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Bruno Stieger
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland

Faculty Member: PHYSIOLOGY > Gastrointestinal physiology [ since 30 September 2005 ]
[ Evaluations ]
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Evaluations

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.
Ge L, Wang J, …, Li BL, Song BL
Cell Metab 2008 Jun 7(6):508-19 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 30 Jun 2008

Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains.
Wang P, Hata S, …, Murray JW, Wolkoff AW
Am J Physiol Gastrointest Liver Physiol 2008 Apr 294(4):G1052-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 12 Jun 2008

Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis.
Salas JT, Banales JM, …, Prieto J, Medina JF
Gastroenterology 2008 May 134(5):1482-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 20 May 2008

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Yang X, Ongusaha PP, …, Field SJ, Evans RM
Nature 2008 Feb 21 451(7181):964-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Boothby / David Wallach / Bruno Stieger
Evaluated 6 May 2008

Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone.
Gälman C, Bonde Y, …, Angelin B, Rudling M
Gastroenterology 2008 Apr 134(4):1127-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 14 Apr 2008

The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis.
Rao A, Haywood J, …, Kruh GD, Dawson PA
Proc Natl Acad Sci U S A 2008 Mar 11 105(10):3891-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 26 Mar 2008


Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells.
Aoi T, Yae K, …, Chiba T, Yamanaka S
Science 2008 Feb 14 [abstract on PubMed] [related articles] [full text]
Selected by | Bruno Stieger / Kenneth Boheler
Evaluated 4 Mar 2008

ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.
Paulusma CC, Folmer DE, …, Verhoeven AJ, Oude Elferink RP
Hepatology 2008 Jan 47(1):268-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 15 Feb 2008


Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Knabl J, Witschi R, …, Möhler H, Zeilhofer HU
Nature 2008 Jan 17 451(7176):330-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger / David P. Wolfer / Gavril Pasternak / Rodolfo Testa
Evaluated 25 Jan 2008


Crystal structure of the sodium-potassium pump.
Morth JP, Pedersen BP, …, Vilsen B, Nissen P
Nature 2007 Dec 13 450(7172):1043-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 8 Jan 2008

Microscale culture of human liver cells for drug development.
Khetani SR, Bhatia SN
Nat Biotechnol 2008 Jan 26(1):120-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger / Geoffrey Tucker
Evaluated 14 Dec 2007

Isoforms of alanine aminotransferases in human tissues and serum--differential tissue expression using novel antibodies.
Lindblom P, Rafter I, …, Cotgreave I, Glinghammar B
Arch Biochem Biophys 2007 Oct 1 466(1):66-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 27 Nov 2007

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
Buch S, Schafmayer C, …, Tepel J, Hampe J
Nat Genet 2007 Aug 39(8):995-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 7 Nov 2007


Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.
Mataki C, Magnier BC, …, Auwerx J, Schoonjans K
Mol Cell Biol 2007 Dec 27(23):8330-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 16 Oct 2007

Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.
van der Velde AE, Vrins CL, …, Kuipers F, Groen AK
Gastroenterology 2007 Sep 133(3):967-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 25 Sep 2007


Lithocholic acid can carry out in vivo functions of vitamin D.
Nehring JA, Zierold C, DeLuca HF
Proc Natl Acad Sci U S A 2007 Jun 12 104(24):10006-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 4 Sep 2007

Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy.
Van Mil SW, Milona A, …, White R, Williamson C
Gastroenterology 2007 Aug 133(2):507-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 16 Aug 2007


Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4.
Morita SY, Kobayashi A, …, Matsuo M, Ueda K
Hepatology 2007 Jul 46(1):188-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 26 Jul 2007

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Wellcome Trust Case Control Consortium
Nature 2007 Jun 7 447(7145):661-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Humphries / Sue Malcolm / Bruno Stieger / David Brook
Evaluated 18 Jul 2007


Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Shu Y, Sheardown SA, …, Brett CM, Giacomini KM
J Clin Invest 2007 May 117(5):1422-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jefferson Tilley / Gerhard Burckhardt / Bruno Stieger / Russ Altman / Peter Wedlund / Munir Pirmohamed
Evaluated 12 Jun 2007

MRP2 haplotypes confer differential susceptibility to toxic liver injury.
Choi JH, Ahn BM, …, Kim KH, Lee MG
Pharmacogenet Genomics 2007 Jun 17(6):403-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 23 May 2007

Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate.
Shin HJ, Anzai N, …, Endou H, Kanai Y
Hepatology 2007 Apr 45(4):1046-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 27 Apr 2007

Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.
Fausther M, Lecka J, …, Dranoff JA, Sévigny J
Am J Physiol Gastrointest Liver Physiol 2007 Mar 292(3):G785-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 20 Apr 2007

Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs.
Iozzo P, Jarvisalo MJ, …, Ferrannini E, Nuutila P
Gastroenterology 2007 Feb 132(2):531-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 20 Mar 2007

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.
Keitel V, Reinehr R, …, Häussinger D, Kubitz R
Hepatology 2007 Mar 45(3):695-704 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 12 Mar 2007

Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2.
Alrefai WA, Annaba F, …, Dudeja PK, Gill RK
Am J Physiol Gastrointest Liver Physiol 2007 Jan 292(1):G369-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 8 Feb 2007

Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates.
DeLeve LD, Wang X, McCuskey MK, McCuskey RS
Am J Physiol Gastrointest Liver Physiol 2006 Dec 291(6):G1187-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger
Evaluated 17 Jan 2007

Self-renewal of embryonic stem cells by a small molecule.
Chen S, Do JT, …, Schultz PG, Ding S
Proc Natl Acad Sci U S A 2006 Nov 14 103(46):17266-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Chernoff / Bruno Stieger
Evaluated 5 Jan 2007

Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.
Lim JH, Park JW, …, Johnson RS, Chun YS
Mol Pharmacol 2006 Dec 70(6):1856-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger
Evaluated 5 Dec 2006

The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity.
Kurnik D, Wood AJ, Wilkinson GR
Clin Pharmacol Ther 2006-09-01 80(3):228-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 16 Nov 2006

Identification of a mammalian mitochondrial porphyrin transporter.
Krishnamurthy PC, Du G, …, Murti KG, Schuetz JD
Nature 2006 Oct 5 443(7111):586-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger / Stephan Nussberger
Evaluated 19 Oct 2006

ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.
Tam SP, Mok L, …, Vasa M, Deeley RG
Am J Physiol Cell Physiol 2006 Sep 291(3):C490-502 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger
Evaluated 27 Sep 2006

Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice.
Plösch T, van der Veen JN, …, Bloks VW, Kuipers F
Am J Physiol Gastrointest Liver Physiol 2006 Sep 291(3):G414-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger
Evaluated 6 Sep 2006

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.
Haughton EL, Tucker SJ, …, Trim JE, Wright MC
Gastroenterology 2006 Jul 131(1):194-209 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 18 Aug 2006

Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
Paulusma CC, Groen A, …, Knisely AS, Oude Elferink RP
Hepatology 2006 Jul 44(1):195-204 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 14 Jul 2006

Farnesoid X receptor is essential for normal glucose homeostasis.
Ma K, Saha PK, Chan L, Moore DD
J Clin Invest 2006 Apr 116(4):1102-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger
Evaluated 12 Jun 2006

Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6.
Jiang Z, Asplin JR, …, Binder HJ, Aronson PS
Nat Genet 2006 Apr 38(4):474-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hugo De Jonge / Bruno Stieger
Evaluated 12 May 2006

Platelet-derived serotonin mediates liver regeneration.
Lesurtel M, Graf R, …, Bader M, Clavien PA
Science 2006 Apr 7 312(5770):104-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger
Evaluated 13 Apr 2006


ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion.
Cater MA, La Fontaine S, …, Deal Y, Mercer JF
Gastroenterology 2006 Feb 130(2):493-506 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 21 Mar 2006

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Inagaki T, Moschetta A, …, Mangelsdorf DJ, Kliewer SA
Proc Natl Acad Sci U S A 2006 Mar 7 103(10):3920-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruno Stieger / Paul Webb / David Cook
Evaluated 27 Feb 2006

Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line.
Weedon-Fekjaer MS, Duttaroy AK, Nebb HI
Placenta 2005 Nov 26(10):721-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 27 Jan 2006

Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver.
Kumaran V, Joseph B, Benten D, Gupta S
Gastroenterology 2005 Nov 129(5):1643-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 4 Jan 2006

Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells.
Ruhnke M, Ungefroren H, …, Kremer B, Fändrich F
Gastroenterology 2005 Jun 128(7):1774-86 [abstract on PubMed] [related articles] [order article]
Selected by | Bruno Stieger
Evaluated 1 Dec 2005

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