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Jefferson Tilley
Discovery Chemistry, Roche Research Center, Hoffmann-La Roche Inc, Nutley, United States of America

Faculty Member: PHARMACOLOGY & DRUG DISCOVERY > Drug discovery & design [ since 12 December 2006 ]
[ Evaluations ]
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Evaluations

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Obach RS, Lombardo F, Waters NJ
Drug Metab Dispos 2008 Apr 21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jefferson Tilley
Evaluated 2 May 2008

Mitochondria-penetrating peptides.
Horton KL, Stewart KM, …, Guo Q, Kelley SO
Chem Biol 2008 Apr 15(4):375-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jefferson Tilley / Gabriel Fenteany
Evaluated 24 Apr 2008

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.
Khojasteh SC, Leipold DD, …, Gadek TR, Kenkare-Mitra S
Xenobiotica 2008 Mar 38(3):340-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jefferson Tilley
Evaluated 17 Mar 2008

Marked strain differences in the pharmacokinetics of an alpha4beta1 integrin antagonist, 4-[1-[3-Chloro-4-[N-(2-methylphenyl)-ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]-methoxybenzoic Acid (D01-4582), in Sprague-Dawley rats are associated with albumin genetic polymorphism.
Ito T, Takahashi M, Sudo K, Sugiyama Y
J Pharmacol Exp Ther 2007 Jan 320(1):124-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jefferson Tilley
Evaluated 28 Jan 2008

Predicting Key Example Compounds in Competitors' Patent Applications Using Structural Information Alone.
Hattori K, Wakabayashi H, Tamaki K
J Chem Inf Model 2008 Jan 5 [abstract on PubMed] [related articles] [full text]
Selected by | Jefferson Tilley / John Proudfoot
Evaluated 11 Jan 2008

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Pfefferkorn JA, Song Y, …, Chen H, Eberstadt M
Bioorg Med Chem Lett 2007 Aug 15 17(16):4538-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jefferson Tilley
Evaluated 14 Aug 2007

Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance.
Yamazaki S, Tan L, …, Bajorath J, Famulok M
Chem Biol 2007 Jul 14(7):804-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jefferson Tilley
Evaluated 8 Aug 2007

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Shu Y, Sheardown SA, …, Brett CM, Giacomini KM
J Clin Invest 2007 May 117(5):1422-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jefferson Tilley / Gerhard Burckhardt / Bruno Stieger / Russ Altman / Peter Wedlund / Munir Pirmohamed
Evaluated 8 May 2007

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.
Heidel JD, Yu Z, …, Kornbrust DJ, Davis ME
Proc Natl Acad Sci U S A 2007 Apr 3 104(14):5715-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jefferson Tilley
Evaluated 19 Apr 2007

Fragment-based drug design: how big is too big?
Hajduk PJ
J Med Chem 2006 Nov 30 49(24):6972-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jefferson Tilley / Wolfgang Jahnke
Evaluated 20 Feb 2007

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