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Megerditch Kiledjian
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway,, United States of America

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 16 September 2002 ]
[ Evaluations ]
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Evaluations

mRNA decapping is promoted by an RNA-binding channel in Dcp2.
Deshmukh MV, Jones BN, …, Darzynkiewicz E, Gross JD
Mol Cell 2008 Feb 15 29(3):324-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian
Evaluated 7 May 2008

Structural basis of dcp2 recognition and activation by dcp1.
She M, Decker CJ, …, Parker R, Song H
Mol Cell 2008 Feb 15 29(3):337-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeff Coller / Megerditch Kiledjian
Evaluated 7 May 2008

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
Mullen TE, Marzluff WF
Genes Dev 2008 Jan 1 22(1):50-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elmar Wahle / Megerditch Kiledjian
Evaluated 27 Mar 2008

Initiation of RNA decay in Escherichia coli by 5' pyrophosphate removal.
Celesnik H, Deana A, Belasco JG
Mol Cell 2007 Jul 6 27(1):79-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian
Evaluated 16 Oct 2007

Components of the Arabidopsis mRNA decapping complex are required for early seedling development.
Goeres DC, Van Norman JM, …, Spencer ML, Sieburth LE
Plant Cell 2007 May 19(5):1549-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian
Evaluated 19 Jul 2007

5'-to-3' exoribonuclease activity in bacteria: role of RNase J1 in rRNA maturation and 5' stability of mRNA.
Mathy N, Bénard L, …, Wen T, Condon C
Cell 2007 May 18 129(4):681-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian / Paul Roepe / Tina Henkin
Evaluated 31 May 2007

Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
Abdelmohsen K, Pullmann R, …, Furneaux H, Gorospe M
Mol Cell 2007 Feb 23 25(4):543-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Abraham / Gabriele Varani / Megerditch Kiledjian
Evaluated 8 May 2007

c-Src activates endonuclease-mediated mRNA decay.
Peng Y, Schoenberg DR
Mol Cell 2007 Mar 9 25(5):779-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian
Evaluated 26 Mar 2007

A single subunit, Dis3, is essentially responsible for yeast exosome core activity.
Dziembowski A, Lorentzen E, Conti E, Séraphin B
Nat Struct Mol Biol 2007 Jan 14(1):15-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian
Evaluated 19 Feb 2007

Reconstitution, activities, and structure of the eukaryotic RNA exosome.
Liu Q, Greimann JC, Lima CD
Cell 2006 Dec 15 127(6):1223-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian / Elena Conti / Arlen Johnson
Evaluated 22 Dec 2006

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.
Bono F, Ebert J, Lorentzen E, Conti E
Cell 2006 Aug 25 126(4):713-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat / Megerditch Kiledjian / Anne-Catherine Dock-Bregeon / Reinhard Luehrmann / Daniel Herschlag / Miles Wilkinson
Evaluated 11 Sep 2006

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
Hollien J, Weissman JS
Science 2006 Jul 7 313(5783):104-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Van Endert / Megerditch Kiledjian / Daniel Gallie / Shiv Pillai / Douglas Cyr
Evaluated 24 Jul 2006

A novel method to detect functional microRNA targets.
Vatolin S, Navaratne K, Weil RJ
J Mol Biol 2006 May 12 358(4):983-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian / Jose Luis Riechmann
Evaluated 8 May 2006

MicroRNAs direct rapid deadenylation of mRNA.
Wu L, Fan J, Belasco JG
Proc Natl Acad Sci U S A 2006 Mar 14 103(11):4034-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jeff Coller / Megerditch Kiledjian / Kevin J. Luebke / Elsebet Lund / Vishvanath Nene / Kathleen Hall
Evaluated 7 Mar 2006

Crystal structures of U8 snoRNA decapping nudix hydrolase, X29, and its metal and cap complexes.
Scarsdale JN, Peculis BA, Wright HT
Structure 2006 Feb 14(2):331-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian
Evaluated 16 Feb 2006

Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J
Mol Cell 2005 Dec 22 20(6):905-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian / Lynne Maquat
Evaluated 3 Jan 2006

Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies.
Brengues M, Teixeira D, Parker R
Science 2005 Oct 21 310(5747):486-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian / Anita Hopper / Claudia Bagni / Linda Breeden
Evaluated 22 Sep 2005

Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.
Stein AJ, Fuchs G, …, Wolin SL, Reinisch KM
Cell 2005 May 20 121(4):529-39 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 6 Jun 2005

Involvement of microRNA in AU-rich element-mediated mRNA instability.
Jing Q, Huang S, …, Gram H, Han J
Cell 2005 Mar 11 120(5):623-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Megerditch Kiledjian / Karsten Weis / Miles Wilkinson / Elsebet Lund
Evaluated 21 Mar 2005

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome.
Orban TI, Izaurralde E
RNA 2005 Apr 11(4):459-69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 3 Mar 2005

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.
Kahvejian A, Svitkin YV, …, M'Boutchou MN, Sonenberg N
Genes Dev 2005 Jan 1 19(1):104-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Maquat / Megerditch Kiledjian
Evaluated 2 Mar 2005

Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
Dunn EF, Hammell CM, Hodge CA, Cole CN
Genes Dev 2005 Jan 1 19(1):90-103 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian / Elmar Wahle
Evaluated 14 Jan 2005

Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.
Kufel J, Bousquet-Antonelli C, Beggs JD, Tollervey D
Mol Cell Biol 2004 Nov 24(21):9646-57 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 4 Nov 2004

Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS.
Cohen LS, Mikhli C, …, Darzynkiewicz E, Davis RE
RNA 2004 Oct 10(10):1609-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 7 Oct 2004

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.
Gherzi R, Lee KY, …, Karin M, Chen CY
Mol Cell 2004 Jun 4 14(5):571-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Walter Keller / Megerditch Kiledjian
Evaluated 20 Aug 2004

Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA.
Yang F, Schoenberg DR
Mol Cell 2004 May 21 14(4):435-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 16 Jun 2004

Crystal structure of Dcp1p and its functional implications in mRNA decapping.
She M, Decker CJ, …, Parker R, Song H
Nat Struct Mol Biol 2004 Mar 11(3):249-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian / Elena Conti
Evaluated 9 Mar 2004

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.
He F, Li X, …, Dong S, Jacobson A
Mol Cell 2003 Dec 12(6):1439-52 [abstract on PubMed] [related articles] [order article]
Selected by | Megerditch Kiledjian
Evaluated 5 Jan 2004

A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.
Dominski Z, Yang XC, …, Dadlez M, Marzluff WF
Mol Cell 2003 Aug 12(2):295-305 [abstract on PubMed] [related articles] [order article]
Selected by | Arlen Johnson / Megerditch Kiledjian
Evaluated 11 Dec 2003

An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation.
Mitchell P, Tollervey D
Mol Cell 2003 May 11(5):1405-13 [abstract on PubMed] [related articles] [order article]
Selected by | Lynne Maquat / Megerditch Kiledjian / Miles Wilkinson
Evaluated 29 Jul 2003

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.
Chen CY, Shyu AB
Mol Cell Biol 2003 Jul 23(14):4805-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arlen Johnson / Elmar Wahle / Megerditch Kiledjian
Evaluated 29 Jul 2003

A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast.
Mazzoni C, Mancini P, …, Herker E, Falcone C
Mol Biol Cell 2003 Feb 14(2):721-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 29 Apr 2003

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.
Chiu SY, Serin G, Ohara O, Maquat LE
RNA 2003 Jan 9(1):77-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 25 Feb 2003

SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.
Anders KR, Grimson A, Anderson P
EMBO J 2003 Feb 3 22(3):641-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 25 Feb 2003

Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence.
Leszczyniecka M, Kang DC, …, Valerie K, Fisher PB
Proc Natl Acad Sci U S A 2002 Dec 24 99(26):16636-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 20 Jan 2003

Inhibition of translation by UAUUUAU and UAUUUUUAU motifs of the AU-rich RNA instability element in the HPV-1 late 3' untranslated region.
Wiklund L, Sokolowski M, …, Rush M, Schwartz S
J Biol Chem 2002 Oct 25 277(43):40462-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian
Evaluated 27 Nov 2002

Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon.
Stevens A, Wang Y, …, Schoenberg DR, Maquat LE
Proc Natl Acad Sci U S A 2002 Oct 1 99(20):12741-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Megerditch Kiledjian / Miles Wilkinson
Evaluated 5 Nov 2002

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