homefeedbacksupportlog on 20-Jul-2008 
  About F1000

 What is F1000 Biology?
 Key features
 How it's organized
 FAQs
 Faculties and sections
 Scope of sections
 List of Faculty Members
 The evaluation system
 Citing F1000
 Take a tour of the site
 Accessing fulltexts
 PubMed linkout
 How to subscribe
 Academic subscriptions
 Corporate subscriptions
 Try F1000 for free
 Who we are
 Media information
 Librarian resources
 Press releases
 In the press
 Developing countries
 F1000 Medicine
 Terms and conditions
 Privacy policy
 Contact us


Paul Webb
Diabetes Center, Methodist Hospital Research Institute, Houston, United States of America

Faculty Member: PHYSIOLOGY > Endocrinology [ since 13 January 2005 ]
[ Evaluations ]
to email [Help]
Evaluations

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.
Kang K, Reilly SM, …, Hatano B, Lee CH
Cell Metab 2008 Jun 7(6):485-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 2 Jul 2008

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.
Odegaard JI, Ricardo-Gonzalez RR, …, Ferrante AW, Chawla A
Cell Metab 2008 Jun 7(6):496-507 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 2 Jul 2008

A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells.
Mao C, Patterson NM, …, Nordeen SK, Shapiro DJ
J Biol Chem 2008 Mar 12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb / Thomas Kodadek
Evaluated 30 Apr 2008

A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Thakur JK, Arthanari H, …, Wagner G, Näär AM
Nature 2008 Apr 3 452(7187):604-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Guilhem Janbon / Paul Webb
Evaluated 30 Apr 2008

The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages.
Hall JM, McDonnell DP
Mol Endocrinol 2007 Aug 21(8):1756-68 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aniko Naray-Fejes-Toth / Paul Webb
Evaluated 11 Mar 2008

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.
Odegaard JI, Ricardo-Gonzalez RR, …, Ferrante AW, Chawla A
Nature 2007 Jun 28 447(7148):1116-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | P'ng Loke / Paul Webb
Evaluated 7 Feb 2008

Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.
Hosey AM, Gorski JJ, …, Mullan PB, Harkin DP
J Natl Cancer Inst 2007 Nov 21 99(22):1683-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 19 Dec 2007

Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity.
Zhou D, Shen R, …, Tso P, Chen S
J Biol Chem 2008 Jan 4 283(1):541-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 21 Nov 2007

Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni.
Wu W, Niles EG, LoVerde PT
BMC Evol Biol 2007 7:150 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 5 Oct 2007

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.
Wang Q, Li W, …, Pienta KJ, Brown M
Mol Cell 2007 Aug 3 27(3):380-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 11 Sep 2007

The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.
Ricketts ML, Boekschoten MV, …, Hofker MH, Moore DD
Mol Endocrinol 2007 Jul 21(7):1603-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 26 Jul 2007

Expression of human nuclear receptors in plants for the discovery of plant-derived ligands.
Doukhanina EV, Apuya NR, …, Hamilton R, Bobzin SC
J Biomol Screen 2007 Apr 12(3):385-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 26 Jul 2007

Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors.
Schug TT, Berry DC, …, Travis SN, Noy N
Cell 2007 May 18 129(4):723-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb / Toshihiko Ogura
Evaluated 19 Jun 2007


Androgen receptor decoy molecules block the growth of prostate cancer.
Quayle SN, Mawji NR, Wang J, Sadar MD
Proc Natl Acad Sci U S A 2007 Jan 23 104(4):1331-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 29 May 2007

Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2.
Wang X, Belguise K, …, Chalbos D, Sonenshein GE
Nat Cell Biol 2007 Apr 9(4):470-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 21 May 2007

Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway.
Ariazi EA, Kraus RJ, …, Jordan VC, Mertz JE
Mol Cancer Res 2007 Jan 5(1):71-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 10 Apr 2007

A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor.
Blaschke F, Takata Y, …, Hsueh WA, Tangirala RK
Circ Res 2006 Dec 8 99(12):e88-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 23 Feb 2007

The nuclear receptor LXR is a glucose sensor.
Mitro N, Mak PA, …, Kreusch A, Saez E
Nature 2007 Jan 11 445(7124):219-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Axel Nohturfft / Paul Webb / Len Neckers
Evaluated 6 Feb 2007

Estrogenic regulation of host immunity against an estrogen receptor-negative human breast cancer.
Curran EM, Judy BM, …, Lubahn DB, Estes DM
Clin Cancer Res 2006 Oct 1 12(19):5641-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 19 Dec 2006

Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation.
Barrero MJ, Malik S
Mol Cell 2006 Oct 20 24(2):233-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 28 Nov 2006

Dynamic regulation of Drosophila nuclear receptor activity in vivo.
Palanker L, Necakov AS, …, Thummel CS, Krause HM
Development 2006 Sep 133(18):3549-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 20 Oct 2006

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.
Wang L, Zuercher WJ, …, Willson TM, Nolte RT
J Biol Chem 2006 Dec 8 281(49):37773-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 5 Oct 2006

Human PXR forms a tryptophan zipper-mediated homodimer.
Noble SM, Carnahan VE, …, McDonnell DP, Redinbo MR
Biochemistry 2006 Jul 18 45(28):8579-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 4 Sep 2006

RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors.
Musatov S, Chen W, …, Kaplitt MG, Ogawa S
Proc Natl Acad Sci U S A 2006-07-05 103(27):10456-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb / Andrea Gore
Evaluated 1 Sep 2006

The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.
Oxelmark E, Roth JM, …, Schneider RJ, Garabedian MJ
Mol Cell Biol 2006 Jul 26(14):5205-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 31 Aug 2006

Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis.
Wang L, Huang J, …, Lee I, Moore DD
Mol Endocrinol 2006 Nov 20(11):2671-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 13 Jul 2006

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients.
Holm C, Rayala S, …, Kumar R, Landberg G
J Natl Cancer Inst 2006 May 17 98(10):671-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 12 Jun 2006

Evolution of hormone-receptor complexity by molecular exploitation.
Bridgham JT, Carroll SM, Thornton JW
Science 2006 Apr 7 312(5770):97-101 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Lenski / Aniko Naray-Fejes-Toth / Paul Webb
Dissenters | John Funder
Author Response | Joseph Thornton
Evaluated 15 May 2006


Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration.
Huang W, Ma K, …, Huang X, Moore DD
Science 2006 Apr 14 312(5771):233-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Cook / Carl Thummel / Paul Webb / Jonathan Slack
Evaluated 15 May 2006


Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.
Sternsdorf T, Phan VT, …, Evans RM, Kogan SC
Cancer Cell 2006 Feb 9(2):81-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 24 Apr 2006

A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone.
Wu SY, Cohen RN, …, Refetoff S, Weiss RE
J Clin Endocrinol Metab 2006 May 91(5):1887-95 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 3 Mar 2006

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.
Yin L, Wang J, Klein PS, Lazar MA
Science 2006 Feb 17 311(5763):1002-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Means / Paul Webb / Andries Kalsbeek / Fraydoon Rastinejad
Evaluated 3 Mar 2006

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Inagaki T, Moschetta A, …, Mangelsdorf DJ, Kliewer SA
Proc Natl Acad Sci U S A 2006 Mar 7 103(10):3920-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger / Paul Webb / David Cook
Evaluated 3 Mar 2006

A fully dissociated compound of plant origin for inflammatory gene repression.
De Bosscher K, Vanden Berghe W, …, Louw A, Haegeman G
Proc Natl Acad Sci U S A 2005 Nov 1 102(44):15827-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 16 Jan 2006

The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.
Yoon HG, Wong J
Mol Endocrinol 2006 May 20(5):1048-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 16 Jan 2006

TNF-alpha enhances estrogen-induced cell proliferation of estrogen-dependent breast tumor cells through a complex containing nuclear factor-kappa B.
Rubio MF, Werbajh S, …, Nahmod VE, Costas MA
Oncogene 2006 Mar 2 25(9):1367-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 16 Jan 2006

Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription.
Herzog B, Cardenas J, …, Granner DK, Kralli A
J Biol Chem 2006 Jan 6 281(1):99-106 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 24 Nov 2005

RIP140-targeted repression of gene expression in adipocytes.
Christian M, Kiskinis E, …, White R, Parker MG
Mol Cell Biol 2005 Nov 25(21):9383-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 15 Nov 2005

Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).
Yi P, Wu RC, …, Means AR, O'Malley BW
Mol Cell Biol 2005 Nov 25(21):9687-99 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 14 Nov 2005

Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220.
Park SW, Li G, …, Roeder RG, Wei LN
Mol Cell 2005 Sep 2 19(5):643-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 19 Oct 2005

Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.
Wang Q, Carroll JS, Brown M
Mol Cell 2005 Sep 2 19(5):631-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 17 Oct 2005

Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.
Zheng FF, Wu RC, Smith CL, O'Malley BW
Mol Cell Biol 2005 Sep 25(18):8273-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 27 Sep 2005

Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes.
Frasor J, Danes JM, Funk CC, Katzenellenbogen BS
Proc Natl Acad Sci U S A 2005 Sep 13 102(37):13153-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 27 Sep 2005

Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.
Bouchard MF, Taniguchi H, Viger RS
Endocrinology 2005 Nov 146(11):4905-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 12 Sep 2005

The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
Annicotte JS, Chavey C, …, Cavailles V, Fajas L
Oncogene 2005 Dec 8 24(55):8167-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 12 Sep 2005

Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters.
Matthews J, Wihlén B, Thomsen J, Gustafsson JA
Mol Cell Biol 2005 Jul 25(13):5317-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 17 Aug 2005

The Drosophila nuclear receptor e75 contains heme and is gas responsive.
Reinking J, Lam MM, …, Edwards A, Krause HM
Cell 2005 Jul 29 122(2):195-207 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb / John Funder / Fraydoon Rastinejad
Evaluated 17 Aug 2005

The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype.
Guerini V, Sau D, …, Motta M, Poletti A
Cancer Res 2005 Jun 15 65(12):5445-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 17 Aug 2005

Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus.
Valley CC, Métivier R, …, Hill L, Alarid ET
Mol Cell Biol 2005 Jul 25(13):5417-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 15 Aug 2005

A bacterial biosensor of endocrine modulators.
Skretas G, Wood DW
J Mol Biol 2005 Jun 10 349(3):464-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 11 Jul 2005

The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.
Luecke HF, Yamamoto KR
Genes Dev 2005 May 1 19(9):1116-27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 11 Jul 2005

The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.
Hartman HB, Yu J, …, Ishizuka T, Lazar MA
EMBO Rep 2005 May 6(5):445-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fyodor Urnov / Paul Webb
Evaluated 11 Jul 2005

Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression.
Ki SH, Cho IJ, Choi DW, Kim SG
Mol Cell Biol 2005 May 25(10):4150-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 11 Jul 2005

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli S, Burghardt R, …, Yoon K, Safe S
J Biol Chem 2005 Jul 1 280(26):24903-14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 25 May 2005

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.
You LR, Lin FJ, …, Tsai MJ, Tsai SY
Nature 2005 May 5 435(7038):98-104 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means / Paul Webb
Evaluated 25 May 2005

Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
Thomas P, Pang Y, Filardo EJ, Dong J
Endocrinology 2005 Feb 146(2):624-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 25 May 2005

Androgen causes growth suppression and reversion of androgen-independent prostate cancer xenografts to an androgen-stimulated phenotype in athymic mice.
Chuu CP, Hiipakka RA, …, Kokontis JM, Liao S
Cancer Res 2005 Mar 15 65(6):2082-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 10 May 2005

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Lin J, Yang R, …, Newgard CB, Spiegelman BM
Cell 2005 Jan 28 120(2):261-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb / Michael Muller
Evaluated 22 Mar 2005

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Krylova IN, Sablin EP, …, Willson TM, Ingraham HA
Cell 2005 Feb 11 120(3):343-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb / Fraydoon Rastinejad
Evaluated 22 Mar 2005

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
Guan HP, Ishizuka T, …, Lehrke M, Lazar MA
Genes Dev 2005 Feb 15 19(4):453-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 21 Feb 2005

Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Wisløff U, Najjar SM, …, Koch LG, Britton SL
Science 2005 Jan 21 307(5708):418-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 21 Feb 2005

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Paik S, Shak S, …, Bryant J, Wolmark N
N Engl J Med 2004 Dec 30 351(27):2817-26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 4 Feb 2005

^Top  Back to Faculty Members


© 1999-2008 Biology Reports Ltd unless otherwise stated < info@f1000.com >   Terms and conditions   Legal info