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Kevin Hardwick
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, United Kingdom

Faculty Member: CELL BIOLOGY > Cell growth & division [ since 29 October 2003 ]
[ Evaluations ]
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Evaluations

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.
Wolthuis R, Clay-Farrace L, …, Medema R, Pines J
Mol Cell 2008 May 9 30(3):290-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick
Evaluated 28 May 2008

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment.
Stumpff J, von Dassow G, …, Asbury C, Wordeman L
Dev Cell 2008 Feb 14(2):252-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Duane Compton / Kevin Hardwick / P. Todd Stukenberg
Evaluated 1 Apr 2008

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment.
Jelluma N, Brenkman AB, …, Medema RH, Kops GJ
Cell 2008 Jan 25 132(2):233-246 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick / Domenico Grieco
Evaluated 4 Feb 2008

Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
Kiyomitsu T, Obuse C, Yanagida M
Dev Cell 2007 Nov 13(5):663-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick
Evaluated 20 Nov 2007

Bub1 maintains centromeric cohesion by activation of the spindle checkpoint.
Perera D, Tilston V, …, Boot-Handford RP, Taylor SS
Dev Cell 2007 Oct 13(4):566-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick
Evaluated 22 Oct 2007

Sequential E2s drive polyubiquitin chain assembly on APC targets.
Rodrigo-Brenni MC, Morgan DO
Cell 2007 Jul 13 130(1):127-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Curt Wittenberg / Kevin Hardwick / Steven Brill
Evaluated 17 Aug 2007

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.
Huang H, Feng J, …, Chan GK, Yen TJ
J Cell Biol 2007 May 7 177(3):413-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 23 May 2007

A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension.
Sandall S, Severin F, …, Hyman A, Desai A
Cell 2006 Dec 15 127(6):1179-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Harold Erickson / Kevin Hardwick / William Earnshaw
Evaluated 2 Feb 2007

Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.
DeLuca JG, Gall WE, …, Musacchio A, Salmon ED
Cell 2006 Dec 1 127(5):969-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Scholey / Claire Walczak / Kevin Hardwick / Bruce McEwen / Harold Erickson
Evaluated 19 Dec 2006

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.
Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A
Cell 2006 Dec 1 127(5):983-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick / Bruce McEwen / William Earnshaw
Evaluated 18 Dec 2006

Anaphase inactivation of the spindle checkpoint.
Palframan WJ, Meehl JB, …, Winey M, Murray AW
Science 2006 Aug 4 313(5787):680-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Kevin Hardwick
Evaluated 14 Aug 2006

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.
Li S, Sandercock AM, …, Williams RL, Kilmartin JV
J Cell Biol 2006 Jun 19 173(6):867-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick / Mark Rose
Evaluated 14 Aug 2006

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
Pinsky BA, Kung C, Shokat KM, Biggins S
Nat Cell Biol 2006 Jan 8(1):78-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick
Evaluated 6 Apr 2006

The processivity of multiubiquitination by the APC determines the order of substrate degradation.
Rape M, Reddy SK, Kirschner MW
Cell 2006 Jan 13 124(1):89-103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Jackson / Kevin Hardwick / Laura Itzhaki
Evaluated 5 Apr 2006

Analysis of kinesin motor function at budding yeast kinetochores.
Tytell JD, Sorger PK
J Cell Biol 2006 Mar 13 172(6):861-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick / Jonathan Scholey
Evaluated 5 Apr 2006

A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.
Bhalla N, Dernburg AF
Science 2005 Dec 9 310(5754):1683-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 16 Dec 2005

Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae.
Daniel JA, Keyes BE, …, Freeman CO, Burke DJ
Genetics 2006 Jan 172(1):53-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 10 Nov 2005

Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.
Morrow CJ, Tighe A, …, Ditchfield C, Taylor SS
J Cell Sci 2005 Aug 15 118(Pt 16):3639-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 25 Aug 2005

The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.
Cheslock PS, Kemp BJ, Boumil RM, Dawson DS
Nat Genet 2005 Jul 37(7):756-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick / R. Scott Hawley
Evaluated 1 Jul 2005

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.
Dorer RK, Zhong S, …, Mitchison TJ, Murray AW
Curr Biol 2005 Jun 7 15(11):1070-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick
Evaluated 10 Jun 2005

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.
De Antoni A, Pearson CG, …, Salmon ED, Musacchio A
Curr Biol 2005 Feb 8 15(3):214-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Duane Compton / Kevin Hardwick
Evaluated 27 Apr 2005

A dual role for Bub1 in the spindle checkpoint and chromosome congression.
Meraldi P, Sorger PK
EMBO J 2005 Apr 20 24(8):1621-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 22 Apr 2005

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.
Indjeian VB, Stern BM, Murray AW
Science 2005 Jan 7 307(5706):130-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 20 Jan 2005

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.
Hanks S, Coleman K, …, Douglas J, Rahman N
Nat Genet 2004 Nov 36(11):1159-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marjori Matzke / Kevin Hardwick / Domenico Grieco / Prasad Jallepalli
Evaluated 10 Nov 2004

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
Tang Z, Shu H, …, Chen S, Yu H
Mol Cell 2004 Nov 5 16(3):387-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Hardwick
Evaluated 10 Nov 2004

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.
Pan J, Chen RH
Genes Dev 2004 Jun 15 18(12):1439-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kevin Hardwick
Evaluated 13 Aug 2004

Timing and checkpoints in the regulation of mitotic progression.
Meraldi P, Draviam VM, Sorger PK
Dev Cell 2004 Jul 7(1):45-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen / Kevin Hardwick / Bruce McEwen
Evaluated 9 Aug 2004

Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast.
Gillett ES, Espelin CW, Sorger PK
J Cell Biol 2004 Feb 16 164(4):535-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Iain Hagan / Kevin Hardwick
Evaluated 15 Apr 2004

The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.
Kitajima TS, Kawashima SA, Watanabe Y
Nature 2004 Feb 5 427(6974):510-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robin Allshire / Kevin Hardwick / Mohan Balasubramanian / William Earnshaw / Mark Rose
Evaluated 19 Feb 2004

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts.
Yamano H, Gannon J, Mahbubani H, Hunt T
Mol Cell 2004 Jan 16 13(1):137-47 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathon Pines / Kevin Hardwick
Evaluated 18 Feb 2004

Suspended animation in C. elegans requires the spindle checkpoint.
Nystul TG, Goldmark JP, Padilla PA, Roth MB
Science 2003 Nov 7 302(5647):1038-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Glotzer / Carl Thummel / Kevin Hardwick
Evaluated 12 Dec 2003

Targets of the cyclin-dependent kinase Cdk1.
Ubersax JA, Woodbury EL, …, Shokat KM, Morgan DO
Nature 2003 Oct 23 425(6960):859-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Iain Hagan / Kevin Hardwick / Arp Schnittger
Evaluated 12 Nov 2003

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