Steven Henikoff performs experimental research on chromosome structure, function, and evolution, and develops tools for sequence comparison, in vivo mapping, and functional genomics.

http://blocks.fhcrc.org/steveh

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Fusion Partner TET1. Tahiliani M, Koh KP, …, Aravind L, Rao A Science 2009 Apr 16 [abstract on PubMed] [related articles] [full text] Selected by | Stephan Beck / Steven Henikoff Evaluated 22 Apr 2009 The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain. Kriaucionis S, Heintz N Science 2009 Apr 16 [abstract on PubMed] [related articles] [full text] Selected by | Steven Henikoff / Dengke K. Ma and Hongjun Song Evaluated 21 Apr 2009 DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Rai K, Huggins IJ, …, Jones DA, Cairns BR Cell 2008 Dec 26 135(7):1201-12 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Leanne De Koning and Genevieve Almouzni / Amy Kenter Evaluated 9 Jan 2009 The DNA-encoded nucleosome organization of a eukaryotic genome. Kaplan N, Moore IK, …, Widom J, Segal E Nature 2009 Mar 19 458(7236):362-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Reza Kalhor and Lin Chen / Ozan Aygun and Jesper Svejstrup Evaluated 7 Jan 2009 Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping. Dutrow N, Nix DA, …, Parnell TJ, Cairns BR Nat Genet 2008 Aug 40(8):977-86 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff / Nick Rhind Evaluated 3 Dec 2008 Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Ng RK, Gurdon JB Nat Cell Biol 2008 Jan 10(1):102-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Amy Wagers Evaluated 10 Jan 2008 Phosphorylated serine 28 of histone H3 is associated with destabilized nucleosomes in transcribed chromatin. Sun JM, Chen HY, Espino PS, Davie JR Nucleic Acids Res 2007 35(19):6640-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 31 Oct 2007 Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1. Rufiange A, Jacques PE, …, Robert F, Nourani A Mol Cell 2007 Aug 3 27(3):393-405 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff Evaluated 23 Aug 2007 Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Jin C, Felsenfeld G Genes Dev 2007 Jun 15 21(12):1519-29 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff Evaluated 18 Jun 2007 High-resolution profiling of histone methylations in the human genome. Barski A, Cuddapah S, …, Chepelev I, Zhao K Cell 2007 May 18 129(4):823-37 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Xing Wang Deng / Michael Meisterernst / Deyou Zheng / Magdalena Zernicka-Goetz Evaluated 22 May 2007 Dynamic changes in histone H3 lysine 9 methylations: identification of a mitosis-specific function for dynamic methylation in chromosome congression and segregation. McManus KJ, Biron VL, …, Underhill DA, Hendzel MJ J Biol Chem 2006 Mar 31 281(13):8888-97 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 8 Sep 2006 Observations of amino acid gain and loss during protein evolution are explained by statistical bias. Goldstein RA, Pollock DD Mol Biol Evol 2006 Jul 23(7):1444-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 8 Aug 2006 A universal trend of amino acid gain and loss in protein evolution. Jordan IK, Kondrashov FA, …, Kondrashov AS, Sunyaev S Nature 2005 Feb 10 433(7026):633-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Nick Grishin / Jeffrey Thorne / Ulf Pettersson / Andrew Wilkie Dissenters | Steven Henikoff Author Response | Eugene Koonin Evaluated 19 Apr 2006 Apparent trends of amino Acid gain and loss in protein evolution due to nearly neutral variation. McDonald JH Mol Biol Evol 2006 Feb 23(2):240-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Dissenters | Eugene Koonin Author Response | John McDonald Evaluated 5 Apr 2006 Global analysis of X-chromosome dosage compensation. Gupta V, Parisi M, …, Eastman PS, Oliver B J Biol 2006 5(1):3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 8 Mar 2006 Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment. Straub T, Neumann MF, …, Haass C, Becker PB Chromosoma 2005 Nov 114(5):352-64 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff Evaluated 15 Dec 2005 Chromatin immunoprecipitation cloning reveals rapid evolutionary patterns of centromeric DNA in Oryza species. Lee HR, Zhang W, …, Cheng Z, Jiang J Proc Natl Acad Sci U S A 2005 Aug 16 102(33):11793-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 1 Sep 2005 Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Hake SB, Garcia BA, …, Hunt DF, Allis CD Proc Natl Acad Sci U S A 2005 May 3 102(18):6344-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 20 May 2005 Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequences of nuclear reorganization. Harmon B, Sedat J PLoS Biol 2005 Mar 3(3):e67 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff / Thomas Cremer Evaluated 16 Mar 2005 Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Kusch T, Florens L, …, Washburn MP, Workman JL Science 2004 Dec 17 306(5704):2084-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Stephen Jackson / Steven Henikoff Evaluated 4 Jan 2005 Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Shi Y, Lan F, …, Casero RA, Shi Y Cell 2004 Dec 29 119(7):941-53 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Thomas Jenuwein / Chris Sander / Winship Herr / Dinah Singer / Robert Dutnall / Eric Selker / Frank Lyko / Daniel Reines / Benoit Coulombe / Robin Allshire Evaluated 21 Dec 2004 Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. Sullivan BA, Karpen GH Nat Struct Mol Biol 2004 Nov 11(11):1076-83 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 17 Nov 2004 Centromere-encoded RNAs are integral components of the maize kinetochore. Topp CN, Zhong CX, Dawe RK Proc Natl Acad Sci U S A 2004 Nov 9 101(45):15986-91 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 3 Nov 2004 A novel meiotic drive locus almost completely distorts segregation in mimulus (monkeyflower) hybrids. Fishman L, Willis JH Genetics 2005 Jan 169(1):347-53 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 12 Oct 2004 Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Sarraf SA, Stancheva I Mol Cell 2004 Aug 27 15(4):595-605 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Eric Selker / Genevieve Almouzni Evaluated 6 Sep 2004 Evidence for nucleosome depletion at active regulatory regions genome-wide. Lee CK, Shibata Y, …, Strahl BD, Lieb JD Nat Genet 2004 Aug 36(8):900-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff Evaluated 20 Aug 2004 Chromatin regulates origin activity in Drosophila follicle cells. Aggarwal BD, Calvi BR Nature 2004 Jul 15 430(6997):372-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / Peter B. Becker Evaluated 6 Aug 2004 Specification of a DNA replication origin by a transcription complex. Danis E, Brodolin K, …, Girard-Reydet C, Méchali M Nat Cell Biol 2004 Aug 6(8):721-30 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff Evaluated 3 Aug 2004 Spontaneous sharp bending of double-stranded DNA. Cloutier TE, Widom J Mol Cell 2004 May 7 14(3):355-62 [abstract on PubMed] [related articles] [order article] Selected by | Ian Willis / Steven Henikoff / Jim Maher Evaluated 27 May 2004 Human centromere repositioning "in progress". Amor DJ, Bentley K, …, Slater H, Choo KH Proc Natl Acad Sci U S A 2004 Apr 27 101(17):6542-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff / Carmen Sapienza Evaluated 20 Apr 2004 Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Ezhkova E, Tansey WP Mol Cell 2004 Feb 13 13(3):435-42 [abstract on PubMed] [related articles] [order article] Selected by | Jerry Workman / Steven Henikoff Evaluated 4 Mar 2004 Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. Mulholland NM, King IF, Kingston RE Genes Dev 2003 Nov 15 17(22):2741-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 8 Dec 2003 Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Lehnertz B, Ueda Y, …, Jenuwein T, Peters AH Curr Biol 2003 Jul 15 13(14):1192-200 [abstract on PubMed] [related articles] [order article] Selected by | Steven Henikoff Evaluated 29 Jul 2003 HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain. Meehan RR, Kao CF, Pennings S EMBO J 2003 Jun 16 22(12):3164-74 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 20 Jun 2003 The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Angelov D, Molla A, …, Bouvet P, Dimitrov S Mol Cell 2003 Apr 11(4):1033-41 [abstract on PubMed] [related articles] [order article] Selected by | Steven Henikoff Evaluated 19 May 2003 An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation. Malagnac F, Bartee L, Bender J EMBO J 2002 Dec 16 21(24):6842-52 [abstract on PubMed] [related articles] [order article] Selected by | Steven Henikoff / Eric Selker Evaluated 12 Feb 2003 ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Zilberman D, Cao X, Jacobsen SE Science 2003 Jan 31 299(5607):716-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff / Ton Bisseling / James Carrington / Daniel Gallie / Thomas Jenuwein Evaluated 11 Feb 2003 RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Hall IM, Noma K, Grewal SI Proc Natl Acad Sci U S A 2003 Jan 7 100(1):193-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 11 Feb 2003 Evidence for large domains of similarly expressed genes in the Drosophila genome. Spellman PT, Rubin GM J Biol 2002 1(1):5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Josep M. Comeron / Steven Henikoff / Andrew Belmont / Peter B. Becker Evaluated 13 Aug 2002 ATP-dependent mobilization of the glucocorticoid receptor during chromatin remodeling. Fletcher TM, Xiao N, …, Warren BS, Hager GL Mol Cell Biol 2002 May 22(10):3255-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Peter B. Becker / Steven Henikoff Evaluated 10 Jul 2002 Meiotic deletion at the BUF1 locus of the fungus Magnaporthe grisea is controlled by interaction with the homologous chromosome. Farman ML Genetics 2002 Jan 160(1):137-48 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 9 Apr 2002 Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Jackson JP, Lindroth AM, Cao X, Jacobsen SE Nature 2002 Apr 4 416(6880):556-60 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff / James Bone / Jerry Workman / Robert Sablowski / Steven Spiker / Thomas Jenuwein Evaluated 25 Mar 2002 Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Soutoglou E, Talianidis I Science 2002 Mar 8 295(5561):1901-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff / Michael Meisterernst / Dinah Singer Evaluated 22 Mar 2002 INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion. Vagnarelli PB, Earnshaw WC Chromosoma 2001 Nov 110(6):393-401 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steven Henikoff Evaluated 22 Jan 2002 Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Heard E, Rougeulle C, …, Allis CD, Spector DL Cell 2001 Dec 14 107(6):727-38 [abstract on PubMed] [related articles] [order article] Selected by | Steven Henikoff / Mitzi Kuroda / Peter B. Becker Evaluated 9 Jan 2002 The domain structure of centromeres is conserved from fission yeast to humans. Kniola B, O'Toole E, …, Hultenby K, Ekwall K Mol Biol Cell 2001 Sep 12(9):2767-75 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 6 Nov 2001 Genomic and genetic definition of a functional human centromere. Schueler MG, Higgins AW, …, Gustashaw K, Willard HF Science 2001 Oct 5 294(5540):109-15 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff Evaluated 2 Nov 2001 Requirement of heterochromatin for cohesion at centromeres. Bernard P, Maure JF, …, Javerzat JP, Allshire RC Science 2001 Dec 21 294(5551):2539-42 [abstract on PubMed] [related articles] [FREE full text] Selected by | Steven Henikoff / Susan Forsburg / Douglas Koshland Evaluated 2 Nov 2001

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