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Klaus Ley
Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, United States of America

Faculty Member: CELL BIOLOGY > Cell adhesion [ since 14 May 2003 ]
[ Homepage ] [ Evaluations ]
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http://www.med.virginia.edu/medicine/inter-dis/cvrc/Faculty/Ley.html

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Evaluations

Mechanisms of the anti-inflammatory effects of hydroxyethyl starch demonstrated in a flow-based model of neutrophil recruitment by endothelial cells.
Matharu NM, Butler LM, …, Vohra RK, Nash GB
Crit Care Med 2008 May 36(5):1536-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 13 Jun 2008

Nanomechanical Control of Cell Rolling in Two Dimensions through Surface Patterning of Receptors.
Karnik R, Hong S, …, Karp JM, Langer R
Nano Lett 2008 Mar 6 [Epub ahead of print] [abstract on PubMed] [related articles] [full text]
Selected by | Klaus Ley
Evaluated 19 Mar 2008

Kindlin-3 is essential for integrin activation and platelet aggregation.
Moser M, Nieswandt B, …, Pozgajova M, Fässler R
Nat Med 2008 Mar 14(3):325-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steve Watson / Martin Humphries / Sanford Shattil / Dietmar Vestweber / Xiaoping Du / Klaus Ley / Mark Ginsberg
Evaluated 11 Mar 2008


Multichannel fluorescence spinning disk microscopy reveals early endogenous CD4 T cell recruitment in contact sensitivity via complement.
Norman MU, Hulliger S, Colarusso P, Kubes P
J Immunol 2008 Jan 1 180(1):510-21 [abstract on PubMed] [related articles] [order article]
Selected by | Klaus Ley
Evaluated 18 Feb 2008

The Hydrodynamically Relevant Endothelial Cell Glycocalyx Observed In Vivo Is Absent In Vitro.
Potter DR, Damiano ER
Circ Res 2008 Feb 7 [abstract on PubMed] [related articles] [full text]
Selected by | Klaus Ley
Evaluated 12 Feb 2008

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
Petrich BG, Marchese P, …, Critchley DR, Ginsberg MH
J Exp Med 2007 Dec 24 204(13):3103-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 4 Jan 2008

Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
Nieswandt B, Moser M, …, Critchley D, Fässler R
J Exp Med 2007 Dec 24 204(13):3113-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 4 Jan 2008

Natural history and early diagnosis of LAD-1/variant syndrome.
Kuijpers TW, van Bruggen R, …, Niemeyer C, Roos D
Blood 2007 Apr 15 109(8):3529-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 26 Nov 2007

Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction.
Guzik TJ, Hoch NE, …, Weyand C, Harrison DG
J Exp Med 2007 Oct 1 204(10):2449-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gregory Fink / Klaus Ley / Jane Salmon
Evaluated 19 Nov 2007

A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
Pasvolsky R, Feigelson SW, …, Etzioni A, Alon R
J Exp Med 2007 Jul 9 204(7):1571-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 27 Jul 2007

A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.
Duchene J, Lecomte F, …, Perretti M, Ahluwalia A
J Immunol 2007 Oct 1 179(7):4849-56 [abstract on PubMed] [related articles] [order article]
Selected by | Klaus Ley
Evaluated 4 Oct 2007

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.
Ghandour H, Cullere X, …, Luscinskas FW, Mayadas TN
Blood 2007 Nov 15 110(10):3682-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 21 Sep 2007

Differential contribution of bacterial N-formyl-methionyl-leucyl- phenylalanine and host-derived CXC chemokines to neutrophil infiltration into pulmonary alveoli during murine pneumococcal pneumonia.
Gauthier JF, Fortin A, …, Champagne ME, Bergeron MG
Infect Immun 2007 Nov 75(11):5361-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 13 Sep 2007

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Chen CJ, Kono H, …, Akira S, Rock KL
Nat Med 2007 Jul 13(7):851-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Grant McFadden / Klaus Ley
Evaluated 15 Aug 2007


Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.
Bergmeier W, Goerge T, …, Graybiel AM, Wagner DD
J Clin Invest 2007 Jun 117(6):1699-707 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 27 Jul 2007

Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs.
Veerman KM, Williams MJ, …, Rosen SD, Ziltener HJ
Nat Immunol 2007 May 8(5):532-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley / Klaus Ley
Evaluated 30 May 2007

Lymphotoxin beta receptor-dependent control of lipid homeostasis.
Lo JC, Wang Y, …, Getz GS, Fu YX
Science 2007 Apr 13 316(5822):285-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 19 Apr 2007


Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
Tsou CL, Peters W, …, Mack M, Charo IF
J Clin Invest 2007 Apr 117(4):902-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley / Steven Kunkel
Evaluated 2 Apr 2007

Images in cardiovascular medicine. Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery.
Maffia P, Zinselmeyer BH, …, Brewer JM, Garside P
Circulation 2007 Mar 20 115(11):e326-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 28 Mar 2007

Structural basis of integrin activation by talin.
Wegener KL, Partridge AW, …, Ginsberg MH, Campbell ID
Cell 2007 Jan 12 128(1):171-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alan Rick Horwitz / Klaus Ley
Evaluated 9 Feb 2007

Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression.
Martinez FO, Gordon S, Locati M, Mantovani A
J Immunol 2006 Nov 15 177(10):7303-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Schwartz / Klaus Ley
Evaluated 6 Dec 2006

Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.
Yago T, Zarnitsyna VI, …, McEver RP, Zhu C
Biophys J 2007 Jan 1 92(1):330-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 15 Nov 2006

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivanov II, McKenzie BS, …, Cua DJ, Littman DR
Cell 2006 Sep 22 126(6):1121-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Caetano Reis e Sousa / Christopher A. Hunter / Casey Weaver / Richard Williams / Dale Umetsu / Klaus Ley / Mercedes Rincon / Rachel Caspi / Fraydoon Rastinejad / Astar Winoto
Evaluated 7 Nov 2006


Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet.
Schröder K, Vecchione C, …, Busse R, Brandes RP
Free Radic Biol Med 2006 Nov 1 41(9):1353-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 27 Oct 2006

Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants.
Hyduk SJ, Chan JR, …, Kapus A, Cybulsky MI
Blood 2007 Jan 1 109(1):176-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 18 Oct 2006

Flow-enhanced adhesion regulated by a selectin interdomain hinge.
Lou J, Yago T, …, Zhu C, McEver RP
J Cell Biol 2006 Sep 25 174(7):1107-17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 6 Oct 2006

Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis.
Jongstra-Bilen J, Haidari M, …, Guha D, Cybulsky MI
J Exp Med 2006 Sep 4 203(9):2073-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 15 Aug 2006

Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force.
Phan UT, Waldron TT, Springer TA
Nat Immunol 2006 Aug 7(8):883-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 4 Aug 2006

STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells.
Mikhak Z, Fleming CM, …, Campanella GS, Luster AD
J Immunol 2006 Apr 15 176(8):4959-67 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 2 Jun 2006

Formation of perfused, functional microvascular tubes in vitro.
Chrobak KM, Potter DR, Tien J
Microvasc Res 2006 May 71(3):185-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley / Mina J. Bissell
Evaluated 19 Apr 2006

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Veldhoen M, Hocking RJ, …, Locksley RM, Stockinger B
Immunity 2006 Feb 24(2):179-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher A. Hunter / Rachel Caspi / Klaus Ley / Dale Umetsu
Evaluated 24 Mar 2006

Innate control of adaptive immunity via remodeling of lymph node feed arteriole.
Soderberg KA, Payne GW, …, Segal SS, Iwasaki A
Proc Natl Acad Sci U S A 2005 Nov 8 102(45):16315-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 9 Jan 2006

Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
Francis SA, Shen X, …, Kaul P, Lerner DJ
Blood 2006 Feb 15 107(4):1627-35 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 25 Nov 2005

Catch bonds govern adhesion through L-selectin at threshold shear.
Yago T, Wu J, …, Zhu C, McEver RP
J Cell Biol 2004 Sep 13 166(6):913-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 12 Sep 2005

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.
Wang L, Fuster M, Sriramarao P, Esko JD
Nat Immunol 2005 Sep 6(9):902-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Kunkel / Klaus Ley
Evaluated 17 Aug 2005

Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin.
Dole VS, Bergmeier W, …, Eichenberger SC, Wagner DD
Blood 2005 Oct 1 106(7):2334-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 23 Jun 2005

CD44 is a physiological E-selectin ligand on neutrophils.
Katayama Y, Hidalgo A, …, Peired A, Frenette PS
J Exp Med 2005 Apr 18 201(8):1183-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 5 May 2005

The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.
Kim M, Carman CV, …, Salas A, Springer TA
J Cell Biol 2004 Dec 20 167(6):1241-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 1 Mar 2005

Blockade of keratinocyte-derived chemokine inhibits endothelial recovery and enhances plaque formation after arterial injury in ApoE-deficient mice.
Liehn EA, Schober A, Weber C
Arterioscler Thromb Vasc Biol 2004 Oct 24(10):1891-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 19 Nov 2004

Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin.
Ramachandran V, Williams M, …, Schmidtke DW, McEver RP
Proc Natl Acad Sci U S A 2004 Sep 14 101(37):13519-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 21 Sep 2004

A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential.
Kögler G, Sensken S, …, Zanjani E, Wernet P
J Exp Med 2004 Jul 19 200(2):123-35 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 8 Sep 2004

Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond.
Evans E, Leung A, Heinrich V, Zhu C
Proc Natl Acad Sci U S A 2004 Aug 3 101(31):11281-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Deborah Leckband / Klaus Ley
Evaluated 17 Aug 2004

Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria.
Macpherson AJ, Uhr T
Science 2004 Mar 12 303(5664):1662-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Maria Rescigno / Klaus Ley
Evaluated 5 May 2004

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Matloubian M, Lo CG, …, Proia RL, Cyster JG
Nature 2004 Jan 22 427(6972):355-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Dustin / Steve Ward / Reina Mebius / Klaus Ley / Pamela Schwartzberg
Evaluated 7 Apr 2004

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases.
Mempel TR, Henrickson SE, Von Andrian UH
Nature 2004 Jan 8 427(6970):154-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Emanuela Handman / Michael McHeyzer-Williams / Klaus Ley / Michael Dustin / Paul Gleeson
Evaluated 29 Jan 2004

Peritoneal macrophages express both P-selectin and PSGL-1.
Tchernychev B, Furie B, Furie BC
J Cell Biol 2003 Dec 8 163(5):1145-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 6 Jan 2004

Talin binding to integrin beta tails: a final common step in integrin activation.
Tadokoro S, Shattil SJ, …, Ginsberg MH, Calderwood DA
Science 2003 Oct 3 302(5642):103-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Humphries / Kenneth Yamada / Eric Brown / Klaus Ley
Evaluated 31 Oct 2003

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.
Kim M, Carman CV, Springer TA
Science 2003 Sep 19 301(5640):1720-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Dustin / Klaus Ley / Kermit Carraway / Peter Ekblom / Jean Schwarzbauer / Charles Streuli
Evaluated 8 Oct 2003

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells.
Mora JR, Bono MR, …, Rosemblatt M, Von Andrian UH
Nature 2003 Jul 3 424(6944):88-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stella C. Knight / Hans Acha-Orbea / James Campbell / Reina Mebius / Klaus Ley
Evaluated 1 Sep 2003

Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin.
Falati S, Liu Q, …, Furie BC, Furie B
J Exp Med 2003 Jun 2 197(11):1585-98 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Klaus Ley
Evaluated 25 Jul 2003

Direct observation of catch bonds involving cell-adhesion molecules.
Marshall BT, Long M, …, McEver RP, Zhu C
Nature 2003 May 8 423(6936):190-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley
Evaluated 19 May 2003

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