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Antony Carr
Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom

Faculty Member: CELL BIOLOGY > Nuclear structure & function [ since 26 July 2001 ]
[ Sponsorship ] [ Biography ] [ Evaluations ]
Sponsorship

Antony Carr sponsors free access to F1000 for University of Medicine and Pharmacy of Iasi, Iasi, Romania. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

Antony M. Carr. Director, Genome Damage and Stability Centre.

I studied for my BSc at Norwich University, graduating in Biological Sciences in 1981. I subsequently studied under Paul Nurse for my D. Phil. For which I was registered at the University of Sussex. The subject of my thesis was ?The Analysis and Function of the cdc2 Gene Region in Fission Yeast?. Over the following years I developed my interest in the checkpoint pathways that respond to DNA damage and replication delays while working on DNA repair at the MRC Cell Mutation Unit, Sussex University. My laboratory currently studies the genetics and biochemistry of these pathways in fission yeast. We are interested in the mechanisms by which checkpoints respond to DNA damage and how these pathways interact with aspects of DNA repair and replication. My laboratory is now part of the Centre for Genome Damage and Stability which is based at Sussex University and funded by the Medical Research Council.

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Evaluations

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage.
Bonilla CY, Melo JA, Toczyski DP
Mol Cell 2008 May 9 30(3):267-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 2 Jun 2008

Tel2 regulates the stability of PI3K-related protein kinases.
Takai H, Wang RC, …, Yang H, de Lange T
Cell 2007 Dec 28 131(7):1248-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner / Antony Carr
Evaluated 4 Feb 2008

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.
Xie A, Hartlerode A, …, Jackson SP, Scully R
Mol Cell 2007 Dec 28 28(6):1045-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 4 Feb 2008

SUMO-targeted ubiquitin ligases in genome stability.
Prudden J, Pebernard S, …, McGowan CH, Boddy MN
EMBO J 2007 Sep 19 26(18):4089-101 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 31 Oct 2007

Postreplicative formation of cohesion is required for repair and induced by a single DNA break.
Ström L, Karlsson C, …, Shirahige K, Sjögren C
Science 2007 Jul 13 317(5835):242-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 31 Aug 2007

DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).
Unal E, Heidinger-Pauli JM, Koshland D
Science 2007 Jul 13 317(5835):245-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr / Kerry Bloom
Evaluated 31 Aug 2007

Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.
Hermand D, Nurse P
Mol Cell 2007 May 25 26(4):553-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gennaro D'Urso / Antony Carr / Stephen Kearsey
Evaluated 22 Jun 2007

RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins.
Magner DB, Blankschien MD, …, Lupski JR, Rosenberg SM
Mol Cell 2007 Apr 27 26(2):273-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 10 May 2007

Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast.
Ide S, Watanabe K, …, Kobayashi T, Maki H
Mol Cell Biol 2007 Jan 27(2):568-78 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philippe Pasero / Antony Carr
Evaluated 8 Mar 2007

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.
Chabes A, Stillman B
Proc Natl Acad Sci U S A 2007 Jan 23 104(4):1183-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 6 Mar 2007

The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.
Azvolinsky A, Dunaway S, …, Bessler JB, Zakian VA
Genes Dev 2006 Nov 15 20(22):3104-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philippe Pasero / Joel Huberman / Antony Carr
Evaluated 29 Jan 2007

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint.
Majka J, Niedziela-Majka A, Burgers PM
Mol Cell 2006 Dec 28 24(6):891-901 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr / Gennaro D'Urso / Nick Rhind
Evaluated 12 Jan 2007

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.
Davidson IF, Li A, Blow JJ
Mol Cell 2006 Nov 3 24(3):433-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 21 Nov 2006

UV irradiation induces a postreplication DNA damage checkpoint.
Callegari AJ, Kelly TJ
Proc Natl Acad Sci U S A 2006 Oct 24 103(43):15877-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Teresa Wang / Antony Carr / Nick Rhind / Matthew O'Connell
Evaluated 16 Nov 2006

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.
Du LL, Nakamura TM, Russell P
Genes Dev 2006 Jun 15 20(12):1583-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 2 Aug 2006

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
Oliver AW, Paul A, …, Mittnacht S, Pearl LH
EMBO J 2006 Jul 12 25(13):3179-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 1 Aug 2006

DNA repeat rearrangements mediated by DnaK-dependent replication fork repair.
Goldfless SJ, Morag AS, …, Sutera VA, Lovett ST
Mol Cell 2006 Mar 3 21(5):595-604 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Marinus / Antony Carr / Tim Humphrey
Evaluated 2 May 2006

TopBP1 activates the ATR-ATRIP complex.
Kumagai A, Lee J, Yoo HY, Dunphy WG
Cell 2006 Mar 10 124(5):943-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Rouse / Antony Carr / Tim Humphrey / Matthew O'Connell / Stephen Elledge / Stephen Jackson
Evaluated 21 Mar 2006

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.
Pebernard S, Wohlschlegel J, …, Yates JR, Boddy MN
Mol Cell Biol 2006 Mar 26(5):1617-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 27 Feb 2006

The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.
Mohanty BK, Bairwa NK, Bastia D
Proc Natl Acad Sci U S A 2006 Jan 24 103(4):897-902 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr / Philippe Pasero
Evaluated 24 Feb 2006

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication.
Arias EE, Walter JC
Nat Cell Biol 2006 Jan 8(1):84-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr / Stephen Kearsey / Anindya Dutta
Evaluated 13 Jan 2006

The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination.
Zhang H, Lawrence CW
Proc Natl Acad Sci U S A 2005 Nov 1 102(44):15954-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 21 Nov 2005

Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.
Tourrière H, Versini G, …, Alabert C, Pasero P
Mol Cell 2005 Sep 2 19(5):699-706 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 7 Oct 2005

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.
Collura A, Blaisonneau J, Baldacci G, Francesconi S
Mol Cell Biol 2005 Sep 25(17):7889-99 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 29 Sep 2005

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
You Z, Chahwan C, …, Hunter T, Russell P
Mol Cell Biol 2005 Jul 25(13):5363-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 8 Jul 2005

RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.
Martin JS, Winkelmann N, …, McIlwraith MJ, Boulton SJ
Mol Cell Biol 2005 Apr 25(8):3127-39 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 5 May 2005

Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.
Schumacher B, Hanazawa M, …, Schedl T, Gartner A
Cell 2005 Feb 11 120(3):357-68 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andy Golden / Antony Carr
Evaluated 4 Apr 2005

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.
Boisvert FM, Déry U, Masson JY, Richard S
Genes Dev 2005 Mar 15 19(6):671-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 17 Mar 2005

Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast.
López-Avilés S, Grande M, …, Millar JB, Aligue R
Mol Cell 2005 Jan 7 17(1):49-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 23 Feb 2005

Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.
Du LL, Moser BA, Russell P
J Biol Chem 2004 Sep 10 279(37):38409-14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 12 Jan 2005

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
Huyen Y, Zgheib O, …, Stavridi ES, Halazonetis TD
Nature 2004 Nov 18 432(7015):406-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 8 Dec 2004

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
Sanders SL, Portoso M, …, Allshire RC, Kouzarides T
Cell 2004 Nov 24 119(5):603-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew O'Connell / Susan Forsburg / Antony Carr
Evaluated 6 Dec 2004

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.
Nakada D, Hirano Y, Sugimoto K
Mol Cell Biol 2004 Nov 24(22):10016-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 9 Nov 2004

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells.
van Vugt MA, Brás A, Medema RH
Mol Cell 2004 Sep 10 15(5):799-811 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr / Michael B. Yaffe
Evaluated 5 Oct 2004

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.
Cortez D, Glick G, Elledge SJ
Proc Natl Acad Sci U S A 2004 Jul 6 101(27):10078-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 2 Aug 2004

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
Lee JH, Paull TT
Science 2004 Apr 2 304(5667):93-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 30 Apr 2004

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.
Liu K, Luo Y, Lin FT, Lin WC
Genes Dev 2004 Mar 15 18(6):673-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 21 Apr 2004

The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes.
Ivessa AS, Lenzmeier BA, …, Schnakenberg SL, Zakian VA
Mol Cell 2003 Dec 12(6):1525-36 [abstract on PubMed] [related articles] [order article]
Selected by | Frederick R. Cross / Antony Carr
Evaluated 24 Mar 2004

Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms.
Lopes M, Cotta-Ramusino C, Liberi G, Foiani M
Mol Cell 2003 Dec 12(6):1499-510 [abstract on PubMed] [related articles] [order article]
Selected by | Antony Carr
Evaluated 3 Feb 2004

A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae.
Gunjan A, Verreault A
Cell 2003 Nov 26 115(5):537-49 [abstract on PubMed] [related articles] [order article]
Selected by | Susan Forsburg / Antony Carr
Evaluated 16 Jan 2004

Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.
Higa LA, Mihaylov IS, …, Zheng J, Zhang H
Nat Cell Biol 2003 Nov 5(11):1008-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Kearsey / Antony Carr
Evaluated 4 Dec 2003

Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis.
Osman F, Dixon J, Doe CL, Whitby MC
Mol Cell 2003 Sep 12(3):761-74 [abstract on PubMed] [related articles] [order article]
Selected by | Antony Carr
Evaluated 3 Dec 2003

Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.
Du LL, Nakamura TM, Moser BA, Russell P
Mol Cell Biol 2003 Sep 23(17):6150-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 23 Oct 2003

ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism.
Nakada D, Matsumoto K, Sugimoto K
Genes Dev 2003 Aug 15 17(16):1957-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 16 Sep 2003

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.
Katou Y, Kanoh Y, …, Sugimoto K, Shirahige K
Nature 2003 Aug 28 424(6952):1078-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Schwob / Antony Carr
Evaluated 5 Sep 2003

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Ayad NG, Rankin S, …, Gygi S, Kirschner MW
Cell 2003 Apr 4 113(1):101-13 [abstract on PubMed] [related articles] [order article]
Selected by | William Kaelin / Antony Carr
Evaluated 25 Jun 2003

Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.
Zhou C, Wee S, …, Dubiel W, Wolf DA
Mol Cell 2003 Apr 11(4):927-38 [abstract on PubMed] [related articles] [order article]
Selected by | Antony Carr
Evaluated 18 Jun 2003

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.
Veaute X, Jeusset J, …, Le Cam E, Fabre F
Nature 2003 May 15 423(6937):309-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 18 Jun 2003

DNA helicase Srs2 disrupts the Rad51 presynaptic filament.
Krejci L, Van Komen S, …, Ellenberger T, Sung P
Nature 2003 May 15 423(6937):305-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Ramsden / Antony Carr
Evaluated 18 Jun 2003

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Groisman R, Polanowska J, …, Tanaka K, Nakatani Y
Cell 2003 May 2 113(3):357-67 [abstract on PubMed] [related articles] [order article]
Selected by | Zhen-Qiang Pan / Antony Carr
Evaluated 17 Jun 2003

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Zou L, Elledge SJ
Science 2003 Jun 6 300(5625):1542-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr / Donald Rio
Evaluated 13 Jun 2003

Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.
Yao R, Zhang Z, …, Stubbe J, Huang M
Proc Natl Acad Sci U S A 2003 May 27 100(11):6628-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 6 Jun 2003

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Groth A, Lukas J, …, Bartek J, Hansen K
EMBO J 2003 Apr 1 22(7):1676-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 29 Apr 2003

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break.
Leroy C, Lee SE, …, Haber JE, Marsolier-Kergoat MC
Mol Cell 2003 Mar 11(3):827-35 [abstract on PubMed] [related articles] [order article]
Selected by | Orna Cohen-Fix / Antony Carr
Evaluated 28 Apr 2003

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.
Lee J, Kumagai A, Dunphy WG
Mol Cell 2003 Feb 11(2):329-40 [abstract on PubMed] [related articles] [order article]
Selected by | Antony Carr
Evaluated 26 Mar 2003

Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.
Majka J, Burgers PM
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2249-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 10 Mar 2003

MDC1 is required for the intra-S-phase DNA damage checkpoint.
Goldberg M, Stucki M, …, Bartek J, Jackson SP
Nature 2003 Feb 27 421(6926):952-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr / Laura Itzhaki / Susan Gasser
Evaluated 10 Mar 2003

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.
Lou Z, Minter-Dykhouse K, Wu X, Chen J
Nature 2003 Feb 27 421(6926):957-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr / Laura Itzhaki / Susan Gasser
Evaluated 10 Mar 2003

MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, …, Taylor AM, Elledge SJ
Nature 2003 Feb 27 421(6926):961-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr / Laura Itzhaki / Susan Gasser
Evaluated 7 Mar 2003

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.
Costanzo V, Shechter D, …, Gottesman M, Gautier J
Mol Cell 2003 Jan 11(1):203-13 [abstract on PubMed] [related articles] [order article]
Selected by | Antony Carr / Stephen Kearsey / Stephen Jackson
Evaluated 14 Feb 2003

DNA damage-induced replication fork regression and processing in Escherichia coli.
Courcelle J, Donaldson JR, Chow KH, Courcelle CT
Science 2003 Feb 14 299(5609):1064-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr / Martin Marinus
Evaluated 7 Feb 2003

ATR regulates fragile site stability.
Casper AM, Nghiem P, Arlt MF, Glover TW
Cell 2002 Dec 13 111(6):779-89 [abstract on PubMed] [related articles] [order article]
Selected by | Charles Brenner / Antony Carr / Stephen Jackson
Evaluated 22 Jan 2003

Checkpoint activation regulates mutagenic translesion synthesis.
Kai M, Wang TS
Genes Dev 2003 Jan 1 17(1):64-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 21 Jan 2003

The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2.
Akiyama H, Fujisawa N, …, Sugiyama A, Tashiro F
J Biol Chem 2003 Mar 21 278(12):10752-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Antony Carr
Evaluated 14 Jan 2003

53BP1, a mediator of the DNA damage checkpoint.
Wang B, Matsuoka S, Carpenter PB, Elledge SJ
Science