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Dan Conrad
Department of Microbiology and Immunology, Virginia Commonwealth University, United States of America

Faculty Member: IMMUNOLOGY > Allergy & hypersensitivity [ since 2 July 2001 ]
[ Evaluations ]
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Evaluations

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.
Yasuda T, Sanjo H, …, Ogata M, Kurosaki T
Immunity 2008 Apr 28(4):499-508 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 19 May 2008

A mechanism for the initiation of allergen-induced T helper type 2 responses.
Sokol CL, Barton GM, Farr AG, Medzhitov R
Nat Immunol 2008 Mar 9(3):310-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maria Rescigno / Christopher Karp / Torben Lund / Dan Conrad / Thomas Wynn
Evaluated 17 Mar 2008

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Koralov SB, Muljo SA, …, Rajewsky N, Rajewsky K
Cell 2008 Mar 7 132(5):860-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad / Pierre Ferrier
Evaluated 17 Mar 2008

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.
Vig M, DeHaven WI, …, Putney JW, Kinet JP
Nat Immunol 2008 Jan 9(1):89-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad / Steve Ward
Evaluated 17 Jan 2008

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.
van Beelen AJ, Zelinkova Z, …, Kapsenberg ML, de Jong EC
Immunity 2007 Oct 27(4):660-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rick Maizels / Steve Ward / Dan Conrad
Evaluated 17 Dec 2007

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
Elias KM, Laurence A, …, Shevach EM, O'Shea JJ
Blood 2007 Oct 19 [abstract on PubMed] [related articles] [full text]
Selected by | Dan Conrad
Evaluated 5 Nov 2007

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
Mucida D, Park Y, …, Kronenberg M, Cheroutre H
Science 2007 Jul 13 317(5835):256-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Christian Engwerda / Steve Ward / Linda Bradley / Dan Conrad
Evaluated 14 Aug 2007


Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.
Maeda T, Merghoub T, …, Cattoretti G, Pandolfi PP
Science 2007 May 11 316(5826):860-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hans-Willem Snoeck / Dan Conrad / Astar Winoto
Evaluated 31 May 2007

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
Korn T, Reddy J, …, Oukka M, Kuchroo VK
Nat Med 2007 Apr 13(4):423-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anne Davidson / Deborah Fowell / Dan Conrad / Paul Lyons
Evaluated 22 May 2007


Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.
Pappu R, Schwab SR, …, Cyster JG, Coughlin SR
Science 2007 Apr 13 316(5822):295-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andy Chan / Dan Conrad
Evaluated 14 May 2007

Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI.
Xu W, He B, …, Santini PA, Cerutti A
Nat Immunol 2007 Mar 8(3):294-303 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maria Rescigno / Dan Conrad
Evaluated 23 Mar 2007


Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.
Gotsman I, Grabie N, …, Sharpe AH, Lichtman AH
Circulation 2006 Nov 7 114(19):2047-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 31 Jan 2007

Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis.
Röhn TA, Jennings GT, …, Kopf M, Bachmann MF
Eur J Immunol 2006 Nov 36(11):2857-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 12 Dec 2006

Modulation of cell adhesion and motility in the immune system by Myo1f.
Kim SV, Mehal WZ, …, Wu D, Flavell RA
Science 2006 Oct 6 314(5796):136-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad / Clifford Lowell
Evaluated 23 Oct 2006

Mast cells are essential intermediaries in regulatory T-cell tolerance.
Lu LF, Lind EF, …, Zheng XX, Noelle RJ
Nature 2006 Aug 31 442(7106):997-1002 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Cobbold / Marie Kosco-Vilbois / Marsha Wills-Karp / Yutaka Tagaya / Dan Conrad / Jay Berzofsky / Richard Grencis
Evaluated 18 Sep 2006


Foxp1 is an essential transcriptional regulator of B cell development.
Hu H, Wang B, …, Tucker PW, Rao A
Nat Immunol 2006 Aug 7(8):819-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kathryn Calame / Cornelius Murre / Dan Conrad / Patrick Matthias
Evaluated 4 Sep 2006

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Feske S, Gwack Y, …, Daly M, Rao A
Nature 2006 May 11 441(7090):179-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roger Hardie / Angus Nairn / Colin Taylor / Tullio Pozzan / Andy Chan / Steve Ward / Anthony DeFranco / Dan Conrad
Evaluated 9 Jun 2006


CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
Vig M, Peinelt C, …, Penner R, Kinet JP
Science 2006 May 26 312(5777):1220-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 9 Jun 2006

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.
Barton GM, Kagan JC, Medzhitov R
Nat Immunol 2006 Jan 7(1):49-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Shiv Pillai / Dan Conrad
Evaluated 13 Apr 2006

Toll-dependent selection of microbial antigens for presentation by dendritic cells.
Blander JM, Medzhitov R
Nature 2006 Apr 6 440(7085):808-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Karp / Torben Lund / Peter Van Endert / Elizabeth Mellins / David Branch Moody / Dan Conrad / Laurence Eisenlohr / Etienne Joly / Marcus Thelen / Victor Nizet
Evaluated 13 Apr 2006

IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.
Kitamura H, Kamon H, …, Murakami M, Hirano T
Immunity 2005 Nov 23(5):491-502 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elizabeth Mellins / Dan Conrad
Evaluated 2 Mar 2006

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.
Kim C, Gajendran N, …, Fischer G, Kaufmann SH
Proc Natl Acad Sci U S A 2005 Mar 29 102(13):4830-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Drusilla Burns / Rino Rappuoli / Dan Conrad
Evaluated 23 Feb 2006

FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.
Victoratos P, Lagnel J, …, Pasparakis M, Kollias G
Immunity 2006 Jan 24(1):65-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Chaplin / Dan Conrad
Evaluated 17 Feb 2006

Control of B-cell responses by Toll-like receptors.
Pasare C, Medzhitov R
Nature 2005 Nov 17 438(7066):364-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Anthony DeFranco / Dan Conrad / Shiv Pillai
Evaluated 25 Jan 2006

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
Harrington LE, Hatton RD, …, Murphy KM, Weaver CT
Nat Immunol 2005 Nov 6(11):1123-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Karp / Richard Grencis / Marsha Wills-Karp / Dan Conrad / Marie Kosco-Vilbois
Evaluated 18 Nov 2005

Cell surface recycling of internalized antigen permits dendritic cell priming of B cells.
Bergtold A, Desai DD, Gavhane A, Clynes R
Immunity 2005 Nov 23(5):503-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad / Shiv Pillai / Colin Watts / Michael Gold
Evaluated 18 Nov 2005

CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.
Wang Y, Carter RH
Immunity 2005 Jun 22(6):749-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 21 Sep 2005

FcgammaRIV: a novel FcR with distinct IgG subclass specificity.
Nimmerjahn F, Bruhns P, Horiuchi K, Ravetch JV
Immunity 2005 Jul 23(1):41-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Underhill / Dan Conrad
Evaluated 14 Sep 2005

Professional antigen-presentation function by human gammadelta T Cells.
Brandes M, Willimann K, Moser B
Science 2005 Jul 8 309(5732):264-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Pedro Romero / Dan Conrad / Stephen Jameson / Peter Van Endert
Evaluated 21 Jul 2005

Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.
Kunikata T, Yamane H, …, Ichikawa A, Narumiya S
Nat Immunol 2005 May 6(5):524-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steve Ward / Dan Conrad
Evaluated 13 Jun 2005

Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1.
Manilay JO, Anderson AC, Kang C, Robey EA
J Immunol 2005 Jun 1 174(11):6732-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 7 Jun 2005

Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM.
Pasquier B, Launay P, …, Blank U, Monteiro RC
Immunity 2005 Jan 22(1):31-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Saxon / Lewis Lanier / Dan Conrad
Evaluated 16 Mar 2005

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Lang KS, Recher M, …, Hengartner H, Zinkernagel RM
Nat Med 2005 Feb 11(2):138-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Matthias von Herrath / Dan Conrad / Barbara Rehermann
Evaluated 22 Feb 2005

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.
Cannons JL, Yu LJ, …, Gardner K, Schwartzberg PL
Immunity 2004 Nov 21(5):693-706 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony DeFranco / Dan Conrad
Evaluated 6 Jan 2005

Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.
Davidson D, Shi X, …, Yanagi Y, Veillette A
Immunity 2004 Nov 21(5):707-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony DeFranco / Dan Conrad
Evaluated 6 Jan 2005

A role for the immunological synapse in lineage commitment of CD4 lymphocytes.
Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH
Nature 2004 Sep 30 431(7008):527-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anuradha Ray / Dan Conrad / Richard Grencis
Evaluated 29 Oct 2004

Defining a link with asthma in mice congenitally deficient in eosinophils.
Lee JJ, Dimina D, …, Irvin CG, Lee NA
Science 2004 Sep 17 305(5691):1773-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Dan Conrad
Evaluated 21 Oct 2004

A critical role for eosinophils in allergic airways remodeling.
Humbles AA, Lloyd CM, …, Orkin SH, Gerard C
Science 2004 Sep 17 305(5691):1776-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Peter Openshaw / Dan Conrad
Evaluated 21 Oct 2004

LPS-induced upregulation of SHIP is essential for endotoxin tolerance.
Sly LM, Rauh MJ, …, Song CH, Krystal G
Immunity 2004 Aug 21(2):227-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steve Ward / Dan Conrad / Christopher Karp
Evaluated 2 Sep 2004

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses.
Watanabe T, Kitani A, Murray PJ, Strober W
Nat Immunol 2004 Aug 5(8):800-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaojing Ma / Steve Ward / Maria Rescigno / Dan Conrad
Evaluated 31 Aug 2004

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
Zhu Z, Zheng T, …, Hamid Q, Elias JA
Science 2004 Jun 11 304(5677):1678-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Grencis / Thomas Nutman / Richard L. Stevens / Dan Conrad / Christopher Karp / James Crowe
Evaluated 13 Jul 2004

Promotion of B cell immune responses via an alum-induced myeloid cell population.
Jordan MB, Mills DM, …, Marrack P, Cambier JC
Science 2004 Jun 18 304(5678):1808-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Locksley / Dan Conrad
Evaluated 12 Jul 2004

Dihydropyridine receptors are selective markers of Th2 cells and can be targeted to prevent Th2-dependent immunopathological disorders.
Savignac M, Gomes B, …, Guéry JC, Pelletier L
J Immunol 2004 May 1 172(9):5206-12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 25 May 2004

Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation.
Kelly-Welch AE, Melo ME, …, Noben-Trauth N, Keegan AD
J Immunol 2004 Apr 1 172(7):4545-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 16 Apr 2004

Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells.
Dahl ME, Dabbagh K, …, Kim S, Lewis DB
Nat Immunol 2004 Mar 5(3):337-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad / Peter Openshaw / Luis J. Montaner
Evaluated 12 Mar 2004

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
Villarino A, Hibbert L, …, Saris C, Hunter CA
Immunity 2003 Nov 19(5):645-55 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Nutman / Eric Denkers / Ricardo Gazzinelli / Dan Conrad / Thomas Wynn
Evaluated 1 Mar 2004

Functional interactions between dendritic cells and NK cells during viral infection.
Andrews DM, Scalzo AA, …, Smyth MJ, Degli-Esposti MA
Nat Immunol 2003 Feb 4(2):175-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 24 Oct 2003

Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.
Ott VL, Cambier JC, …, Marrack P, Swanson BJ
Nat Immunol 2003 Oct 4(10):974-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad / Reina Mebius / Steve Ward
Evaluated 18 Sep 2003

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells.
Liu N, Ohnishi N, …, Akira S, Bacon KB
Nat Immunol 2003 Jul 4(7):687-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Steve Ward / Shiv Pillai / Dan Conrad
Evaluated 28 Aug 2003

The influence of transcriptional orientation on endogenous switch region function.
Shinkura R, Tian M, …, Fujiwara Y, Alt FW
Nat Immunol 2003 May 4(5):435-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Lieber / Dan Conrad
Evaluated 27 Jun 2003

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
Yu K, Chedin F, …, Wilson TE, Lieber MR
Nat Immunol 2003 May 4(5):442-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 27 Jun 2003

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
Iwakoshi NN, Lee AH, …, Rajewsky K, Glimcher LH
Nat Immunol 2003 Apr 4(4):321-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 30 Apr 2003

Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism.
Suzuki K, Nakajima H, …, Akira S, Iwamoto I
J Exp Med 2002 Jul 1 196(1):27-38 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 3 Mar 2003

Essential role of Id2 in negative regulation of IgE class switching.
Sugai M, Gonda H, …, Yokota Y, Shimizu A
Nat Immunol 2003 Jan 4(1):25-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Dan Conrad
Evaluated 5 Feb 2003

Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.
Wentworth P, McDunn JE, …, Eschenmoser A, Lerner RA
Science 2002 Dec 13 298(5601):2195-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rino Rappuoli / Dan Conrad / Stefan Kaufmann
Evaluated 14 Jan 2003

A critical role for IL-21 in regulating immunoglobulin production.
Ozaki K, Spolski R, …, Schwartzberg PL, Leonard WJ
Science 2002 Nov 22 298(5598):1630-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dan Conrad
Evaluated 9 Dec 2002

Mast cells: a cellular link between autoantibodies and inflammatory arthritis.
Lee DM, Friend DS, …, Mathis D, Brenner MB
Science 2002 Sep 6 297(5587):1689-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Betty Tsao / Dan Conrad
Evaluated 31 Oct 2002

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.
Litinskiy MB, Nardelli B, …, Casali P, Cerutti A
Nat Immunol 2002 Sep 3(9):822-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Randolph Noelle / Janet Stavnezer / Dan Conrad / Kendall Smith
Evaluated 2 Oct 2002

IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13.
Fallon PG, Jolin HE, …, Smith P, McKenzie AN
Immunity 2002 Jul 17(1):7-17 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 4 Sep 2002

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
Parravicini V, Gadina M, …, O'Shea JJ, Rivera J
Nat Immunol 2002 Aug 3(8):741-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 21 Aug 2002

The crystal structure of IgE Fc reveals an asymmetrically bent conformation.
Wan T, Beavil RL, …, Gould HJ, Sutton BJ
Nat Immunol 2002 Jul 3(7):681-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dan Conrad
Evaluated 11 Jul 2002

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.
Ahonen C, Manning E, …, Kehry MR, Noelle RJ
Nat Immunol 2002 May 3(5):451-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yongwon Choi / Dan Conrad
Evaluated 19 Jun 2002

Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation.
Zhu J, Guo L, …, Tsichlis PN, Paul WE
Immunity 2002 May 16(5):733-44 [abstract on PubMed] [related articles] [order article]