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Reinhard Luehrmann
Dep.100 Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 24 September 2002 ]
[ Evaluations ]
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Evaluations

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast.
Boon KL, Grainger RJ, …, Inglehearn CF, Beggs JD
Nat Struct Mol Biol 2007 Nov 14(11):1077-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 5 Nov 2007

Concurrent splicing and transcription are not sufficient to enhance splicing efficiency.
Lazarev D, Manley JL
RNA 2007 Sep 13(9):1546-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 26 Oct 2007

A complex signaling pathway regulates SRp38 phosphorylation and pre-mrna splicing in response to heat shock.
Shi Y, Manley JL
Mol Cell 2007 Oct 12 28(1):79-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 23 Oct 2007

Splicing factor SF3b as a target of the antitumor natural product pladienolide.
Kotake Y, Sagane K, …, Iwata M, Mizui Y
Nat Chem Biol 2007 Sep 3(9):570-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 16 Oct 2007

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Kaida D, Motoyoshi H, …, Horinouchi S, Yoshida M
Nat Chem Biol 2007 Sep 3(9):576-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Czarnik / Reinhard Luehrmann
Evaluated 16 Oct 2007

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches.
Cheah MT, Wachter A, Sudarsan N, Breaker RR
Nature 2007 May 24 447(7143):497-500 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann / Günter Mayer / Matthew Sachs
Evaluated 16 May 2007

AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.
Vasudevan S, Steitz JA
Cell 2007 Mar 23 128(6):1105-18 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Amy Pasquinelli / Reinhard Luehrmann / Charles Query
Evaluated 20 Apr 2007

The gene encoding the splicing factor SF2/ASF is a proto-oncogene.
Karni R, de Stanchina E, …, Mu D, Krainer AR
Nat Struct Mol Biol 2007 Mar 14(3):185-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 20 Apr 2007

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.
Hilliker AK, Mefford MA, Staley JP
Genes Dev 2007 Apr 1 21(7):821-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 17 Apr 2007

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.
Perriman RJ, Ares M
Genes Dev 2007 Apr 1 21(7):811-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 17 Apr 2007

A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional.
Tardiff DF, Lacadie SA, Rosbash M
Mol Cell 2006 Dec 28 24(6):917-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann / Lynne Maquat
Evaluated 15 Jan 2007

Differential recruitment of the splicing machinery during transcription predicts genome-wide patterns of mRNA splicing.
Moore MJ, Schwartzfarb EM, Silver PA, Yu MC
Mol Cell 2006 Dec 28 24(6):903-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 15 Jan 2007

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.
Heyd F, ten Dam G, Möröy T
Nat Immunol 2006 Aug 7(8):859-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 13 Dec 2006

RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.
de la Mata M, Kornblihtt AR
Nat Struct Mol Biol 2006 Nov 13(11):973-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Rosbash / Reinhard Luehrmann
Evaluated 13 Dec 2006

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.
Bono F, Ebert J, Lorentzen E, Conti E
Cell 2006 Aug 25 126(4):713-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Megerditch Kiledjian / Anne-Catherine Dock-Bregeon / Reinhard Luehrmann / Daniel Herschlag / Miles Wilkinson
Evaluated 21 Nov 2006

PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins.
Shi Y, Reddy B, Manley JL
Mol Cell 2006 Sep 15 23(6):819-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 13 Oct 2006

The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.
Small EC, Leggett SR, Winans AA, Staley JP
Mol Cell 2006 Aug 4 23(3):389-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 3 Oct 2006

Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.
Soares LM, Zanier K, …, Sattler M, Valcárcel J
Science 2006 Jun 30 312(5782):1961-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 13 Jul 2006

Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly.
Tardiff DF, Rosbash M
RNA 2006 Jun 12(6):968-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 22 May 2006

Exon ligation is proofread by the DExD/H-box ATPase Prp22p.
Mayas RM, Maita H, Staley JP
Nat Struct Mol Biol 2006 Jun 13(6):482-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 16 May 2006

Structure of PTB bound to RNA: specific binding and implications for splicing regulation.
Oberstrass FC, Auweter SD, …, Black DL, Allain FH
Science 2005 Sep 23 309(5743):2054-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lawrence Chasin / Reinhard Luehrmann
Evaluated 7 Oct 2005

Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets.
Denis MM, Tolley ND, …, Zimmerman GA, Weyrich AS
Cell 2005 Aug 12 122(3):379-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 26 Sep 2005


Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes.
Bühler M, Mohn F, Stalder L, Mühlemann O
Mol Cell 2005 Apr 29 18(3):307-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 9 May 2005

The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
Muratani M, Kung C, Shokat KM, Tansey WP
Cell 2005 Mar 25 120(6):887-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann / Ronald Conaway / Cheng-Ming Chiang
Evaluated 19 Apr 2005

The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.
Kwan SS, Brow DA
RNA 2005 May 11(5):808-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 14 Apr 2005

Nanoarchaeum equitans creates functional tRNAs from separate genes for their 5'- and 3'-halves.
Randau L, Münch R, …, Jahn D, Söll D
Nature 2005 Feb 3 433(7025):537-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kiyoshi Nagai / Reinhard Luehrmann
Evaluated 7 Apr 2005

mRNA helicase activity of the ribosome.
Takyar S, Hickerson RP, Noller HF
Cell 2005 Jan 14 120(1):49-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kathleen Hall / Gloria Culver / Richard Gourse / Reinhard Luehrmann
Evaluated 7 Apr 2005

Systematic identification and analysis of exonic splicing silencers.
Wang Z, Rolish ME, …, Mawson M, Burge CB
Cell 2004 Dec 17 119(6):831-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald Rio / Reinhard Luehrmann
Evaluated 5 Jan 2005

Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine.
Batey RT, Gilbert SD, Montange RK
Nature 2004 Nov 18 432(7015):411-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann / Eric Westhof / Gabriele Varani
Evaluated 25 Nov 2004

Substrate-assisted catalysis of peptide bond formation by the ribosome.
Weinger JS, Parnell KM, …, Green R, Strobel SA
Nat Struct Mol Biol 2004 Nov 11(11):1101-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann / Arieh Warshel / Samuel Gunderson / Andrea Barta / Shelley Copley / Alfred Wittinghofer
Evaluated 16 Nov 2004

The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock.
Allen TA, Von Kaenel S, Goodrich JA, Kugel JF
Nat Struct Mol Biol 2004 Sep 11(9):816-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Samuel Butcher / Reinhard Luehrmann / Jerry Workman
Evaluated 14 Sep 2004

Modular aptameric sensors.
Stojanovic MN, Kolpashchikov DM
J Am Chem Soc 2004 Aug 4 126(30):9266-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann / Ilan Davis
Evaluated 9 Sep 2004

New tertiary constraints between the RNA components of active yeast spliceosomes: a photo-crosslinking study.
Ryan DE, Kim CH, …, Stockley PG, Abelson J
RNA 2004 Aug 10(8):1251-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 11 Aug 2004

Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization.
Hachet O, Ephrussi A
Nature 2004 Apr 29 428(6986):959-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roy Long / Lynne Maquat / Ilan Davis / Gabriele Varani / Reinhard Luehrmann
Evaluated 3 Jun 2004

Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K. Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D. Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
Evaluated 17 May 2004

Protein displacement by DExH/D "RNA helicases" without duplex unwinding.
Fairman ME, Maroney PA, …, Nilsen TW, Jankowsky E
Science 2004 Apr 30 304(5671):730-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 12 May 2004

Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.
Xu YZ, Newnham CM, …, Konarska MM, Query CC
EMBO J 2004 Jan 28 23(2):376-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kathleen Hall / Reinhard Luehrmann
Evaluated 18 Feb 2004

Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts.
Skordis LA, Dunckley MG, …, Eperon IC, Muntoni F
Proc Natl Acad Sci U S A 2003 Apr 1 100(7):4114-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 1 Dec 2003

Correction of disease-associated exon skipping by synthetic exon-specific activators.
Cartegni L, Krainer AR
Nat Struct Biol 2003 Feb 10(2):120-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 1 Dec 2003

ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.
Perriman R, Barta I, …, Abelson J, Ares M
Proc Natl Acad Sci U S A 2003 Nov 25 100(24):13857-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann
Evaluated 28 Nov 2003

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