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Michael Muller
Department of Nutrition, Metabolism & Genomics, Wageningen University, Wageningen, Netherlands

Faculty Member: PHYSIOLOGY > Gastrointestinal physiology [ since 10 March 2005 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Contact details:
Division of Human Nutrition, Nutrition, Metabolism and Genomics group
Wageningen University, Bomenweg 2, 6703 HD Wageningen
The Netherlands
email: michael.muller@wur.nl
phone: 31-(0)317-482590

Michael Müller has a background in biochemistry and gene regulation. He is full professor and has the chair of Nutrition, Metabolism and Genomics in the Division of Human Nutrition at Wageningen University/The Netherlands. He studied chemistry at the University of Freiburg/Germany and performed a PhD thesis in Biochemistry on 'Liver drug transporters'. After a 5-year period as post-doc at the German Cancer Research Centre in Heidelberg/Germany, he moved in 1993 to the University of Groningen (Netherlands) to become head of the 'Liver transporter group', later in the position of associate professor. He is editorial board member of the European Journal of Nutrition, Molecular Cancer Therapeutics and World Journal of Gastroenterology. He is director of the Netherlands Nutrigenomics Consortium (NGI/TIFN) and board member of the Network of Excellence Nutrigenomics (European Community KP6).

Research interests:
We are fascinated by fat in particular by fatty acids and their role as powerful signaling molecules. We use Affymetrix microarray analysis and molecular nutrition tools to characterize organ-specific fat-sensing mechanisms.
Our group studies the effects of fatty acids and other nutrients on gene expression and metabolic pathways with the focus on 4 major topics:
1. Molecular pathways involved in nutrient-dependent changes in gene expression
2. Impact of specific genes for energy metabolism
3. Bioavailability of nutrients and the role of transporter proteins
4. Gene expression signatures of health and stress (the "two hits")

Home page

http://nutrigene.4t.com/

to email [Help]
Evaluations

Comparisons of Diets Used in Animal Models of High-Fat Feeding.
Warden CH, Fisler JS
Cell Metab 2008 Apr 9 7(4):277 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Muller
Evaluated 9 May 2008

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.
Zhang X, Yeung DC, …, Lam KS, Xu A
Diabetes 2008 May 57(5):1246-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Muller
Evaluated 8 May 2008

High-fat diet disrupts behavioral and molecular circadian rhythms in mice.
Kohsaka A, Laposky AD, …, Turek FW, Bass J
Cell Metab 2007 Nov 6(5):414-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fraydoon Rastinejad / Michael Muller
Evaluated 12 Feb 2008

Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.
Koza RA, Nikonova L, …, Skaf J, Kozak LP
PLoS Genet 2006 May 2(5):e81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Muller
Evaluated 4 Jul 2007

Nuclear receptor expression links the circadian clock to metabolism.
Yang X, Downes M, …, Mangelsdorf DJ, Evans RM
Cell 2006 Aug 25 126(4):801-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Muller
Evaluated 30 Oct 2006

Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein.
Mithieux G, Misery P, …, Rajas F, Zitoun C
Cell Metab 2005 Nov 2(5):321-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Muller
Evaluated 31 Jan 2006

Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
Oike Y, Akao M, …, Kadowaki T, Suda T
Nat Med 2005 Apr 11(4):400-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Muller
Evaluated 19 Jul 2005

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Lin J, Yang R, …, Newgard CB, Spiegelman BM
Cell 2005 Jan 28 120(2):261-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb / Michael Muller
Evaluated 8 Apr 2005

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