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Joachim Lingner
Swiss Institute for Experimental Cancer Research (ISREC), Epalinges s/Lausanne, Switzerland

Faculty Member: CELL BIOLOGY > Cell growth & division [ since 18 November 2004 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

I received a PhD in 1992 at the Biocenter of the University of Basel in the laboratory of Dr. Walter Keller where I studied the polyadenylation of mRNA precursors. As a postdoc I joined the laboratory of Dr. Thomas Cech at the Howard Hughes Medical Institute of the University of Colorado at Boulder where I started to work on telomerase. In 1997 I joined ISREC with a START-fellowship from the Swiss National Science Foundation and was promoted to senior scientist in 2002.

The long-term goal of our research is to understand the mechanism and regulation of telomere maintenance. We combine in vitro biochemistry, molecular genetics and cell biology to study telomere replication in human cells and in the yeast Saccharomyces cerevisiae.

Home page

http://www.isrec.ch/research/groups/research_groups_detail_eid_1699_lid_2.htm

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Evaluations

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita.
Savage SA, Giri N, …, Lansdorp PM, Alter BP
Am J Hum Genet 2008 Feb 82(2):501-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 4 Jun 2008

Tel2 regulates the stability of PI3K-related protein kinases.
Takai H, Wang RC, …, Yang H, de Lange T
Cell 2007 Dec 28 131(7):1248-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner / Antony Carr
Evaluated 24 Jan 2008

A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.
Bae NS, Baumann P
Mol Cell 2007 May 11 26(3):323-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 24 May 2007

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Xin H, Liu D, …, O'Connor MS, Songyang Z
Nature 2007 Feb 1 445(7127):559-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 22 Feb 2007

The POT1-TPP1 telomere complex is a telomerase processivity factor.
Wang F, Podell ER, …, Cech TR, Lei M
Nature 2007 Feb 1 445(7127):506-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 22 Feb 2007

DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase.
Vodenicharov MD, Wellinger RJ
Mol Cell 2006 Oct 6 24(1):127-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 30 Oct 2006

Proteasome-dependent degradation of Est1p regulates the cell cycle-restricted assembly of telomerase in Saccharomyces cerevisiae.
Osterhage JL, Talley JM, Friedman KL
Nat Struct Mol Biol 2006 Aug 13(8):720-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 30 Aug 2006

Cell cycle-regulated trafficking of human telomerase to telomeres.
Tomlinson RL, Ziegler TD, …, Terns RM, Terns MP
Mol Biol Cell 2006 Feb 17(2):955-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joachim Lingner
Evaluated 16 Feb 2006

Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres.
Jády BE, Richard P, Bertrand E, Kiss T
Mol Biol Cell 2006 Feb 17(2):944-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joachim Lingner
Evaluated 16 Feb 2006

Functional human telomeres are recognized as DNA damage in G2 of the cell cycle.
Verdun RE, Crabbe L, Haggblom C, Karlseder J
Mol Cell 2005 Nov 23 20(4):551-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 24 Nov 2005

Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.
Kaygun H, Marzluff WF
Nat Struct Mol Biol 2005 Sep 12(9):794-800 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 12 Sep 2005

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Celli GB, de Lange T
Nat Cell Biol 2005 Jul 7(7):712-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 26 Jul 2005

Telomere-end processing the terminal nucleotides of human chromosomes.
Sfeir AJ, Chai W, Shay JW, Wright WE
Mol Cell 2005 Apr 1 18(1):131-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 26 Apr 2005

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
Crabbe L, Verdun RE, Haggblom CI, Karlseder J
Science 2004 Dec 10 306(5703):1951-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joachim Lingner
Evaluated 17 Dec 2004

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Lei M, Podell ER, Cech TR
Nat Struct Mol Biol 2004 Dec 11(12):1223-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joachim Lingner
Evaluated 3 Dec 2004

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