homefeedbacksupportlog on 6-Jul-2009 
  About F1000

 What is F1000?
 Key features
 How it's organized
 FAQs
 Faculties and sections
 Scope of sections
 Intl Advisory Board
 List of Faculty Members
 Associate Faculty Members
 The evaluation system
 Citing F1000
 Take a tour of the site
 Accessing fulltexts
 PubMed linkout
 How to subscribe
 Academic subscriptions
 Corporate subscriptions
 Try F1000 for free
 Who we are
 Media information
 Librarian resources
 Press releases
 In the press
 Developing countries
 F1000 Medicine
 Terms and conditions
 Privacy policy
 Contact us


Stephen R Holbrook

No longer a member of F1000[ 13-JUL-2001 - 02-DEC-2008 ]
[ Biography ] [ Evaluations ]
Biography

Received a B.S. in Chemistry from the Univ. of Oklahoma in 1969. Received a Ph.D. in Physical Chemistry from the Univ. of Oklahoma in 1974 in area of small molecule X-ray crystallography. Did Postdoctoral studies with S.-H. Kim at Duke University from 1974-1978. Employed by Lawrence Berkeley National Laboratory as Staff Scientist from 1978-present. Current appointments in the Computational and Theoretical Biology Departments and Structural Biology Departments of the Physical Biosciences Division of LBNL. Research areas include Structural studies of RNA, RNA-protein complexes and DNA repair proteins, computational biology applied to problems of RNA structure and function, protein structure and function and RNA gene prediction. Funded by DOE, LBNL and NIH.

to email [Help]
Evaluations

Identification of new noncoding RNAs in Listeria monocytogenes and prediction of mRNA targets.
Mandin P, Repoila F, …, Geissmann T, Cossart P
Nucleic Acids Res 2007 35(3):962-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 31 May 2007

A backbone-based theory of protein folding.
Rose GD, Fleming PJ, Banavar JR, Maritan A
Proc Natl Acad Sci U S A 2006 Nov 7 103(45):16623-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Henchman / Stephen Holbrook
Evaluated 7 Dec 2006

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution.
Farh KK, Grimson A, …, Burge CB, Bartel DP
Science 2005 Dec 16 310(5755):1817-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John / Phillip Zamore / Fritz Eckstein / Stephen Holbrook
Evaluated 9 Jan 2006

Predicting candidate genomic sequences that correspond to synthetic functional RNA motifs.
Laserson U, Gan HH, Schlick T
Nucleic Acids Res 2005 33(18):6057-69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 28 Nov 2005

RNA backbone is rotameric.
Murray LJ, Arendall WB, Richardson DC, Richardson JS
Proc Natl Acad Sci U S A 2003 Nov 25 100(24):13904-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 15 Jun 2005

RNA kink turns to the left and to the right.
Strobel SA, Adams PL, Stahley MR, Wang J
RNA 2004 Dec 10(12):1852-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 23 Dec 2004

Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme.
Ghosh T, Peterson B, Tomasevic N, Peculis BA
Mol Cell 2004 Mar 26 13(6):817-28 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen Holbrook
Evaluated 13 Jul 2004

The genome sequence of the extreme thermophile Thermus thermophilus.
Henne A, Brüggemann H, …, Gottschalk G, Fritz HJ
Nat Biotechnol 2004 May 22(5):547-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Holbrook
Evaluated 19 Apr 2004

Prediction of RNA-binding proteins from primary sequence by a support vector machine approach.
Han LY, Cai CZ, …, Chung MC, Chen YZ
RNA 2004 Mar 10(3):355-68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 10 Mar 2004

Automated identification of RNA conformational motifs: theory and application to the HM LSU 23S rRNA.
Hershkovitz E, Tannenbaum E, …, Tannenbaum A, Williams LD
Nucleic Acids Res 2003 Nov 1 31(21):6249-57 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 18 Nov 2003

Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family.
Kang LW, Gabelli SB, …, Bessman MJ, Amzel LM
J Bacteriol 2003 Jul 185(14):4110-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 24 Jul 2003

The functional anatomy of an intrinsic transcription terminator.
Schwartz A, Rahmouni AR, Boudvillain M
EMBO J 2003 Jul 1 22(13):3385-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 24 Jul 2003

HIV-1 RNA dimerization initiation site is structurally similar to the ribosomal A site and binds aminoglycoside antibiotics.
Ennifar E, Paillart JC, …, Dumas P, Walter P
J Biol Chem 2003 Jan 24 278(4):2723-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 30 Jan 2003

Location of 2(')-O-methyl nucleotides in 26S rRNA and methylation guide snoRNAs in Caenorhabditis elegans.
Higa S, Maeda N, Kenmochi N, Tanaka T
Biochem Biophys Res Commun 2002 Oct 11 297(5):1344-9 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen Holbrook
Evaluated 11 Nov 2002

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
Schumacher MA, Pearson RF, …, Valentin-Hansen P, Brennan RG
EMBO J 2002 Jul 1 21(13):3546-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook / Stephen Busby
Evaluated 24 Jul 2002

Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA.
Brodersen DE, Clemons WM, …, Wimberly BT, Ramakrishnan V
J Mol Biol 2002 Feb 22 316(3):725-68 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Holbrook
Evaluated 26 Apr 2002

NMR structure of a ribosomal RNA hairpin containing a conserved CUCAA pentaloop.
Nagaswamy U, Gao X, Martinis SA, Fox GE
Nucleic Acids Res 2001 Dec 15 29(24):5129-39 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Holbrook
Evaluated 8 Mar 2002

Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization.
Sherlin LD, Bullock TL, …, Uhlenbeck OC, Scaringe SA
RNA 2001 Nov 7(11):1671-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Scott K Silverman / Stephen Holbrook
Evaluated 9 Jan 2002

Inducible regulation of the S. cerevisiae cell cycle mediated by an RNA aptamer-ligand complex.
Grate D, Wilson C
Bioorg Med Chem 2001 Oct 9(10):2565-70 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen Holbrook
Evaluated 5 Nov 2001

The structure of helix III in Xenopus oocyte 5 S rRNA: an RNA stem containing a two-nucleotide bulge.
Huber PW, Rife JP, Moore PB
J Mol Biol 2001 Sep 28 312(4):823-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Holbrook / Thorsten Dieckmann
Evaluated 5 Nov 2001

^Top  Back to Faculty Members



© 1999-2009 Biology Reports Ltd unless otherwise stated. < info@f1000.com >   Terms and conditions   Legal info