John Kuriyan HHMI - Department of Molecular Cell Biology and Department of Chemistry, University of California, Berkeley, Berkeley, United States of America
Head of Faculty: Structural Biology [ since 1 November 2001 ]
Structural biology of cellular signaling and DNA replication signal transduction
Our laboratory explores how particular structures and atomic interactions underlie the transmission of information from the cell surface to the nucleus and the components of chromosomal DNA replication. We study STAT proteins that directly couple receptor activation to gene transcription, tyrosine kinases such as the product of the src oncogene, and protein kinases and phosphatases that act on serine and threonine. The laboratory also conducts structural analysis of the highly processive DNA polymerases responsible for chromosomal replication to understand the mechanisms and regulation of these enzymes.
