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Alexandra Joyner
Developmental Biology Program, Sloan-Kettering Institute, New York, United States of America

Faculty Member: Genomics & Genetics > Animal Genetics [ since 5 July 2001 ]
[ Evaluations ]
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Evaluations

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.
Verheyden JM, Sun X
Nature 2008 Jul 31 454(7204):638-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Alexandra Joyner
Evaluated 13 Aug 2008

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning.
Chamberlain CE, Jeong J, …, Allen BL, McMahon AP
Development 2008 Mar 135(6):1097-106 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Briscoe / Harukazu Nakamura / Bruce Morgan / John Wallingford / Alexandra Joyner
Evaluated 19 Mar 2008

Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells.
Han YG, Spassky N, …, Schneider-Maunoury S, Alvarez-Buylla A
Nat Neurosci 2008 Mar 11(3):277-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexandra Joyner
Evaluated 10 Mar 2008

Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning.
Dahn RD, Davis MC, Pappano WN, Shubin NH
Nature 2007 Jan 18 445(7125):311-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexandra Joyner
Evaluated 20 Jul 2007

Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity.
Alexandre P, Bachy I, Marcou M, Wassef M
Development 2006 Aug 133(15):2905-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alexandra Joyner
Evaluated 12 Jul 2006

Vertebrate Smoothened functions at the primary cilium.
Corbit KC, Aanstad P, …, Stainier DY, Reiter JF
Nature 2005 Oct 13 437(7061):1018-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen / Alexandra Joyner
Evaluated 23 Nov 2005

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.
Oliver TG, Read TA, …, Lin SM, Wechsler-Reya RJ
Development 2005 May 132(10):2425-39 [abstract on PubMed] [related articles] [FREE full text]
Selected by | James Briscoe / Alexandra Joyner
Evaluated 4 May 2005

Endocytosis controls spreading and effective signaling range of Fgf8 protein.
Scholpp S, Brand M
Curr Biol 2004 Oct 26 14(20):1834-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexandra Joyner
Evaluated 13 Dec 2004

Hedgehog signaling from the ZLI regulates diencephalic regional identity.
Kiecker C, Lumsden A
Nat Neurosci 2004 Nov 7(11):1242-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Claudio Stern / Alexandra Joyner
Evaluated 10 Dec 2004

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.
Scherz PJ, Harfe BD, McMahon AP, Tabin CJ
Science 2004 Jul 16 305(5682):396-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruce Morgan / Alexandra Joyner
Evaluated 20 Sep 2004

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.
Casali A, Struhl G
Nature 2004 Sep 2 431(7004):76-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Briscoe / Alexandra Joyner / David Bilder
Evaluated 17 Sep 2004

Bmp4 and morphological variation of beaks in Darwin's finches.
Abzhanov A, Protas M, …, Grant PR, Tabin CJ
Science 2004 Sep 3 305(5689):1462-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Graham / Alexandra Joyner / Erez Raz
Evaluated 16 Sep 2004

Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons.
Li J, Ishii T, Feinstein P, Mombaerts P
Nature 2004 Mar 25 428(6981):393-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexandra Joyner
Evaluated 13 Apr 2004

Mice cloned from olfactory sensory neurons.
Eggan K, Baldwin K, …, Axel R, Jaenisch R
Nature 2004 Mar 4 428(6978):44-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Ngai / Frank Lyko / Lawrence C. Katz / Alexandra Joyner
Evaluated 5 Apr 2004

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration.
Sanai N, Tramontin AD, …, Berger MS, Alvarez-Buylla A
Nature 2004 Feb 19 427(6976):740-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marina Picciotto / Alexandra Joyner / Elaine Tuomanen
Evaluated 5 Apr 2004

fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo.
Dubrulle J, Pourquié O
Nature 2004 Jan 29 427(6973):419-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gordon Fishell / David Ish-Horowicz / Juan Carlos Izpisua Belmonte / Ali H. Brivanlou / Scott Holley / Alexandra Joyner
Evaluated 5 Apr 2004

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
Chambers I, Colby D, …, Tweedie S, Smith A
Cell 2003 May 30 113(5):643-55 [abstract on PubMed] [related articles] [order article]
Selected by | Alexandra Joyner / Stephen Dalton
Evaluated 6 Jun 2003

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.
Mitsui K, Tokuzawa Y, …, Maeda M, Yamanaka S
Cell 2003 May 30 113(5):631-42 [abstract on PubMed] [related articles] [order article]
Selected by | Alexandra Joyner / Stephen Dalton
Evaluated 6 Jun 2003

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.
Ishibashi M, McMahon AP
Development 2002 Oct 129(20):4807-19 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alexandra Joyner
Evaluated 2 Jan 2003

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors.
Kenney AM, Cole MD, Rowitch DH
Development 2003 Jan 130(1):15-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alexandra Joyner
Evaluated 19 Dec 2002

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.
Persson M, Stamataki D, …, Ericson J, Briscoe J
Genes Dev 2002 Nov 15 16(22):2865-78 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Rubenstein / Alexandra Joyner
Evaluated 19 Dec 2002

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.
Wijgerde M, McMahon JA, Rule M, McMahon AP
Genes Dev 2002 Nov 15 16(22):2849-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Rubenstein / Alexandra Joyner
Evaluated 19 Dec 2002

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.
Litingtung Y, Dahn RD, …, Fallon JF, Chiang C
Nature 2002 Aug 29 418(6901):979-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Miguel Torres / Alexandra Joyner
Evaluated 12 Sep 2002

Medulloblastoma growth inhibition by hedgehog pathway blockade.
Berman DM, Karhadkar SS, …, Olson JM, Beachy PA
Science 2002 Aug 30 297(5586):1559-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lee Rubin / Alexandra Joyner / Andrew Lumsden
Evaluated 11 Sep 2002

Patched acts catalytically to suppress the activity of Smoothened.
Taipale J, Cooper MK, Maiti T, Beachy PA
Nature 2002 Aug 22 418(6900):892-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michel Labouesse / Alexandra Joyner / Andrew Lumsden / Marek Mlodzik
Evaluated 11 Sep 2002

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
Jia J, Amanai K, …, Wang B, Jiang J
Nature 2002 Apr 4 416(6880):548-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Randall Moon / Patricia Simpson / Alexandra Joyner
Evaluated 20 May 2002

Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.
Duman-Scheel M, Weng L, Xin S, Du W
Nature 2002 May 16 417(6886):299-304 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexandra Joyner / Daniel Kalderon
Evaluated 20 May 2002

The lac operator-repressor system is functional in the mouse.
Cronin CA, Gluba W, Scrable H
Genes Dev 2001 Jun 15 15(12):1506-17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alexandra Joyner / Luis Parada
Evaluated 24 Oct 2001

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.
Lewis PM, Dunn MP, …, St-Jacques B, McMahon AP
Cell 2001 Jun 1 105(5):599-612 [abstract on PubMed] [related articles] [order article]
Selected by | Alexandra Joyner
Evaluated 24 Oct 2001

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