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 | Charles Brenner
Departments of Genetics and Biochemistry, Dartmouth Medical School, Lebanon, United States of America | | | Faculty Member: Chemical Biology > Chemical Biology of the Cell [ since 16 January 2002 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
There are three projects in the Brenner group.
Our histidine triad group defined crystal structures of nucleotide-bound forms of the Hint and Fhit tumor suppressors and determined that the pro-apoptotic function of Fhit is limited by substrate-binding. They have now identified the immediate early consequences of Fhit loss in two nonmalignant systems and are working out the cellular mechanisms of this gatekeeping system.
Our Chfr group identified Chf1 and Chf2, the two yeast homologs of the Chfr tumor suppressor, as interactors with Cdc123, a conserved cell cycle protein. They have now established genetic, cellular and biochemical systems to characterize the function and targets of the Cdc123-Chf pathway in yeast.
Our NAD+ group discovered the eukaryotic nicotinamide riboside kinase pathway. They continue to discover novel genes and pathways in NAD+ metabolism and are investigating the roles of nicotinamide riboside metabolism in age-related processes. | Home page
http://www.dartmouth.edu/~brenner |
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