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Joe Heitman
Program in Genetics, Duke University Medical Center, Durham, United States of America

Faculty Member: Microbiology > Microbial Growth & Development [ since 4 July 2001 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Joseph Heitman, MD, PhD is James B. Duke professor in the Departments of Molecular Genetics and Microbiology, Pharmacology and Cancer Biology, and Medicine at Duke University, director of the Center for Microbial Pathogenesis, and director of the Duke University Program in Genetics and Genomics. His research focuses on how cells sense extracellular cues via signal transduction cascades, the evolution and molecular basis of fungal virulence, the role of the mating type locus in the establishment of cell type identity, and novel antifungal therapeutic approaches.
He is a recipient of the Burroughs Wellcome Scholar Award in Molecular Pathogenic Mycology, the 2002 ASBMB AMGEN award for significant contributions using molecular biology to our understanding of human disease, and the 2003 Squibb Award from the Infectious Diseases Society of America (IDSA) for outstanding contributions to infectious disease research. Dr. Heitman has been an instructor since 1998 at the Woods Hole Molecular Mycology Course at Woods Hole, MA, is an editor of the ASM journal Eukaryotic Cell, was elected a member of the American Society for Clinical Investigation (ASCI) in 2003, a fellow of the Infectious Diseases Society of America (IDSA) in 2003, a fellow of the American Academy of Microbiology in 2004, and a fellow of the American Association for the Advancement of Science (AAAS) in 2004. Dr. Heitman was also an investigator of the Howard Hughes Medical Institute from 1992 to 2005.


Telephone: 919-684-2824
email: heitm001@duke.edu

Home page

http://mgm.duke.edu/microbial/mycology/heitman/

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Evaluations

Antigenic variation in Giardia lamblia is regulated by RNA interference.
Prucca CG, Slavin I, …, Carranza PG, Luján HD
Nature 2008 Dec 11 456(7223):750-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | L. David Sibley / Roberto Docampo / Gloria Rudenko / Ashesh Saraiya and Upinder Singh / Barbara Papadopoulou / Xuying Wang and Joe Heitman
Evaluated 25 Mar 2009

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Cowen LE, Singh SD, …, Whitesell L, Lindquist S
Proc Natl Acad Sci U S A 2009 Feb 5 [abstract on PubMed] [related articles] [full text]
Selected by | Camile P Semighini and Joe Heitman
Evaluated 13 Feb 2009

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor.
Rancati G, Pavelka N, …, Seidel CW, Li R
Cell 2008 Nov 28 135(5):879-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew Welch / Min Ni and Joe Heitman / Timothy Yen / Judith Berman / Jurg Bahler
Evaluated 28 Jan 2009

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus.
O'Gorman CM, Fuller HT, Dyer PS
Nature 2008 Nov 30 457(7228):471-474 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | June Kwon-Chung / Marianna Feretzaki and Joe Heitman
Evaluated 28 Jan 2009


FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast.
Smukalla S, Caldara M, …, Foster KR, Verstrepen KJ
Cell 2008 Nov 14 135(4):726-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Rose / Lukasz Kozubowski and Joe Heitman / Romain Libbrecht and Laurent Keller / Gerhard Braus / Vincent Jansen
Evaluated 19 Dec 2008

Bacterial protection of beetle-fungus mutualism.
Scott JJ, Oh DC, …, Clardy J, Currie CR
Science 2008 Oct 3 322(5898):63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Keith Chater / Yen-Ping Hsueh and Joe Heitman
Evaluated 24 Oct 2008

Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Xu XL, Lee RT, …, Zhu Y, Wang Y
Cell Host Microbe 2008 Jul 17 4(1):28-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Bastidas and Joe Heitman / David Soll
Evaluated 4 Sep 2008


The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.
Nakashima A, Maruki Y, …, Yonezawa K, Kamada Y
PLoS ONE 2008 3(5):e2223 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Cecelia Shertz and Maria E. Cardenas and Joe Heitman
Evaluated 23 Jun 2008

Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi.
Corradi N, Akiyoshi DE, …, Tzipori S, Keeling PJ
PLoS ONE 2007 2(12):e1277 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Soo Chan Lee and Joe Heitman
Evaluated 20 Jun 2008

Evidence for karyogamy and exchange of genetic material in the binucleate intestinal parasite Giardia intestinalis.
Poxleitner MK, Carpenter ML, …, Dawson SC, Cande WZ
Science 2008 Mar 14 319(5869):1530-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Upinder Singh / Jacqueline Upcroft / Joe Heitman
Evaluated 20 Jun 2008

Evidence of recombination in mixed-mating-type and alpha-only populations of Cryptococcus gattii sourced from single eucalyptus tree hollows.
Saul N, Krockenberger M, Carter D
Eukaryot Cell 2008 Apr 7(4):727-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 22 May 2008

Long-distance dispersal and recombination in environmental populations of Cryptococcus neoformans var. grubii from India.
Hiremath SS, Chowdhary A, …, Sun S, Xu J
Microbiology 2008 May 154(Pt 5):1513-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 22 May 2008

Unicellular Ca2+ Signaling 'Toolkit' at the Origin of Metazoa.
Cai X
Mol Biol Evol 2008 Apr 2 [abstract on PubMed] [related articles] [full text]
Selected by | Joe Heitman
Evaluated 22 May 2008

A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.
Tsaousis AD, Kunji ER, …, Hirt RP, Embley TM
Nature 2008 May 22 453(7194):553-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edmond Byrnes and Joe Heitman / C. Graham Clark
Evaluated 21 May 2008

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
King N, Westbrook MJ, …, Grigoriev IV, Rokhsar D
Nature 2008 Feb 14 451(7180):783-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Max Telford / Rafael Zardoya / Charles Streuli / Laura Landweber / Joe Heitman
Evaluated 19 May 2008

Identification of mating type genes in the bipolar basidiomycetous yeast Rhodosporidium toruloides: first insight into the MAT locus structure of the Sporidiobolales.
Coelho MA, Rosa A, …, Fonseca A, Gonçalves P
Eukaryot Cell 2008 Apr 11 [abstract on PubMed] [related articles] [full text]
Selected by | Joe Heitman
Evaluated 15 May 2008

AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles.
Takahashi F, Yamagata D, …, Wada M, Kataoka H
Proc Natl Acad Sci U S A 2007 Dec 4 104(49):19625-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 11 Jan 2008

Kwoniella mangroviensis gen. nov., sp. nov. (Tremellales, Basidiomycota), a teleomorphic yeast from mangrove habitats in the Florida Everglades and Bahamas.
Statzell-Tallman A, Belloch C, Fell JW
FEMS Yeast Res 2008 Jan 8(1):103-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 20 Dec 2007

Evolution of nematode-trapping cells of predatory fungi of the Orbiliaceae based on evidence from rRNA-encoding DNA and multiprotein sequences.
Yang Y, Yang E, An Z, Liu X
Proc Natl Acad Sci U S A 2007 May 15 104(20):8379-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 19 Dec 2007

Genetic variation in a human odorant receptor alters odour perception.
Keller A, Zhuang H, …, Vosshall LB, Matsunami H
Nature 2007 Sep 27 449(7161):468-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Garrity / Joe Heitman
Evaluated 1 Nov 2007

Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora.
Levy O, Appelbaum L, …, Miller DJ, Hoegh-Guldberg O
Science 2007 Oct 19 318(5849):467-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 1 Nov 2007

Blue-light-activated histidine kinases: two-component sensors in bacteria.
Swartz TE, Tseng TS, …, Briggs WR, Bogomolni RA
Science 2007 Aug 24 317(5841):1090-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Spiro / Emmanuel Liscum / Joe Heitman
Evaluated 1 Nov 2007

DNA sequence characterization and molecular evolution of MAT1 and MAT2 mating-type loci of the self-compatible ascomycete mold Neosartorya fischeri.
Rydholm C, Dyer PS, Lutzoni F
Eukaryot Cell 2007 May 6(5):868-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 5 Sep 2007

Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans.
Paoletti M, Seymour FA, …, Archer DB, Dyer PS
Curr Biol 2007 Aug 21 17(16):1384-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 5 Sep 2007

In vivo and in vitro anaerobic mating in Candida albicans.
Dumitru R, Navarathna DH, …, Atkin AL, Nickerson KW
Eukaryot Cell 2007 Mar 6(3):465-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Juergen Wendland / Joe Heitman
Evaluated 16 Aug 2007

Virulence is positively selected by transmission success between mammalian hosts.
Wickham ME, Brown NF, …, Coombes BK, Finlay BB
Curr Biol 2007 May 1 17(9):783-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | L. David Sibley / Joe Heitman
Evaluated 12 Jun 2007

Population structure and evolutionary origins of Microsporum canis, M. ferrugineum and M. audouinii.
Kaszubiak A, Klein S, de Hoog GS, Gräser Y
Infect Genet Evol 2004 Sep 4(3):179-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 12 Jun 2007

Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species.
Eremeeva ME, Gerns HL, …, Dasch GA, Koehler JE
N Engl J Med 2007 Jun 7 356(23):2381-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.
Asara JM, Schweitzer MH, …, Phillips M, Cantley LC
Science 2007 Apr 13 316(5822):280-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.
Jung WH, Sham A, White R, Kronstad JW
PLoS Biol 2006 Nov 4(12):e410 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Guilhem Janbon / Joe Heitman
Evaluated 7 Jun 2007

Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi.
Dadachova E, Bryan RA, …, Nosanchuk JD, Casadevall A
PLoS ONE 2007 2:e457 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Coates / Joe Heitman / John Perfect
Evaluated 7 Jun 2007

Multiple losses of sex within a single genus of Microsporidia.
Ironside JE
BMC Evol Biol 2007 7:48 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans.
Schoustra SE, Debets AJ, Slakhorst M, Hoekstra RF
PLoS Genet 2007 Apr 27 3(4):e68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 7 Jun 2007

Reconstructing the early evolution of Fungi using a six-gene phylogeny.
James TY, Kauff F, …, Spatafora JW, Vilgalys R
Nature 2006 Oct 19 443(7113):818-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Martin / Marcel van der Heijden / Joe Heitman
Evaluated 6 Jun 2007

An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Dong B, Kim S, …, Chow SA, Silverman RH
Proc Natl Acad Sci U S A 2007 Jan 30 104(5):1655-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Bryan Williams
Evaluated 6 Feb 2007

A virus in a fungus in a plant: three-way symbiosis required for thermal tolerance.
Márquez LM, Redman RS, Rodriguez RJ, Roossinck MJ
Science 2007 Jan 26 315(5811):513-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / June Kwon-Chung / Julia Kehr / Daniel Gallie / Marc Knight / Ben Lugtenberg
Evaluated 5 Feb 2007

Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans.
Huang G, Wang H, …, Chen J, Liu H
Proc Natl Acad Sci U S A 2006 Aug 22 103(34):12813-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 5 Feb 2007

Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
Urisman A, Molinaro RJ, …, Silverman RH, DeRisi JL
PLoS Pathog 2006 Mar 2(3):e25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 2 Feb 2007


Methanogenic Archaea and human periodontal disease.
Lepp PW, Brinig MM, …, Armitage GC, Relman DA
Proc Natl Acad Sci U S A 2004 Apr 20 101(16):6176-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arcady Mushegian / Joe Heitman
Evaluated 2 Feb 2007

An obesity-associated gut microbiome with increased capacity for energy harvest.
Turnbaugh PJ, Ley RE, …, Mardis ER, Gordon JI
Nature 2006 Dec 21 444(7122):1027-131 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Robertson / Joel Elmquist / Matthias Maiwald / Liang Tong / Joanna Goldberg / Marc Lecuit / Stefan Kaufmann / Joe Heitman / David Bilder
Evaluated 1 Feb 2007

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
Pan F, Sun L, …, Pardoll DM, Liu JO
Nature 2007 Jan 25 445(7126):433-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / Anthony Means
Evaluated 1 Feb 2007

Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages.
Alvarez M, Casadevall A
Curr Biol 2006 Nov 7 16(21):2161-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / June Kwon-Chung / Carol Munro / Juergen Wendland
Evaluated 23 Nov 2006

Genome-wide genetic analysis of polyploidy in yeast.
Storchová Z, Breneman A, …, O'Toole E, Pellman D
Nature 2006 Oct 5 443(7111):541-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 1 Nov 2006

After the duplication: gene loss and adaptation in Saccharomyces genomes.
Cliften PF, Fulton RS, Wilson RK, Johnston M
Genetics 172(2):863-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 1 Nov 2006

Distinct white collar-1 genes control specific light responses in Mucor circinelloides.
Silva F, Torres-Martínez S, Garre V
Mol Microbiol 2006 Aug 61(4):1023-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Identifying transcription factor functions and targets by phenotypic activation.
Chua G, Morris QD, …, Boone C, Hughes TR
Proc Natl Acad Sci U S A 2006 Aug 8 103(32):12045-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Regulation by blue light and heat shock of gene transcription in the fungus Phycomyces: proteins required for photoinduction and mechanism for adaptation to light.
Rodríguez-Romero J, Corrochano LM
Mol Microbiol 2006 Aug 61(4):1049-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

The calcineurin regulator sra plays an essential role in female meiosis in Drosophila.
Takeo S, Tsuda M, …, Matsuo T, Aigaki T
Curr Biol 2006 Jul 25 16(14):1435-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features.
Derelle E, Ferraz C, …, Van de Peer Y, Moreau H
Proc Natl Acad Sci U S A 2006 Aug 1 103(31):11647-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 9 Aug 2006

Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
Selmecki A, Forche A, Berman J
Science 2006 Jul 21 313(5785):367-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Guilhem Janbon / Carol Munro / Tamara Doering / Paula Sundstrom
Evaluated 9 Aug 2006

A phylogenomic inventory of meiotic genes; evidence for sex in Giardia and an early eukaryotic origin of meiosis.
Ramesh MA, Malik SB, Logsdon JM
Curr Biol 2005 Jan 26 15(2):185-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | C. Graham Clark / Jacqueline Upcroft / Upinder Singh / Joe Heitman
Evaluated 31 Jul 2006

Genomic and experimental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicillium marneffei.
Woo PC, Chong KT, …, Lau SK, Yuen KY
FEBS Lett 2006 Jun 12 580(14):3409-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 31 Jul 2006

The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues.
Little DY, Rao H, …, Krapp A, Malamy JE
Proc Natl Acad Sci U S A 2005 Sep 20 102(38):13693-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Brian Forde / Joe Heitman
Evaluated 31 Jul 2006

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
Cramer RA, Gamcsik MP, …, Abraham SN, Steinbach WJ
Eukaryot Cell 2006 Jun 5(6):972-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 13 Jun 2006

Feedback control of morphogenesis in fungi by aromatic alcohols.
Chen H, Fink GR
Genes Dev 2006 May 1 20(9):1150-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gerhard Braus / Mohan Balasubramanian / Joe Heitman
Evaluated 22 May 2006

Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.
Sanna B, Brandt EB, …, Benoit SC, Molkentin JD
Proc Natl Acad Sci U S A 2006 May 9 103(19):7327-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 22 May 2006

Global control of dimorphism and virulence in fungi.
Nemecek JC, Wüthrich M, Klein BS
Science 2006 Apr 28 312(5773):583-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | June Kwon-Chung / Joe Heitman / Jose Ruiz-Herrera
Evaluated 22 May 2006

Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function.
James TY, Srivilai P, Kües U, Vilgalys R
Genetics 2006 Mar 172(3):1877-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 21 Feb 2006

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
Belov K, Deakin JE, …, Graves JA, Miller RD
PLoS Biol 2006 Mar 4(3):e46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ted Hansen / Lutz Walter / Joe Heitman / Stephan Beck
Evaluated 15 Feb 2006


Asynchronous nuclear division cycles in multinucleated cells.
Gladfelter AS, Hungerbuehler AK, Philippsen P
J Cell Biol 2006 Jan 30 172(3):347-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Mohan Balasubramanian
Evaluated 10 Feb 2006

Birth of a metabolic gene cluster in yeast by adaptive gene relocation.
Wong S, Wolfe KH
Nat Genet 2005 Jul 37(7):777-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 24 Jan 2006

Genome sequencing and analysis of Aspergillus oryzae.
Machida M, Asai K, …, Ogasawara N, Kikuchi H
Nature 2005 Dec 22 438(7071):1157-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Joe Heitman
Evaluated 17 Jan 2006

Pathogenic fungus harbours endosymbiotic bacteria for toxin production.
Partida-Martinez LP, Hertweck C
Nature 2005 Oct 6 437(7060):884-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Leo Eberl / June Kwon-Chung / Joern Piel / Pascale Cossart / Joe Heitman
Evaluated 15 Dec 2005

The role of innate immune responses in the outcome of interspecies competition for colonization of mucosal surfaces.
Lysenko ES, Ratner AJ, Nelson AL, Weiser JN
PLoS Pathog 2005 Sep 1(1):e1 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Eric Denkers / Joe Heitman / Scott Gray-Owen / Lalita Ramakrishnan
Evaluated 4 Nov 2005

BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis.
Kojic M, Kostrub CF, Buchman AR, Holloman WK
Mol Cell 2002 Sep 10(3):683-91 [abstract on PubMed] [related articles] [order article]
Selected by | Joe Heitman
Evaluated 3 Nov 2005

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.
Gantner BN, Simmons RM, Underhill DM
EMBO J 2005 Mar 23 24(6):1277-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Paula Sundstrom / Siamon Gordon / Joe Heitman
Evaluated 3 Nov 2005

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.
Cowen LE, Lindquist S
Science 2005 Sep 30 309(5744):2185-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Wiley Schell
Evaluated 10 Oct 2005

Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis.
Gutierrez MC, Brisse S, …, Supply P, Vincent V
PLoS Pathog 2005 Sep 1(1):e5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Julian Parkhill
Evaluated 29 Sep 2005

Yeast model uncovers dual roles of mitochondria in action of artemisinin.
Li W, Mo W, …, Gitschier JM, Zhou B
PLoS Genet 2005 Sep 1(3):e36 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / L. David Sibley
Evaluated 29 Sep 2005

In vitro generation of infectious scrapie prions.
Castilla J, Saá P, Hetz C, Soto C
Cell 2005 Apr 22 121(2):195-206 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David P. Wolfer / Matthias Maiwald / Joe Heitman
Evaluated 11 Aug 2005

Genome sequencing in microfabricated high-density picolitre reactors.
Margulies M, Egholm M, …, Begley RF, Rothberg JM
Nature 2005 Sep 15 437(7057):376-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Cristina Takacs-Vesbach / Bernd Weisshaar / Stephan Beck / Sachdev Sidhu
Evaluated 11 Aug 2005

A novel mechanism of nuclear envelope break-down in a fungus: nuclear migration strips off the envelope.
Straube A, Weber I, Steinberg G
EMBO J 2005 May 4 24(9):1674-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | June Kwon-Chung / Joe Heitman
Evaluated 18 Jul 2005

Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus.
Paoletti M, Rydholm C, …, Denning DW, Dyer PS
Curr Biol 2005 Jul 12 15(13):1242-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 18 Jul 2005

Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae.
Hall C, Brachat S, Dietrich FS
Eukaryot Cell 2005 Jun 4(6):1102-15 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 24 Jun 2005

Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p.
Nobile CJ, Mitchell AP
Curr Biol 2005 Jun 21 15(12):1150-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 24 Jun 2005

Cryptococcus neoformans capsule structure evolution in vitro and during murine infection.
Garcia-Hermoso D, Dromer F, Janbon G
Infect Immun 2004 Jun 72(6):3359-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 23 Jun 2005

Fungal pathogen reduces potential for malaria transmission.
Blanford S, Chan BH, …, Read AF, Thomas MB
Science 2005 Jun 10 308(5728):1638-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Yvonne Graeser
Evaluated 21 Jun 2005

An entomopathogenic fungus for control of adult African malaria mosquitoes.
Scholte EJ, Ng'habi K, …, Killeen GF, Knols BG
Science 2005 Jun 10 308(5728):1641-2 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Ken Wilson
Evaluated 21 Jun 2005

X-inactivation profile reveals extensive variability in X-linked gene expression in females.
Carrel L, Willard HF
Nature 2005 Mar 17 434(7031):400-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter B. Becker / Joe Heitman
Evaluated 20 Jun 2005

The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans.
Lafon A, Seo JA, …, Yu JH, d'Enfert C
Genetics 2005 Sep 171(1):71-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 20 Jun 2005

Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology.
Khan SM, Franke-Fayard B, …, Mann M, Waters AP
Cell 2005 Jun 3 121(5):675-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 13 Jun 2005

Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements.
Guiral S, Mitchell TJ, Martin B, Claverys JP
Proc Natl Acad Sci U S A 2005 Jun 14 102(24):8710-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Rino Rappuoli
Evaluated 9 Jun 2005

Comparative genomics in hemiascomycete yeasts: evolution of sex, silencing, and subtelomeres.
Fabre E, Muller H, …, Dujon B, Fairhead C
Mol Biol Evol 2005 Apr 22(4):856-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 9 Jun 2005

Sex increases the efficacy of natural selection in experimental yeast populations.
Goddard MR, Godfray HC, Burt A
Nature 2005 Mar 31 434(7033):636-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / Yvonne Graeser
Evaluated 29 Apr 2005

Increased virulence and competitive advantage of a/alpha over a/a or alpha/alpha offspring conserves the mating system of Candida albicans.
Lockhart SR, Wu W, …, Zhao R, Soll DR
Genetics 2005 Apr 169(4):1883-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | June Kwon-Chung / Joe Heitman
Evaluated 20 Apr 2005

Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.
Wellendorph P, Hansen KB, …, Egebjerg J, Bräuner-Osborne H
Mol Pharmacol 2005 Mar 67(3):589-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 7 Mar 2005

Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans.
Wang P, Cutler J, King J, Palmer D
Eukaryot Cell 2004 Aug 3(4):1028-35 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 10 Jan 2005

Preserving genome integrity: the DdrA protein of Deinococcus radiodurans R1.
Harris DR, Tanaka M, …, Cox MM, Battista JR
PLoS Biol 2004 Oct 2(10):e304 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan A Eisen / Joe Heitman
Evaluated 2 Dec 2004

Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution.
Rens W, Grützner F, …, Graves JA, Ferguson-Smith MA
Proc Natl Acad Sci U S A 2004 Nov 16 101(46):16257-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 26 Nov 2004

Evolution of the MAT locus and its Ho endonuclease in yeast species.
Butler G, Kenny C, …, Gaillardin C, Wolfe KH
Proc Natl Acad Sci U S A 2004 Feb 10 101(6):1632-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 23 Nov 2004

A programmed strand-specific and modified nick in S. pombe constitutes a novel type of chromosomal imprint.
Kaykov A, Arcangioli B
Curr Biol 2004 Nov 9 14(21):1924-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 10 Nov 2004

Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements.
Doulatov S, Hodes A, …, Zimmerly S, Miller JF
Nature 2004 Sep 23 431(7007):476-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wendy Gibson / Joe Heitman
Evaluated 30 Sep 2004

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.
Sayah DM, Sokolskaja E, Berthoux L, Luban J
Nature 2004 Jul 29 430(6999):569-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 10 Sep 2004

Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite.
Billker O, Dechamps S, …, Franke-Fayard B, Brinkmann V
Cell 2004 May 14 117(4):503-14 [abstract on PubMed] [related articles] [order article]
Selected by | Dominique Soldati / L. David Sibley / Joe Heitman
Evaluated 16 Jul 2004

Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans.
Missall TA, Pusateri ME, Lodge JK
Mol Microbiol 2004 Mar 51(5):1447-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 16 Jul 2004

The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.
Dietrich FS, Voegeli S, …, Gaffney TD, Philippsen P
Science 2004 Apr 9 304(5668):304-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 15 Jul 2004

Apoptosis induced by environmental stresses and amphotericin B in Candida albicans.
Phillips AJ, Sudbery I, Ramsdale M
Proc Natl Acad Sci U S A 2003 Nov 25 100(24):14327-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 20 Jan 2004

Microarray-based detection and genotyping of viral pathogens.
Wang D, Coscoy L, …, Ganem D, DeRisi JL
Proc Natl Acad Sci U S A 2002 Nov 26 99(24):15687-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 20 Jan 2004

A B cell-based sensor for rapid identification of pathogens.
Rider TH, Petrovick MS, …, Chen J, Hollis MA
Science 2003 Jul 11 301(5630):213-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rino Rappuoli / Joe Heitman
Evaluated 20 Jan 2004

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin.
Ryeom S, Greenwald RJ, Sharpe AH, McKeon F
Nat Immunol 2003 Sep 4(9):874-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 17 Dec 2003

Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection.
Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL
Eukaryot Cell 2003 Oct 2(5):1053-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 27 Oct 2003

Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism.
Smith DG, Garcia-Pedrajas MD, Gold SE, Perlin MH
Mol Microbiol 2003 Oct 50(1):259-75 [abstract on PubMed] [related articles] [order article]
Selected by | Joe Heitman
Evaluated 24 Oct 2003

An unusual MAP kinase is required for efficient penetration of the plant surface by Ustilago maydis.
Brachmann A, Schirawski J, Müller P, Kahmann R
EMBO J 2003 May 1 22(9):2199-210 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 24 Oct 2003

Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection.
Dadachova E, Nakouzi A, Bryan RA, Casadevall A
Proc Natl Acad Sci U S A 2003 Sep 16 100(19):10942-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 24 Oct 2003

Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.
Luberto C, Martinez-Mariño B, …, Balish E, Del Poeta M
J Clin Invest 2003 Oct 112(7):1080-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Jennifer Lodge / Arturo Casadevall
Evaluated 8 Oct 2003

Skin facilitates Candida albicans mating.
Lachke SA, Lockhart SR, Daniels KJ, Soll DR
Infect Immun 2003 Sep 71(9):4970-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Paula Sundstrom
Evaluated 18 Sep 2003

Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling.
Zeitlinger J, Simon I, …, Fink GR, Young RA
Cell 2003 May 2 113(3):395-404 [abstract on PubMed] [related articles] [order article]
Selected by | Andrew D. Sharrocks / Dinah Singer / Joe Heitman
Evaluated 26 Jun 2003

Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains.
Bennett RJ, Johnson AD
EMBO J 2003 May 15 22(10):2505-15 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 26 Jun 2003

Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.
Uhl MA, Biery M, Craig N, Johnson AD
EMBO J 2003 Jun 2 22(11):2668-78 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Paula Sundstrom
Evaluated 26 Jun 2003

Three mating type-like loci in Candida glabrata.
Srikantha T, Lachke SA, Soll DR
Eukaryot Cell 2003 Apr 2(2):328-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 20 May 2003

The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.
Bürglin TR
Dev Genes Evol 2003 Feb 213(1):50-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 19 May 2003

Mating type gene homologues in Aspergillus fumigatus.
Varga J
Microbiology 2003 Apr 149(Pt 4):816-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 19 May 2003

Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.
Wong S, Fares MA, …, Butler G, Wolfe KH
Genome Biol 2003 4(2):R10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yvonne Graeser / Joe Heitman
Evaluated 19 May 2003

Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant.
Siekhaus DE, Drubin DG
Nat Cell Biol 2003 Mar 5(3):231-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 6 Mar 2003

A Saccharomyces cerevisiae mutant with increased virulence.
Wheeler RT, Kupiec M, …, Abeijon C, Fink GR
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2766-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 6 Mar 2003

Cell biology of mating in Candida albicans.
Lockhart SR, Daniels KJ, …, Wessels D, Soll DR
Eukaryot Cell 2003 Feb 2(1):49-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paula Sundstrom / Joe Heitman
Evaluated 6 Mar 2003

A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.
Hobbs MR, Udhayakumar V, …, Anstey NM, Weinberg JB
Lancet 2002 Nov 9 360(9344):1468-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ferric Fang / Joe Heitman / Terri Beaty
Evaluated 4 Dec 2002

Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages.
Steenbergen JN, Shuman HA, Casadevall A
Proc Natl Acad Sci U S A 2001 Dec 18 98(26):15245-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jennifer Lodge / Luigina Romani / Yvonne Graeser / Joe Heitman
Evaluated 19 Nov 2002

Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage.
Liu M, Deora R, …, Parkhill J, Miller JF
Science 2002 Mar 15 295(5562):2091-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Robert Kelley
Evaluated 16 Oct 2002

Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis.
Shankar N, Baghdayan AS, Gilmore MS
Nature 2002 Jun 13 417(6890):746-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 26 Sep 2002

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.
Huai Q, Kim HY, …, Liu JO, Ke H
Proc Natl Acad Sci U S A 2002 Sep 17 99(19):12037-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 17 Sep 2002

White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating.
Miller MG, Johnson AD
Cell 2002 Aug 9 110(3):293-302 [abstract on PubMed] [related articles] [order article]
Selected by | Karin Romisch / Mark Rose / Joe Heitman / Paula Sundstrom
Evaluated 16 Sep 2002

Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans.
Steen BR, Lian T, …, Jones SJ, Kronstad JW
Genome Res 2002 Sep 12(9):1386-400 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 16 Sep 2002

Regulation of MAPK function by direct interaction with the mating-specific Galpha in yeast.
Metodiev MV, Matheos D, Rose MD, Stone DE
Science 2002 May 24 296(5572):1483-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 25 Jun 2002

Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa.
Lamont IL, Beare PA, …, Vasil AI, Vasil ML
Proc Natl Acad Sci U S A 2002 May 14 99(10):7072-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tracy Raivio / Joe Heitman
Evaluated 19 Jun 2002

A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization.
Morice MC, Serruys PW, …, Falotico R, RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patients with de Novo Native Coronary Artery Lesions
N Engl J Med 2002 Jun 6 346(23):1773-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 13 Jun 2002

Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation.
Drenkard E, Ausubel FM
Nature 2002 Apr 18 416(6882):740-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rino Rappuoli / Esther Bullitt / Robert Palmer / Joe Heitman
Evaluated 13 Jun 2002

Dissecting the architecture of a quantitative trait locus in yeast.
Steinmetz LM, Sinha H, …, McCusker JH, Davis RW
Nature 2002 Mar 21 416(6878):326-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Greg Gibson / Joe Heitman / Bruno Sobral
Evaluated 11 Apr 2002

Ectopic expression of a Chlamydomonas mt+-specific homeodomain protein in mt- gametes initiates zygote development without gamete fusion.
Zhao H, Lu M, Singh R, Snell WJ
Genes Dev 2001 Oct 15 15(20):2767-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 14 Jan 2002

Systematic genetic analysis with ordered arrays of yeast deletion mutants.
Tong AH, Evangelista M, …, Tyers M, Boone C
Science 2001 Dec 14 294(5550):2364-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Miguel Penalva / Mark Rose
Evaluated 11 Jan 2002

Deficiency of D-erythroascorbic acid attenuates hyphal growth and virulence of Candida albicans.
Huh WK, Kim ST, …, Jeong G, Kang SO
Infect Immun 2001 Jun 69(6):3939-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman
Evaluated 24 Sep 2001

Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms.
Singh PK, Schaefer AL, …, Welsh MJ, Greenberg EP
Nature 2000 Oct 12 407(6805):762-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 24 Sep 2001

The hgl1 gene is required for dimorphism and teliospore formation in the fungal pathogen Ustilago maydis.
Dürrenberger F, Laidlaw RD, Kronstad JW
Mol Microbiol 2001 Jul 41(2):337-48 [abstract on PubMed] [related articles] [order article]
Selected by | Joe Heitman / Jennifer Lodge
Evaluated 24 Sep 2001

The glyoxylate cycle is required for fungal virulence.
Lorenz MC, Fink GR
Nature 2001 Jul 5 412(6842):83-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman / Luigina Romani / Jean-Jacques Sanglier
Evaluated 24 Sep 2001

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