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Alfonso Martinez Arias
Department of Genetics, University of Cambridge, United Kingdom

Faculty Member: Developmental Biology > Developmental Molecular Mechanisms [ since 27 February 2003 ]
[ Homepage ] [ Evaluations ]
Home page

http://www.gen.cam.ac.uk/Research/martinezarias.htm

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Evaluations

The ground state of embryonic stem cell self-renewal.
Ying QL, Wray J, …, Cohen P, Smith A
Nature 2008 May 22 453(7194):519-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Chernoff / Alfonso Martinez Arias
Evaluated 22 Jul 2008

Multistable and multistep dynamics in neutrophil differentiation.
Chang HH, Oh PY, Ingber DE, Huang S
BMC Cell Biol 2006 7:11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 22 Jul 2008

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells.
Chang HH, Hemberg M, …, Ingber DE, Huang S
Nature 2008 May 22 453(7194):544-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Graf / Alfonso Martinez Arias / Stephen Schwartz
Evaluated 22 Jul 2008

A single type of progenitor cell maintains normal epidermis.
Clayton E, Doupé DP, …, Simons BD, Jones PH
Nature 2007 Mar 8 446(7132):185-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Morgan / Kathleen J. Green / Alfonso Martinez Arias
Evaluated 1 May 2008

Cell fates as high-dimensional attractor states of a complex gene regulatory network.
Huang S, Eichler G, Bar-Yam Y, Ingber DE
Phys Rev Lett 2005 Apr 1 94(12):128701 [abstract on PubMed] [related articles] [order article]
Selected by | Elena Alvarez-Buylla / Alfonso Martinez Arias
Evaluated 30 Apr 2008

Kinetics of morphogen gradient formation.
Kicheva A, Pantazis P, …, Jülicher F, González-Gaitán M
Science 2007 Jan 26 315(5811):521-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 28 Feb 2008

Nanog safeguards pluripotency and mediates germline development.
Chambers I, Silva J, …, Grotewold L, Smith A
Nature 2007 Dec 20 450(7173):1230-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Mullins / Alfonso Martinez Arias
Evaluated 26 Feb 2008

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism.
Dessaud E, Yang LL, …, Novitch BG, Briscoe J
Nature 2007 Nov 29 450(7170):717-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert S Krauss / Alfonso Martinez Arias
Evaluated 26 Feb 2008

Stability and nuclear dynamics of the bicoid morphogen gradient.
Gregor T, Wieschaus EF, …, Bialek W, Tank DW
Cell 2007 Jul 13 130(1):141-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alfonso Martinez Arias
Evaluated 20 Sep 2007

Probing the limits to positional information.
Gregor T, Tank DW, Wieschaus EF, Bialek W
Cell 2007 Jul 13 130(1):153-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alfonso Martinez Arias
Evaluated 13 Sep 2007

Pre-steady-state decoding of the Bicoid morphogen gradient.
Bergmann S, Sandler O, …, Shilo BZ, Barkai N
PLoS Biol 2007 Feb 5(2):e46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 7 Mar 2007

The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking.
Jaekel R, Klein T
Dev Cell 2006 Nov 11(5):655-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marta Llimargas / Alfonso Martinez Arias
Evaluated 7 Mar 2007

The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.
Carmena A, Speicher S, Baylies M
PLoS ONE 2006 1:e66 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 6 Mar 2007

Shavenbaby couples patterning to epidermal cell shape control.
Chanut-Delalande H, Fernandes I, …, Payre F, Plaza S
PLoS Biol 2006 Sep 4(9):e290 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Helen Chamberlin / Alfonso Martinez Arias / Andrew Chisholm / Artyom Kopp / Michel Labouesse
Evaluated 20 Sep 2006

Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution.
Tischler J, Lehner B, Chen N, Fraser AG
Genome Biol 2006 7(8):R69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 1 Sep 2006

Transiently reorganized microtubules are essential for zippering during dorsal closure in Drosophila melanogaster.
Jankovics F, Brunner D
Dev Cell 2006 Sep 11(3):375-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Martin / Alfonso Martinez Arias / Thomas Lecuit / Elizabeth Gavis
Evaluated 31 Aug 2006

Internalization is required for proper Wingless signaling in Drosophila melanogaster.
Seto ES, Bellen HJ
J Cell Biol 2006 Apr 10 173(1):95-106 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michel Labouesse / Alfonso Martinez Arias
Evaluated 4 May 2006

Wnt signals can function as positional cues in establishing cell polarity.
Goldstein B, Takeshita H, Mizumoto K, Sawa H
Dev Cell 2006 Mar 10(3):391-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Podbilewicz / Alfonso Martinez Arias / Robert K Herman
Evaluated 2 May 2006

Notch promotes neural lineage entry by pluripotent embryonic stem cells.
Lowell S, Benchoua A, Heavey B, Smith AG
PLoS Biol 2006 May 4(5):e121 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 2 May 2006

Diffusion and scaling during early embryonic pattern formation.
Gregor T, Bialek W, …, Tank DW, Wieschaus EF
Proc Natl Acad Sci U S A 2005 Dec 20 102(51):18403-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mark Fortini / Alfonso Martinez Arias
Evaluated 8 Mar 2006

Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless.
Koelzer S, Klein T
Dev Biol 2006 Jan 1 289(1):77-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raphael Kopan / Alfonso Martinez Arias
Evaluated 3 Mar 2006

Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila.
Thompson BJ, Mathieu J, …, Rørth P, Cohen SM
Dev Cell 2005 Nov 9(5):711-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valeri Vasioukhin / Alfonso Martinez Arias / Harald Stenmark / Marcos Gonzalez-Gaitan
Evaluated 14 Dec 2005

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth.
Moberg KH, Schelble S, Burdick SK, Hariharan IK
Dev Cell 2005 Nov 9(5):699-710 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valeri Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias
Evaluated 14 Dec 2005

The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking.
Vaccari T, Bilder D
Dev Cell 2005 Nov 9(5):687-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valeri Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias / Harald Stenmark / Marcos Gonzalez-Gaitan
Evaluated 12 Dec 2005

Endocytic control of epithelial polarity and proliferation in Drosophila.
Lu H, Bilder D
Nat Cell Biol 2005 Dec 7(12):1232-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Harald Stenmark / Elizabeth Smythe / Alfonso Martinez Arias / Heike Folsch / Thomas Lecuit
Evaluated 12 Dec 2005

Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
Huppert SS, Ilagan MX, De Strooper B, Kopan R
Dev Cell 2005 May 8(5):677-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mary Baylies / Alfonso Martinez Arias
Evaluated 18 Jul 2005

Single cell profiling of potentiated phospho-protein networks in cancer cells.
Irish JM, Hovland R, …, Gjertsen BT, Nolan GP
Cell 2004 Jul 23 118(2):217-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Woodgett / Linda Huang / Alfonso Martinez Arias
Evaluated 15 Jul 2005

Distinct functions of the Tribolium zerknüllt genes in serosa specification and dorsal closure.
van der Zee M, Berns N, Roth S
Curr Biol 2005 Apr 12 15(7):624-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alfonso Martinez Arias
Evaluated 20 Apr 2005

Functional genomic analysis of the Wnt-wingless signaling pathway.
DasGupta R, Kaykas A, Moon RT, Perrimon N
Science 2005 May 6 308(5723):826-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias / Bruce Morgan / Kermit Carraway / Valeri Vasioukhin
Evaluated 19 Apr 2005

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.
Ozdamar B, Bose R, …, Zhang Y, Wrana JL
Science 2005 Mar 11 307(5715):1603-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Victor Thannickal / Keith Mostov / David Wotton / David Bilder / Valeri Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias / Andreas Wodarz / Francisco Sanchez-Madrid
Evaluated 19 Apr 2005

Ligand-binding and signaling properties of the Ax[M1] form of Notch.
Pérez L, Milán M, Bray S, Cohen SM
Mech Dev 2005 Apr 122(4):479-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alfonso Martinez Arias
Evaluated 18 Apr 2005

Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing.
Gibson MC, Perrimon N
Science 2005 Mar 18 307(5716):1785-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marta Llimargas / Thomas Lecuit / Alfonso Martinez Arias
Evaluated 4 Apr 2005

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.
Pan Y, Lin MH, …, Shen J, Kopan R
Dev Cell 2004 Nov 7(5):731-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Morgan / Alfonso Martinez Arias
Evaluated 3 Feb 2005

Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling.
Cox VT, Baylies MK
Development 2005 Feb 132(4):713-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 2 Feb 2005

Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless.
Chen CM, Strapps W, Tomlinson A, Struhl G
Proc Natl Acad Sci U S A 2004 Nov 9 101(45):15961-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias
Evaluated 31 Jan 2005

Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.
Belenkaya TY, Han C, …, Liu H, Lin X
Cell 2004 Oct 15 119(2):231-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden / Ken Irvine / Deborah Andrew / Jean-Paul Vincent / Jeffrey Axelrod / Alain Prochiantz
Dissenters | Alfonso Martinez Arias
Author Response | Xinhua Lin
Evaluated 30 Nov 2004


Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.
Gottardi CJ, Gumbiner BM
J Cell Biol 2004 Oct 25 167(2):339-49 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias / Valeri Vasioukhin
Evaluated 25 Oct 2004

Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination.
Raya A, Kawakami Y, …, Feijó JA, Izpisúa Belmonte JC
Nature 2004 Jan 8 427(6970):121-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raphael Kopan / Ken Irvine / David Ish-Horowicz / Alfonso Martinez Arias
Evaluated 25 Oct 2004

Control of stochasticity in eukaryotic gene expression.
Raser JM, O'Shea EK
Science 2004 Jun 18 304(5678):1811-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias / Andrey Rzhetsky
Evaluated 29 Jul 2004

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation.
Bertet C, Sulak L, Lecuit T
Nature 2004 Jun 10 429(6992):667-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ben Zion Shilo / Michel Labouesse / Jeffrey Axelrod / Maria Leptin / Carien Niessen / Vivian Tang / Alfonso Martinez Arias
Evaluated 29 Jul 2004

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Suzuki H, Watkins DN, …, Herman JG, Baylin SB
Nat Genet 2004 Apr 36(4):417-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Alfonso Martinez Arias
Evaluated 27 May 2004

Notch1 functions as a tumor suppressor in mouse skin.
Nicolas M, Wolfer A, …, Dotto GP, Radtke F
Nat Genet 2003 Mar 33(3):416-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alfonso Martinez Arias
Evaluated 29 Mar 2004

Combinatorial synthesis of genetic networks.
Guet CC, Elowitz MB, Hsing W, Leibler S
Science 2002 May 24 296(5572):1466-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Greg Gibson / Christos Ouzounis / Alfonso Martinez Arias
Evaluated 17 Mar 2004

Establishment of developmental precision and proportions in the early Drosophila embryo.
Houchmandzadeh B, Wieschaus E, Leibler S
Nature 2002 Feb 14 415(6873):798-802 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Greg Gibson / Patricia Simpson / Marta Llimargas / Ilan Davis / Alfonso Martinez Arias
Evaluated 17 Mar 2004

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
Staal FJ, Noort Mv M, Strous GJ, Clevers HC
EMBO Rep 2002 Jan 3(1):63-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Randall Moon / Mariann Bienz / Alfonso Martinez Arias
Evaluated 3 Oct 2003

Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.
Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL
Nat Cell Biol 2003 May 5(5):410-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kees Jalink / Michael Gold / Robert Parton / Alfonso Martinez Arias
Evaluated 1 Sep 2003

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