Thomas Kodadek sponsors free access to F1000 for University of Rio Cuarto, Rio Cuarto, Argentina. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Areas of interest: Proteomics, chemical biology and the enymology of gene expression.

http://www.utsouthwestern.edu/findfac/professional/0,2356,32680,00.html

Highly active and selective endopeptidases with programmed substrate specificities. Varadarajan N, Rodriguez S, …, Georgiou G, Iverson BL Nat Chem Biol 2008 May 4(5):290-4 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 7 May 2008 A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. Mao C, Patterson NM, …, Nordeen SK, Shapiro DJ J Biol Chem 2008 Mar 12 [abstract on PubMed] [related articles] [FREE full text] Selected by | Paul Webb / Thomas Kodadek Evaluated 7 May 2008 Site-Specific Prodrug Release Using Visible Light. Jiang MY, Dolphin D J Am Chem Soc 2008 Mar 12 0 [abstract on PubMed] [related articles] [full text] Selected by | Thomas Kodadek Evaluated 26 Mar 2008 Noninvasive assessment of cancer response to therapy. Han Z, Fu A, …, Onishko H, Hallahan DE Nat Med 2008 Feb 24 [abstract on PubMed] [related articles] [full text] Selected by | Thomas Kodadek Evaluated 3 Mar 2008 Selective acylation of primary amines in peptides and proteins. Abello N, Kerstjens HA, Postma DS, Bischoff R J Proteome Res 2007 Dec 6(12):4770-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 10 Jan 2008 Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2. Murray E, McKenna EO, …, Pitt A, Hupp TR Biochemistry 2007 Dec 4 46(48):13742-51 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 4 Jan 2008 Quantifying small numbers of antibodies with a 'near-universal' protein-DNA chimera. Burbulis I, Yamaguchi K, …, Resnekov O, Brent R Nat Methods 2007 Dec 4(12):1011-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 21 Dec 2007 E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Christensen DE, Brzovic PS, Klevit RE Nat Struct Mol Biol 2007 Oct 14(10):941-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Brian Kuhlman / Jane Endicott / Thomas Kodadek Evaluated 2 Nov 2007 Gal11p dosage-compensates transcriptional activator deletions via Taf14p. Lim MK, Tang V, …, Bongards C, Lehming N J Mol Biol 2007 Nov 16 374(1):9-23 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 2 Nov 2007 Design of recombinant antibody microarrays for serum protein profiling: targeting of complement proteins. Ingvarsson J, Larsson A, …, Borrebaeck CA, Wingren C J Proteome Res 2007 Sep 6(9):3527-36 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 19 Sep 2007 In vivo dynamics of RNA polymerase II transcription. Darzacq X, Shav-Tal Y, …, Phair RD, Singer RH Nat Struct Mol Biol 2007 Sep 14(9):796-806 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Dinah Singer / Thomas Kodadek / Daniel Reines / Sui Huang Evaluated 18 Sep 2007 A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity. Rosebrock TR, Zeng L, …, Xiao F, Martin GB Nature 2007 Jul 19 448(7151):370-4 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 1 Aug 2007 Mapping of transcription factor binding regions in mammalian cells by ChIP: comparison of array- and sequencing-based technologies. Euskirchen GM, Rozowsky JS, …, Ruan Y, Snyder M Genome Res 2007 Jun 17(6):898-909 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 10 Jul 2007 The ubiquitin-specific protease USP28 is required for MYC stability. Popov N, Wanzel M, …, Elledge SJ, Eilers M Nat Cell Biol 2007 Jul 9(7):765-74 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 10 Jul 2007 Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Kanin EI, Kipp RT, …, Shokat KM, Ansari AZ Proc Natl Acad Sci U S A 2007 Apr 3 104(14):5812-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek / Jane Endicott Evaluated 16 Apr 2007 A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Li W, Tu D, Brunger AT, Ye Y Nature 2007 Mar 15 446(7133):333-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek / David Wotton Evaluated 21 Mar 2007 Activity-based probes for proteomic profiling of histone deacetylase complexes. Salisbury CM, Cravatt BF Proc Natl Acad Sci U S A 2007 Jan 23 104(4):1171-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 5 Feb 2007 A smart magnetic resonance contrast agent for selective copper sensing. Que EL, Chang CJ J Am Chem Soc 2006 Dec 20 128(50):15942-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 29 Jan 2007 The proteasome restricts permissive transcription at tissue-specific gene loci in embryonic stem cells. Szutorisz H, Georgiou A, Tora L, Dillon N Cell 2006 Dec 29 127(7):1375-88 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek / Shiv Pillai / Miles Wilkinson Evaluated 12 Jan 2007 Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe. Luo Y, Knuckley B, …, Pellechia PJ, Thompson PR J Am Chem Soc 2006 Nov 15 128(45):14468-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 10 Jan 2007 "Click to chelate": synthesis and installation of metal chelates into biomolecules in a single step. Mindt TL, Struthers H, …, Tourwé D, Schibli R J Am Chem Soc 2006 Nov 29 128(47):15096-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 10 Jan 2007 Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium. Chan WK, Ho CM, Wong MK, Che CM J Am Chem Soc 2006 Nov 22 128(46):14796-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 10 Jan 2007 ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Liu CW, Li X, …, Thomas PJ, DeMartino GN Mol Cell 2006 Oct 6 24(1):39-50 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 19 Oct 2006 A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Ju BG, Lunyak VV, …, Glass CK, Rosenfeld MG Science 2006 Jun 23 312(5781):1798-802 [abstract on PubMed] [related articles] [FREE full text] Selected by | Michael B. Yaffe / Andrew Belmont / Thomas Kodadek / Miles Wilkinson Evaluated 25 Jul 2006 Structure of the p53 core domain dimer bound to DNA. Ho WC, Fitzgerald MX, Marmorstein R J Biol Chem 2006 Jul 21 281(29):20494-502 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 25 Jul 2006 Targeting retroviral Zn finger-DNA interactions: a small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds. Anzellotti AI, Liu Q, …, Scarsdale JN, Farrell N Chem Biol 2006 May 13(5):539-48 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 6 Jun 2006 PNA-based reagents for the direct and site-specific synthesis of thymine dimer lesions in genomic DNA. Pieck JC, Kuch D, …, Haas C, Carell T J Am Chem Soc 2006 Feb 8 128(5):1404-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 3 Mar 2006 Defining the sequence-recognition profile of DNA-binding molecules. Warren CL, Kratochvil NC, …, Phillips GN, Ansari AZ Proc Natl Acad Sci U S A 2006 Jan 24 103(4):867-72 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 31 Jan 2006 Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae. Martens JA, Wu PY, Winston F Genes Dev 2005 Nov 15 19(22):2695-704 [abstract on PubMed] [related articles] [FREE full text] Selected by | Daniel Reines / Thomas Kodadek Evaluated 3 Jan 2006 Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Lummis SC, Beene DL, …, Broadhurst RW, Dougherty DA Nature 2005 Nov 10 438(7065):248-52 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deyou Zheng / Thomas Kodadek Evaluated 28 Nov 2005 A rapid library screen for tailoring beta-peptide structure and function. Kritzer JA, Luedtke NW, Harker EA, Schepartz A J Am Chem Soc 2005 Oct 26 127(42):14584-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 1 Nov 2005 Difference in mass analysis using labeled lysines (DIMAL-K): a new, efficient proteomic quantification method applied to the analysis of astrocytic secretomes. Delcourt N, Jouin P, …, Marin P, Galéotti N Mol Cell Proteomics 2005 Aug 4(8):1085-94 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 23 Aug 2005 Switching on a signaling pathway with an organoruthenium complex. Williams DS, Atilla GE, …, Klein PS, Meggers E Angew Chem Int Ed Engl 2005 Mar 18 44(13):1984-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 17 Jun 2005 Serum protein markers for early detection of ovarian cancer. Mor G, Visintin I, …, Bray-Ward P, Ward DC Proc Natl Acad Sci U S A 2005 May 24 102(21):7677-82 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 20 May 2005 Enrichment and analysis of peptide subsets using fluorous affinity tags and mass spectrometry. Brittain SM, Ficarro SB, Brock A, Peters EC Nat Biotechnol 2005 Apr 23(4):463-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 6 Apr 2005 Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Rankin EB, Higgins DF, …, Bradfield CA, Haase VH Mol Cell Biol 2005 Apr 25(8):3163-72 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek / William Kaelin Evaluated 6 Apr 2005 Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Kung C, Kenski DM, …, Madhani HD, Shokat KM Proc Natl Acad Sci U S A 2005 Mar 8 102(10):3587-92 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 17 Mar 2005 Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells. Müerköster S, Arlt A, …, Fölsch UR, Schäfer H Cancer Res 2005 Feb 15 65(4):1316-24 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 17 Mar 2005 A kinase-independent function of Cks1 and Cdk1 in regulation of transcription. Yu VP, Baskerville C, Grünenfelder B, Reed SI Mol Cell 2005 Jan 7 17(1):145-51 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 19 Jan 2005 Mapping the dynamic organization of the nuclear pore complex inside single living cells. Rabut G, Doye V, Ellenberg J Nat Cell Biol 2004 Nov 6(11):1114-21 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Susan Wente / Thomas Kodadek Evaluated 17 Dec 2004 Small molecule transcription factor mimic. Kwon Y, Arndt HD, …, Dervan PB, Uesugi M J Am Chem Soc 2004 Dec 15 126(49):15940-1 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 17 Dec 2004 A systematic method for identifying small-molecule modulators of protein-protein interactions. Horswill AR, Savinov SN, Benkovic SJ Proc Natl Acad Sci U S A 2004 Nov 2 101(44):15591-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek / Robert Kelley / Dorothee Kern Evaluated 3 Nov 2004 Human PAD4 regulates histone arginine methylation levels via demethylimination. Wang Y, Wysocka J, …, Allis CD, Coonrod SA Science 2004 Oct 8 306(5694):279-83 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek / Cheng-Ming Chiang / Robert Dutnall Evaluated 18 Oct 2004 Interior surface modification of bacteriophage MS2. Hooker JM, Kovacs EW, Francis MB J Am Chem Soc 2004 Mar 31 126(12):3718-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Anthony Czarnik / Thomas Kodadek Evaluated 13 Sep 2004 VP16 and ubiquitin; binding of P-TEFb via its activation domain and ubiquitin facilitates elongation of transcription of target genes. Kurosu T, Peterlin BM Curr Biol 2004 Jun 22 14(12):1112-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 16 Aug 2004 A mechanism-based cross-linker for the identification of kinase-substrate pairs. Maly DJ, Allen JA, Shokat KM J Am Chem Soc 2004 Aug 4 126(30):9160-1 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ross Weatherman / Thomas Kodadek / Manfred Schliwa / Wen-hong Li / Karen Anderson Evaluated 16 Aug 2004 A tethered catalysis, two-hybrid system to identify protein-protein interactions requiring post-translational modifications. Guo D, Hazbun TR, …, Fields S, Kuo MH Nat Biotechnol 2004 Jul 22(7):888-92 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Benoit Coulombe / Thomas Kodadek / Igor Stagljar Evaluated 28 Jul 2004 Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes. Kalodimos CG, Biris N, …, Boelens R, Kaptein R Science 2004 Jul 16 305(5682):386-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Ladbury / Thomas Kodadek / Antonio Rosato / James Hu / Jim Maher Evaluated 27 Jul 2004 Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox. Sem DS, Bertolaet B, …, Villar H, Yu L Chem Biol 2004 Feb 11(2):185-94 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 27 May 2004 Building addressable libraries: the use of electrochemistry for generating reactive Pd(II) reagents at preselected sites on a chip. Tesfu E, Maurer K, Ragsdale SR, Moeller KD J Am Chem Soc 2004 May 26 126(20):6212-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 27 May 2004 Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Mieda M, Willie JT, …, Sakurai T, Yanagisawa M Proc Natl Acad Sci U S A 2004 Mar 30 101(13):4649-54 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 15 Apr 2004 Antimicrobial drug discovery through bacteriophage genomics. Liu J, Dehbi M, …, Pelletier J, DuBow M Nat Biotechnol 2004 Feb 22(2):185-91 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 15 Apr 2004 Dedifferentiation of lineage-committed cells by a small molecule. Chen S, Zhang Q, …, Schultz PG, Ding S J Am Chem Soc 2004 Jan 21 126(2):410-1 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek / James Stivers Evaluated 27 Jan 2004 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Métivier R, Penot G, …, Kos M, Gannon F Cell 2003 Dec 12 115(6):751-63 [abstract on PubMed] [related articles] [order article] Selected by | Michael Meisterernst / Thomas Kodadek / Ross Weatherman / Peter B. Becker Evaluated 7 Jan 2004 Protein surface recognition by rational design: nanomolar ligands for potassium channels. Gradl SN, Felix JP, …, Garcia ML, Trauner D J Am Chem Soc 2003 Oct 22 125(42):12668-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek / Thomas W. von Geldern / Dan Yang Evaluated 11 Nov 2003 A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. Brès V, Kiernan RE, …, Scheffner M, Benkirane M Nat Cell Biol 2003 Aug 5(8):754-61 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 9 Sep 2003 Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. Koehler AN, Shamji AF, Schreiber SL J Am Chem Soc 2003 Jul 16 125(28):8420-1 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek / Dennis Hall Evaluated 22 Jul 2003 Diagnostic potential of serum proteomic patterns in prostate cancer. Bañez LL, Prasanna P, …, Moul JW, Srivastava S J Urol 2003 Aug 170(2 Pt 1):442-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Kodadek Evaluated 21 Jul 2003 The Escherichia coli RecQ helicase functions as a monomer. Xu HQ, Deprez E, …, Auclair C, Xi XG J Biol Chem 2003 Sep 12 278(37):34925-33 [abstract on PubMed] [related articles] [FREE full text] Selected by | Thomas Kodadek Evaluated 23 Jun 2003 A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. Asada S, Choi Y, Uesugi M J Am Chem Soc 2003 Apr 30 125(17):4992-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Koh / Thomas Kodadek Evaluated 16 May 2003

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