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Peter Wipf
Department of Chemistry, University of Pittsburgh, Pittsburgh, United States of America

Faculty Member: Pharmacology & Drug Discovery > Drug Discovery & Design [ since 28 June 2006 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Research in the Wipf Group focuses on the total synthesis of natural products, organometallic and heterocyclic chemistry, combinatorial, medicinal and computational chemistry. At the center of this research program is the study of chemical reactivity and the use of synthesis to augment the chemical toolbox and develop new therapeutic strategies. A major emphasis involves the efficient preparation of polyfunctionalized nitrogen-containing building blocks for biological screening and natural product target-directed synthesis. The discovery of fundamentally new reaction pathways is stimulated by exploratory studies of transition metal complexes, in particular zirconocenes.

Home page

http://ccc.chem.pitt.edu/wipf/index.html

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Evaluations

Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
Zhang MQ, Gaisser S, …, Wilkinson B, Martin CJ
J Med Chem 2008 Sep 25 51(18):5494-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 27 Oct 2008

Palladium N-Heterocyclic Carbene Catalysts for Synthesis of Diaryl Ethers
Akkoc M, Gürbüz N, Cetinkaya E, Özdemir I
Synlett 2008 2008:1781-1784 [full text]
Selected by | Peter Wipf
Evaluated 29 Sep 2008

The Many Roles for Fluorine in Medicinal Chemistry.
Hagmann WK
J Med Chem 2008 Jun 21 0 [abstract on PubMed] [related articles] [full text]
Selected by | Peter Wipf
Evaluated 24 Jun 2008

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions.
Reindl W, Yuan J, …, Strebhardt K, Berg T
Chem Biol 2008 May 15(5):459-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 20 May 2008

Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease.
Liverton NJ, Holloway MK, …, Olsen DB, Vacca JP
J Am Chem Soc 2008 Apr 9 130(14):4607-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 20 May 2008

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp.
Hughes CC, Prieto-Davo A, Jensen PR, Fenical W
Org Lett 2008 Feb 21 10(4):629-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 18 Feb 2008

Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL.
Jacobs AT, Marnett LJ
J Biol Chem 2007 Nov 16 282(46):33412-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Burcham / Peter Wipf
Evaluated 26 Nov 2007

2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors.
Adams DR, Abraham A, …, Spinks D, Takano Y
Bioorg Med Chem Lett 2007 Dec 1 17(23):6579-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf / Celerino Abad-Zapatero
Evaluated 18 Oct 2007

Synthesis of pentafluorosulfanylpyrazole and pentafluorosulfanyl-1,2,3-triazole and their derivatives as energetic materials by click chemistry.
Ye C, Gard GL, …, Twamley B, Shreeve JM
Org Lett 2007 Sep 13 9(19):3841-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 29 Aug 2007

Total synthesis of tubulysins U and V.
Sani M, Fossati G, Huguenot F, Zanda M
Angew Chem Int Ed Engl 2007 46(19):3526-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 23 Apr 2007

Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant alpha-GalCer.
Lee T, Cho M, …, Kang CY, Kim S
J Med Chem 2007 Feb 8 50(3):585-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 19 Feb 2007

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism.
Pelicano H, Xu RH, …, Plunkett W, Huang P
J Cell Biol 2006 Dec 18 175(6):913-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Wipf / Takashi Tsuruo
Evaluated 3 Jan 2007

Redox regulation of neuronal survival mediated by electrophilic compounds.
Satoh T, Lipton SA
Trends Neurosci 2007 Jan 30(1):37-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 13 Dec 2006

The total synthesis of tubulysin D.
Peltier HM, McMahon JP, Patterson AW, Ellman JA
J Am Chem Soc 2006 Dec 20 128(50):16018-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 13 Dec 2006

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.
Di Micco R, Fumagalli M, …, Pelicci PG, d'Adda di Fagagna F
Nature 2006 Nov 30 444(7119):638-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf / Lucio Comai
Evaluated 13 Dec 2006

SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers.
Bugaut A, Toulmé JJ, Rayner B
Org Biomol Chem 2006 Nov 21 4(22):4082-8 [abstract on PubMed] [related articles] [order article]
Selected by | Peter Wipf / Scott K. Silverman / Günter Mayer
Evaluated 27 Nov 2006

Total synthesis of tubulysin U and V.
Dömling A, Beck B, …, Lu Y, Wessjohann LA
Angew Chem Int Ed Engl 2006 Nov 6 45(43):7235-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 18 Oct 2006

Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.
Kopp F, Grünewald J, Mahlert C, Marahiel MA
Biochemistry 2006 Sep 5 45(35):10474-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Subhash Sinha / Peter Wipf
Evaluated 25 Sep 2006

Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.
Dabydeen DA, Burnett JC, …, Gussio R, Hamel E
Mol Pharmacol 2006 Dec 70(6):1866-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Wipf
Evaluated 25 Sep 2006

Chemoselective hydrogenation of nitro compounds with supported gold catalysts.
Corma A, Serna P
Science 2006 Jul 21 313(5785):332-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Wipf
Evaluated 22 Aug 2006

Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles.
Wagner B, Schumann D, …, Koert U, Marahiel MA
J Am Chem Soc 2006 Aug 16 128(32):10513-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 22 Aug 2006

Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities.
Ma D, Zou B, …, Hu X, Liu JO
Chemistry 2006 Oct 10 12(29):7615-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 26 Jul 2006

E and Z alpha-C-galactosylceramides by Julia-Lythgoe-Kocienski chemistry: a test of the receptor-binding model for glycolipid immunostimulants.
Chen G, Chien M, Tsuji M, Franck RW
Chembiochem 2006 Jul 7(7):1017-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 4 Jul 2006

p53 regulates mitochondrial respiration.
Matoba S, Kang JG, …, Bunz F, Hwang PM
Science 2006 Jun 16 312(5780):1650-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Means / Jonathan Gleadle / Axel Nohturfft / Peter Wipf / Philip Tsichlis / Ulf Pettersson
Evaluated 30 Jun 2006

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