Michele Pagano is a Professor of Pathology at the New York University School of Medicine and NYU Cancer Institute. In 1989, Dr. Pagano received his doctorate in Medicine with Honors in Molecular Endocrinology from the Federico II University in Naples, Italy. He was subsequently a post-doctoral fellow at the EMBL, Heidelberg, Germany (1990-92) and a principal investigator and scientific co-founder of Mitotix Inc., Cambridge, MA (1992-96). Dr. Pagano¹s current research focuses on the kinases and ubiquitylating enzymes that control the cell cycle machinery. By studying how this regulatory network is deregulated in cancer cells, his group is also committed to the integration of basic research results with an understanding of malignant transformation.

http://www.med.nyu.edu/pathology/Pagano

Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Nickeleit I, Zender S, …, Frank R, Malek NP Cancer Cell 2008 Jul 8 14(1):23-35 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano / Dieter Wolf Evaluated 9 Jul 2008 WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Hu J, Zacharek S, …, Duronio RJ, Xiong Y Genes Dev 2008 Apr 1 22(7):866-71 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 9 Apr 2008 Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. Liu H, Cheng EH, Hsieh JJ Genes Dev 2007 Oct 1 21(19):2385-98 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 23 Nov 2007 Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Ray D, Terao Y, …, Christov K, Kiyokawa H Cancer Res 2007 Jul 15 67(14):6605-11 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 9 Aug 2007 Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Li X, Amazit L, …, Monaco JJ, O'Malley BW Mol Cell 2007 Jun 22 26(6):831-42 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 13 Jul 2007 Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. Keller UB, Old JB, …, Reed SI, Cleveland JL EMBO J 2007 May 16 26(10):2562-74 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 19 Jun 2007 Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Burkard ME, Randall CL, …, Fisher RP, Jallepalli PV Proc Natl Acad Sci U S A 2007 Mar 13 104(11):4383-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 24 Apr 2007 Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer. Timmerbeul I, Garrett-Engele CM, …, Roberts JM, Malek NP Proc Natl Acad Sci U S A 2006 Sep 19 103(38):14009-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 26 Sep 2006 Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region. Nacusi LP, Sheaff RJ Cell Div 2006 1:11 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 12 Sep 2006 Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Berthet C, Klarmann KD, …, Kiyokawa H, Kaldis P Dev Cell 2006 May 10(5):563-73 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 24 May 2006 The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Eldridge AG, Loktev AV, …, Reimann JD, Jackson PK Cell 2006 Jan 27 124(2):367-80 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 10 Mar 2006 Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability. Ke PY, Kuo YY, Hu CM, Chang ZF Genes Dev 2005 Aug 15 19(16):1920-33 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 15 Nov 2005 Cdc2-cyclin E complexes regulate the G1/S phase transition. Aleem E, Kiyokawa H, Kaldis P Nat Cell Biol 2005 Aug 7(8):831-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martine Roussel / Michele Pagano / Jane Endicott Evaluated 28 Sep 2005 Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Yamashita M, Ying SX, …, Deng CX, Zhang YE Cell 2005 Apr 8 121(1):101-13 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Yigong Shi / Michele Pagano Evaluated 13 Jul 2005 Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism. Van Regenmortel MH EMBO Rep 2004 Nov 5(11):1016-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano / Charles Auffray Evaluated 24 Mar 2005 The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Moberg KH, Mukherjee A, …, Artavanis-Tsakonas S, Hariharan IK Curr Biol 2004 Jun 8 14(11):965-74 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Laura Johnston / Michele Pagano Evaluated 3 Dec 2004 N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Coulombe P, Rodier G, …, Thibault P, Meloche S Mol Cell Biol 2004 Jul 24(14):6140-50 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 12 Aug 2004 The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue. Ben-Saadon R, Fajerman I, …, Schwartz AL, Ciechanover A J Biol Chem 2004 Oct 1 279(40):41414-21 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 12 Aug 2004 Skp2-mediated degradation of p27 regulates progression into mitosis. Nakayama K, Nagahama H, …, Natsume T, Nakayama KI Dev Cell 2004 May 6(5):661-72 [abstract on PubMed] [related articles] [order article] Selected by | Michele Pagano / Jane Endicott Evaluated 8 Jun 2004 A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. Cong F, Zhang J, …, Zhou P, Varmus H BMC Mol Biol 2003 Sep 29 4:10 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 26 Jan 2004 Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Kamura T, Hara T, …, Nakayama K, Nakayama KI Proc Natl Acad Sci U S A 2003 Sep 2 100(18):10231-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 5 Sep 2003 Dp1 is required for extra-embryonic development. Kohn MJ, Bronson RT, …, Dyson NJ, Yamasaki L Development 2003 Apr 130(7):1295-305 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 8 Jul 2003 Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Lukas C, Falck J, …, Bartek J, Lukas J Nat Cell Biol 2003 Mar 5(3):255-60 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Stephen Jackson / Michele Pagano Evaluated 22 May 2003 Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Shim EH, Johnson L, …, Zeiss C, Zhang H Cancer Res 2003 Apr 1 63(7):1583-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 4 Apr 2003 Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Bai F, Pei XH, Godfrey VL, Xiong Y Mol Cell Biol 2003 Feb 23(4):1269-77 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 4 Feb 2003 Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Philipp-Staheli J, Kim KH, …, Longton G, Kemp CJ Cancer Cell 2002 May 1(4):355-68 [abstract on PubMed] [related articles] [order article] Selected by | Michele Pagano Evaluated 11 Sep 2002 The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. Tateishi K, Omata M, Tanaka K, Chiba T J Cell Biol 2001 Nov 12 155(4):571-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sharad Kumar / Michele Pagano Evaluated 19 Jul 2002 Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Wing JP, Schreader BA, …, White K, Nambu JR Nat Cell Biol 2002 Jun 4(6):451-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Sharad Kumar / Michele Pagano / John Abrams Evaluated 17 Jun 2002 Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Dai RM, Li CC Nat Cell Biol 2001 Aug 3(8):740-4 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michele Pagano Evaluated 11 Jun 2002 Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. Ishida N, Hara T, …, Nakayama K, Nakayama KI J Biol Chem 2002 Apr 26 277(17):14355-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 20 Mar 2002 Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. Hara T, Kamura T, …, Hatakeyama S, Nakayama K J Biol Chem 2001 Dec 28 276(52):48937-43 [abstract on PubMed] [related articles] [FREE full text] Selected by | Hiroto Okayama / Michele Pagano Evaluated 31 Jan 2002 Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Brantley DM, Chen CL, …, Kerr LD, Yull FE Mol Biol Cell 2001 May 12(5):1445-55 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 22 Jan 2002 Typhlocolitis in NF-kappa B-deficient mice. Erdman S, Fox JG, …, Feldman D, Horwitz BH J Immunol 2001 Feb 1 166(3):1443-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 9 Jan 2002 Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Wan Y, Kirschner MW Proc Natl Acad Sci U S A 2001 Nov 6 98(23):13066-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 3 Dec 2001 Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein. Yedidia Y, Horonchik L, …, Yanai A, Taraboulos A EMBO J 2001 Oct 1 20(19):5383-91 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michele Pagano Evaluated 19 Oct 2001

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