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Marc Rothenberg
Division of Allergy and Immunology Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America

Faculty Member: IMMUNOLOGY > Allergy & hypersensitivity [ since 13 March 2006 ]
[ Biography ] [ Evaluations ]
Biography


1. Richard JP, Rothenberg ME, Jencks WP. Formation and stability of ring-substituted 1-phenylethyl carbocations. J Am Chem Soc 1984; 106:1361-1372.

2. Rothenberg ME, Richard JP, Jencks WP. Equilibrium constants for the interconversion of substituted 1-phenylethyl alcohols and esters. A measurement of intramolecular electrostatic interactions. J Am Chem Soc 1985; 107:1370-1376.

3. Rothenberg ME, Caulfield JP, Austen KF, Hein A, Edmiston K, Newburger PE, Stevens RL. Biochemical and morphological characteristics of basophilic leukocytes from two patients with myelogenous leukemia. J Immun 1987; 138: 2616-2625.

4. Rothenberg ME, Owen WF Jr., Silberstein DS, Soberman RJ, Austen KF, Stevens RL. Eosinophils cocultured with endothelial cells have increased survival and functional properties. Science 1987; 237:645-647.

5. Owen WF Jr., Rothenberg ME, Silberstein DS, Gasson JC, Stevens RL, Austen KF, Soberman RJ. Regulation of human eosinophil viability, density, and function by granulocyte-macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J Exp Med 1987; 166:129-141.

6. Rothenberg ME, Pomerantz JL, Owen WF Jr., Avraham S, Soberman RJ, Austen KF, Stevens RL. Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J Biol Chem 1988; 263:13901-13908.

7. Rothenberg, ME, Owen WF Jr., Silberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest 1988; 81:1986-1992.

8. Rothenberg ME, Owen WF Jr., Stevens RL. Mast cells and eosinophils. Int Ophthalmol Clin 1988; 28:267-274.

9. Owen WF, Rothenberg ME, Petersen J, Weller PF, Silberstein D, Sheffer AL, Stevens RL, Soberman RJ, Austen KF. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. J Exp Med 1989; 170:343-348.

10. Rothenberg ME, Owen WF. Cytokines regulate eosinophil production and differentiation. Allergy Today 1989; 3:8-10.5.

11. Rothenberg ME, Petersen J, Stevens RL, Silberstein DS, McKenzie DT, Austen KF, Owen WF. Interleukin-5 dependent conversion of human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J Immunol 1989; 143:801-806.

12. Caulfield JP, Hein A, Rothenberg ME, Owen WF, Soberman RJ, Stevens RL, Austen KF. A morphometric study of normodense human eosinophils and hypodense human eosinophils that are derived in vivo and in vitro. Am J Pathol; 1990; 137:27-41.

13. Rothenberg ME, White F, Chilmonczyck B, Chatila T. A syndrome involving immunodeficiency and multiple intestinal atresias. Immunodeficiency; 1995; 5:171-178.

14. Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med; 1995; 181:1211-1216.

15. Post TW, Bozic CR, Rothenberg, ME, Luster, AD, Gerard N, Gerard C. Molecular characterization of two murine eosinophil ? chemokine receptors. J Immunol; 1995; 155:5299-5305.

16. Rothenberg, ME, Luster AD, Leder P. Murine Eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin-4 induced tumor suppression. Proc Natl Acad Sci USA; 1995; 92:8960-8964.

17. Garcia-Zepeda E, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nature Med; 1996; 2:449-456.

18. Gao J-L, Sen AI, Kitaura M, Yoshie O, Rothenberg ME, Murphy PM, Luster AD, Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem Biophys Res Comm, 1996; 233: 679-684.

19. Rothenberg ME, Weber WEJ, Longtine J, Hafler DA. Cytotoxic ?? T lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clin Immunol Immunopath; 1996; 80:266-272.

20. Garcia-Zepeda EA, Combadiere C, Rothenberg ME, Sarafi M, Lavigne F, Hamid Q, Murphy PM, Luster AD. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol, 1996; 157:5613-5626.

21. Rothenberg ME, Ownbey R, Mehlhop PD, Loiselle PM, van de Rijn M, Bonventre JV, Oettgen HC, Leder P, Luster AD. Eotaxin triggers eosinophil selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin-5 in mice. Molec Med; 1996; 2: 334-348.

22. Lilly CM, Nakamura H, Kesselman H, Nagler-Anderson C, Asano K, Garcia-Zepeda EA, Rothenberg ME, Drazen JM, Luster AD. Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids. J Clin Invest. 1997; 99: 1767-1773.

23. Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, Sarafi M, Morton CC, Luster AD. Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. Genomics 1997; 41:471-476.

24. Luster AD, Rothenberg ME. Role of the monocyte chemoattractant protein and eotaxin sub-family of chemokines in allergic inflammation. J Leukoc Biol 1997; 62:620-633.

25. Rothenberg ME, MacLean JA, Pearlman E, Luster A, Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med; 1997; 185:785-790.

26. Lamkhioued, B, Renzi, PM, Abi-Younes S, Garcia-Zepeda EA, Allakhverdi Z, Ghaffar O, Rothenberg ME, Luster AD, Hamid Q. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 1997; 159:4593-4601.

27. Minshall E, Cameron L., Levigne F, Leung DYM, Hamilos D, Garcia-Zepeda EA, Rothenberg M, Luster A, Hamid Q. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am J Respir Cell Mol Biol, 1997; 17:683-690.

28. Matthews AN, Friend C, Zimmermann N, Sarafi MN, Luster AD, Pearlman E, Wert SE, Rothenberg ME. Eotaxin is required for the baseline level of tissue eosinophils. Proc Natl Acad Sci USA, 1998; 95:6273-6278.

29. Cook EB, Stahl JL, Lilly CM, Haley KJ, Sanchez H, Luster AD, Graziano FM, Rothenberg ME. Epithelial cells are a major cellular source of the chemokine eotaxin in the guinea pig lung. Allergy Asthma Proceedings, 1998; 19:15-22.

30. Rothenberg ME. Eosinophilia. N Engl J Med, 1998; 338:1592-1600.

31. van de Rijn M, Mehlhop PD, Judkins A, Rothenberg ME, Luster AD, Oettgen HC. A murine model of allergic rhinitis: Studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin. J Allergy Clin Immunol, 1998; 102:65-74.

32. Huang WW, Garcia-Zepeda EA, Sauty A, Oettgen HC, Rothenberg ME, Luster AD. Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils, J Exp Med, 1998; 188:1063-1074.

33. Zimmermann N, Bernstein J, Rothenberg ME. Polymorphisms in the human CC chemokine receptor-3 gene. Biochimica et Biophysica Acta, 1998; 1442:170-176.

34. Hogan SP, Mould AW, Young JM, Rothenberg ME, Ramsay AJ, Matthaei K, Young IG, Foster PS. Cellular and molecular regulation of eosinophil trafficking to the lung, J Immunol Cell Biol, 1998; 76:454-460.

35. Zimmermann N, Conkright JJ, Rothenberg ME. CC chemokine receptor-3 undergoes
prolonged ligand-induced internalization, J Biol Chem, 1999; 274:12611-12618.

36. Mishra A, Hogan S, Lee J, Foster PS, Rothenberg ME. Fundamental signals that regulate eosinophil homing into the gastrointestinal tract, J Clin Invest, 1999; 103:1719-1727.

37. Rothenberg ME. Eotaxin: an essential mediator of eosinophil trafficking into mucosal tissues, Am J Respir Cell Mol Biol, 1999; 21:291-295.

38. Rothenberg ME, Zimmermann N, Mishra A, Brandt E, Birkenberger LA, Hogan SP, Foster PS. Chemokines and chemokine receptors: Their role in allergic airway disease. J Clin Immunol. 1999; 19:250-265.

39. Rosa-Rosa L, Zimmermann N, Bernstein JA, Rothenberg ME, Khurana Hershey GK. The R576 interleukin-4 receptor allele correlates with asthma severity. J Allergy Clin Immunol, 1999; 104:1008-1014.

40. Zimmermann N, Daugherty, BL, Stark JM, Rothenberg ME. Molecular analysis of CCR-3 events in eosinophilic cells. J Immunol, 2000; 164:1055-1064.

41. Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothenberg ME, Foster PS. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity, J Immunol, 2000; 164:2142-2150.

42. Gouon-Evans V, Rothenberg ME, Pollard JW. Postnatal mammary gland development requires macrophages and eosinophils, Development, 2000; 127:2269-2282.

43. Hogan SP, Mishra A, Brandt E, Foster PS, Rothenberg ME. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastroenteritis, Proc Natl Acad Sci USA, 2000; 97:6681-6686.

44. Mishra A, Hogan SP, Brandt E, Rothenberg ME. Peyer¿s patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin, Blood, 2000; 96:1538-1544.

45. Zimmermann N, Daugherty BL, Kavanaugh JL, El Awar FY, Moulton EA, Rothenberg ME. Analysis of the CC chemokine receptor 3 gene reveals a complex 5¿ exon organization, a functional role for untranslated exon 1, and a broadly active promoter, Blood, 2000; 96:2346-2354.

46. Zimmermann N, Hogan SP, Mishra A, Brandt EB, Bodette T, Pope, SM, Finkelman FD, Rothenberg ME. Murine eotaxin-2: A constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression, J Immunol, 2000; 165:5839-5846.

47. Mishra A, Hogan SP, Brandt E, Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis, J Clin Invest, 2001; 107:83-90.

48. Mishra A, Beck D, Weaver T, Rothenberg ME. Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice, J Biol Chem, 2001; 276:8453-8459.

49. Rothenberg ME, Mishra A, Brandt EB, Hogan SP. Gastrointestinal Eosinophils. Immunol Rev, 2001; 179:139-155.

50. Rothenberg ME, Mishra A, Brandt EB, Hogan SP. Gastrointestinal Eosinophils in Health and Disease. Adv Immunol, 2001; 78:291-328.

51. Foster PS, Mould AW, Yang M, Mackenzie J, Mattes J, Hogan SP, Mahalingam S, Mckenzie ANJ, Rothenberg ME, Young IG, Matthaei KI, Webb DC. Elemental Signals Regulating Eosinophil Accumulation in the Lung. Immunol Rev, 2001; 179:173-181.

52. Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, Foster PS, Rothenberg ME. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation, Nat Immunol, 2001; 2:353-360.

53. Webb D, McKenzie A, Matthaei K, Rothenberg M, Foster P. Distinct spatial requirement for eosinophil-induced airways hyperreactivity. Immunol Cell Biol, 2001; 79:165-169.

54. Brandt EB, Rothenberg ME. Eosinophil levels in mice are significantly higher in small blood vessels than in large blood vessels, J Allergy Clin Immunol, 2001; 108:142-143.

55. Wong GW, Li L, Madhusudhan MS, Krilis SA, Gurish MF, Rothenberg ME, Sali A, Stevens RL. Tryptase 4: a new member of the chromosome 17 family of mouse serine proteases. J Biol Chem, 2001; 276:20648-20658.

56. Pope SM, Brandt EB, Mishra A, Hogan SP, Zimmermann N, Matthaei KI, Foster, PS, Rothenberg ME. Interleukin-13 induces eosinophil recruitment to the lung by an interleukin-5 and eotaxin-dependent mechanism, J Allergy Clin Immunol, 2001; 108:594-601.

57. Yang M, Hogan SP, Henry PJ, Matthaei KI, McKenzie ANJ, Young IG, Pope SM, Rothenberg ME, Foster PS. Interleukin-13 mediates airways hyperreactivity through the IL-4-receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin, Am J Resp Cell Mol Biol, 2001; 25:522-530.

58. Rothenberg ME, Mishra A, Collins MH, Putnam PE. Pathogenesis and clinical features of eosinophilic esophagitis. J Allergy Clin Immunol. 2001; 108:891-894.

59. Mishra A, Hogan SP, Brandt, EB, Rothenberg ME. Interleukin-5 promotes eosinophil trafficking to the esophagus, J Immunol, 2002, 168:2464-2469.

60. Mishra A, Hogan SP, Brandt EB, Wagner, N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking, J Biol Chem, 2002; 277:4406-4412.

61. Hogan SP, Foster PS, Rothenberg ME. Experimental analysis of eosinophil-associated gastrointestinal diseases, Curr Opin Allergy Clin Immunol, 2002; 2:239-248.

62. Yang M, Mahalingam S, Kuehr J, Webb D, Simson L, Hogan SP, Koskinen A, McKenzie AN, Dent L, Rothenberg ME, Matthaei KI, Young IG and Foster PS. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma, J Exp Med, 2002; 195:1433-1444.

63. Bueno OF, Brandt EB, Rothenberg ME, Molkentin JD. Defective T cell development and function in calcineurin A?-deficient mice, Proc Nat¿l Acad Sci USA, 2002; 99:9398-9403.

64. Guajardo JR, Plotnick L, Putnam PE, Collins M, Assa'ad A, Rothenberg ME. Eosinophil-associated gastrointestinal disorders: A World-Wide-Web based registry, J Pediatr, 2002; 141:576-581.

65. Zimmermann N, Rothenberg ME. Receptor internalization is required for eotaxin-induced responses in human eosinophils, J Allergy Clin Immunol, 2003; 111:97-105.

66. Khaldoyanidi S, Sikora L, Broide DH, Rothenberg ME, Sriramarao P. Constitutive overexpression of IL-5 induces extramedulary hematopoiesis in the spleen, Blood, 2003; 101:863-868.

67. Mattes J, Hulett M, Xie W, Hogan S, Rothenberg ME, Foster PS, Parish C. Immunotherapy of cytotoxic T cell resistant tumors by T helper 2 cells: An eotaxin and STAT-6 dependent process, J Exp Med, 2003;197:387-393.

68. Zimmermann N, Hershey G K, Rothenberg ME, Foster PS. Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol, 2003 111:227-42.

69. Rothenberg ME. Major link between mast cells and the idiopathic hypereosinophilic syndrome. Blood, 2003 101:4647-4648.

70. Rothenberg ME. CD44 ¿ a sticky target for asthma. J Clin Invest, 2003; 111:1460-62.

71. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, Hamid Q, Rothenberg ME. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest, 2003; 111:1863-1874.

72. Smart V, Foster PS, Rothenberg ME, Higgins TJV, Hogan SP. A plant-based allergy vaccine suppresses experimental asthma via an IFN-? and CD4+CD45RBlow T cell-dependent mechanism. J Immunol, 2003; 171:2116-2126.

73. Nikolaidis NM, Zimmermann N, King NE, Mishra A, Pope S, Finkelman FD, Rothenberg ME. Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung, Am J Respir Cell Molec Biol, 2003; 29:458-64.

74. Aizawa H, Zimmermann N, Carrigan PE, Lee JJ, Rothenberg ME, Bochner BS. Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of moust orthologs of Siglect-5 (mSiglec-F) and Siglec-10 (mSiglec-G), Genomics, 2003; 82:521-530.

75. Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophil esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism, Gastroenterology 2003; 125:1419-1427.

76. Yang M, Hogan SP, Mahalingam S, Matthaei KI, Dent L, McKenzie ANJ, Young IG, Pope SM, Zimmermann N, Rothenberg ME, Foster PS. Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity, J Allergy Clin Immunol, 2003; 112: 935-943.

77. Brandt EB, Strait RT, Hershko D, Wang Q, Muntel EE, Scribner TA, Zimmermann N, Finkelman FD, Rothenberg ME. Mast cells are required for experimental oral allegen-induced diarrhea, J Clin Invest, 2003: 112: 1666-1677.

78. Sutton SA, Assa¿ad AH, Steinmetz C, Rothenberg ME. A negative double-blind placebo controlled challenge to genetically modified corn. J Allergy Clin Immunol, 2003: 112:1011-2.

79. Hogan SP, Rothenberg ME, Forbes E, Smart VE, Matthaei KI, Foster PS. Chemokines in eosinophil-associated gastrointestinal disorders, Curr Allergy Asthma Rep 2004; 4:74-82.

80. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol, 2004; 113:11-28.

81. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DE, Boyce JA, Beck LA, Filipovich A, Villanueva JM, Sutton SA, Assa¿ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol, 2004; 113: 115-9.

82. Fulkerson PC, Zimmermann N, Brandt EB, Muntel EE, Doepker MP, Kavanaugh JL, Mishra A, Witte DP, Farber JM, Yang M, Foster PS, Rothenberg ME. Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-? (Mig, CXCL9), Proc Nat¿l Acad Sci USA, 2004; 101:1987-1992.

83. Wan J, Kaestner KH, Ang S-L, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson PC,7 Rothenberg ME, Whitsett JA. Foxa2 regulates alveolarization and goblet cell hyperplasia, Development, 2004;131:953-64.

84. Zimmermann N, Mishra A, King NE, Fulkerson PC, Doepker MP, Nikolaidis NM, Kindinger LE, Moulton EA, Aronow BJ, Rothenberg ME. Transcript signatures in experimental asthma: identification of STAT6 dependent and independent pathways, J Immunol, 2004;172:1815-24.

85. Noel RJ, Putnam PE, Collins MH, Assa¿ad AH, Guajardo JR, Jameson SC, Rothenberg ME. Heterogeneous clinical and immunopathological responses to swallowed fluticasone propionate for eosinophilic esophagitis, Clin Gastroenterol Hepatol, 2004; 2:568-75.

86. Forbes E, Smart V, D'Aprile A, Henry P, Yang M, Matthaei KI, Rothenberg ME, Foster PS, Hogan SP. Bronchial hyperresponsiveness in experimental eosinophil-associated GI diseases is critically regulated by CD4+ T-cells, interleukin-13 and eotaxin-1, Gastroenterology, 2004; 127:105-18.

87. King NE, Zimmermann N, Pope SM, Fulkerson PC, Nikolaidis, NM, Mishra A, Witte DP, Rothenberg ME. Expression and regulation of a disintegrin and metalloproteinase (ADAM)8 in experimental asthma, Am J Respir Cell Mol Biol, 2004; 31:257-65.

88. Noel RJ, Putnam PE, Rothenberg, ME. Eosinophilic esophagitis, N Engl J Med, 2004; 351:940-1.

89. Rothenberg ME. VEGF obstructs the lungs. Nature Med, 2004: 10:10941-1042.

90. King NE, Rothenberg ME, Zimmermann N. Arginine in asthma and lung inflammation. J Nutrition, 2004; 134:2830S-2836S.

91. Hogan SP, Rothenberg ME. Review Article: the eosinophil as a therapeutic target in gastrointestinal disease. Aliment Pharmacol Ther, 2004; 20:1231-40.

92. Fulkerson PC, Zimmermann N, Hassman LM, Finkelman FD, Rothenberg ME. Pulmonary chemokine expression is coordinately regulated by Stat1, Stat6, and IFN?, J Immunol, 2004;173:7565-74.

93. Simons JE, Rothenberg ME, Lawrence RA. Eotaxin-1 regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection, Eur J Immunol, 2005; 35:189-97.

94. Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT. Molecular mechanisms of anaphylaxis: Lessons from studies with murine models, J Allergy Clin Immunol, 2005: 115:449-57.

95. Pope SM, Fulkerson PC, Nikolaidis N, Blanchard C, Zimmermann N, Molkentin JD, Rothenberg ME. Identification of a cooperative mechanism involving IL-13 and eotaxin-2 in experimental allergic lung inflammation, J Biol Chem, in press 2005 Jan 12; [Epub ahead of print].

96. Sutton SA, Assa¿ad AH, Rothenberg ME. Anti-IL-5 and hypereosinophilic syndromes. Clin Immunol, in press.

97. Zimmermann N, Doepker MP, Witte DP, Stringer KF, Fulkerson PC, Pope, SM, Brandt EB, Mishra A, King NE, Nikolaidis NM, Wills-Karp M, Finkelman FD, Rothenberg ME. Expression and regulation of small proline rich proteins (SPRR)2 in allergic inflammation, Am J Respir Cell Mol Biol, in press 2005 Feb 24 [Epub ahead of print].

98. Finkelman FD, Yang M, Perkins C. Schleifer K, Sproles A, Santeliz JA, Bernstein J, Rothenberg ME, Morris SC, Wills Karp M. Suppressive effect of IL-4 on IL-13-induced genes in mouse lung, J Immunol, in press.

99. Fulkerson PC, Zhu, Hongyan, Zimmermann, Nives, Rothenberg ME. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism, Blood, in press.

100. Zimmermann N, Colyer JL, Koch LE, Rothenberg ME. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1. BioMed Central Immunol, in press.

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Evaluations

Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
Milner JD, Brenchley JM, …, Paul WE, Douek DC
Nature 2008 Apr 10 452(7188):773-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 18 Apr 2008


Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Romani L, Fallarino F, …, Segal BH, Puccetti P
Nature 2008 Jan 10 451(7175):211-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Williams / Andrea Cooper / Gary Bokoch / Marc Rothenberg
Evaluated 11 Mar 2008

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.
Feltenmark S, Gautam N, …, Björkholm M, Claesson HE
Proc Natl Acad Sci U S A 2008 Jan 15 105(2):680-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marc Rothenberg
Evaluated 28 Jan 2008

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.
Yang D, Chen Q, …, Zhang N, Oppenheim JJ
J Exp Med 2008 Jan 21 205(1):79-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 28 Jan 2008

Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13.
Bansal G, Xie Z, …, Nocka KH, Druey KM
Nat Immunol 2008 Jan 9(1):73-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg / Thomas Wynn
Evaluated 3 Dec 2007

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
Grayson MH, Cheung D, …, Kim EY, Holtzman MJ
J Exp Med 2007 Oct 29 204(11):2759-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 3 Dec 2007

Childhood asthma after bacterial colonization of the airway in neonates.
Bisgaard H, Hermansen MN, …, Stage M, Pipper CB
N Engl J Med 2007 Oct 11 357(15):1487-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 9 Nov 2007


IgEb immune complexes activate macrophages through FcgammaRIV binding.
Hirano M, Davis RS, …, Stephan RP, Cooper MD
Nat Immunol 2007 Jul 8(7):762-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 5 Sep 2007

Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide.
McCusker CT, Wang Y, …, Michael H, Fixman ED
J Immunol 2007 Aug 15 179(4):2556-64 [abstract on PubMed] [related articles] [order article]
Selected by | Marc Rothenberg
Evaluated 5 Sep 2007

Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes.
Monteseirín J, Vega A, …, Pérez-Cano R, Conde J
J Immunol 2007 Aug 15 179(4):2634-41 [abstract on PubMed] [related articles] [order article]
Selected by | Marc Rothenberg
Evaluated 5 Sep 2007

Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
Sun J, Sukhova GK, …, Clair JM, Shi GP
Nat Med 2007 Jun 13(6):719-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg / Stephen Schwartz
Evaluated 6 Jul 2007

Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus.
Phipps S, Lam CE, …, Foster PS, Matthaei KI
Blood 2007 Sep 1 110(5):1578-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg / Richard L. Stevens
Evaluated 21 May 2007


Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease.
Benahmed M, Meresse B, …, Hermine O, Cerf-Bensussan N
Gastroenterology 2007 Mar 132(3):994-1008 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 22 Mar 2007

Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells.
Allakhverdi Z, Comeau MR, …, Sarfati M, Delespesse G
J Exp Med 2007 Feb 19 204(2):253-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | P'ng Loke / Marc Rothenberg / Dale Umetsu
Evaluated 8 Mar 2007

IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production.
Zhen G, Park SW, …, Paquet AC, Erle DJ
Am J Respir Cell Mol Biol 2007 Feb 36(2):244-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 17 Nov 2006

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.
Kullberg MC, Jankovic D, …, Maloy KJ, Sher A
J Exp Med 2006 Oct 30 203(11):2485-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marc Rothenberg / Xiaojing Ma
Evaluated 16 Nov 2006

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection.
Chromek M, Slamová Z, …, Agerberth B, Brauner A
Nat Med 2006 Jun 12(6):636-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 24 Aug 2006


Reprogramming of CTLs into natural killer-like cells in celiac disease.
Meresse B, Curran SA, …, Guandalini S, Jabri B
J Exp Med 2006 May 15 203(5):1343-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Luis J. Montaner / Marc Rothenberg
Evaluated 12 Jul 2006


Mast cells can promote the development of multiple features of chronic asthma in mice.
Yu M, Tsai M, …, Zehnder J, Galli SJ
J Clin Invest 2006 Jun 116(6):1633-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marc Rothenberg
Evaluated 30 May 2006

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
Palmer CN, Irvine AD, …, Mukhopadhyay S, McLean WH
Nat Genet 2006 Apr 38(4):441-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg / Michele Ramsay
Evaluated 2 May 2006


IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.
Strait RT, Morris SC, Finkelman FD
J Clin Invest 2006 Mar 116(3):833-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marc Rothenberg / Andrew Saxon
Evaluated 31 Mar 2006

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