Ashok Venkitaraman learnt and practiced medicine in India, before completing his PhD at University College London in 1988. After post-doctoral work at the MRC Laboratory of Molecular Biology in Cambridge (1988-91), he remained there as a faculty member until 1998. He now holds a joint appointment in the University of Cambridge Department of Oncology and the MRC Cancer Cell Unit. In his current research, Ashok seeks to understand the role of chromosomal instability in cancer predisposition. His lab works on the physiologic mechanisms that maintain the integrity of chromosome structure and number, and on how their disruption can contribute to carcinogenesis.

http://www.hutchison-mrc.cam.ac.uk/Venkitaraman.html

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. Ditchfield C, Johnson VL, …, Keen N, Taylor SS J Cell Biol 2003 Apr 28 161(2):267-80 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman / David Glover Evaluated 7 May 2003 A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. O'Driscoll M, Ruiz-Perez VL, …, Jeggo PA, Goodship JA Nat Genet 2003 Apr 33(4):497-501 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Sue Malcolm / Ashok Venkitaraman Evaluated 6 May 2003 Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Elia AE, Cantley LC, Yaffe MB Science 2003 Feb 21 299(5610):1228-31 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sally Kornbluth / Ashok Venkitaraman / Kermit Carraway / Angel Nebreda / Andrew D. Sharrocks / Francis Barr Evaluated 27 Feb 2003 BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Yang H, Jeffrey PD, …, Lee WH, Pavletich NP Science 2002 Sep 13 297(5588):1837-48 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman / Kristina Downing / Jane Endicott / Stephen Jackson Evaluated 16 Sep 2002 A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Sui G, Soohoo C, …, Forrester WC, Shi Y Proc Natl Acad Sci U S A 2002 Apr 16 99(8):5515-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman / Andrew D. Sharrocks / Surender Kharbanda Evaluated 25 Apr 2002 A system for stable expression of short interfering RNAs in mammalian cells. Brummelkamp TR, Bernards R, Agami R Science 2002 Apr 19 296(5567):550-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sharad Kumar / Ashok Venkitaraman / William Kaelin / Michael Meisterernst / Richard Vile / David Glover / Andrea Barta Evaluated 23 Apr 2002 Stable suppression of gene expression by RNAi in mammalian cells. Paddison PJ, Caudy AA, Hannon GJ Proc Natl Acad Sci U S A 2002 Feb 5 99(3):1443-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman / Vishvanath Nene Evaluated 28 Feb 2002 Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Hu F, Wang Y, …, Qin J, Elledge SJ Cell 2001 Nov 30 107(5):655-65 [abstract on PubMed] [related articles] [order article] Selected by | Ashok Venkitaraman Evaluated 11 Dec 2001 Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair. Hartsuiker E, Vaessen E, Carr AM, Kohli J EMBO J 2001 Dec 3 20(23):6660-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman Evaluated 5 Dec 2001 Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Tanaka K, Russell P Nat Cell Biol 2001 Nov 3(11):966-72 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Ashok Venkitaraman / Antony Carr / Stephen Jackson Evaluated 30 Nov 2001 Mrc1 transduces signals of DNA replication stress to activate Rad53. Alcasabas AA, Osborn AJ, …, Carr AM, Elledge SJ Nat Cell Biol 2001 Nov 3(11):958-65 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Ashok Venkitaraman / Stephen Jackson Evaluated 30 Nov 2001 ATR and ATRIP: partners in checkpoint signaling. Cortez D, Guntuku S, Qin J, Elledge SJ Science 2001 Nov 23 294(5547):1713-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman / Paul Russell / Stephen Jackson Evaluated 28 Nov 2001 Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Costanzo V, Robertson K, …, Carroll D, Gautier J Mol Cell 2001 Jul 8(1):137-47 [abstract on PubMed] [related articles] [order article] Selected by | Ashok Venkitaraman Evaluated 28 Sep 2001 Redistribution of BRCA1 among four different protein complexes following replication blockage. Chiba N, Parvin JD J Biol Chem 2001 Oct 19 276(42):38549-54 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ashok Venkitaraman Evaluated 28 Sep 2001 The mouse Mps1p-like kinase regulates centrosome duplication. Fisk HA, Winey M Cell 2001 Jul 13 106(1):95-104 [abstract on PubMed] [related articles] [order article] Selected by | Ashok Venkitaraman Evaluated 28 Sep 2001

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