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 | Julian E. Davies
Department of Microbiology, University of of British Columbia, Vancouver, Canada | | | Head of Faculty: MICROBIOLOGY [ since 1 November 2001 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
Research interests:
Microbial secondary metabolism presents many interesting scientific problems and commercial opportunities. The best known secondary metabolites are the antibiotics. Apart from their therapeutic applications, antibiotics are useful tools in studying cell biochemistry; the analysis of their mode of action has provided insights into the specific interaction of macromolecules and low molecular weight ligands.
Another type of secondary metabolic activity found in microbes is the degradation of exotic, man-made organic compounds (xenobiotics). The Davies laboratory is studying the genetics and biochemistry of the degradtion of aromztic acids derived from lignin by streptomycetes. The strains are isolated from a variety of sites in British Columbia. Several such pathways have been characterized and novel steps have been identified.
Antibiotic resistance is a serious impediment to the treatment of infectious diseases. Ever since the introduction of antibiotics, the development of resistant strains by mutation and gene acquisition has taken place. However, very little is known of the way in which resistance comes about; for examples, mutations to resistance are often deletions to growth and compensating mutations are necessary to restore fitness. The origins of plasmid-encoded resistance genes are not known, but it's believed that they are derived from antibiotic-producing bacteria and acquired by a specific integrase-driven process. These mechanisms are being studied in the laboratory.
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http://www.microbiology.ubc.ca/jdavies.htm |
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