Faculty of 1000 Biology | Faculty member: Douglas Cyr

4-Jul-2008

	Douglas Cyr Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
	Faculty Member: CELL BIOLOGY > Control of gene expression [ since 1 November 2004 ]

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Evaluations

Adapting proteostasis for disease intervention.
Balch WE, Morimoto RI, Dillin A, Kelly JW
Science 2008 Feb 15 319(5865):916-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr
Evaluated 21 Apr 2008

Structural basis of J cochaperone binding and regulation of Hsp70.
Jiang J, Maes EG, …, Lafer EM, Sousa R
Mol Cell 2007 Nov 9 28(3):422-33 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Douglas Cyr
Evaluated 3 Jan 2008

Selected by | Douglas Cyr
Evaluated 23 Oct 2007

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
Dai C, Whitesell L, Rogers AB, Lindquist S
Cell 2007 Sep 21 130(6):1005-18 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Carlos Dotti / Douglas Cyr / Paul Workman
Evaluated 23 Oct 2007

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Roberson ED, Scearce-Levie K, …, Yu GQ, Mucke L
Science 2007 May 4 316(5825):750-4 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr / Stanley Appel / Karen Hsiao Ashe
Evaluated 15 May 2007

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
Dickey CA, Kamal A, …, Burrows F, Petrucelli L
J Clin Invest 2007 Mar 117(3):648-58 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Douglas Cyr
Evaluated 22 Feb 2007

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.
Meyer AE, Hung NJ, …, Johnson AW, Craig EA
Proc Natl Acad Sci U S A 2007 Jan 30 104(5):1558-63 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Douglas Cyr
Evaluated 19 Feb 2007

Selected by | Peter Van Endert / Megerditch Kiledjian / Daniel Gallie / Shiv Pillai / Douglas Cyr
Evaluated 14 Aug 2006

Activity-dependent dynamics and sequestration of proteasomes in dendritic spines.
Bingol B, Schuman EM
Nature 2006 Jun 29 441(7097):1144-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr
Evaluated 4 Aug 2006

Membrane lateral diffusion and capture of CFTR within transient confinement zones.
Bates IR, Hébert B, …, Wiseman PW, Hanrahan JW
Biophys J 2006 Aug 1 91(3):1046-58 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Douglas Cyr
Evaluated 14 Jun 2006

Selected by | Douglas Cyr
Evaluated 7 Apr 2006

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Chandra S, Gallardo G, …, Schlüter OM, Südhof TC
Cell 2005 Nov 4 123(3):383-96 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David Robertson / Eileen Lafer / Douglas Cyr
Evaluated 6 Jan 2006

Structural basis of interdomain communication in the Hsc70 chaperone.
Jiang J, Prasad K, Lafer EM, Sousa R
Mol Cell 2005 Nov 23 20(4):513-24 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ron Prywes / Douglas Cyr / Jose Valpuesta / Bernd Bukau
Evaluated 1 Dec 2005

Selected by | Douglas Cyr / Tom Stevens
Evaluated 3 Oct 2005

Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation.
Hinnerwisch J, Fenton WA, …, Farr GW, Horwich AL
Cell 2005 Jul 1 121(7):1029-41 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr
Evaluated 13 Jul 2005

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.
Westhoff B, Chapple JP, …, Höhfeld J, Cheetham ME
Curr Biol 2005 Jun 7 15(11):1058-64 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr / Len Neckers
Evaluated 13 Jul 2005

Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous.
Hundley HA, Walter W, Bairstow S, Craig EA
Science 2005 May 13 308(5724):1032-4 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Douglas Cyr / Koreaki Ito
Evaluated 13 Apr 2005

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.
Du K, Sharma M, Lukacs GL
Nat Struct Mol Biol 2005 Jan 12(1):17-25 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr
Evaluated 19 Jan 2005

Side chain and backbone contributions of Phe508 to CFTR folding.
Thibodeau PH, Brautigam CA, Machius M, Thomas PJ
Nat Struct Mol Biol 2005 Jan 12(1):10-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Douglas Cyr
Evaluated 18 Jan 2005