Dr. Rosenberg obtained her M.D. and Ph.D degrees from the joint program at The Rockefeller University and Cornell University Medical College. Following postdoctoral research at Harvard University, she joined the NIH in 1991, and became Section Head in 2002. Dr. Rosenberg's group focuses on the biology and function of the eosinophilic leukocyte and the role played by these cells in respiratory physiology. Her group has developed a novel mouse model of using the natural rodent pathogen, pneumonia virus of mice as part of an exploration of the role of eosinophils in the pathophysiologic immune responses to respiratory virus infection in vivo.

http://www.niaid.nih.gov/dir/labs/lad/rosenberg.htm

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. Voskas D, Babichev Y, …, Ciruna B, Dumont DJ J Leukoc Biol 2008 Apr 28 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 2 Jun 2008 Leukotriene B4 Induces Release of Antimicrobial Peptides in Lungs of Virally Infected Mice. Gaudreault E, Gosselin J J Immunol 2008 May 1 180(9):6211-6221 [abstract on PubMed] [related articles] [order article] Selected by | Helene Rosenberg Evaluated 25 Apr 2008 Treatment of patients with the hypereosinophilic syndrome with mepolizumab. Rothenberg ME, Klion AD, …, Gleich GJ, Mepolizumab HES Study Group N Engl J Med 2008 Mar 20 358(12):1215-28 [abstract on PubMed] [related articles] [FREE full text] Selected by | Richard L. Stevens / Helene Rosenberg Evaluated 9 Apr 2008 Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. Jacobsen EA, Ochkur SI, …, Lee NA, Lee JJ J Exp Med 2008 Mar 3 [abstract on PubMed] [related articles] [full text] Selected by | Helene Rosenberg Evaluated 10 Mar 2008 Pivotal Advance: Eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production. Wang HB, Weller PF J Leukoc Biol 2008 Apr 83(4):817-21 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg / Charles Czuprynski Evaluated 6 Feb 2008 Therapy of infection with pneumonia virus of mice (PVM); effect of a polysaccharide on the multiplication cycles of the virus and on the course of the viral pneumonia. Ginsberg HS, Horsfall FL J Exp Med 1951 Feb 93(2):161-71 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 11 Jan 2008 Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. Wang HB, Ghiran I, Matthaei K, Weller PF J Immunol 2007 Dec 1 179(11):7585-92 [abstract on PubMed] [related articles] [order article] Selected by | Helene Rosenberg Evaluated 14 Dec 2007 Chronic calorie restriction increases susceptibility of laboratory mice (Mus musculus) to a primary intestinal parasite infection. Kristan DM Aging Cell 2007 Dec 6(6):817-25 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 21 Nov 2007 Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. Crabtree B, Thiyagarajan N, …, Subramanian V, Acharya KR Biochemistry 2007 Oct 23 46(42):11810-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 17 Oct 2007 Endocytotic internalization as a crucial factor for the cytotoxicity of ribonucleases. Leich F, Stöhr N, …, Ulbrich-Hofmann R, Arnold U J Biol Chem 2007 Sep 21 282(38):27640-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 18 Sep 2007 Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. Wise EL, Duchesnes C, …, Williams TJ, Pease JE J Biol Chem 2007 Sep 21 282(38):27935-43 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 16 Aug 2007 Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Toscano MA, Bianco GA, …, Baum LG, Rabinovich GA Nat Immunol 2007 Aug 8(8):825-34 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Linda Bradley / Helene Rosenberg / Paul Gleeson / Mauro Perretti Evaluated 19 Jul 2007 Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma. Ochkur SI, Jacobsen EA, …, Lee JJ, Lee NA J Immunol 2007 Jun 15 178(12):7879-89 [abstract on PubMed] [related articles] [order article] Selected by | Helene Rosenberg Evaluated 21 Jun 2007 Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Kubach J, Lutter P, …, Schmitt E, Jonuleit H Blood 2007 Sep 1 110(5):1550-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 6 Jun 2007 Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. Simson L, Ellyard JI, …, Smyth MJ, Parish CR J Immunol 2007 Apr 1 178(7):4222-9 [abstract on PubMed] [related articles] [order article] Selected by | Helene Rosenberg Evaluated 14 May 2007 Transforming growth factor beta enhances respiratory syncytial virus replication and tumor necrosis factor alpha induction in human epithelial cells. McCann KL, Imani F J Virol 2007 Mar 81(6):2880-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 24 Apr 2007 Zebrafish ribonucleases are bactericidal: implications for the origin of the vertebrate RNase A superfamily. Cho S, Zhang J Mol Biol Evol 2007 May 24(5):1259-68 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 5 Apr 2007 The histopathology of fatal untreated human respiratory syncytial virus infection. Johnson JE, Gonzales RA, …, Wright PF, Graham BS Mod Pathol 2007 Jan 20(1):108-19 [abstract on PubMed] [related articles] [full text] [order article] Selected by | James Crowe / Helene Rosenberg Evaluated 5 Mar 2007 Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Zhang M, Angata T, …, Broide DH, Varki A Blood 2007 May 15 109(10):4280-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 15 Feb 2007 Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria. Phillips JD, Steensma DP, …, Spangrude GJ, Kushner JP Blood 2007 Mar 15 109(6):2618-21 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 26 Jan 2007 The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. Huang YC, Lin YM, …, Wu SH, Liao YD J Biol Chem 2007 Feb 16 282(7):4626-33 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 11 Jan 2007 A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus. Johnson RJ, Lin SR, Raines RT FEBS J 2006 Dec 273(23):5457-65 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 3 Jan 2007 The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A. Taddeo B, Roizman B J Virol 2006 Sep 80(18):9341-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 15 Dec 2006 The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity. Whitehead GS, Wang T, …, Graham GJ, Cook DN Am J Respir Crit Care Med 2007 Feb 1 175(3):243-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 20 Nov 2006 Eosinophils are a major intravascular location for tissue factor storage and exposure. Moosbauer C, Morgenstern E, …, Patel KD, Engelmann B Blood 2007 Feb 1 109(3):995-1002 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 1 Nov 2006 Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Ricagno S, Egloff MP, …, Ziebuhr J, Canard B Proc Natl Acad Sci U S A 2006 Aug 8 103(32):11892-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 6 Oct 2006 Genetic selection for critical residues in ribonucleases. Smith BD, Raines RT J Mol Biol 2006 Sep 22 362(3):459-78 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 25 Sep 2006 Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. Cheong HS, Shin HD, …, Oh B, Park CS J Hum Genet 2006 51(9):781-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 8 Sep 2006 Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells. Tian B, Zhang Y, …, Sinha M, Brasier AR J Virol 2002 Jul 76(13):6800-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 14 Aug 2006 Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys. Zhang J Nat Genet 2006 Jul 38(7):819-23 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nicolas Galtier / Joshua Akey / Helene Rosenberg Evaluated 31 Jul 2006 Pivotal Advance: passively acquired membrane proteins alter the functional capacity of bovine polymorphonuclear cells. Whale TA, Wilson HL, …, Babiuk LA, Griebel PJ J Leukoc Biol 2006 Sep 80(3):481-91 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg / Charles Czuprynski Evaluated 13 Jul 2006 Angiogenins: a new class of microbicidal proteins involved in innate immunity. Hooper LV, Stappenbeck TS, Hong CV, Gordon JI Nat Immunol 2003 Mar 4(3):269-73 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Caetano Reis e Sousa / Jonathan Howard / Helene Rosenberg Evaluated 26 Jun 2006 Systemic eosinophil response induced by respiratory syncytial virus. Lindemans CA, Kimpen JL, …, van der Ent CK, Koenderman L Clin Exp Immunol 2006 Jun 144(3):409-17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 15 Jun 2006 Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves. Valarcher JF, Furze J, …, Herrler G, Taylor G J Gen Virol 2006 Jun 87(Pt 6):1659-67 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 5 Jun 2006 Virokinin, a bioactive peptide of the tachykinin family, is released from the fusion protein of bovine respiratory syncytial virus. Zimmer G, Rohn M, …, Conzelmann KK, Herrler G J Biol Chem 2003 Nov 21 278(47):46854-61 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 17 May 2006 Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. Cormier SA, Taranova AG, …, Lee JJ, Lee NA J Leukoc Biol 2006 Jun 79(6):1131-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 2 May 2006 Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation. Das AM, Vaddi KG, …, Carter PH, Davies P J Pharmacol Exp Ther 2006 Jul 318(1):411-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 24 Apr 2006 Suppression of pattern-recognition receptor TLR4 sensing does not alter lung responses to pneumovirus infection. Faisca P, Tran Anh DB, Thomas A, Desmecht D Microbes Infect 2006 Mar 8(3):621-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 6 Apr 2006 Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Grosse J, Chitu V, …, Nehls M, Stanley ER Blood 2006 Apr 15 107(8):3350-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 20 Mar 2006 Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Spencer LA, Melo RC, …, Dvorak AM, Weller PF Proc Natl Acad Sci U S A 2006 Feb 28 103(9):3333-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 8 Mar 2006 Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. Blanchard C, Wang N, …, Aronow BJ, Rothenberg ME J Clin Invest 2006 Feb 116(2):536-47 [abstract on PubMed] [related articles] [FREE full text] Selected by | Helene Rosenberg Evaluated 22 Feb 2006 Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. Kristjansson S, Bjarnarson SP, …, Haraldsson A, Jonsdottir I J Allergy Clin Immunol 2005 Oct 116(4):805-11 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Helene Rosenberg Evaluated 7 Feb 2006

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