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Mina J. Bissell
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, United States of America

Faculty Member: CELL BIOLOGY > Cell adhesion [ since 20 July 2006 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Dr. Bissell is a world renowned leader in the area of the role of extracellular matrix (ECM) and microenvironment in regulation of tissue-specific function with special emphasis in breast cancer where she has changed some established paradigms. She earned an A.B. with honors in chemistry from Harvard/Radcliffe College and a Ph.D. in bacterial genetics from Harvard University in 1969. She was a Milton Fellow at Harvard and an American Cancer Society Fellow in the Department of Molecular Biology at U.C. Berkeley. She joined the Lawrence Berkeley National Laboratory in 1972. Dr. Bissell became a Senior Scientist in 1977, the Director of Cell & Molecular Biology in 1988 and was appointed Director of all of Life Sciences in 1992.
Dr. Bissell has authored more than 265 publications and sits on editorial board of many scientific journals, most recently Science magazine. She also sits on a number of National and International scientific and government boards. She has received numerous awards and citations and has given more than 70 `named¿ lectures. She was a Fogarty Fellow in 1984, a Guggenheim fellow in 1992 and was elected an AAAS fellow in 1994. She received the 1996 Ernest Orlando Lawrence Award and medal, the highest honor of the US Department of Energy. In 1997, she was elected to the Institute of Medicine of the National Academy of Sciences and served as President of the American Society for Cell Biology. In 1998, she received the Mellon Award from the University of Pittsburgh and was the 1999 recipient of the Eli Lilly/Clowes Award of the American Association for Cancer Research. In 2001, Dr. Bissell received both an honorary doctorate from the Pierre & Marie Curie University in Paris, and the first ¿Innovator Award¿ of the US Army breast cancer program. In 2002, she was elected to the American Academy of Arts and Sciences and was the President of the International Society of Differentiation. Upon stepping down as the Life Science¿s Division Director, she was named Distinguished Scientist (one of seven, the only woman, and the only life scientist to achieve this status) and Senior Advisor to the Laboratory Director on Biology. In 2003, she received the Brinker Award from the Susan G. Komen Breast Cancer Foundation. In 2004, Dr. Bissell, was among the 13 recipients of the first Discovery Health Channel Medical Honor and received another honorary doctorate from the University of Copenhagen. In 2005, she became the first OBER/DOE Distinguished Scientist Fellow in Life Sciences and received a $1.25 million award for 5 years.

Home page

http://www.lbl.gov/lifesciences/labs/bissell_lab.html

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Evaluations

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation.
Zhao R, Kakihara Y, …, Yip CM, Houry WA
J Cell Biol 2008 Feb 11 180(3):563-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mina J. Bissell
Evaluated 14 May 2008

Systemic spread is an early step in breast cancer.
Hüsemann Y, Geigl JB, …, Riethmüller G, Klein CA
Cancer Cell 2008 Jan 13(1):58-68 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | J. Thomas Parsons / Mina J. Bissell
Evaluated 13 Feb 2008

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Wolf K, Wu YI, …, Stack MS, Friedl P
Nat Cell Biol 2007 Aug 9(8):893-904 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Gold / Gabriel Fenteany / Mina J. Bissell
Evaluated 23 Aug 2007

Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control.
Aranda V, Haire T, …, Pawson T, Muthuswamy SK
Nat Cell Biol 2006 Nov 8(11):1235-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Keith Mostov / Mina J. Bissell / Andreas Wodarz / Thomas Ried
Evaluated 20 Dec 2006

Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.
Golubkov VS, Chekanov AV, …, Golubkova NV, Strongin AY
Cancer Res 2006 Nov 1 66(21):10460-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mina J. Bissell
Evaluated 13 Dec 2006

Formation of perfused, functional microvascular tubes in vitro.
Chrobak KM, Potter DR, Tien J
Microvasc Res 2006 May 71(3):185-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley / Mina J. Bissell
Evaluated 8 Dec 2006

Matrix-specific suppression of integrin activation in shear stress signaling.
Orr AW, Ginsberg MH, …, Deckmyn H, Schwartz MA
Mol Biol Cell 2006 Nov 17(11):4686-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mina J. Bissell
Evaluated 8 Dec 2006

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
Kim KK, Kugler MC, …, Sheppard D, Chapman HA
Proc Natl Acad Sci U S A 2006 Aug 29 103(35):13180-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Giulio Gabbiani / Mina J. Bissell
Evaluated 13 Oct 2006

A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres.
Strauss B, Adams RJ, Papalopulu N
Development 2006 Oct 133(19):3883-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mina J. Bissell
Evaluated 3 Oct 2006

Cell and fibronectin dynamics during branching morphogenesis.
Larsen M, Wei C, Yamada KM
J Cell Sci 2006 Aug 15 119(Pt 16):3376-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mina J. Bissell / Keith Mostov
Evaluated 14 Aug 2006

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