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Frank Lyko
Arbeitsgruppe Epigenetik, German Cancer Research Center, Germany

Faculty Member: GENOMICS & GENETICS > Animal genetics [ since 5 July 2001 ]
[ Evaluations ]
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Evaluations

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Kondo Y, Shen L, …, Huang TH, Issa JP
Nat Genet 2008 Jun 40(6):741-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 5 Jun 2008

Nutritional control of reproductive status in honeybees via DNA methylation.
Kucharski R, Maleszka J, Foret S, Maleszka R
Science 2008 Mar 28 319(5871):1827-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Azim Surani
Evaluated 25 Mar 2008

A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins.
Rothbauer U, Zolghadr K, …, Cardoso MC, Leonhardt H
Mol Cell Proteomics 2008 Feb 7(2):282-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 12 Feb 2008

Evidence for Transgenerational Transmission of Epigenetic Tumor Susceptibility in Drosophila.
Xing Y, Shi S, Silver-Morse L, Li WX
PLoS Genet 2007 Sep 7 3:151 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 19 Sep 2007

Biological functions of DNA methyltransferase 1 require its methyltransferase activity.
Damelin M, Bestor TH
Mol Cell Biol 2007 Jun 27(11):3891-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 3 Apr 2007

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
Schlesinger Y, Straussman R, …, Simon I, Cedar H
Nat Genet 2007 Feb 39(2):232-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 23 Jan 2007

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.
Egger G, Jeong S, …, Jones PA, Liang G
Proc Natl Acad Sci U S A 2006 Sep 19 103(38):14080-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 29 Sep 2006

Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis.
Zhang X, Yazaki J, …, Jacobsen SE, Ecker JR
Cell 2006 Sep 22 126(6):1189-201 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sui Huang / Craig Pikaard / Xing Wang Deng / Frank Lyko / Eric Selker / Vivian Irish / Motoaki Seki
Evaluated 26 Sep 2006

DNA methylation supports intrinsic epigenetic memory in mammalian cells.
Feng YQ, Desprat R, …, Aladjem MI, Bouhassira EE
PLoS Genet 2006 Apr 2(4):e65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 24 May 2006

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.
Frigola J, Song J, …, Peinado MA, Clark SJ
Nat Genet 2006 May 38(5):540-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Andrew Belmont
Evaluated 5 May 2006

Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage.
Suzuki K, Suzuki I, …, Yamashita K, Perucho M
Cancer Cell 2006 Mar 9(3):199-207 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 11 Apr 2006

De novo CpG island methylation in human cancer cells.
Jair KW, Bachman KE, …, Baylin SB, Schuebel KE
Cancer Res 2006 Jan 15 66(2):682-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 31 Jan 2006

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.
Ferres-Marco D, Gutierrez-Garcia I, …, Gutierrez-Aviño FJ, Dominguez M
Nature 2006 Jan 26 439(7075):430-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Ross Cagan / Marta Llimargas / Thomas Jenuwein
Evaluated 31 Jan 2006

Global loss of imprinting leads to widespread tumorigenesis in adult mice.
Holm TM, Jackson-Grusby L, …, Rideout WM, Jaenisch R
Cancer Cell 2005 Oct 8(4):275-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 31 Oct 2005

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.
Metzger E, Wissmann M, …, Buettner R, Schüle R
Nature 2005 Sep 15 437(7057):436-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Jenuwein / Frank Lyko
Evaluated 19 Sep 2005

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation.
Ting AH, Schuebel KE, Herman JG, Baylin SB
Nat Genet 2005 Aug 37(8):906-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marjori Matzke / Frank Lyko / Barbara Trask
Evaluated 4 Aug 2005

MicroRNA expression profiles classify human cancers.
Lu J, Getz G, …, Horvitz HR, Golub TR
Nature 2005 Jun 9 435(7043):834-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Julie Ahringer / Frank Lyko / Fritz Eckstein / Charles Auffray / Miles Wilkinson
Evaluated 13 Jun 2005

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.
Hochedlinger K, Yamada Y, Beard C, Jaenisch R
Cell 2005 May 6 121(3):465-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 17 May 2005

Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis.
Lolle SJ, Victor JL, Young JM, Pruitt RE
Nature 2005 Mar 24 434(7032):505-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Shigeru Iida / Kay Schneitz / Judy Wall / Marjori Matzke / James Carrington / Jose Luis Riechmann / Christian Hardtke / John Bowman / James Hu / Caren Chang / Venkatesan Sundaresan / Philip Benfey / Stephan Beck / Magnus Nordborg / Neelima Sinha / Martin Parniske / Elena Alvarez-Buylla / Elizabeth Kellogg / Elizabeth Hood
Dissenters | Alejandro Sanchez-Alvarado
Evaluated 24 Mar 2005


Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation.
Onodera Y, Haag JR, …, Pontes O, Pikaard CS
Cell 2005 Mar 11 120(5):613-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Frank Lyko / Sui Huang / Lucio Comai / Vivian Irish / Motoaki Seki
Evaluated 22 Mar 2005

Genomic maps and comparative analysis of histone modifications in human and mouse.
Bernstein BE, Kamal M, …, Schreiber SL, Lander ES
Cell 2005 Jan 28 120(2):169-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Jean Wang
Evaluated 4 Feb 2005

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Shi Y, Lan F, …, Casero RA, Shi Y
Cell 2004 Dec 29 119(7):941-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Henikoff / Thomas Jenuwein / Chris Sander / Winship Herr / Dinah Singer / Robert Dutnall / Eric Selker / Frank Lyko / Daniel Reines / Benoit Coulombe / Robin Allshire
Evaluated 12 Jan 2005

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.
Gius D, Cui H, …, Mitchell JB, Feinberg AP
Cancer Cell 2004 Oct 6(4):361-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 28 Oct 2004

Reprogramming of a melanoma genome by nuclear transplantation.
Hochedlinger K, Blelloch R, …, Chin L, Jaenisch R
Genes Dev 2004 Aug 1 18(15):1875-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko / Thomas Ried / Buzz Baum
Evaluated 11 Aug 2004

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops.
Murrell A, Heeson S, Reik W
Nat Genet 2004 Aug 36(8):889-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 5 Aug 2004

Epigenetic programming by maternal behavior.
Weaver IC, Cervoni N, …, Szyf M, Meaney MJ
Nat Neurosci 2004 Aug 7(8):847-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / David P. Wolfer / Laurence H. Tecott / Elizabeth Gould
Evaluated 2 Aug 2004

CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.
Ting AH, Jair KW, …, Baylin SB, Schuebel KE
Nat Genet 2004 Jun 36(6):582-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 3 Jun 2004

Germline epimutation of MLH1 in individuals with multiple cancers.
Suter CM, Martin DI, Ward RL
Nat Genet 2004 May 36(5):497-501 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 20 May 2004

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Suzuki H, Watkins DN, …, Herman JG, Baylin SB
Nat Genet 2004 Apr 36(4):417-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Alfonso Martinez Arias
Evaluated 16 Apr 2004

Mice cloned from olfactory sensory neurons.
Eggan K, Baldwin K, …, Axel R, Jaenisch R
Nature 2004 Mar 4 428(6978):44-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Ngai / Frank Lyko / Lawrence C. Katz / Alexandra Joyner
Evaluated 12 Mar 2004

HP1 is essential for DNA methylation in neurospora.
Freitag M, Hickey PC, …, Read ND, Selker EU
Mol Cell 2004 Feb 13 13(3):427-34 [abstract on PubMed] [related articles] [order article]
Selected by | Frank Lyko / David Catcheside
Evaluated 19 Feb 2004

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery.
Pal-Bhadra M, Leibovitch BA, …, Birchler JA, Elgin SC
Science 2004 Jan 30 303(5658):669-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 19 Feb 2004

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
Peters AH, Kubicek S, …, Martens JH, Jenuwein T
Mol Cell 2003 Dec 12(6):1577-89 [abstract on PubMed] [related articles] [order article]
Selected by | Frank Lyko / Thomas Cremer
Evaluated 5 Jan 2004

Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos.
Huynh KD, Lee JT
Nature 2003 Dec 18 426(6968):857-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 22 Dec 2003

Dicer is essential for mouse development.
Bernstein E, Kim SY, …, Anderson KV, Hannon GJ
Nat Genet 2003 Nov 35(3):215-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Carthew / Frank Lyko / Yasushi Okazaki / Fritz Eckstein
Evaluated 29 Oct 2003

The small RNA profile during Drosophila melanogaster development.
Aravin AA, Lagos-Quintana M, …, Meyer J, Tuschl T
Dev Cell 2003 Aug 5(2):337-50 [abstract on PubMed] [related articles] [order article]
Selected by | Ken Irvine / Marjori Matzke / Frank Lyko
Evaluated 5 Sep 2003

Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin.
Tariq M, Saze H, …, Habu Y, Paszkowski J
Proc Natl Acad Sci U S A 2003 Jul 22 100(15):8823-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Wendy Bickmore / Frank Lyko / Eric Selker / Thomas Jenuwein
Evaluated 17 Jul 2003

The role of DNA methylation in setting up chromatin structure during development.
Hashimshony T, Zhang J, …, Bustin M, Cedar H
Nat Genet 2003 Jun 34(2):187-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Thomas Jenuwein
Evaluated 2 Jun 2003

Induction of tumors in mice by genomic hypomethylation.
Gaudet F, Hodgson JG, …, Leonhardt H, Jaenisch R
Science 2003 Apr 18 300(5618):489-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko / Andrew Saxon
Evaluated 23 Apr 2003

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.
Cui H, Cruz-Correa M, …, Powe NR, Feinberg AP
Science 2003 Mar 14 299(5613):1753-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 31 Mar 2003

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Robert MF, Morin S, …, Barsalou A, MacLeod AR
Nat Genet 2003 Jan 33(1):61-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 21 Feb 2003

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.
Sollars V, Lu X, …, Garfinkel MD, Ruden DM
Nat Genet 2003 Jan 33(1):70-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Wendy Bickmore
Evaluated 7 Jan 2003

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.
Fuks F, Hurd PJ, …, Bird AP, Kouzarides T
J Biol Chem 2003 Feb 7 278(6):4035-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko
Evaluated 4 Dec 2002

The polycomb group protein EZH2 is involved in progression of prostate cancer.
Varambally S, Dhanasekaran SM, …, Rubin MA, Chinnaiyan AM
Nature 2002 Oct 10 419(6907):624-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 17 Oct 2002

Active genes are tri-methylated at K4 of histone H3.
Santos-Rosa H, Schneider R, …, Mellor J, Kouzarides T
Nature 2002 Sep 26 419(6905):407-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Eric Selker
Evaluated 30 Sep 2002

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Volpe TA, Kidner C, …, Grewal SI, Martienssen RA
Science 2002 Sep 13 297(5588):1833-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | L. Alison McInnes / Robin Allshire / Rivka Dikstein / Frank Lyko / Timothy Yen / Kerry Bloom / James Carrington / Thomas Jenuwein
Evaluated 25 Sep 2002

A chromatin remodelling complex that loads cohesin onto human chromosomes.
Hakimi MA, Bochar DA, …, Yokomori K, Shiekhattar R
Nature 2002 Aug 29 418(6901):994-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Antony Carr
Evaluated 3 Sep 2002

Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1.
Gendrel AV, Lippman Z, …, Colot V, Martienssen RA
Science 2002 Sep 13 297(5588):1871-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko / Eric Richards / Shigeru Iida
Evaluated 31 Jul 2002

A molecular programme for the specification of germ cell fate in mice.
Saitou M, Barton SC, Surani MA
Nature 2002 Jul 18 418(6895):293-300 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Patrick Tam / David Ish-Horowicz
Evaluated 30 Jul 2002

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
Tachibana M, Sugimoto K, …, Kato H, Shinkai Y
Genes Dev 2002 Jul 15 16(14):1779-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko / James Bone / En Li
Evaluated 26 Jul 2002

Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.
Yang X, Zhang F, Kudlow JE
Cell 2002 Jul 12 110(1):69-80 [abstract on PubMed] [related articles] [order article]
Selected by | Frank Lyko / Suzanne Walker / Linda C. Hsieh-Wilson / Andrew D. Sharrocks / Ronald Conaway
Evaluated 23 Jul 2002

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination.
Rosenberg MI, Parkhurst SM
Cell 2002 May 17 109(4):447-58 [abstract on PubMed] [related articles] [order article]
Selected by | Frank Lyko
Evaluated 17 Jun 2002

A global disorder of imprinting in the human female germ line.
Judson H, Hayward BE, Sheridan E, Bonthron DT
Nature 2002 Apr 4 416(6880):539-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Sue Malcolm
Evaluated 8 Apr 2002

Monoclonal mice generated by nuclear transfer from mature B and T donor cells.
Hochedlinger K, Jaenisch R
Nature 2002 Feb 28 415(6875):1035-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / David Nemazee
Evaluated 7 Mar 2002

The non-coding Air RNA is required for silencing autosomal imprinted genes.
Sleutels F, Zwart R, Barlow DP
Nature 2002 Feb 14 415(6873):810-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Peter B. Becker / Marisa Bartolomei
Evaluated 21 Feb 2002

Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts.
Lopatina N, Haskell JF, …, Saldanha S, Tollefsbol T
J Cell Biochem 2002 84(2):324-34 [abstract on PubMed] [related articles] [order article]
Selected by | Frank Lyko
Evaluated 16 Jan 2002

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa.
Tamaru H, Selker EU
Nature 2001 Nov 15 414(6861):277-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Allis / Daniel Reines / Frank Lyko / Steven Reiner
Evaluated 7 Dec 2001

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Peters AH, O'Carroll D, …, Sibilia M, Jenuwein T
Cell 2001 Nov 2 107(3):323-37 [abstract on PubMed] [related articles] [order article]
Selected by | David Allis / Frank Lyko
Evaluated 30 Nov 2001

CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.
Malone CS, Miner MD, …, Wall R, Teitell M
Proc Natl Acad Sci U S A 2001 Aug 28 98(18):10404-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Lyko / Xiaodong Cheng
Evaluated 10 Oct 2001

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins.
Saurin AJ, Shao Z, …, Tempst P, Kingston RE
Nature 2001 Aug 9 412(6847):655-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Rivka Dikstein
Evaluated 7 Sep 2001

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus.
Filippova GN, Thienes CP, …, Lobanenkov VV, Tapscott SJ
Nat Genet 2001 Aug 28(4):335-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko
Evaluated 5 Sep 2001

General transcription factors bind promoters repressed by Polycomb group proteins.
Breiling A, Turner BM, Bianchi ME, Orlando V
Nature 2001 Aug 9 412(6847):651-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Rivka Dikstein / James Kadonaga
Evaluated 29 Aug 2001

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