsen P
J Cell Biol 2006 Jan 30 172(3):347-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Mohan Balasubramanian
Evaluated 10 Feb 2006

Birth of a metabolic gene cluster in yeast by adaptive gene relocation.
Wong S, Wolfe KH
Nat Genet 2005 Jul 37(7):777-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 24 Jan 2006

Genome sequencing and analysis of Aspergillus oryzae.
Machida M, Asai K, …, Ogasawara N, Kikuchi H
Nature 2005 Dec 22 438(7071):1157-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Joe Heitman
Evaluated 17 Jan 2006

Pathogenic fungus harbours endosymbiotic bacteria for toxin production.
Partida-Martinez LP, Hertweck C
Nature 2005 Oct 6 437(7060):884-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Leo Eberl / June Kwon-Chung / Joern Piel / Pascale Cossart / Joe Heitman
Evaluated 15 Dec 2005

The role of innate immune responses in the outcome of interspecies competition for colonization of mucosal surfaces.
Lysenko ES, Ratner AJ, Nelson AL, Weiser JN
PLoS Pathog 2005 Sep 1(1):e1 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Eric Denkers / Joe Heitman / Scott Gray-Owen / Lalita Ramakrishnan
Evaluated 4 Nov 2005

BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis.
Kojic M, Kostrub CF, Buchman AR, Holloman WK
Mol Cell 2002 Sep 10(3):683-91 [abstract on PubMed] [related articles] [order article]
Selected by | Joe Heitman
Evaluated 3 Nov 2005

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.
Gantner BN, Simmons RM, Underhill DM
EMBO J 2005 Mar 23 24(6):1277-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Paula Sundstrom / Siamon Gordon / Joe Heitman
Evaluated 3 Nov 2005

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.
Cowen LE, Lindquist S
Science 2005 Sep 30 309(5744):2185-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Wiley Schell
Evaluated 10 Oct 2005

Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis.
Gutierrez MC, Brisse S, …, Supply P, Vincent V
PLoS Pathog 2005 Sep 1(1):e5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Julian Parkhill
Evaluated 29 Sep 2005

Yeast model uncovers dual roles of mitochondria in action of artemisinin.
Li W, Mo W, …, Gitschier JM, Zhou B
PLoS Genet 2005 Sep 1(3):e36 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / L. David Sibley
Evaluated 29 Sep 2005

In vitro generation of infectious scrapie prions.
Castilla J, Saá P, Hetz C, Soto C
Cell 2005 Apr 22 121(2):195-206 [abstract on PubMed] [related articles] [full text] [order article