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Lynne Maquat
University of Rochester School of Medicine and Dentistry, United States of America

Faculty Member: Cell Biology > Control of Gene Expression [ since 25 July 2001 ]
[ Homepage ] [ Evaluations ]
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http://dbb.urmc.rochester.edu/bcbp/members/faculty/maquat_lynne.html

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Evaluations

Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome.
Jopling CL, Schütz S, Sarnow P
Cell Host Microbe 2008 Jul 17 4(1):77-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat with Olaf Isken
Evaluated 15 Aug 2008

Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
Chernyakov I, Whipple JM, …, Grayhack EJ, Phizicky EM
Genes Dev 2008 May 15 22(10):1369-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 2 Jun 2008

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
Chamieh H, Ballut L, Bonneau F, Le Hir H
Nat Struct Mol Biol 2008 Jan 15(1):85-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat
Evaluated 4 Jan 2008

Switching from repression to activation: microRNAs can up-regulate translation.
Vasudevan S, Tong Y, Steitz JA
Science 2007 Dec 21 318(5858):1931-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Oliver Hobert / Rivka Dikstein / Lynne Maquat / Roy Long / Laura Johnston / Peter Sarnow / Michael Kiebler / Daniel Gallie / Nicola Gray
Evaluated 21 Dec 2007

Molecular basis for target RNA recognition and cleavage by human RISC.
Ameres SL, Martinez J, Schroeder R
Cell 2007 Jul 13 130(1):101-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Oliver Weichenrieder
Evaluated 13 Aug 2007

A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional.
Tardiff DF, Lacadie SA, Rosbash M
Mol Cell 2006 Dec 28 24(6):917-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhard Luehrmann / Lynne Maquat
Evaluated 15 Jan 2007

An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.
Millevoi S, Loulergue C, …, Antoniou M, Vagner S
EMBO J 2006 Oct 18 25(20):4854-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Blumenthal / Lynne Maquat
Evaluated 8 Dec 2006

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.
Bono F, Ebert J, Lorentzen E, Conti E
Cell 2006 Aug 25 126(4):713-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Megerditch Kiledjian / Anne-Catherine Dock-Bregeon / Reinhard Luehrmann / Daniel Herschlag / Miles Wilkinson
Evaluated 6 Sep 2006

Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation.
Doma MK, Parker R
Nature 2006 Mar 23 440(7083):561-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Michael Yarus / Miles Wilkinson
Evaluated 31 Mar 2006

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
Kashima I, Yamashita A, …, Dreyfuss G, Ohno S
Genes Dev 2006 Feb 1 20(3):355-67 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 8 Feb 2006

Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J
Mol Cell 2005 Dec 22 20(6):905-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian / Lynne Maquat
Evaluated 4 Jan 2006

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.
Ballut L, Marchadier B, …, Séraphin B, Le Hir H
Nat Struct Mol Biol 2005 Oct 12(10):861-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Kimberly Mowry / Michael Kiebler
Evaluated 23 Sep 2005

Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae.
Shaheen HH, Hopper AK
Proc Natl Acad Sci U S A 2005 Aug 9 102(32):11290-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Maraia / Lynne Maquat
Evaluated 10 Aug 2005

Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation.
Kim TD, Kim JS, …, Koh DS, Kim KT
Mol Cell Biol 2005 Apr 25(8):3232-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 27 Apr 2005

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.
Kahvejian A, Svitkin YV, …, M'Boutchou MN, Sonenberg N
Genes Dev 2005 Jan 1 19(1):104-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Megerditch Kiledjian
Evaluated 24 Jan 2005

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.
Unterholzner L, Izaurralde E
Mol Cell 2004 Nov 19 16(4):587-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat
Evaluated 29 Nov 2004

Involvement of SR proteins in mRNA surveillance.
Zhang Z, Krainer AR
Mol Cell 2004 Nov 19 16(4):597-607 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat
Evaluated 29 Nov 2004

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.
Mendell JT, Sharifi NA, …, Martinez-Murillo F, Dietz HC
Nat Genet 2004 Oct 36(10):1073-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Michael O'Donovan / Sue Malcolm
Evaluated 5 Oct 2004

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila.
Gatfield D, Izaurralde E
Nature 2004 Jun 3 429(6991):575-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle / Lynne Maquat / Miles Wilkinson
Evaluated 29 Jun 2004

Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization.
Hachet O, Ephrussi A
Nature 2004 Apr 29 428(6986):959-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roy Long / Lynne Maquat / Ilan Davis / Gabriele Varani / Reinhard Luehrmann
Evaluated 13 May 2004

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.
Kadlec J, Izaurralde E, Cusack S
Nat Struct Mol Biol 2004 Apr 11(4):330-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Elena Conti
Evaluated 18 Mar 2004

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.
Palacios IM, Gatfield D, St Johnston D, Izaurralde E
Nature 2004 Feb 19 427(6976):753-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Ilan Davis / Miles Wilkinson / Gabriele Varani
Evaluated 2 Mar 2004

What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
Pöyry TA, Kaminski A, Jackson RJ
Genes Dev 2004 Jan 1 18(1):62-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 3 Feb 2004

eIF4A3 is a novel component of the exon junction complex.
Chan CC, Dostie J, …, Rappsilber J, Dreyfuss G
RNA 2004 Feb 10(2):200-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Miles Wilkinson
Evaluated 3 Feb 2004

Exon junction complexes mediate the enhancing effect of splicing on mRNA expression.
Wiegand HL, Lu S, Cullen BR
Proc Natl Acad Sci U S A 2003 Sep 30 100(20):11327-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 29 Sep 2003

Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast.
Takahashi S, Araki Y, Sakuno T, Katada T
EMBO J 2003 Aug 1 22(15):3951-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Miles Wilkinson
Evaluated 7 Aug 2003

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways.
Gatfield D, Unterholzner L, …, Bork P, Izaurralde E
EMBO J 2003 Aug 1 22(15):3960-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 7 Aug 2003

An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation.
Mitchell P, Tollervey D
Mol Cell 2003 May 11(5):1405-13 [abstract on PubMed] [related articles] [order article]
Selected by | Lynne Maquat / Megerditch Kiledjian / Miles Wilkinson
Evaluated 28 May 2003

Nuclear protein synthesis: a re-evaluation.
Nathanson L, Xia T, Deutscher MP
RNA 2003 Jan 9(1):9-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Miles Wilkinson
Evaluated 17 Jan 2003

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.
Shin BS, Maag D, …, Lorsch JR, Dever TE
Cell 2002 Dec 27 111(7):1015-25 [abstract on PubMed] [related articles] [order article]
Selected by | Lynne Maquat
Evaluated 16 Jan 2003

Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Calero G, Wilson KF, …, Clardy JC, Cerione RA
Nat Struct Biol 2002 Dec 9(12):912-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat
Evaluated 6 Dec 2002

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
Bohnsack MT, Regener K, …, Hartmann E, Görlich D
EMBO J 2002 Nov 15 21(22):6205-15 [abstract on PubMed] [related articles] [order article]
Selected by | Richard Maraia / Lynne Maquat / Elsebet Lund / Tom Rapoport
Evaluated 15 Nov 2002

The hDcp2 protein is a mammalian mRNA decapping enzyme.
Wang Z, Jiao X, Carr-Schmid A, Kiledjian M
Proc Natl Acad Sci U S A 2002 Oct 1 99(20):12663-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 16 Oct 2002

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts.
Mendell JT, ap Rhys CM, Dietz HC
Science 2002 Oct 11 298(5592):419-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 16 Oct 2002

A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer.
Caputi M, Kendzior RJ, Beemon KL
Genes Dev 2002 Jul 15 16(14):1754-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 6 Aug 2002

Ribosome components are associated with sites of transcription.
Brogna S, Sato TA, Rosbash M
Mol Cell 2002 Jul 10(1):93-104 [abstract on PubMed] [related articles] [order article]
Selected by | Lynne Maquat / David Tollervey / Carl Thummel / Peter B. Becker / Miles Wilkinson / Jonathan R. Warner / Elsebet Lund
Evaluated 6 Aug 2002

Stop codons affect 5' splice site selection by surveillance of splicing.
Li B, Wachtel C, …, Sperling R, Sperling J
Proc Natl Acad Sci U S A 2002 Apr 16 99(8):5277-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Arlen Johnson / Miles Wilkinson
Evaluated 28 May 2002

An mRNA surveillance mechanism that eliminates transcripts lacking termination codons.
Frischmeyer PA, van Hoof A, …, Parker R, Dietz HC
Science 2002 Mar 22 295(5563):2258-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Roy Long / Arlen Johnson
Evaluated 27 Mar 2002

Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.
van Hoof A, Frischmeyer PA, Dietz HC, Parker R
Science 2002 Mar 22 295(5563):2262-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Roy Long / Arlen Johnson
Evaluated 27 Mar 2002

T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts.
Gudikote JP, Wilkinson MF
EMBO J 2002 Jan 15 21(1-2):125-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 5 Feb 2002

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Carpten J, Nupponen N, …, Isaacs W, Trent J
Nat Genet 2002 Feb 30(2):181-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat
Evaluated 4 Feb 2002

The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.
Coller JM, Tucker M, …, Valencia-Sanchez MA, Parker R
RNA 2001 Dec 7(12):1717-27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat
Evaluated 23 Jan 2002

Delineation of mRNA export pathways by the use of cell-permeable peptides.
Gallouzi IE, Steitz JA
Science 2001 Nov 30 294(5548):1895-901 [abstract on PubMed] [related articles] [FREE full text]
Selected by | A. Gregory Matera / Anita Hopper / Lynne Maquat / Elsebet Lund
Evaluated 23 Jan 2002

Precursor RNAs harboring nonsense codons accumulate near the site of transcription.
Mühlemann O, Mock-Casagrande CS, …, Wilkinson MF, Moore MJ
Mol Cell 2001 Jul 8(1):33-43 [abstract on PubMed] [related articles] [order article]
Selected by | Lynne Maquat / Thomas Blumenthal
Evaluated 24 Sep 2001

A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria.
Miranda-Ríos J, Navarro M, Soberón M
Proc Natl Acad Sci U S A 2001 Aug 14 98(17):9736-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Tina Henkin / Michael Yarus
Evaluated 12 Sep 2001

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.
Hutvágner G, McLachlan J, …, Tuschl T, Zamore PD
Science 2001 Aug 3 293(5531):834-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Mitzi Kuroda
Evaluated 10 Sep 2001

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