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 | Clifford Harding
Department of Pathology, Case Western Reserve University, Cleveland, United States of America | | | Faculty Member: IMMUNOLOGY > Antigen processing & recognition [ since 4 July 2001 ] |
| | [ Biography ] [ Evaluations ] | Biography
Biographical Sketch: Clifford V. Harding, M.D., Ph.D.
Clifford Harding attended Harvard College and in 1979 received his A.B. degree magna cum laude with highest honors in Biology, Phi Beta Kappa. He then entered the Medical Scientist Training Program (MSTP) for M.D./Ph.D. training at Washington University, St. Louis, where he received his M.D. and Ph.D. in Cell Biology in 1985. For his Ph.D. thesis, he worked with Philip Stahl and John Heuser on transferrin receptor function, transport and recycling, as well as other aspects of endosome/lysosome function and membrane transport. He entered a residency in Anatomic Pathology at Washington University/Barnes Hospital (1985-1989) and was later appointed Chief Resident in Anatomic Pathology and Instructor in Pathology (1989-1990). In 1989 he received the Experimental Pathologist-in-Training Award from the American Association of Pathologists (now American Society for Investigative Pathology). From 1987-1990 he worked in the laboratory of Dr. Emil Unanue on antigen processing and the function of major histocompatibility complex (MHC) molecules, which started the development of his interests in immunology. In 1990 he joined the faculty at Washington University as an Assistant Professor in Pathology (clinical appointment at Barnes Hospital), and in 1993 he moved to the Department of Pathology at Case Western Reserve University (clinical appointment at University Hospitals of Cleveland). He received a Pfizer Scholar Award in 1991 and an American Cancer Society Junior Faculty Research Award in 1991. He is currently Professor of Pathology and Oncology, CWRU.
Dr. Harding has been active in research relating to several aspects of immunology, cell biology, infectious disease and oncology. His research interests include antigen processing for class I and II MHC antigen presentation, functions of MHC molecules, modulation of antigen processing and immune responses by microbial substances (e.g. CpG DNA, lipoproteins of Mycobacterium tuberculosis and cholera toxin), macrophage-pathogen interactions, intracellular protein transport and functions of endocytic compartments (endosomes, lyso-somes, phagosomes and phagolysosomes), tumor immunology and defects in tumor antigen processing. He is a member of the CWRU Cancer Research Center and the CWRU Center for Aids Research (CFAR). He has authored over 90 scientific publications in these areas. His laboratory receives funding from the National Institutes of Health (NIH).
Dr. Harding is a member of a number of national scientific societies and journal editorial boards, including the editorial boards of Advances in Anatomic Pathology, Traffic and Cellular Microbiology. He has served on many grant study sections at the NIH and other organizations, including the NIH AITRC study section (1996-2001), of which he was the chairman (1999-2001).
Dr. Harding has been active in teaching at CWRU School of Medicine, has served as the Section Leader for Biological Basis of Disease (comprising 164 hours of the first year medical curriculum) and is a member of the Curriculum Leadership Council. He has also trains graduate students and is a member of the CWRU Program in Cell Biology and the CWRU Program in the Molecular and Cellular Basis of Disease. In 2001 he became the Director of the Medical Scientist Training Program (M.D./Ph.D. program) at CWRU. |
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