My research focuses on the mechanisms and molecules that direct the formation of the vertebrate head. This is a complex issue, as it involves multiple interactions between a number of disparate embryonic cell types, and our long term aim is to characterise these interactions and define how they are co-ordinated, and thus to ascertain how the nerves, muscles and skeletal components of the head are laid down and organised into a functioning apparatus. A major difference between the vertebrates and our nearest relatives lie in the organisation of the head, and these difference are thought to have their basis in alterations to the programme that underlies the development of the head. Consequently, our work also feeds into our understanding of vertebrate evolution.

Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Paris M, Escriva H, …, Holland ND, Laudet V Curr Biol 2008 Jun 3 18(11):825-30 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 9 Jun 2008 Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Holstege JC, de Graaff W, …, Akker EV, Deschamps J Proc Natl Acad Sci U S A 2008 Apr 22 105 [abstract on PubMed] [related articles] [full text] Selected by | Anthony Graham Evaluated 2 May 2008 Neural crest invasion is a spatially-ordered progression into the head with higher cell proliferation at the migratory front as revealed by the photoactivatable protein, KikGR. Kulesa PM, Teddy JM, …, Smith SE, McLennan R Dev Biol 2008 Feb 7 316 [abstract on PubMed] [related articles] [full text] Selected by | Anthony Graham Evaluated 4 Apr 2008 Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis. Merrill AE, Eames BF, …, Heath T, Schneider RA Development 2008 Feb 20 [abstract on PubMed] [related articles] [full text] Selected by | Anthony Graham Evaluated 3 Mar 2008 A conserved role for FGF signaling in chordate otic/atrial placode formation. Kourakis MJ, Smith WC Dev Biol 2007 Dec 1 312(1):245-57 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 19 Dec 2007 The blastoporal organiser of a sea anemone Kraus Y, Fritzenwanker JH, Genikhovich G, Technau U Current Biology 2007 17:R874-R876 [order article] Selected by | Anthony Graham Evaluated 29 Oct 2007 Embryonic origin of gustatory cranial sensory neurons. Harlow DE, Barlow LA Dev Biol 2007 Oct 15 310(2):317-28 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 11 Oct 2007 Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution. Tessmar-Raible K, Raible F, …, Hausen H, Arendt D Cell 2007 Jun 29 129(7):1389-400 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 3 Jul 2007 Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance. Lassiter RN, Dude CM, …, Baker CV, Stark MR Dev Biol 2007 Aug 15 308(2):392-406 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Andy Groves Evaluated 3 Jul 2007 Hagfish embryology with reference to the evolution of the neural crest. Ota KG, Kuraku S, Kuratani S Nature 2007 Apr 5 446(7136):672-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Victoria Prince / Adam Summers Evaluated 23 Mar 2007 Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost. Kurokawa D, Sakurai Y, …, Amemiya CT, Aizawa S Proc Natl Acad Sci U S A 2006 Dec 19 103(51):19350-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 5 Jan 2007 Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Järvinen E, Salazar-Ciudad I, …, Jernvall J, Thesleff I Proc Natl Acad Sci U S A 2006 Dec 5 103(49):18627-32 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 18 Dec 2006 Arteries define the position of the thyroid gland during its developmental relocalisation. Alt B, Elsalini OA, …, Krude H, Rohr KB Development 2006 Oct 133(19):3797-804 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 18 Sep 2006 Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map. Oury F, Murakami Y, …, Ren SY, Rijli FM Science 2006 Sep 8 313(5792):1408-13 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham / Andrew Lumsden Evaluated 13 Sep 2006 Precraniate origin of cranial motoneurons. Dufour HD, Chettouh Z, …, Joly JS, Brunet JF Proc Natl Acad Sci U S A 2006 Jun 6 103(23):8727-32 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sebastian Shimeld / Anthony Graham Evaluated 13 Jun 2006 Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan. Thewissen JG, Cohn MJ, …, Heyning J, Horton WE Proc Natl Acad Sci U S A 2006 May 30 103(22):8414-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham / David Fitch Evaluated 6 Jun 2006 A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Shore EM, Xu M, …, Brown MA, Kaplan FS Nat Genet 2006 May 38(5):525-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Len Neckers Evaluated 2 May 2006 Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton. Zhang G, Miyamoto MM, Cohn MJ Proc Natl Acad Sci U S A 2006 Feb 28 103(9):3180-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham / Billie Swalla Evaluated 3 Mar 2006 The development of archosaurian first-generation teeth in a chicken mutant. Harris MP, Hasso SM, Ferguson MW, Fallon JF Curr Biol 2006 Feb 21 16(4):371-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 27 Feb 2006 Developmental origin of shark electrosensory organs. Freitas R, Zhang G, …, Evans DH, Cohn MJ Evol Dev 2006 Jan-Feb 8(1):74-80 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 13 Jan 2006 A role for foxd3 and sox10 in the differentiation of gonadotropin-releasing hormone (GnRH) cells in the zebrafish Danio rerio. Whitlock KE, Smith KM, Kim H, Harden MV Development 2005 Dec 132(24):5491-502 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 22 Nov 2005 Slow muscle regulates the pattern of trunk neural crest migration in zebrafish. Honjo Y, Eisen JS Development 2005 Oct 132(20):4461-70 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham / Kristin Artinger Evaluated 10 Oct 2005 Drosophila Grainyhead specifies late programmes of neural proliferation by regulating the mitotic activity and Hox-dependent apoptosis of neuroblasts. Cenci C, Gould AP Development 2005 Sep 132(17):3835-45 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 23 Aug 2005 Neural crest origins of the neck and shoulder. Matsuoka T, Ahlberg PE, …, McMahon AP, Koentges G Nature 2005 Jul 21 436(7049):347-55 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 25 Jul 2005 Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects. McNulty CL, Peres JN, …, van den Akker WM, Durston AJ Development 2005 Jun 132(12):2861-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 3 Jun 2005 The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells. Benito-Gutiérrez E, Nake C, …, Comella JX, Garcia-Fernàndez J Development 2005 May 132(9):2191-202 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 6 Apr 2005 Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development. Eames BF, Schneider RA Development 2005 Apr 132(7):1499-509 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 18 Mar 2005 Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Gompel N, Prud'homme B, …, Kassner VA, Carroll SB Nature 2005 Feb 3 433(7025):481-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Filippo Rijli / Andrew S. McCallion Evaluated 8 Feb 2005 A dermal niche for multipotent adult skin-derived precursor cells. Fernandes KJ, McKenzie IA, …, Hui CC, Miller FD Nat Cell Biol 2004 Nov 6(11):1082-93 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Dissenters | Bruce Morgan Author Response | Freda Miller Evaluated 11 Nov 2004 Migratory neural crest-like cells form body pigmentation in a urochordate embryo. Jeffery WR, Strickler AG, Yamamoto Y Nature 2004 Oct 7 431(7009):696-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Filippo Rijli / Judith S. Eisen Evaluated 8 Oct 2004 Bmp4 and morphological variation of beaks in Darwin's finches. Abzhanov A, Protas M, …, Grant PR, Tabin CJ Science 2004 Sep 3 305(5689):1462-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham / Alexandra Joyner / Erez Raz Evaluated 7 Sep 2004 Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Vokes SA, Yatskievych TA, …, Antin PB, Krieg PA Development 2004 Sep 131(17):4371-80 [abstract on PubMed] [related articles] [FREE full text] Selected by | Brant Weinstein / Anthony Graham Evaluated 3 Sep 2004 Instability of Hes7 protein is crucial for the somite segmentation clock. Hirata H, Bessho Y, …, Lewis J, Kageyama R Nat Genet 2004 Jul 36(7):750-4 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 12 Jul 2004 SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Ruf RG, Xu PX, …, Petit C, Hildebrandt F Proc Natl Acad Sci U S A 2004 May 25 101(21):8090-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham Evaluated 28 May 2004 Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Shapiro MD, Marks ME, …, Schluter D, Kingsley DM Nature 2004 Apr 15 428(6984):717-23 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Siegfried Roth / Carl Thummel / Magnus Nordborg / Tony Long / David Bilder Evaluated 20 Apr 2004 Rhombomere-specific patterns of apoptosis in the tree shrew Tupaia belangeri. Knabe W, Washausen S, Brunnett G, Kuhn HJ Cell Tissue Res 2004 Apr 316(1):1-13 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham Evaluated 15 Mar 2004 A conserved developmental program for sensory organ formation in Drosophila melanogaster. Niwa N, Hiromi Y, Okabe M Nat Genet 2004 Mar 36(3):293-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Mark Fortini / Anthony Graham / Patricia Simpson Evaluated 9 Mar 2004 A central role for the notochord in vertebral patterning. Fleming A, Keynes R, Tannahill D Development 2004 Feb 131(4):873-80 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Graham / Brant Weinstein Evaluated 1 Mar 2004

^Top  Back to Faculty Members