Contact details:
Department of Immunology, IMM1
The Scripps Research Institute
10550 N. Torrey Pines Rd.
La Jolla, CA 92037, USA
Email: gascoigne@scripps.edu

Research interests:
T cell recognition, activation and development.

http://www.scripps.edu/imm/gascoigne/

Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET. Shyu YJ, Suarez CD, Hu CD Proc Natl Acad Sci U S A 2008 Jan 8 105(1):151-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Gascoigne Evaluated 11 Jan 2008 Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes. Felix NJ, Donermeyer DL, …, Suri A, Allen PM Nat Immunol 2007 Apr 8(4):388-97 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Gascoigne / David Woodland Evaluated 26 Mar 2007 ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes. Matei IR, Gladdy RA, …, Guidos CJ, Danska JS Blood 2007 Mar 1 109(5):1887-96 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Gascoigne / Pierre Ferrier Evaluated 22 Nov 2006 Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling. Sohn HW, Tolar P, Jin T, Pierce SK Proc Natl Acad Sci U S A 2006 May 23 103(21):8143-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne Evaluated 2 Jun 2006 Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Holst J, Vignali KM, Burton AR, Vignali DA Nat Methods 2006 Mar 3(3):191-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Gascoigne / Friedemann Kiefer / Paul Gleeson Evaluated 16 Mar 2006 Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. Schamel WW, Arechaga I, …, Valpuesta JM, Alarcón B J Exp Med 2005 Aug 15 202(4):493-503 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne / Michael Dustin Evaluated 24 Aug 2005 Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW Nat Immunol 2005 May 6(5):490-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Gascoigne / Christopher Garcia Evaluated 18 Apr 2005 Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice. Lacorazza HD, Nikolich-Zugich J J Immunol 2004 Nov 1 173(9):5591-600 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne Evaluated 24 Nov 2004 Discs large (Dlg1) complexes in lymphocyte activation. Xavier R, Rabizadeh S, …, Swat W, Seed B J Cell Biol 2004 Jul 19 166(2):173-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne / Steve Ward Evaluated 11 Aug 2004 Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. Workman CJ, Cauley LS, …, Woodland DL, Vignali DA J Immunol 2004 May 1 172(9):5450-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne Evaluated 10 Jun 2004 Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Faroudi M, Utzny C, …, Müller S, Valitutti S Proc Natl Acad Sci U S A 2003 Nov 25 100(24):14145-50 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne Evaluated 21 Nov 2003 Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Huppa JB, Gleimer M, Sumen C, Davis MM Nat Immunol 2003 Aug 4(8):749-55 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Gascoigne / Anjana Rao / Andrea Sant / Michael Dustin Evaluated 18 Aug 2003 Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Holler PD, Kranz DM Immunity 2003 Feb 18(2):255-64 [abstract on PubMed] [related articles] [order article] Selected by | Nick Gascoigne Evaluated 27 Feb 2003 Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules. Ge Q, Stone JD, …, Chen J, Stern LJ Proc Natl Acad Sci U S A 2002 Oct 15 99(21):13729-34 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne Evaluated 16 Oct 2002 Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Schott E, Bertho N, …, Maurice MM, Ploegh HL Proc Natl Acad Sci U S A 2002 Oct 15 99(21):13735-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | Nick Gascoigne Evaluated 16 Oct 2002 Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding. Moody AM, Chui D, …, Marth JD, Reinherz EL Cell 2001 Nov 16 107(4):501-12 [abstract on PubMed] [related articles] [order article] Selected by | Nick Gascoigne Evaluated 15 Jul 2002 CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Daniels MA, Devine L, …, Hogquist KA, Jameson SC Immunity 2001 Dec 15(6):1051-61 [abstract on PubMed] [related articles] [order article] Selected by | Nick Gascoigne Evaluated 15 Jul 2002 Quantifying the energetics of cooperativity in a ternary protein complex. Andersen PS, Schuck P, …, Karjalainen K, Mariuzza RA Biochemistry 2002 Apr 23 41(16):5177-84 [abstract on PubMed] [related articles] [order article] Selected by | Nick Gascoigne Evaluated 15 Jul 2002 Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Gil D, Schamel WW, …, Sánchez-Madrid F, Alarcón B Cell 2002 Jun 28 109(7):901-12 [abstract on PubMed] [related articles] [order article] Selected by | Nick Gascoigne / Kristin Hogquist / Michael Dustin / Christopher Garcia Evaluated 15 Jul 2002

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