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Marsha Wills-Karp
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America

Faculty Member: IMMUNOLOGY > Allergy & hypersensitivity [ since 2 July 2001 ]
[ Evaluations ]
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Evaluations

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies.
Wenzel S, Wilbraham D, …, Getz EB, Longphre M
Lancet 2007 Oct 20 370(9596):1422-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp
Evaluated 26 Oct 2007

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.
Idzko M, Hammad H, …, Virchow JC, Lambrecht BN
Nat Med 2007 Aug 13(8):913-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / David Chaplin / Jens Leipziger
Evaluated 7 Aug 2007


Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
Moffatt MF, Kabesch M, …, Lathrop GM, Cookson WO
Nature 2007 Jul 26 448(7152):470-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp
Evaluated 7 Aug 2007

Interleukin-17 is a negative regulator of established allergic asthma.
Schnyder-Candrian S, Togbe D, …, Ryffel B, Schnyder B
J Exp Med 2006 Nov 27 203(12):2715-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Patricia Finn
Evaluated 9 Mar 2007

Mast cells are essential intermediaries in regulatory T-cell tolerance.
Lu LF, Lind EF, …, Zheng XX, Noelle RJ
Nature 2006 Aug 31 442(7106):997-1002 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Cobbold / Marie Kosco-Vilbois / Marsha Wills-Karp / Yutaka Tagaya / Dan Conrad / Jay Berzofsky / Richard Grencis
Evaluated 12 Sep 2006


Transforming growth factor-beta induces development of the T(H)17 lineage.
Mangan PR, Harrington LE, …, Schoeb TR, Weaver CT
Nature 2006 May 11 441(7090):231-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Marsha Wills-Karp / Stefan Kaufmann / Dennis Taub
Evaluated 30 May 2006

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Bettelli E, Carrier Y, …, Weiner HL, Kuchroo VK
Nature 2006 May 11 441(7090):235-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Christian Engwerda / Torben Lund / Rachel Caspi / Stefan Kaufmann / Paul Gleeson / Andrew Weinberg
Evaluated 18 May 2006

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
Park H, Li Z, …, Tian Q, Dong C
Nat Immunol 2005 Nov 6(11):1133-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Christopher Karp / Marsha Wills-Karp / Marie Kosco-Vilbois / Barbara Rehermann
Evaluated 8 Nov 2005


Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
Harrington LE, Hatton RD, …, Murphy KM, Weaver CT
Nat Immunol 2005 Nov 6(11):1123-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Karp / Richard Grencis / Marsha Wills-Karp / Dan Conrad / Marie Kosco-Vilbois
Evaluated 8 Nov 2005

A chimeric human-cat fusion protein blocks cat-induced allergy.
Zhu D, Kepley CL, …, Yamada T, Saxon A
Nat Med 2005 Apr 11(4):446-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Dale Umetsu
Evaluated 5 May 2005

Defining a link with asthma in mice congenitally deficient in eosinophils.
Lee JJ, Dimina D, …, Irvin CG, Lee NA
Science 2004 Sep 17 305(5691):1773-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Dan Conrad
Evaluated 30 Sep 2004

A critical role for eosinophils in allergic airways remodeling.
Humbles AA, Lloyd CM, …, Orkin SH, Gerard C
Science 2004 Sep 17 305(5691):1776-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Peter Openshaw / Dan Conrad
Evaluated 30 Sep 2004

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen.
de Heer HJ, Hammad H, …, Hoogsteden HC, Lambrecht BN
J Exp Med 2004 Jul 5 200(1):89-98 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ann Hill / Marsha Wills-Karp
Evaluated 23 Sep 2004

Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma.
Redecke V, Häcker H, …, Broide DH, Raz E
J Immunol 2004 Mar 1 172(5):2739-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp
Evaluated 8 Mar 2004

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.
Ling EM, Smith T, …, Carr VA, Robinson DS
Lancet 2004 Feb 21 363(9409):608-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp
Evaluated 8 Mar 2004

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells.
Liu N, Ohnishi N, …, Akira S, Bacon KB
Nat Immunol 2003 Jul 4(7):687-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Steve Ward / Shiv Pillai / Dan Conrad
Evaluated 7 Jul 2003

Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity.
Kabashima K, Murata T, …, Ushikubi F, Narumiya S
Nat Immunol 2003 Jul 4(7):694-701 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Michael Dustin
Evaluated 7 Jul 2003

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ.
Constant SL, Brogdon JL, …, Ruddle NH, Bottomly K
J Clin Invest 2002 Nov 110(10):1441-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp
Evaluated 16 Jan 2003

Essential role of Id2 in negative regulation of IgE class switching.
Sugai M, Gonda H, …, Yokota Y, Shimizu A
Nat Immunol 2003 Jan 4(1):25-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Dan Conrad
Evaluated 15 Jan 2003

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.
Belkaid Y, Piccirillo CA, …, Shevach EM, Sacks DL
Nature 2002 Dec 5 420(6915):502-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marie Kosco-Vilbois / Christopher Karp / Stefan Kaufmann / Marsha Wills-Karp / Luciano Adorini
Evaluated 15 Jan 2003

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).
Levy BD, De Sanctis GT, …, Drazen JM, Serhan CN
Nat Med 2002 Sep 8(9):1018-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp
Evaluated 30 Sep 2002

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.
Avni O, Lee D, …, Glimcher LH, Rao A
Nat Immunol 2002 Jul 3(7):643-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp
Evaluated 17 Jun 2002

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.
Rengarajan J, Mowen KA, …, Singh H, Glimcher LH
J Exp Med 2002 Apr 15 195(8):1003-12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp
Evaluated 23 Apr 2002

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.
Finotto S, Neurath MF, …, De Sanctis GT, Glimcher LH
Science 2002 Jan 11 295(5553):336-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Dan Conrad
Evaluated 12 Feb 2002

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
McIntire JJ, Umetsu SE, …, Umetsu DT, DeKruyff RH
Nat Immunol 2001 Dec 2(12):1109-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Betty Tsao
Evaluated 4 Dec 2001

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3.
Kishikawa H, Sun J, …, Miaw SC, Ho IC
J Immunol 2001 Oct 15 167(8):4414-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp
Evaluated 20 Nov 2001

A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects.
Dolganov GM, Woodruff PG, …, Szubin R, Fahy JV
Genome Res 2001 Sep 11(9):1473-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp
Evaluated 28 Sep 2001

Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein.
Webb DC, McKenzie AN, Foster PS
J Biol Chem 2001 Nov 9 276(45):41969-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp
Evaluated 28 Sep 2001

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