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Chaya Kalcheim
Department of Anatomy and Cell Biology , Hebrew University of Jerusalem, Jerusalem, Israel

Faculty Member: NEUROSCIENCE > Neurodevelopment [ since 12 June 2001 ]
[ Sponsorship ] [ Biography ] [ Homepage ] [ Evaluations ]
Sponsorship

Chaya Kalcheim sponsors free access to F1000 for Medical University of Southern Africa, Pretoria, South Africa. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

We are currenty investigating cellular and molecular mechanisms controlling the development of the nervous and skeletal systems during embryogenesis.

Developmental Neurobiology: Mechanisms underlying the onset and progression of neural crest migration; control of cell cycle and differentiation of neural crest and neural tube progenitors.

Development of the skeletal system: The molecular basis of intrasomitic diversification in relation to vertebral development and to segmentation of the peripheral nervous system. The multiwave nature of myotome formation.

Home page

http://www.md.huji.ac.il/depts/anatomy/kalc.html

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Evaluations

Signals from the neural crest regulate beta-cell mass in the pancreas.
Nekrep N, Wang J, Miyatsuka T, German MS
Development 2008 Jun 135(12):2151-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 4 Jun 2008

c-Jun is a negative regulator of myelination.
Parkinson DB, Bhaskaran A, …, Mirsky R, Jessen KR
J Cell Biol 2008 May 19 181(4):625-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 4 Jun 2008

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
Wu X, Tu X, …, Williams DA, Long F
Cell 2008 Apr 18 133(2):340-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Filippo Giancotti / Gregory Dressler / John Wallingford
Evaluated 22 Apr 2008


An extended transcriptional network for pluripotency of embryonic stem cells.
Kim J, Chu J, …, Wang J, Orkin SH
Cell 2008 Mar 21 132(6):1049-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 27 Mar 2008

colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis.
Ignatius MS, Moose HE, El-Hodiri HM, Henion PD
Dev Biol 2008 Jan 15 313(2):568-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 15 Feb 2008

Ets-1 confers cranial features on neural crest delamination.
Théveneau E, Duband JL, Altabef M
PLoS ONE 2007 2(11):e1142 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 15 Nov 2007

Lrp6 is required for convergent extension during Xenopus gastrulation.
Tahinci E, Thorne CA, …, Coffey RJ, Lee E
Development 2007 Nov 134(22):4095-106 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Herbert Steinbeisser
Evaluated 5 Nov 2007

Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube.
Galli LM, Barnes TL, …, Kadowaki T, Burrus LW
Development 2007 Sep 134(18):3339-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 29 Aug 2007

A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.
Smolen GA, Schott BJ, …, Peterson RT, Haber DA
Genes Dev 2007 Sep 1 21(17):2131-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 28 Aug 2007

The generation of adipocytes by the neural crest.
Billon N, Iannarelli P, …, Dani C, Dupin E
Development 2007 Jun 134(12):2283-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / Judith S. Eisen
Evaluated 5 Jun 2007

c-Met is essential for wound healing in the skin.
Chmielowiec J, Borowiak M, …, Birchmeier C, Birchmeier W
J Cell Biol 2007 Apr 9 177(1):151-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / Kathleen J. Green
Evaluated 10 Apr 2007

A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis.
Tawk M, Araya C, …, Tada M, Clarke JD
Nature 2007 Apr 12 446(7137):797-800 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Rhona Mirsky
Evaluated 10 Apr 2007

Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest.
Kee Y, Hwang BJ, Sternberg PW, Bronner-Fraser M
Genes Dev 2007 Feb 15 21(4):391-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 5 Mar 2007

P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.
Yang L, Lin C, Liu ZR
Cell 2006 Oct 6 127(1):139-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Filippo Giancotti
Evaluated 22 Nov 2006

Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.
Zhu X, Zhang J, …, Kageyama R, Rosenfeld MG
Genes Dev 2006 Oct 1 20(19):2739-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 11 Oct 2006

Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain.
Berndt JD, Halloran MC
Development 2006 Oct 133(20):3983-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kristin Artinger / Chaya Kalcheim
Evaluated 9 Oct 2006

Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells.
Shinin V, Gayraud-Morel B, Gomès D, Tajbakhsh S
Nat Cell Biol 2006 Jul 8(7):677-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rong Li / Jürgen Knoblich / Chaya Kalcheim / Domenico Grieco
Evaluated 15 Aug 2006

Germline transmission of genetically modified primordial germ cells.
van de Lavoir MC, Diamond JH, …, Delany ME, Etches RJ
Nature 2006 Jun 8 441(7094):766-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 13 Jun 2006

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.
Kenchappa RS, Zampieri N, …, Hempstead BL, Carter BD
Neuron 2006 Apr 20 50(2):219-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 26 Apr 2006

Influences on neural lineage and mode of division in the zebrafish retina in vivo.
Poggi L, Vitorino M, Masai I, Harris WA
J Cell Biol 2005 Dec 19 171(6):991-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Wilson / Chaya Kalcheim
Evaluated 14 Feb 2006

The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons.
Marmigère F, Montelius A, …, Reichardt LF, Ernfors P
Nat Neurosci 2006 Feb 9(2):180-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 7 Feb 2006

Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression.
Shu T, Tseng HC, …, Reiner O, Tsai LH
Neuron 2006 Jan 5 49(1):25-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 9 Jan 2006

Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration.
Manes T, Zheng DQ, …, Marchisio PC, Languino LR
J Cell Biol 2003 May 26 161(4):817-26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 16 Dec 2005

Regulation of cell proliferation by a morphogen gradient.
Rogulja D, Irvine KD
Cell 2005 Nov 4 123(3):449-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / James Briscoe / Iswar Hariharan / Beat Suter / Carl Thummel / David Ish-Horowicz
Evaluated 8 Nov 2005

Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability.
Ishitani T, Matsumoto K, Chitnis AB, Itoh M
Nat Cell Biol 2005 Nov 7(11):1106-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Judith S. Eisen
Evaluated 25 Oct 2005

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis.
Zhao Y, Samal E, Srivastava D
Nature 2005 Jul 14 436(7048):214-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / John Kyriakis / Andrew D. Sharrocks
Evaluated 18 Jul 2005

Bone marrow stromal cells generate muscle cells and repair muscle degeneration.
Dezawa M, Ishikawa H, …, Ide C, Nabeshima Y
Science 2005 Jul 8 309(5732):314-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / Elizabeth McNally
Evaluated 13 Jul 2005

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.
Park JI, Kim SW, …, Moon RT, McCrea PD
Dev Cell 2005 Jun 8(6):843-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Frans Van Roy / Valeri Vasioukhin
Evaluated 17 Jun 2005

The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts.
Liu G, Bafico A, Aaronson SA
Mol Cell Biol 2005 May 25(9):3475-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jean-Paul Vincent / Chaya Kalcheim
Evaluated 17 Jun 2005

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.
Hjerling-Leffler J, Marmigère F, …, Enerbäck S, Ernfors P
Development 2005 Jun 132(11):2623-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 19 May 2005

Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains.
Marquardt T, Shirasaki R, …, Hunter T, Pfaff SL
Cell 2005 Apr 8 121(1):127-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Judith S. Eisen / Paola Chiarugi / Catherine Krull / David Wilkinson
Evaluated 12 Apr 2005

Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina.
Van Raay TJ, Moore KB, …, Harris WA, Vetter ML
Neuron 2005 Apr 7 46(1):23-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 12 Apr 2005

Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo.
Vermot J, Gallego Llamas J, …, Chambon P, Dollé P
Science 2005 Apr 22 308(5721):563-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 8 Mar 2005

Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping.
Sgaier SK, Millet S, …, Song C, Joyner AL
Neuron 2005 Jan 6 45(1):27-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 11 Jan 2005

Neural crest cell lineage segregation in the mouse neural tube.
Wilson YM, Richards KL, …, Panthier JJ, Murphy M
Development 2004 Dec 131(24):6153-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 7 Dec 2004

Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.
Ryoo HD, Gorenc T, Steller H
Dev Cell 2004 Oct 7(4):491-501 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Peter Gallant / Jessica E. Treisman
Evaluated 27 Oct 2004

Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS.
Maro GS, Vermeren M, …, Charnay P, Topilko P
Nat Neurosci 2004 Sep 7(9):930-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Genevieve Rougon / Judith S. Eisen / Chaya Kalcheim
Evaluated 8 Sep 2004

Mouse development and cell proliferation in the absence of D-cyclins.
Kozar K, Ciemerych MA, …, Akashi K, Sicinski P
Cell 2004 Aug 20 118(4):477-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Marcus Clark
Evaluated 1 Sep 2004

A two-step mechanism for myotome formation in chick.
Gros J, Scaal M, Marcelle C
Dev Cell 2004 Jun 6(6):875-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Chaya Kalcheim / Olivier Pourquie
Evaluated 28 Jul 2004

Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.
Arenkiel BR, Tvrdik P, Gaufo GO, Capecchi MR
Genes Dev 2004 Jul 1 18(13):1539-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wilkinson / Chaya Kalcheim / Alain Ghysen
Evaluated 8 Jul 2004

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.
Yang J, Mani SA, …, Richardson A, Weinberg RA
Cell 2004 Jun 25 117(7):927-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Filippo Giancotti / Kathleen J. Green / Surender Kharbanda / Daniel Flynn
Evaluated 2 Jul 2004

Divergent functions of murine Pax3 and Pax7 in limb muscle development.
Relaix F, Rocancourt D, Mansouri A, Buckingham M
Genes Dev 2004 May 1 18(9):1088-105 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / David Sassoon
Evaluated 27 May 2004

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Seoane J, Le HV, …, Anderson SA, Massagué J
Cell 2004 Apr 16 117(2):211-23 [abstract on PubMed] [related articles] [order article]
Selected by | Chaya Kalcheim / David Wotton / John Rubenstein
Evaluated 20 Apr 2004

Efficient isolation and gene expression profiling of small numbers of neural crest stem cells and developing Schwann cells.
Buchstaller J, Sommer L, …, Suter U, Mantei N
J Neurosci 2004 Mar 10 24(10):2357-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 16 Mar 2004

Distinct activities of Msx1 and Msx3 in dorsal neural tube development.
Liu Y, Helms AW, Johnson JE
Development 2004 Mar 131(5):1017-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 4 Mar 2004

Reiterated Wnt signaling during zebrafish neural crest development.
Lewis JL, Bonner J, …, Dorsky RI, Raible DW
Development 2004 Mar 131(6):1299-308 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / Judith S. Eisen / Kristin Artinger
Evaluated 3 Mar 2004

Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome.
Cortés F, Daggett D, …, Keenan D, Currie PD
Dev Cell 2003 Dec 5(6):865-76 [abstract on PubMed] [related articles] [order article]
Selected by | Judith S. Eisen / Chaya Kalcheim / Douglas DeSimone / Sharon Amacher
Evaluated 6 Jan 2004

Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration.
Yebra M, Montgomery AM, …, Tessier-Lavigne M, Cirulli V
Dev Cell 2003 Nov 5(5):695-707 [abstract on PubMed] [related articles] [order article]
Selected by | Chaya Kalcheim / Charles Streuli / Orly Reiner
Evaluated 4 Dec 2003

Intrinsic, Hox-dependent cues determine the fate of skeletal muscle precursors.
Alvares LE, Schubert FR, …, Lumsden A, Dietrich S
Dev Cell 2003 Sep 5(3):379-90 [abstract on PubMed] [related articles] [order article]
Selected by | Chaya Kalcheim
Evaluated 19 Sep 2003

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.
Pinto D, Gregorieff A, Begthel H, Clevers H
Genes Dev 2003 Jul 15 17(14):1709-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Valeri Vasioukhin / Chaya Kalcheim
Evaluated 2 Sep 2003

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.
Yan C, Martinez-Quiles N, …, Rosen FS, Alt FW
EMBO J 2003 Jul 15 22(14):3602-12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 18 Jul 2003

SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells.
Kim J, Lo L, Dormand E, Anderson DJ
Neuron 2003 Apr 10 38(1):17-31 [abstract on PubMed] [related articles] [order article]
Selected by | Chaya Kalcheim
Evaluated 2 May 2003

Reversal of developmental restrictions in neural crest lineages: transition from Schwann cells to glial-melanocytic precursors in vitro.
Dupin E, Real C, …, Vaigot P, Le Douarin NM
Proc Natl Acad Sci U S A 2003 Apr 29 100(9):5229-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 1 May 2003

Induction of neural crest in Xenopus by transcription factor AP2alpha.
Luo T, Lee YH, Saint-Jeannet JP, Sargent TD
Proc Natl Acad Sci U S A 2003 Jan 21 100(2):532-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 14 Mar 2003

In vivo time-lapse imaging of cell divisions during neurogenesis in the developing zebrafish retina.
Das T, Payer B, Cayouette M, Harris WA
Neuron 2003 Feb 20 37(4):597-609 [abstract on PubMed] [related articles] [order article]
Selected by | Harukazu Nakamura / Chaya Kalcheim / Alain Ghysen / Rachel Wong
Evaluated 12 Mar 2003

The cellular and molecular origins of beak morphology.
Schneider RA, Helms JA
Science 2003 Jan 24 299(5606):565-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / Harukazu Nakamura
Evaluated 27 Jan 2003

Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.
Kioussi C, Briata P, …, Wynshaw-Boris A, Rosenfeld MG
Cell 2002 Nov 27 111(5):673-85 [abstract on PubMed] [related articles] [order article]
Selected by | Valeri Vasioukhin / Chaya Kalcheim
Evaluated 10 Dec 2002

Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion.
Rhee J, Mahfooz NS, …, Balsamo J, VanBerkum MF
Nat Cell Biol 2002 Oct 4(10):798-805 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valeri Vasioukhin / Dietmar Vestweber / Chaya Kalcheim / Kathleen J. Green / Yoshimi Takai / Christine Holt
Evaluated 29 Oct 2002

Negative effect of Hox gene expression on the development of the neural crest-derived facial skeleton.
Creuzet S, Couly G, Vincent C, Le Douarin NM
Development 2002 Sep 129(18):4301-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 29 Aug 2002

REN: a novel, developmentally regulated gene that promotes neural cell differentiation.
Gallo R, Zazzeroni F, …, Screpanti I, Gulino A
J Cell Biol 2002 Aug 19 158(4):731-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim
Evaluated 23 Aug 2002

Regulation of motor neuron pool sorting by differential expression of type II cadherins.
Price SR, De Marco Garcia NV, Ranscht B, Jessell TM
Cell 2002 Apr 19 109(2):205-16 [abstract on PubMed] [related articles] [order article]
Selected by | Judith S. Eisen / Chris Henderson / Susan K. McConnell / Chaya Kalcheim
Evaluated 2 Jul 2002

Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord.
Gross MK, Dottori M, Goulding M
Neuron 2002 May 16 34(4):535-49 [abstract on PubMed] [related articles] [order article]
Selected by | Chaya Kalcheim / Andrew Lumsden
Evaluated 20 May 2002

Endogenous patterns of BMP signaling during early chick development.
Faure S, de Santa Barbara P, Roberts DJ, Whitman M
Dev Biol 2002 Apr 1 244(1):44-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Chaya Kalcheim
Evaluated 10 Apr 2002

Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
Trainor PA, Ariza-McNaughton L, Krumlauf R
Science 2002 Feb 15 295</