Acknowledgements:
The members of my lab assist me with making evaluations for Faculty 1000: Nebojsa Mirkovic, Paul Murray, Anna Mulgrew, Laura Rogers, Zhaohui Li, Andrew Parnassa and David Grandy.


Research interests: Macromolecular interactions in subcellular localization

Our research focuses on using computational approaches to understand the physical and molecular basis of the protein-lipid interactions that contribute to subcellular localization and the subsequent organization of proteins and lipids that leads to the assembly of macromolecular complexes at membrane surfaces.

We are currently dissecting two processes in which the targeting of proteins to membranes is crucial for function:

1) phosphoinositide signaling pathways, and
2) the assembly of new retroviruses in infected cells.

Copine A, a calcium-dependent membrane-binding protein, transiently localizes to the plasma membrane and intracellular vacuoles in Dictyostelium. Damer CK, Bayeva M, …, Rivera J, Socec CI BMC Cell Biol 2005 6:46 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 14 Feb 2006 Simulations of (an)isotropic diffusion on curved biological surfaces. Sbalzarini IF, Hayer A, Helenius A, Koumoutsakos P Biophys J 2006 Feb 1 90(3):878-85 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 2 Feb 2006 Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. Gokhale NA, Abraham A, …, Gratton E, Cho W J Biol Chem 2005 Dec 30 280(52):42831-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 24 Jan 2006 Assembly of human immunodeficiency virus precursor gag proteins. Huseby D, Barklis RL, Alfadhli A, Barklis E J Biol Chem 2005 May 6 280(18):17664-70 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 15 Mar 2005 Membrane-bound orientation and position of the synaptotagmin C2B domain determined by site-directed spin labeling. Rufener E, Frazier AA, …, Hinderliter A, Cafiso DS Biochemistry 2005 Jan 11 44(1):18-28 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Axel Brunger / Diana Murray Evaluated 15 Mar 2005 Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. Okahara F, Ikawa H, Kanaho Y, Maehama T J Biol Chem 2004 Oct 29 279(44):45300-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 27 Oct 2004 Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane. Ono A, Ablan SD, …, Nagashima K, Freed EO Proc Natl Acad Sci U S A 2004 Oct 12 101(41):14889-94 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 19 Oct 2004 High-resolution structure of a retroviral capsid hexameric amino-terminal domain. Mortuza GB, Haire LF, …, Stoye JP, Taylor IA Nature 2004 Sep 23 431(7007):481-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Tony Crowther / Diana Murray Evaluated 12 Oct 2004 The stoichiometry of Gag protein in HIV-1. Briggs JA, Simon MN, …, Vogt VM, Johnson MC Nat Struct Mol Biol 2004 Jul 11(7):672-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Diana Murray Evaluated 4 Aug 2004 The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo. Dunn R, Klos DA, Adler AS, Hicke L J Cell Biol 2004 Apr 165(1):135-44 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 5 May 2004 Entropic switch regulates myristate exposure in the HIV-1 matrix protein. Tang C, Loeliger E, …, Beckett D, Summers MF Proc Natl Acad Sci U S A 2004 Jan 13 101(2):517-22 [abstract on PubMed] [related articles] [FREE full text] Selected by | Diana Murray Evaluated 24 Mar 2004

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