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Joern Piel
Kekule Institute of Organic Chemistry and Biochemistry, University of Bonn, Bonn, Germany

Faculty Member: Chemical Biology > Directed Molecular Evolution [ since 6 October 2003 ]
[ Evaluations ]
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Evaluations

Epigenetic remodeling of the fungal secondary metabolome.
Williams RB, Henrikson JC, …, Lee AE, Cichewicz RH
Org Biomol Chem 2008 Jun 7 6(11):1895-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 20 May 2008

GNAT-like strategy for polyketide chain initiation.
Gu L, Geders TW, …, Smith JL, Sherman DH
Science 2007 Nov 9 318(5852):970-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 29 Nov 2007

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.
Geders TW, Gu L, …, Sherman DH, Smith JL
J Biol Chem 2007 Dec 7 282(49):35954-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joern Piel
Evaluated 18 Oct 2007

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica.
Udwary DW, Zeigler L, …, Jensen PR, Moore BS
Proc Natl Acad Sci U S A 2007 Jun 19 104(25):10376-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 25 Jun 2007

An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.
Eleftherianos I, Boundy S, …, ffrench-Constant RH, Reynolds SE
Proc Natl Acad Sci U S A 2007 Feb 13 104(7):2419-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joern Piel
Evaluated 26 Mar 2007

Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians.
Donia MS, Hathaway BJ, …, Ravel J, Schmidt EW
Nat Chem Biol 2006 Dec 2(12):729-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 2 Jan 2007

Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities.
Coulthurst SJ, Williamson NR, …, Spring DR, Salmond GP
Microbiology 2006 Jul 152(Pt 7):1899-911 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joern Piel
Evaluated 25 Sep 2006

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, …, Cully D, Singh SB
Nature 2006-05-18 441(7091):358-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiayang Qiu / Joern Piel / Liang Tong / Russell Hill / Jean-Jacques Sanglier / Jean Pieters
Evaluated 30 May 2006

Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry.
Dorrestein PC, Blackhall J, …, Walsh CT, Kelleher NL
Biochemistry 2006 Feb 14 45(6):1537-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 9 Mar 2006

Synthetic biology: engineering Escherichia coli to see light.
Levskaya A, Chevalier AA, …, Marcotte EM, Voigt CA
Nature 2005 Nov 24 438(7067):441-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel / James Hu
Evaluated 23 Dec 2005

Pathogenic fungus harbours endosymbiotic bacteria for toxin production.
Partida-Martinez LP, Hertweck C
Nature 2005 Oct 6 437(7060):884-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Leo Eberl / June Kwon-Chung / Joern Piel / Pascale Cossart / Joe Heitman
Evaluated 21 Oct 2005

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL
Cell 2005 Jul 15 122(1):107-18 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel / Torben Lund / Emanuela Handman / Ben Lugtenberg / Rino Rappuoli / Shiv Pillai / Richard Grencis / Lora Hooper
Evaluated 25 Jul 2005

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
Schmidt EW, Nelson JT, …, Haygood MG, Ravel J
Proc Natl Acad Sci U S A 2005 May 17 102(20):7315-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Russell Hill / Joern Piel
Evaluated 27 May 2005

Combinatorial biosynthesis of antitumor indolocarbazole compounds.
Sánchez C, Zhu L, …, Méndez C, Salas JA
Proc Natl Acad Sci U S A 2005 Jan 11 102(2):461-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joern Piel
Evaluated 15 Mar 2005

Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase.
Witkowski A, Ghosal A, …, Asturias FJ, Smith S
Chem Biol 2004 Dec 11(12):1667-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 11 Jan 2005

Reaction discovery enabled by DNA-templated synthesis and in vitro selection.
Kanan MW, Rozenman MM, …, Snyder TM, Liu DR
Nature 2004 Sep 30 431(7008):545-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jennifer Cha / Joern Piel
Evaluated 14 Oct 2004

Compound 800, a natural product isolated from genetically engineered Pseudomonas: proposed structure, reactivity, and putative relation to heme d1.
Youn HS, Liang Q, …, Cai M, Timkovich R
Biochemistry 2004 Aug 24 43(33):10730-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angela Wilks / Joern Piel
Evaluated 6 Sep 2004

Labeling proteins with small molecules by site-specific posttranslational modification.
Yin J, Liu F, Li X, Walsh CT
J Am Chem Soc 2004 Jun 30 126(25):7754-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Blake R. Peterson / Joern Piel
Evaluated 6 Jul 2004

Nitration of a peptide phytotoxin by bacterial nitric oxide synthase.
Kers JA, Wach MJ, …, Crane BR, Loria R
Nature 2004 May 6 429(6987):79-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel / Mark Nelson
Evaluated 17 May 2004

Community structure and metabolism through reconstruction of microbial genomes from the environment.
Tyson GW, Chapman J, …, Rokhsar DS, Banfield JF
Nature 2004 Mar 4 428(6978):37-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Julian Parkhill / Joern Piel / Michael Wagner / Donald Ward / Ian M. Head
Evaluated 16 Mar 2004

Crystal structure and mechanism of a bacterial fluorinating enzyme.
Dong C, Huang F, …, O'Hagan D, Naismith JH
Nature 2004 Feb 5 427(6974):561-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel / Wilhelm Boland / Dehua Pei / Mark Nelson
Evaluated 17 Feb 2004

Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
Olano C, Wilkinson B, …, Leadlay PF, Salas JA
Chem Commun (Camb) 2003 Nov 21 (22):2780-2 [abstract on PubMed] [related articles]
Selected by | Joern Piel
Evaluated 9 Jan 2004

Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster.
He J, Hertweck C
Chem Biol 2003 Dec 10(12):1225-32 [abstract on PubMed] [related articles] [order article]
Selected by | Joern Piel
Evaluated 9 Jan 2004

Creation of the first anomeric D/L-sugar kinase by means of directed evolution.
Hoffmeister D, Yang J, Liu L, Thorson JS
Proc Natl Acad Sci U S A 2003 Nov 11 100(23):13184-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joern Piel
Evaluated 1 Dec 2003

Polyketide chain length control by chain length factor.
Tang Y, Tsai SC, Khosla C
J Am Chem Soc 2003 Oct 22 125(42):12708-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel / Rowena Matthews
Evaluated 22 Oct 2003

The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.
Duchaud E, Rusniok C, …, Danchin A, Kunst F
Nat Biotechnol 2003 Nov 21(11):1307-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joern Piel
Evaluated 9 Oct 2003

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