Faculty of 1000 Biology | Faculty member: Jefferson Tilley

17-May-2008

	Jefferson Tilley Discovery Chemistry, Roche Research Center, Hoffmann-La Roche Inc, Nutley, United States of America
	Faculty Member: PHARMACOLOGY & DRUG DISCOVERY > Drug discovery & design [ since 12 December 2006 ]

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Evaluations

Selected by | Jefferson Tilley
Evaluated 2 May 2008

Mitochondria-penetrating peptides.
Horton KL, Stewart KM, …, Guo Q, Kelley SO
Chem Biol 2008 Apr 15(4):375-82 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jefferson Tilley / Gabriel Fenteany

Evaluated 24 Apr 2008

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.
Khojasteh SC, Leipold DD, …, Gadek TR, Kenkare-Mitra S
Xenobiotica 2008 Mar 38(3):340-52 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jefferson Tilley
Evaluated 17 Mar 2008

Selected by | Jefferson Tilley
Evaluated 28 Jan 2008

Predicting Key Example Compounds in Competitors' Patent Applications Using Structural Information Alone.
Hattori K, Wakabayashi H, Tamaki K
J Chem Inf Model 2008 Jan 5 [abstract on PubMed] [related articles] [full text]

Selected by | Jefferson Tilley / John Proudfoot
Evaluated 11 Jan 2008

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Pfefferkorn JA, Song Y, …, Chen H, Eberstadt M
Bioorg Med Chem Lett 2007 Aug 15 17(16):4538-44 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jefferson Tilley
Evaluated 14 Aug 2007

Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance.
Yamazaki S, Tan L, …, Bajorath J, Famulok M
Chem Biol 2007 Jul 14(7):804-12 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jefferson Tilley
Evaluated 8 Aug 2007

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Shu Y, Sheardown SA, …, Brett CM, Giacomini KM
J Clin Invest 2007 May 117(5):1422-31 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Jefferson Tilley / Gerhard Burckhardt / Bruno Stieger / Russ Altman / Peter Wedlund / Munir Pirmohamed
Evaluated 8 May 2007

Selected by | Jefferson Tilley
Evaluated 19 Apr 2007

Fragment-based drug design: how big is too big?
Hajduk PJ
J Med Chem 2006 Nov 30 49(24):6972-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jefferson Tilley / Wolfgang Jahnke
Evaluated 20 Feb 2007