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David Newman
Natural Products Branch, National Cancer Institute, Frederick, Maryland, United States of America

Faculty Member: MICROBIOLOGY > Applied microbiology [ since 9 August 2001 ]
[ Evaluations ]
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Evaluations

Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome.
Eustáquio AS, Moore BS
Angew Chem Int Ed Engl 2008 47(21):3936-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 19 May 2008

Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system.
Huang X, He J, …, Sattler I, Hertweck C
Angew Chem Int Ed Engl 2008 47(21):3995-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 19 May 2008

Yeast cells with an artificial mineral shell: protection and modification of living cells by biomimetic mineralization.
Wang B, Liu P, …, Xu X, Tang R
Angew Chem Int Ed Engl 2008 47(19):3560-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 19 May 2008

Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.
Zhang X, Alemany LB, …, Goodfellow M, Parry RJ
Antimicrob Agents Chemother 2008 Feb 52(2):574-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 14 Feb 2008

Self-Sufficient Baeyer-Villiger Monooxygenases: Effective Coenzyme Regeneration for Biooxygenation by Fusion Engineering.
Torres Pazmiño DE, Snajdrova R, …, Mihovilovic MD, Fraaije MW
Angew Chem Int Ed Engl 2008 Jan 25 [abstract on PubMed] [related articles] [full text]
Selected by | David Newman
Evaluated 13 Feb 2008

A Revised Pathway Proposed for Staphylococcus aureus Wall Teichoic Acid Biosynthesis Based on In Vitro Reconstitution of the Intracellular Steps.
Brown S, Zhang YH, Walker S
Chem Biol 2008 Jan 15(1):12-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 13 Feb 2008

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis.
Umejiego NN, Gollapalli D, …, Striepen B, Hedstrom L
Chem Biol 2008 Jan 15(1):70-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 13 Feb 2008

Structure and biosynthesis of heat-stable antifungal factor (HSAF), a broad-spectrum antimycotic with a novel mode of action.
Yu F, Zaleta-Rivera K, …, Li XC, Du L
Antimicrob Agents Chemother 2007 Jan 51(1):64-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 8 Mar 2007

A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus.
Partida-Martinez LP, Hertweck C
Chembiochem 2007 Jan 2 8(1):41-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 8 Mar 2007

Alpha-Proteobacterial Symbionts of Marine Bryozoans in the Genus Watersipora.
Anderson CM, Haygood MG
Appl Environ Microbiol 2007 Jan 73:303-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 7 Mar 2007

Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora.
Jensen PR, Williams PG, …, Zeigler L, Fenical W
Appl Environ Microbiol 2007 Feb 73(4):1146-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jean-Jacques Sanglier / David Newman
Evaluated 6 Mar 2007

High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
Baniecki ML, Wirth DF, Clardy J
Antimicrob Agents Chemother 2007 Feb 51(2):716-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 5 Mar 2007

Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts.
Partida-Martinez LP, de Looss CF, …, Buder K, Hertweck C
Appl Environ Microbiol 2007 Feb 73(3):793-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 5 Mar 2007

Vertical transmission of diverse microbes in the tropical sponge Corticium sp.
Sharp KH, Eam B, Faulkner DJ, Haygood MG
Appl Environ Microbiol 2007 Jan 73(2):622-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 5 Mar 2007

Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.
Austin MB, Saito T, …, Kay RR, Noel JP
Nat Chem Biol 2006 Sep 2(9):494-502 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 7 Sep 2006

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.
Watanabe K, Hotta K, …, Oguri H, Oikawa H
Nat Chem Biol 2006 Aug 2(8):423-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 2 Aug 2006

Siphonazole, an unusual metabolite from Herpetosiphon sp.
Nett M, Erol O, …, Neu E, König GM
Angew Chem Int Ed Engl 2006 Jun 2 45(23):3863-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 27 Jun 2006

Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold.
Barluenga S, Dakas PY, …, Meijer L, Winssinger N
Angew Chem Int Ed Engl 2006 Jun 12 45(24):3951-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 27 Jun 2006

Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin.
Amna T, Puri SC, …, Spiteller M, Qazi GN
Can J Microbiol 2006 Mar 52(3):189-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 11 Apr 2006

Discovery of FabH/FabF inhibitors from natural products.
Young K, Jayasuriya H, …, Singh SB, Wang J
Antimicrob Agents Chemother 2006 Feb 50(2):519-26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman / Harald Labischinski
Evaluated 7 Apr 2006

Genomic mining for Aspergillus natural products.
Bok JW, Hoffmeister D, …, Glasner JD, Keller NP
Chem Biol 2006 Jan 13(1):31-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard / David Newman
Evaluated 17 Feb 2006

Characterization of a forest soil metagenome clone that confers indirubin and indigo production on Escherichia coli.
Lim HK, Chung EJ, …, Cho KY, Lee SW
Appl Environ Microbiol 2005 Dec 71(12):7768-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 14 Feb 2006

Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.
Zhou Y, Gregor VE, …, Wall D, Hermann T
Antimicrob Agents Chemother 2005 Dec 49(12):4942-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 14 Feb 2006

Discovery of complex mixtures of novel long-chain quorum sensing signals in free-living and host-associated marine alphaproteobacteria.
Wagner-Döbler I, Thiel V, …, Pukall R, Schulz S
Chembiochem 2005 Dec 6(12):2195-206 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 15 Dec 2005

Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system.
Wipf P, Lynch SM, …, Birmingham A, Englund EE
Org Biomol Chem 2005 Nov 7 3(21):3880-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 10 Nov 2005

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli.
Besong GE, Bostock JM, …, Fishwick CW, Johnson AP
Angew Chem Int Ed Engl 2005 Oct 7 44(39):6403-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 7 Nov 2005

Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production.
Long PF, Dunlap WC, Battershill CN, Jaspars M
Chembiochem 2005 Oct 6(10):1760-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 16 Sep 2005

Novel chemoautotrophic endosymbiosis between a member of the Epsilonproteobacteria and the hydrothermal-vent gastropod Alviniconcha aff. hessleri (Gastropoda: Provannidae) from the Indian Ocean.
Suzuki Y, Sasaki T, …, Nealson KH, Horikoshi K
Appl Environ Microbiol 2005 Sep 71(9):5440-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 14 Sep 2005

Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance.
Mukhtar TA, Koteva KP, Wright GD
Chem Biol 2005 Feb 12(2):229-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 4 May 2005

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.
Hong H, Spencer JB, …, Leadlay PF, Stinear T
Chembiochem 2005 Apr 6(4):643-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 3 May 2005

Generation of novel landomycins M and O through targeted gene disruption.
Luzhetskyy A, Zhu L, …, Rohr J, Bechthold A
Chembiochem 2005 Apr 6(4):675-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 3 May 2005

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.
Liu Y, Shreder KR, …, Ferris DK, Rosenblum JS
Chem Biol 2005 Jan 12(1):99-107 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman / Michael B. Yaffe
Evaluated 8 Feb 2005

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.
Rao FV, Houston DR, …, Omura S, van Aalten DM
Chem Biol 2005 Jan 12(1):65-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 8 Feb 2005

Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons.
Kruger RG, Lu W, …, Kahne D, Walsh CT
Chem Biol 2005 Jan 12(1):131-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 8 Feb 2005

Synthesis and biological validation of a ubiquitous quorum-sensing molecule.
Meijler MM, Hom LG, …, Matsushita M, Janda KD
Angew Chem Int Ed Engl 2004 Apr 13 43(16):2106-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 1 Jun 2004

The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones.
Weidner-Wells MA, Werblood HM, …, Wira E, Macielag MJ
Bioorg Med Chem Lett 2004 Jun 21 14(12):3069-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 1 Jun 2004

Filling a gap in the central metabolism of archaea: prediction of a novel aconitase by comparative-genomic analysis.
Makarova KS, Koonin EV
FEMS Microbiol Lett 2003 Oct 10 227(1):17-23 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 15 Oct 2003

Synthetic compound libraries displayed on the surface of encoded bacteriophage.
Woiwode TF, Haggerty JE, …, Dower WJ, Cwirla SE
Chem Biol 2003 Sep 10(9):847-58 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman / Burckhard Seelig
Evaluated 15 Oct 2003

Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus.
Capon RJ, Skene C, …, Heiland K, Friedel T
Org Biomol Chem 2003 Jun 7 1(11):1856-62 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 7 Aug 2003

Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin.
Sorensen JL, Vederas JC
Chem Commun (Camb) 2003 Jul 7 (13):1492-3 [abstract on PubMed] [related articles]
Selected by | David Newman
Evaluated 14 Jul 2003

Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes.
Jin M, Liu L, …, Beer SV, Clardy J
Angew Chem Int Ed Engl 2003 Jun 30 42(25):2898-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 11 Jul 2003

Proteomic approach to understanding antibiotic action.
Bandow JE, Brötz H, …, Labischinski H, Hecker M
Antimicrob Agents Chemother 2003 Mar 47(3):948-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 11 Jul 2003

Coupling of bacterial endosymbiont and host mitochondrial genomes in the hydrothermal vent clam Calyptogena magnifica.
Hurtado LA, Mateos M, Lutz RA, Vrijenhoek RC
Appl Environ Microbiol 2003 Apr 69(4):2058-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 16 Apr 2003

Engineering Streptomyces clavuligerus deacetoxycephalosporin C synthase for optimal ring expansion activity toward penicillin G.
Wei CL, Yang YB, …, Hsu JS, Tsai YC
Appl Environ Microbiol 2003 Apr 69(4):2306-12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 16 Apr 2003

The role of Mo atoms in nitrogen fixation: balancing substrate reduction and dihydrogen production.
Bell J, Dunford AJ, Hollis E, Henderson RA
Angew Chem Int Ed Engl 2003 Mar 10 42(10):1149-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 14 Mar 2003

The selective incorporation of alkenes into proteins in Escherichia coli.
Zhang Z, Wang L, Brock A, Schultz PG
Angew Chem Int Ed Engl 2002 Aug 2 41(15):2840-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 2 Sep 2002

Synthesis of neo-peptidoglycans: an unexpected activity of proteases.
Wehofsky N, Löser R, …, Welzel P, Bordusa F
Angew Chem Int Ed Engl 2002 Aug 2 41(15):2735-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 2 Sep 2002

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds.
Rodríguez L, Aguirrezabalaga I, …, Méndez C, Salas JA
Chem Biol 2002 Jun 9(6):721-9 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 23 Jul 2002

Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site.
Vicens Q, Westhof E
Chem Biol 2002 Jun 9(6):747-55 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 23 Jul 2002

New Methods for Proteomic Research: Preparation of Proteins with N-Terminal Cysteines for Labeling and Conjugation.
Tolbert TJ, Wong C-H
Angew Chem Int Ed 2002 41:2171-2174 [order article]
Selected by | David Newman
Evaluated 24 Jun 2002

Catalytic Enantioselective Synthesis of beta2-amino acids.
Davies HML, Venkataramani C
Angew Chem Int Ed 2002 41:2197-2199 [order article]
Selected by | David Newman
Evaluated 24 Jun 2002

New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.
Hu JF, Schetz JA, …, Wilkins SP, Hamann MT
J Nat Prod 2002 Apr 65(4):476-80 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 7 May 2002

Malevamide D: isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydnoides.
Horgen FD, Kazmierski EB, …, Yoshida WY, Scheuer PJ
J Nat Prod 2002 Apr 65(4):487-91 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 3 May 2002

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides.
Cane DE, Kudo F, Kinoshita K, Khosla C
Chem Biol 2002 Jan 9(1):131-42 [abstract on PubMed] [related articles] [order article]
Selected by | David Newman
Evaluated 19 Mar 2002

Combination bacteriolytic therapy for the treatment of experimental tumors.
Dang LH, Bettegowda C, …, Kinzler KW, Vogelstein B
Proc Natl Acad Sci U S A 2001 Dec 18 98(26):15155-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Newman
Evaluated 18 Mar 2002

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