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 | Geraldine Clough
| | | No longer a member of F1000[ 15-FEB-2005 - 18-JUN-2008 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
My current studies are directed towards an understanding of the role of the microvascularendothelium in determining the response of tissues to an inflammatory stimulus including those in response to endogenous mediators, environmental factors and xenobiotics, as well as in models of tissue breakdown and remodelling. It involves interrogation of the vascular endothelium both in vivo and in vitro and aims to bridge the gap between molecular biology and systems biology by using relevant models in which to perform mechanistic, functional and therapeutic investigations.
Many of our studies have been performed in healthy volunteers and patients, using the skin as an in vivo model organ. The techniques we employ are unique to the group and are being used to address novel functional issues in a highly relevant model. They allow us to explore physiological and pathophysiological changes in microvascular function such as those occurring as a result of early life programming or in inflammatory and allergic disease, and to relate these to phenotypic and/or genotypic changes endothelial cell structure and function. To extend and compliment our functional studies in humans, in vivo, I have recently expanded our research programme to make use of isolated human and animal tissues and primary cells in order to take a more mechanistic approach and to explore the signalling processes underlying the pathogenesis of microvascular dysfunction.
| Home page
http://www.som.soton.ac.uk/research/iir/AIR/members/GFC1/CloughGF.htm |
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