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David Triggle
SUNY at Buffalo, Buffalo, United States of America

Faculty Member: Pharmacology & Drug Discovery > Drug Discovery & Design [ since 31 July 2006 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Contact information: David J. Triggle, University Professor and SUNY Distinguished Professor, School of Pharmacy and Pharmaceutical Sciences, SUNY at Buffalo, Buffalo NY 14260. Tel: 716 645 7315; email, triggle@buffalo.edu.

David Triggle received his education in the United Kingdom where he received B.Sc. and Ph.D. degrees in chemistry from the Universities of Southampton and Hull, respectively. Following post-doctoral work at the University of Ottawa and the University of London, he assumed a position at the University of Buffao in the School of Pharmacy. His subsequent positions were Chair, Department of Biochemical Pharmacology; Dean, School of Pharmacy; Dean of the Graduate School; and University Provost. He is currently the University Professor and President of the Center for Inquiry Institute. He is the author and editor of several books dealing with the autonomic nervous system and drug-receptor interactions, some two hundred and fifty research papers and some one hundred and fifty chapters and reviews. He is currently the editor (with John Tayor) of Comprehensive Medicinal Chemistry (second edition), a series of books entitled, "Drugs. The straight facts", and most recently of "Voltage-gated ion channels as drug targets" (with three of his previous graduate students).

His research interests have always been at the interface of chemistry and pharmacology, with emphasis on drug interactions at neurotransmitter receptors and ion channels. A particular emphasis has been on voltage-gated calcium channels and their interactions with calcium channel ligands. A particular interest has been in the chemistry and pharmacology of 1,4-dihydropyridines, a particularly versatile pharmacophore. Currently, his research and teaching interests have expanded to include the philosophical basis of ethics and issues around the science-policy-public interface through the Center for Inquiry Institute.

Home page

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Evaluations

Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells.
Lu F, Zahid M, Cavalieri EL, Rogan EG
Cancer Prev Res 2008 1:135-145 [full text]
Selected by | David Triggle
Evaluated 30 Jul 2008

Drug target identification using side-effect similarity.
Campillos M, Kuhn M, …, Jensen LJ, Bork P
Science 2008 Jul 11 321(5886):263-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 30 Jul 2008

Substrate-targeting gamma-secretase modulators.
Kukar TL, Ladd TB, …, Koo EH, Golde TE
Nature 2008 Jun 12 453(7197):925-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 30 Jul 2008


Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
Rajendran L, Schneider A, …, Knölker HJ, Simons K
Science 2008 Apr 25 320(5875):520-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle / Richard Silverman with Fengtian Xue
Evaluated 14 May 2008


Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption.
Ellekvist P, Maciel J, …, Klaerke DA, Kumar N
Proc Natl Acad Sci U S A 2008 Apr 29 105(17):6398-402 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle / Igor Stagljar
Evaluated 14 May 2008

Chemical composition of vintage preban absinthe with special reference to thujone, fenchone, pinocamphone, methanol, copper, and antimony concentrations.
Lachenmeier DW, Nathan-Maister D, …, Schoeberl K, Kuballa T
J Agric Food Chem 2008 May 14 56(9):3073-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Triggle
Evaluated 14 May 2008

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.
Ruan B, Pong K, …, Abou-Gharbia M, Graziani EI
Proc Natl Acad Sci U S A 2008 Jan 8 105(1):33-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle / Barrie Wilkinson
Evaluated 7 Mar 2008

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.
Nagamune K, Hicks LM, …, Chini EN, Sibley LD
Nature 2008 Jan 10 451(7175):207-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dominique Soldati / Michael Blatt / Paul Roepe / Antony Galione / David Triggle
Evaluated 3 Mar 2008

A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity.
Dietz JD, Du S, …, Funder JW, Hu X
Hypertension 2008 Mar 51(3):742-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 3 Mar 2008


The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.
Beeton C, Smith BJ, …, Pennington MW, Norton RS
J Biol Chem 2008 Jan 11 283(2):988-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Triggle
Evaluated 5 Feb 2008

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, Lambert PD, …, Elliott PJ, Westphal CH
Nature 2007 Nov 29 450(7170):712-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William H. Colledge / David Triggle
Evaluated 18 Dec 2007

Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.
Hulsman N, Medema JP, …, Richel D, Wijtmans M
J Med Chem 2007 May 17 50(10):2424-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Larry K. Keefer / David Triggle
Evaluated 17 Dec 2007

Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.
Binshtok AM, Bean BP, Woolf CJ
Nature 2007 Oct 4 449(7162):607-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bernd Nilius / Ian Hall / Michael Andresen / David Triggle / Gavril Pasternak / Emery Brown / Jaime García-Añoveros
Evaluated 30 Oct 2007


A functional circuit underlying male sexual behaviour in the female mouse brain.
Kimchi T, Xu J, Dulac C
Nature 2007 Aug 30 448(7157):1009-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David P. Wolfer / Kent Berridge / David Triggle
Evaluated 30 Oct 2007

Type 5 adenylyl cyclase disruption increases longevity and protects against stress.
Yan L, Vatner DE, …, Sadoshima J, Vatner SF
Cell 2007 Jul 27 130(2):247-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carmen Dessauer / David Triggle
Evaluated 15 Aug 2007

'Rejuvenation' protects neurons in mouse models of Parkinson's disease.
Chan CS, Guzman JN, …, Meredith GE, Surmeier DJ
Nature 2007 Jun 28 447(7148):1081-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | J. Paul Bolam / David Triggle / Johannes Hell / Monte Gates / Amnon Hoffman
Evaluated 9 Jul 2007

The anti-schistosomal drug praziquantel is an adenosine antagonist.
Angelucci F, Basso A, …, Pica Mattoccia L, Valle C
Parasitology 2007 Aug 134(Pt 9):1215-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 1 May 2007

HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.
Nakajima T, Hayashi K, …, Balser JR, Kupershmidt S
J Biol Chem 2007 Feb 23 282(8):5506-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 22 Feb 2007

An SCN9A channelopathy causes congenital inability to experience pain.
Cox JJ, Reimann F, …, Gribble FM, Woods CG
Nature 2006 Dec 14 444(7121):894-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gavril Pasternak / Angela Vincent / Igor Stagljar / David Triggle / Gerald Zamponi / Ellen A. Lumpkin
Evaluated 11 Jan 2007


Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function.
Badou A, Jha MK, …, Flockerzi V, Flavell RA
Proc Natl Acad Sci U S A 2006 Oct 17 103(42):15529-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Annette Dolphin / David Triggle
Evaluated 27 Nov 2006

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.
Burgess SJ, Selzer A, …, Riscoe MK, Peyton DH
J Med Chem 2006 Sep 7 49(18):5623-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 26 Sep 2006

Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore.
Peterson BZ, Catterall WA
Mol Pharmacol 2006 Aug 70(2):667-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Triggle
Evaluated 25 Aug 2006

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