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Markus Heilig
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America

Faculty Member: Pharmacology & Drug Discovery > Neuropharmacology & Psychopharmacology [ since 4 May 2006 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Markus Heilig received his MD in 1986 and his PhD in Psychiatric Neurochemistry in 1989, both from Lund University, Sweden. His thesis work described for the first time the anti-stress and anxiety reducing effects of neuropeptide Y (NPY). He received postdoctoral training with prof. George Koob at the Neuropharmacology Dept., The Scripps Research Institute, LaJolla, CA 1990 - 1992. Upon returning to Sweden and completing residency and fellowship training in psychiatry, he served at the Karolinska Institute, Stockholm, Swede, in various clinical and academic leadership capacities until 2004. At this time he became the Clinical Director and chief, Laboratory of Clinical and Translational studies, at the National Inst on Alcohol Abuse and Alcoholism. Heilig's research interests are centered around regulation of negative affect, as it applies to affective, anxiety and addictive disorders. Current program efforts are focused on identifying novel treatment targets for pharmacological treatments of alcohol dependence, and developing such treatments from preclinical target discovery and validation to early human proof-of-concept trials. Currently pursued targets include several systems involved in stress- and negative affect, such as NPY, CRH, neurokinins, nociceptin, glutamate and cannabinoids.

Home page

http://www.niaaa.nih.gov/ResearchInformation/IntramuralResearch/AboutDICBR/LCTS/

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Evaluations

Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning.
Kolber BJ, Roberts MS, …, Sands MS, Muglia LJ
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):12004-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Herman / Markus Heilig
Evaluated 20 May 2009

The incentive salience of alcohol: translating the effects of genetic variant in CNR1.
Hutchison KE, Haughey H, …, Horton WJ, Filbey F
Arch Gen Psychiatry 2008 Jul 65(7):841-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 3 Sep 2008

Brain chromatin remodeling: a novel mechanism of alcoholism.
Pandey SC, Ugale R, …, Tang L, Prakash A
J Neurosci 2008 Apr 2 28(14):3729-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 8 Apr 2008


Topiramate for treating alcohol dependence: a randomized controlled trial.
Johnson BA, Rosenthal N, …, Topiramate for Alcoholism Advisory Board, Topiramate for Alcoholism Study Group
JAMA 2007 Oct 10 298(14):1641-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 15 Jan 2008

Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study.
Addolorato G, Leggio L, …, Haber PS, Gasbarrini G
Lancet 2007 Dec 8 370(9603):1915-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 14 Jan 2008


Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.
Steensland P, Simms JA, …, Richards JK, Bartlett SE
Proc Natl Acad Sci U S A 2007 Jul 24 104(30):12518-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Markus Heilig / Neil Grunberg
Evaluated 3 Oct 2007

Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort.
Paddock S, Laje G, …, Manji H, McMahon FJ
Am J Psychiatry 2007 Aug 164(8):1181-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 10 Aug 2007

Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: implications for the integration of limbic inputs.
Choi DC, Furay AR, …, Ulrich-Lai YM, Herman JP
J Neurosci 2007 Feb 21 27(8):2025-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Markus Heilig
Evaluated 2 Apr 2007

Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.
Funk CK, O'Dell LE, Crawford EF, Koob GF
J Neurosci 2006 Nov 1 26(44):11324-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Markus Heilig
Evaluated 15 Nov 2006

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
Funk CK, Zorrilla EP, …, Rice KC, Koob GF
Biol Psychiatry 2007 Jan 1 61(1):78-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 5 Sep 2006

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.
Treutlein J, Kissling C, …, Mann K, Schumann G
Mol Psychiatry 2006 Jun 11(6):594-602 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 5 Sep 2006

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.
Spanagel R, Pendyala G, …, Schumann G, Albrecht U
Nat Med 2005 Jan 11(1):35-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Markus Heilig
Evaluated 9 Jun 2006

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