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Paul Gleeson
Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia

Faculty Member: Immunology > Autoimmunity [ since 4 July 2001 ]
[ Evaluations ]
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Evaluations

Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells.
Stummvoll GH, DiPaolo RJ, …, Ward JM, Shevach EM
J Immunol 2008 Aug 1 181(3):1908-16 [abstract on PubMed] [related articles] [order article]
Selected by | Paul Gleeson
Evaluated 4 Sep 2008

Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.
Luckashenak N, Schroeder S, …, Deeg CA, Brocker T
Immunity 2008 Apr 28(4):521-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson
Evaluated 15 Apr 2008

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.
Feuerer M, Jiang W, …, Mathis D, Benoist C
Proc Natl Acad Sci U S A 2007 Nov 13 104(46):18181-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson
Evaluated 13 Dec 2007

Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Dominitzki S, Fantini MC, …, Neurath MF, Becker C
J Immunol 2007 Aug 15 179(4):2041-5 [abstract on PubMed] [related articles] [order article]
Selected by | Paul Gleeson
Evaluated 17 Aug 2007

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Toscano MA, Bianco GA, …, Baum LG, Rabinovich GA
Nat Immunol 2007 Aug 8(8):825-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley / Helene Rosenberg / Paul Gleeson / Mauro Perretti
Evaluated 2 Aug 2007

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Zuo T, Wang L, …, Zheng P, Liu Y
Cell 2007 Jun 29 129(7):1275-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaojing Ma / Paul Gleeson / Mercedes Rincon
Evaluated 4 Jul 2007

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.
Aschenbrenner K, D'Cruz LM, …, Rolink A, Klein L
Nat Immunol 2007 Apr 8(4):351-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Kyewski / Paul Gleeson
Evaluated 13 Apr 2007

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice.
Kim JM, Rasmussen JP, Rudensky AY
Nat Immunol 2007 Feb 8(2):191-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Anderson / Paul Gleeson
Evaluated 19 Jan 2007

T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity.
Zehn D, Bevan MJ
Immunity 2006-08-01 25(2):261-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bart Roep / Matthias von Herrath / Paul Gleeson / Michael Dustin
Evaluated 2 Nov 2006

Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.
Holst J, Vignali KM, Burton AR, Vignali DA
Nat Methods 2006 Mar 3(3):191-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nick Gascoigne / Friedemann Kiefer / Paul Gleeson
Evaluated 13 Jul 2006

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Bettelli E, Carrier Y, …, Weiner HL, Kuchroo VK
Nature 2006 May 11 441(7090):235-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Christian Engwerda / Torben Lund / Rachel Caspi / Stefan Kaufmann / Paul Gleeson / Andrew Weinberg
Evaluated 21 Jun 2006

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Tang Q, Adams JY, …, Krummel MF, Bluestone JA
Nat Immunol 2006 Jan 7(1):83-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Chaplin / Richard Williams / Matthias von Herrath / Nicholas Restifo / Michael Dustin / Paul Gleeson
Evaluated 9 Jan 2006

Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells.
Setiady YY, Ohno K, …, She JX, Tung KS
Blood 2006 Feb 1 107(3):1056-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson
Evaluated 9 Jan 2006

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.
Watanabe N, Wang YH, …, Cao W, Liu YJ
Nature 2005 Aug 25 436(7054):1181-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerald Nepom / Chen Dong / Steve Ward / Dale Umetsu / William A Muller / Paul Gleeson / Elizabeth Mellins
Evaluated 23 Sep 2005


Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level.
Roncador G, Brown PJ, …, Powrie F, Banham AH
Eur J Immunol 2005 Jun 35(6):1681-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson
Evaluated 8 Jul 2005

Regulatory T cell lineage specification by the forkhead transcription factor foxp3.
Fontenot JD, Rasmussen JP, …, Farr AG, Rudensky AY
Immunity 2005 Mar 22(3):329-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chen Dong / Santa Jeremy Ono / Torben Lund / Christopher Karp / Paul Gleeson
Evaluated 22 Apr 2005

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice.
Kuroda N, Mitani T, …, Yamada G, Matsumoto M
J Immunol 2005 Feb 15 174(4):1862-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson
Evaluated 8 Mar 2005

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.
van Santen HM, Benoist C, Mathis D
J Exp Med 2004 Nov 15 200(10):1221-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Harald von Boehmer / Paul Gleeson
Evaluated 9 Dec 2004

Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments.
Trucco A, Polishchuk RS, …, Mironov AA, Luini A
Nat Cell Biol 2004 Nov 6(11):1071-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson / Robert Parton
Evaluated 9 Nov 2004

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.
Hsieh CS, Liang Y, …, Liggitt D, Rudensky AY
Immunity 2004 Aug 21(2):267-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthias von Herrath / Jose Alberola-Ila / Paul Gleeson / Thomas Hunig
Evaluated 27 Aug 2004

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.
Arighi CN, Hartnell LM, …, Haft CR, Bonifacino JS
J Cell Biol 2004 Apr 165(1):123-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tom Stevens / Jean Gruenberg / Paul Gleeson
Evaluated 20 Aug 2004

In vivo instruction of suppressor commitment in naive T cells.
Apostolou I, von Boehmer H
J Exp Med 2004 May 17 199(10):1401-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kendall Smith / Paul Gleeson / Barry Rouse / Barbara Rehermann
Evaluated 7 Jun 2004

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases.
Mempel TR, Henrickson SE, Von Andrian UH
Nature 2004 Jan 8 427(6970):154-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Emanuela Handman / Michael McHeyzer-Williams / Klaus Ley / Michael Dustin / Paul Gleeson
Evaluated 27 Feb 2004

Phagosomes are competent organelles for antigen cross-presentation.
Houde M, Bertholet S, …, Sacks D, Desjardins M
Nature 2003 Sep 25 425(6956):402-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karin Romisch / Lutz Walter / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Shiv Pillai / Frank Momburg / Stefan Kaufmann / Edward Collins / Paul Gleeson / Sergio Grinstein
Evaluated 31 Oct 2003

Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells.
Yamazaki S, Iyoda T, …, Inaba K, Steinman RM
J Exp Med 2003 Jul 21 198(2):235-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson / Hugh McDevitt
Evaluated 15 Aug 2003

Aire regulates negative selection of organ-specific T cells.
Liston A, Lesage S, …, Peltonen L, Goodnow CC
Nat Immunol 2003 Apr 4(4):350-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson / Jin-Xiong She
Evaluated 18 Mar 2003

T cell regulation as a side effect of homeostasis and competition.
Barthlott T, Kassiotis G, Stockinger B
J Exp Med 2003 Feb 17 197(4):451-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Jameson / Paul Gleeson / David Serreze
Evaluated 12 Mar 2003

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.
Lesage S, Hartley SB, …, Townsend M, Goodnow CC
J Exp Med 2002 Nov 4 196(9):1175-88 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Torben Lund / Paul Gleeson
Evaluated 3 Jan 2003

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.
Scheinecker C, McHugh R, Shevach EM, Germain RN
J Exp Med 2002 Oct 21 196(8):1079-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fiona Powrie / Paul Gleeson
Evaluated 2 Jan 2003

Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model.
Bhandoola A, Tai X, …, Rosenberg AS, Singer A
Immunity 2002 Oct 17(4):425-36 [abstract on PubMed] [related articles] [order article]
Selected by | Paul Gleeson
Evaluated 2 Jan 2003

Origin of regulatory T cells with known specificity for antigen.
Apostolou I, Sarukhan A, Klein L, von Boehmer H
Nat Immunol 2002 Aug 3(8):756-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson / Tim Elliott
Evaluated 2 Aug 2002

Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes.
Le Campion A, Bourgeois C, …, Pénit C, Lucas B
Proc Natl Acad Sci U S A 2002 Apr 2 99(7):4538-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson
Evaluated 26 Apr 2002

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.
Leadbetter EA, Rifkin IR, …, Shlomchik MJ, Marshak-Rothstein A
Nature 2002 Apr 11 416(6881):603-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson / Luigina Romani / Anthony DeFranco / Betty Tsao
Evaluated 22 Apr 2002

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.
Shimizu J, Yamazaki S, …, Ishida Y, Sakaguchi S
Nat Immunol 2002 Feb 3(2):135-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Gleeson / Jonathan Ashwell / Hugh McDevitt / Andy Chan / Nicole Suciu-Foca
Evaluated 14 Feb 2002

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells.
Bensinger SJ, Bandeira A, …, Caton AJ, Laufer TM
J Exp Med 2001 Aug 20 194(4):427-38 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson
Evaluated 8 Jan 2002

Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen.
Thorstenson KM, Khoruts A
J Immunol 2001 Jul 1 167(1):188-95 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson
Evaluated 3 Dec 2001

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells.
Kleijmeer M, Ramm G, …, Stoorvogel W, Geuze HJ
J Cell Biol 2001 Oct 1 155(1):53-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson / Lisa Denzin / Judith Klumperman / Peter Jensen
Evaluated 29 Oct 2001

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.
Hawiger D, Inaba K, …, Steinman RM, Nussenzweig MC
J Exp Med 2001 Sep 17 194(6):769-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Gleeson / Luciano Adorini / Jeffrey Bluestone
Evaluated 28 Oct 2001

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta.
Nakamura K, Kitani A, Strober W
J Exp Med 2001 Sep 3 194(5):629-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Luciano Adorini / Paul Gleeson / W. Evan Secor / Bruce Blazar
Evaluated 28 Oct 2001

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