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Angel Nebreda
Molecular Oncology Programme, Spanish National Cancer Center, Madrid, Spain

Faculty Member: CELL BIOLOGY > Cell growth & division [ since 24 August 2001 ]
[ Homepage ] [ Evaluations ]
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http://www.cnio.es/ing/grupos/plantillas/curriculum.asp?pag=74

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Evaluations

A deadenylation negative feedback mechanism governs meiotic metaphase arrest.
Belloc E, Méndez R
Nature 2008 Apr 24 452(7190):1017-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 23 May 2008

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling.
Varjosalo M, Björklund M, …, Ojala P, Taipale J
Cell 2008 May 2 133(3):537-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Toshihiko Ogura / Angel Nebreda / Heng Zhu
Evaluated 23 May 2008

Hedgehog regulates smoothened activity by inducing a conformational switch.
Zhao Y, Tong C, Jiang J
Nature 2007 Nov 8 450(7167):252-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 7 Dec 2007

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB
Cancer Cell 2007 Feb 11(2):175-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 14 Aug 2007

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
Goga A, Yang D, …, Morgan DO, Bishop JM
Nat Med 2007 Jul 13(7):820-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Copeland / Angel Nebreda
Evaluated 14 Aug 2007

Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition.
Wang R, He G, …, Kirschner MW, Kuang J
Cell 2007 Mar 23 128(6):1119-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 23 Apr 2007

Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
Khurana A, Nakayama K, …, Mustelin T, Ronai Z
J Biol Chem 2006 Nov 17 281(46):35316-26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 26 Feb 2007

Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.
Peregrin S, Jurado-Pueyo M, …, Mayor F, Murga C
Curr Biol 2006 Oct 24 16(20):2042-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Andrew D. Sharrocks
Evaluated 11 Dec 2006

c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity.
Stepniak E, Ricci R, …, Hui L, Wagner EF
Genes Dev 2006 Aug 15 20(16):2306-14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 11 Oct 2006

The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform.
Silva G, Cunha A, …, Seldon MP, Soares MP
J Immunol 2006 Aug 1 177(3):1894-903 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 11 Oct 2006

p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.
Zohn IE, Li Y, …, Han J, Niswander L
Cell 2006 Jun 2 125(5):957-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 16 Jun 2006

Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20.
Shoji S, Yoshida N, …, Kajikawa E, Perry AC
EMBO J 2006 Feb 22 25(4):834-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 13 Feb 2006

BRAF mutation predicts sensitivity to MEK inhibition.
Solit DB, Garraway LA, …, Sellers WR, Rosen N
Nature 2006 Jan 19 439(7074):358-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Channing Der / Angel Nebreda
Evaluated 24 Nov 2005

Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
Nutt LK, Margolis SS, …, Rathmell JC, Kornbluth S
Cell 2005 Oct 7 123(1):89-103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 24 Nov 2005

Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation.
Rauh NR, Schmidt A, …, Nigg EA, Mayer TU
Nature 2005 Oct 13 437(7061):1048-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / William Earnshaw
Evaluated 19 Oct 2005

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
Dimitri CA, Dowdle W, …, Blenis J, Murphy LO
Curr Biol 2005 Jul 26 15(14):1319-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Kyriakis / Angel Nebreda
Evaluated 18 Aug 2005

Cdk1-dependent regulation of the mitotic inhibitor Wee1.
Harvey SL, Charlet A, …, Gygi SP, Kellogg DR
Cell 2005 Aug 12 122(3):407-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Iain Hagan / Linda Huang / Arp Schnittger / Francesc Posas
Evaluated 18 Aug 2005

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Ma L, Chen Z, …, Tempst P, Pandolfi PP
Cell 2005 Apr 22 121(2):179-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Hall / Angel Nebreda
Evaluated 23 May 2005

The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Salvador JM, Mittelstadt PR, …, Fornace AJ, Ashwell JD
Nat Immunol 2005 Apr 6(4):396-402 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 20 May 2005

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Salvador JM, Mittelstadt PR, …, Fornace AJ, Ashwell JD
Nat Immunol 2005 Apr 6(4):390-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Andy Chan
Evaluated 20 May 2005

APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs.
Yamamoto TM, Iwabuchi M, Ohsumi K, Kishimoto T
Dev Biol 2005 Mar 15 279(2):345-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 18 Mar 2005

The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.
Inoue D, Sagata N
EMBO J 2005 Mar 9 24(5):1057-67 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 11 Feb 2005

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
Manke IA, Nguyen A, …, Elia AE, Yaffe MB
Mol Cell 2005 Jan 7 17(1):37-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Jane Endicott
Evaluated 21 Jan 2005

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.
O'Neill E, Rushworth L, Baccarini M, Kolch W
Science 2004 Dec 24 306(5705):2267-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Angel Nebreda
Evaluated 21 Jan 2005

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.
Escoté X, Zapater M, Clotet J, Posas F
Nat Cell Biol 2004 Oct 6(10):997-1002 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 3 Dec 2004

Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.
Paronetto MP, Giorda E, …, Geremia R, Sette C
EMBO J 2004 Nov 24 23(23):4649-59 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 3 Dec 2004

Emi1 is required for cytostatic factor arrest in vertebrate eggs.
Reimann JD, Jackson PK
Nature 2002 Apr 25 416(6883):850-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen / Joan Ruderman / Angel Nebreda
Evaluated 20 May 2002

Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest.
Ohsumi K, Koyanagi A, …, Gotoh T, Kishimoto T
Proc Natl Acad Sci U S A 2004 Aug 24 101(34):12531-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda / Jonathon Pines
Evaluated 31 Aug 2004

A novel mechanism for mitogen-activated protein kinase localization.
Bind E, Kleyner Y, …, Dynlacht BD, Sánchez I
Mol Biol Cell 2004 Oct 15(10):4457-66 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 25 Aug 2004

Self-assembling protein microarrays.
Ramachandran N, Hainsworth E, …, Walter JC, LaBaer J
Science 2004 Jul 2 305(5680):86-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda / Gerard Nau / Stephen Kearsey / Sachdev Sidhu / Jean Wang
Evaluated 22 Jul 2004

A feedback loop in the polo-like kinase activation pathway.
Erikson E, Haystead TA, Qian YW, Maller JL
J Biol Chem 2004 Jul 30 279(31):32219-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 23 Jun 2004

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Wada T, Joza N, …, Nishina H, Penninger JM
Nat Cell Biol 2004 Mar 6(3):215-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 4 May 2004

Ca(2+)(cyt) negatively regulates the initiation of oocyte maturation.
Sun L, Machaca K
J Cell Biol 2004 Apr 165(1):63-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 4 May 2004

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.
De Nadal E, Zapater M, …, Mas G, Posas F
Nature 2004 Jan 22 427(6972):370-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Andrew D. Sharrocks / Anne Osbourn / Peter Taylor
Evaluated 3 Feb 2004

The Drosophila MOS ortholog is not essential for meiosis.
Ivanovska I, Lee E, …, Fenger DD, Orr-Weaver TL
Curr Biol 2004 Jan 6 14(1):75-80 [abstract on PubMed] [related articles] [order article]
Selected by | Angel Nebreda / Andy Golden
Evaluated 21 Jan 2004

Mechanism of p38 MAP kinase activation in vivo.
Brancho D, Tanaka N, …, Flavell RA, Davis RJ
Genes Dev 2003 Aug 15 17(16):1969-78 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 9 Sep 2003

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.
Bulavin DV, Higashimoto Y, …, Piwnica-Worms H, Fornace AJ
Nat Cell Biol 2003 Jun 5(6):545-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 21 Aug 2003

JunD mediates survival signaling by the JNK signal transduction pathway.
Lamb JA, Ventura JJ, …, Flavell RA, Davis RJ
Mol Cell 2003 Jun 11(6):1479-89 [abstract on PubMed] [related articles] [order article]
Selected by | Angel Nebreda / Deborah Morrison
Evaluated 25 Jun 2003

Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
Coulombe P, Rodier G, …, Pellerin J, Meloche S
Mol Cell Biol 2003 Jul 23(13):4542-58 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 25 Jun 2003

Unmasking the S-phase-promoting potential of cyclin B1.
Moore JD, Kirk JA, Hunt T
Science 2003 May 9 300(5621):987-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 6 Jun 2003

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.
Zhu Y, Rice CD, …, Pace M, Thomas P
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2231-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda / Ross Weatherman
Evaluated 12 Mar 2003

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor.
Zhu Y, Bond J, Thomas P
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2237-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 12 Mar 2003

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Elia AE, Cantley LC, Yaffe MB
Science 2003 Feb 21 299(5610):1228-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sally Kornbluth / Ashok Venkitaraman / Kermit Carraway / Angel Nebreda / Andrew D. Sharrocks / Francis Barr
Evaluated 11 Mar 2003

G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Duckworth BC, Weaver JS, Ruderman JV
Proc Natl Acad Sci U S A 2002 Dec 24 99(26):16794-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 13 Jan 2003

Dissection of c-MOS degron.
Sheng J, Kumagai A, Dunphy WG, Varshavsky A
EMBO J 2002 Nov 15 21(22):6061-71 [abstract on PubMed] [related articles] [order article]
Selected by | Angel Nebreda
Evaluated 26 Nov 2002

Cdc6 synthesis regulates replication competence in Xenopus oocytes.
Whitmire E, Khan B, Coué M
Nature 2002 Oct 17 419(6908):722-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Kearsey / Angel Nebreda
Evaluated 12 Nov 2002

Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation.
Lemaître JM, Bocquet S, Méchali M
Nature 2002 Oct 17 419(6908):718-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Kearsey / Angel Nebreda
Evaluated 12 Nov 2002

Molecular interpretation of ERK signal duration by immediate early gene products.
Murphy LO, Smith S, …, Fingar DC, Blenis J
Nat Cell Biol 2002 Aug 4(8):556-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carlos Ibanez / Kermit Carraway / Ron Prywes / Nancy Allbritton / Angel Nebreda / Mani Ramaswami
Evaluated 17 Sep 2002

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
Ouwens DM, de Ruiter ND, …, Maassen JA, van Dam H
EMBO J 2002 Jul 15 21(14):3782-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 25 Jul 2002

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
Lu Z, Xu S, …, Cobb MH, Hunter T
Mol Cell 2002 May 9(5):945-56 [abstract on PubMed] [related articles] [order article]
Selected by | Joan Ruderman / Angel Nebreda / Anjana Rao
Evaluated 28 Jun 2002

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.
Wang W, Chen JX, …, Huang S, Sun P
Mol Cell Biol 2002 May 22(10):3389-403 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 20 May 2002

Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
Koo HM, VanBrocklin M, …, Duesbery NS, Woude GF
Proc Natl Acad Sci U S A 2002 Mar 5 99(5):3052-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 20 May 2002

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
Wiggin GR, Soloaga A, …, Cohen P, Arthur JS
Mol Cell Biol 2002 Apr 22(8):2871-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 20 May 2002

Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction.
Mendez R, Barnard D, Richter JD
EMBO J 2002 Apr 2 21(7):1833-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 17 Apr 2002

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
Ge B, Gram H, …, Luo Y, Han J
Science 2002 Feb 15 295(5558):1291-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 20 Feb 2002

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.
Kang D, Chen J, Wong J, Fang G
J Cell Biol 2002 Jan 21 156(2):249-59 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 18 Feb 2002

Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.
Okumura E, Fukuhara T, …, Tachibana K, Kishimoto T
Nat Cell Biol 2002 Feb 4(2):111-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda
Evaluated 18 Feb 2002

Mammalian TOR: a homeostatic ATP sensor.
Dennis PB, Jaeschke A, …, Kozma SC, Thomas G
Science 2001 Nov 2 294(5544):1102-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Hall / Sally Leevers / Stephen Jackson / Thomas Neufeld / Angel Nebreda
Evaluated 18 Jan 2002

Forkhead transcription factors contribute to execution of the mitotic programme in mammals.
Alvarez B, Martínez-A C, Burgering BM, Carrera AC
Nature 2001 Oct 18 413(6857):744-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Helen Piwnica-Worms / Andrius Kazlauskas / Sally Leevers / Angel Nebreda
Evaluated 18 Jan 2002

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
Nash P, Tang X, …, Pawson T, Tyers M
Nature 2001 Nov 29 414(6863):514-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sara Courtneidge / Steven Reed / Jeffrey Wade Harper / John Stults / Angel Nebreda / Michael B. Yaffe / Andrius Kazlauskas / Joan Ruderman
Evaluated 18 Jan 2002

New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation.
Hochegger H, Klotzbücher A, …, Sohail M, Hunt T
Development 2001 Oct 128(19):3795-807 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 12 Dec 2001

C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.
Buck M, Poli V, Hunter T, Chojkier M
Mol Cell 2001 Oct 8(4):807-16 [abstract on PubMed] [related articles] [order article]
Selected by | Angel Nebreda
Evaluated 12 Dec 2001

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
Knebel A, Morrice N, Cohen P
EMBO J 2001 Aug 15 20(16):4360-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Angel Nebreda
Evaluated 11 Oct 2001

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.
Abrieu A, Magnaghi-Jaulin L, …, Cleveland DW, Labbé JC
Cell 2001 Jul 13 106(1):83-93 [abstract on PubMed] [related articles] [order article]
Selected by | Angel Nebreda
Evaluated 11 Oct 2001

Bistability in the JNK cascade.
Bagowski CP, Ferrell JE
Curr Biol 2001 Aug 7 11(15):1176-82 [abstract on PubMed] [related articles] [order article]