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Mariann Bienz
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

Faculty Member: DEVELOPMENTAL BIOLOGY > Developmental molecular mechanisms [ since 5 July 2001 ]
[ Evaluations ]
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Evaluations

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
Cselenyi CS, Jernigan KK, …, Lee LA, Lee E
Proc Natl Acad Sci U S A 2008 Jun 10 105(23):8032-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mariann Bienz
Evaluated 13 Jun 2008

The C. elegans SYS-1 protein is a bona fide beta-catenin.
Liu J, Phillips BT, …, Kimble J, Xu W
Dev Cell 2008 May 14(5):751-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kimelman / Mariann Bienz
Evaluated 22 May 2008

AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane.
Grohmann A, Tanneberger K, …, Schneikert J, Behrens J
J Cell Sci 2007 Nov 1 120(Pt 21):3738-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mariann Bienz
Evaluated 10 Jan 2008

Identification of stem cells in small intestine and colon by marker gene Lgr5.
Barker N, van Es JH, …, Peters PJ, Clevers H
Nature 2007 Oct 25 449(7165):1003-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Salvador Aznar-Benitah / Matthew John Smalley / Maarten van Lohuizen / Amy Wagers / Leanne Jones / Mariann Bienz
Evaluated 10 Jan 2008


Myc deletion rescues Apc deficiency in the small intestine.
Sansom OJ, Meniel VS, …, Clevers H, Clarke AR
Nature 2007 Apr 5 446(7136):676-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Salvador Aznar-Benitah / Mariann Bienz / Martine Roussel
Evaluated 17 Apr 2007

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.
Sierra J, Yoshida T, Joazeiro CA, Jones KA
Genes Dev 2006 Mar 1 20(5):586-600 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz
Evaluated 31 Mar 2006

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.
Drees F, Pokutta S, …, Nelson WJ, Weis WI
Cell 2005 Dec 2 123(5):903-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rong Li / Kenneth Yamada / Mariann Bienz / Frans Van Roy / William A Muller / Michel Labouesse / Marie-France Carlier / Kathleen J. Green / Carien Niessen
Evaluated 20 Dec 2005

Deconstructing the cadherin-catenin-actin complex.
Yamada S, Pokutta S, …, Weis WI, Nelson WJ
Cell 2005 Dec 2 123(5):889-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rong Li / Kenneth Yamada / Mariann Bienz / Frans Van Roy / William A Muller / Michel Labouesse / Thomas Lecuit / Kathleen J. Green / Carien Niessen / Jeff Hardin
Evaluated 20 Dec 2005

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.
Daniels DL, Weis WI
Nat Struct Mol Biol 2005 Apr 12(4):364-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Randall Moon / Mariann Bienz
Evaluated 25 May 2005

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Brembeck FH, Schwarz-Romond T, …, Hammerschmidt M, Birchmeier W
Genes Dev 2004 Sep 15 18(18):2225-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gregory Dressler / Valeri Vasioukhin / David Kimelman / Carien Niessen / Mariann Bienz
Evaluated 19 Oct 2004

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference.
Matsubayashi H, Sese S, …, Tomita T, Yanagawa S
Mol Cell Biol 2004 Mar 24(5):2012-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Norbert Perrimon / Mariann Bienz
Evaluated 24 Jun 2004

Requirement for a nuclear function of beta-catenin in Wnt signaling.
Cong F, Schweizer L, Chamorro M, Varmus H
Mol Cell Biol 2003 Dec 23(23):8462-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz / Lilianna Solnica-Krezel
Evaluated 18 Dec 2003

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Xu L, Wei Y, …, Elledge SJ, Harper JW
Nature 2003 Sep 18 425(6955):316-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arp Schnittger / Mariann Bienz
Evaluated 3 Oct 2003

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
Pintard L, Willis JH, …, Bowerman B, Peter M
Nature 2003 Sep 18 425(6955):311-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arp Schnittger / Mariann Bienz
Evaluated 3 Oct 2003

Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.
Yamashita YM, Jones DL, Fuller MT
Science 2003 Sep 12 301(5639):1547-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andreas Wodarz / Mariann Bienz / Sally Temple / Mark Van Doren / Jeffrey Axelrod / Iain Hagan / Inke Nathke
Evaluated 30 Sep 2003

Regions of GAL4 critical for binding to a promoter in vivo revealed by a visual DNA-binding analysis.
Mizutani A, Tanaka M
EMBO J 2003 May 1 22(9):2178-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz
Evaluated 13 May 2003

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
van de Wetering M, Sancho E, …, Medema R, Clevers H
Cell 2002 Oct 18 111(2):241-50 [abstract on PubMed] [related articles] [order article]
Selected by | Mariann Bienz / Carien Niessen
Evaluated 12 Nov 2002

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Batlle E, Henderson JT, …, Pawson T, Clevers H
Cell 2002 Oct 18 111(2):251-63 [abstract on PubMed] [related articles] [order article]
Selected by | Mariann Bienz / Fiona Watt / Carien Niessen
Evaluated 12 Nov 2002

Attenuated APC alleles produce functional protein from internal translation initiation.
Heppner Goss K, Trzepacz C, Tuohy TM, Groden J
Proc Natl Acad Sci U S A 2002 Jun 11 99(12):8161-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sue Malcolm / Mariann Bienz
Evaluated 2 Jul 2002

Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila.
Parker DS, Jemison J, Cadigan KM
Development 2002 Jun 129(11):2565-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz
Evaluated 23 May 2002

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.
Kramps T, Peter O, …, Züllig S, Basler K
Cell 2002 Apr 5 109(1):47-60 [abstract on PubMed] [related articles] [order article]
Selected by | Rudolf Grosschedl / Manfred Frasch / Randall Moon / David Kimelman / Mariann Bienz / Caroline Hill
Evaluated 26 Apr 2002

Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
Ahmed Y, Nouri A, Wieschaus E
Development 2002 Apr 129(7):1751-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Manfred Frasch / Mariann Bienz
Evaluated 15 Apr 2002

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila.
Yanagawa S, Matsuda Y, …, Kadowaki T, Ishimoto A
EMBO J 2002 Apr 2 21(7):1733-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz
Evaluated 12 Apr 2002

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
Staal FJ, Noort Mv M, Strous GJ, Clevers HC
EMBO Rep 2002 Jan 3(1):63-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Randall Moon / Mariann Bienz / Alfonso Martinez Arias
Evaluated 30 Jan 2002

Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.
Tutter AV, Fryer CJ, Jones KA
Genes Dev 2001 Dec 15 15(24):3342-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Randall Moon / Mariann Bienz
Evaluated 29 Jan 2002

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.
Elbashir SM, Harborth J, …, Weber K, Tuschl T
Nature 2001 May 24 411(6836):494-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean Schwarzbauer / Andrew Belmont / Brenda Bass / Mariann Bienz / Ian Dunham
Evaluated 9 Jan 2002

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling.
Axelrod JD
Genes Dev 2001 May 15 15(10):1182-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz
Evaluated 23 Nov 2001

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