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Martin Van den Berg
Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, Netherlands

Faculty Member: Pharmacology & Drug Discovery > Toxicology [ since 20 November 2006 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Martin van den Berg is Professor in Veterinary Environmental Sciences and Toxicology, deputy director of the Institute of Risk Assessment Sciences(formerly RITOX) of the University of Utrecht, The Netherlands and head of the Toxicology Division of IRAS. The Toxicology Division of IRAS consists of 30 to 40 scientists, technicians and supporting staff. His teaching responsibilities are in the area of Environmental Sciences, Toxicology and Chemistry at both undergraduate and postgraduate level at the Faculties of Veterinary Medicine, Biology, Medical Biology and Environmental Sciences. He is also appointed as an honorary professor in environmental toxicology at the University of Queensland (Brisbane) and an adjunct professor at the Asean Institute of Technology/Royal Chulabohorn Research Institute in Bangkok. In autumn 2006 he received an honorary doctorate from the University of Umea, Sweden for his research on dioxinlike compounds.
His areas of research include: toxicokinetics, metabolism and reproductive and interactive effects of halogenated polyaromatics, interactions of xenobiotics on steroid hormone syhthesis, metabolism and their relation with hormone dependent tumors, development of in vitro assays to detect endocrine disruptors. These studies are done with mammals, birds and fish as well as in in vitro systems. The results of his scientific work and that of his research group have been published in more than 200 scientific articles and papers. He is a European registered toxicologist.

Home page

http://www.iras.uu.nl/

to email [Help]
Evaluations

Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population.
Uemura H, Arisawa K, …, Nagai M, Suzuki T
Environ Health Perspect 2009 Apr 117(4):568-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 23 Jun 2009

Structural basis for androgen specificity and oestrogen synthesis in human aromatase.
Ghosh D, Griswold J, Erman M, Pangborn W
Nature 2009 Jan 8 457(7226):219-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 3 Mar 2009

Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD.
Goldstone JV, Jönsson ME, …, Nelson DR, Stegeman JJ
Arch Biochem Biophys 2009 Feb 482(1-2):7-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 26 Feb 2009

The relationship between prenatal PCB exposure and intelligence (IQ) in 9-year-old children.
Stewart PW, Lonky E, …, Gump BB, Darvill T
Environ Health Perspect 2008 Oct 116(10):1416-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 27 Jan 2009

Polybrominated diphenyl ethers in aircraft cabins - A source of human exposure?
Christiansson A, Hovander L, …, Jakobsson K, Bergman K
Chemosphere 2008 Sep 9 [abstract on PubMed] [related articles] [full text]
Selected by | Martin Van den Berg
Evaluated 3 Oct 2008

Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults.
Lang IA, Galloway TS, …, Wallace RB, Melzer D
JAMA 2008 Sep 17 300(11):1303-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 26 Sep 2008


A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner.
Howdeshell KL, Wilson VS, …, Hotchkiss AK, Gray LE
Toxicol Sci 2008 Sep 105(1):153-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Foster / Martin Van den Berg
Evaluated 18 Sep 2008

MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
Lui K, Tamura T, …, Zhou D, Chen S
Biochem Pharmacol 2008 Jul 15 76(2):208-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 7 Aug 2008

1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells.
Aubé M, Larochelle C, Ayotte P
Breast Cancer Res 2008 10(1):R16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Van den Berg
Evaluated 2 Jul 2008

Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish.
van Boxtel AL, Kamstra JH, …, Brouwer A, Legler J
Environ Sci Technol 2008 Mar 1 42(5):1773-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 11 Jun 2008

Environmental exposures and puberty in inner-city girls.
Wolff MS, Britton JA, …, Larson S, Forman J
Environ Res 2008 May 12 [abstract on PubMed] [related articles] [full text]
Selected by | Martin Van den Berg
Evaluated 27 May 2008

Triclocarban enhances testosterone action: a new type of endocrine disruptor?
Chen J, Ahn KC, …, Hammock BD, Lasley BL
Endocrinology 2008 Mar 149(3):1173-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg / Andrea Gore
Evaluated 23 Apr 2008

Gestational exposure to perfluorooctane sulfonate (PFOS) suppresses immune function in B6C3F1 mice.
Keil DE, Mehlmann T, Butterworth L, Peden-Adams MM
Toxicol Sci 2008 Feb 5 [abstract on PubMed] [related articles] [full text]
Selected by | Martin Van den Berg
Evaluated 29 Feb 2008

Characterisation of aromatase expression in the human adipocyte cell line SGBS.
McInnes KJ, Brown KA, …, Clyne CD, Simpson ER
Breast Cancer Res Treat 2008 Jan 5 [abstract on PubMed] [related articles] [full text]
Selected by | Martin Van den Berg
Evaluated 16 Jan 2008

Coexposure of Neonatal Mice to a Flame Retardant PBDE 99 (2,2',4,4',5-Pentabromodiphenyl Ether) and Methyl Mercury Enhances Developmental Neurotoxic Defects.
Fischer C, Fredriksson A, Eriksson P
Toxicol Sci 2008 Feb 101(2):275-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 14 Jan 2008

Flame retardants in placenta and breast milk and cryptorchidism in newborn boys.
Main KM, Kiviranta H, …, Skakkebaek NE, Toppari J
Environ Health Perspect 2007 Oct 115(10):1519-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 21 Dec 2007

Effects of tobacco smoke condensate on estrogen receptor-alpha gene expression and activity.
Martin MB, Reiter R, …, Wang A, Stoica A
Endocrinology 2007 Oct 148(10):4676-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 12 Dec 2007

The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer.
Lauber SN, Gooderham NJ
Cancer Res 2007 Oct 1 67(19):9597-602 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 11 Oct 2007

Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer.
Xu WH, Dai Q, …, Zheng W, Shu XO
Am J Epidemiol 2007 Dec 15 166(12):1420-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Van den Berg
Evaluated 28 Sep 2007

Endocrine-disrupting activities in vivo of the fungicides tebuconazole and epoxiconazole.
Taxvig C, Hass U, …, Andeasen HR, Vinggaard AM
Toxicol Sci 2007 Dec 100(2):464-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 13 Sep 2007

Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes.
Howdeshell KL, Furr J, …, Wilson VS, Gray LE
Toxicol Sci 2007 Sep 99(1):190-202 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg / Paul Foster
Evaluated 20 Aug 2007

Influence of breastfeeding in the accumulation of polybromodiphenyl ethers during the first years of child growth.
Carrizo D, Grimalt JO, …, Sunyer J, Torrent M
Environ Sci Technol 2007 Jul 15 41(14):4907-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 14 Aug 2007

Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer.
Gallo D, Mantuano E, …, De Stefano I, Scambia G
Endocr Relat Cancer 2007 Jun 14(2):317-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 3 Aug 2007

Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study.
Monroe KR, Murphy SP, Kolonel LN, Pike MC
Br J Cancer 2007 Aug 6 97(3):440-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 20 Jul 2007

Aromatase and COX in breast cancer: enzyme inhibitors and beyond.
Brueggemeier RW, Su B, …, Díaz-Cruz ES, Davis DD
J Steroid Biochem Mol Biol 2007 Aug-Sep 106(1-5):16-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 20 Jul 2007

Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans.
Fan W, Yanase T, …, Takayanagi R, Nawata H
Environ Health Perspect 2007 May 115(5):720-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 7 Jun 2007

Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk.
Wen W, Ren Z, …, Gao YT, Zheng W
Cancer Epidemiol Biomarkers Prev 2007 May 16(5):917-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 24 May 2007

Development of a neurotoxic equivalence scheme of relative potency for assessing the risk of PCB mixtures.
Simon T, Britt JK, James RC
Regul Toxicol Pharmacol 2007 Jul 48(2):148-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 24 May 2007

Developmental exposure to endocrine disruptors and the obesity epidemic.
Newbold RR, Padilla-Banks E, …, Phillips TM, Jefferson WN
Reprod Toxicol 2007 Apr-May 23(3):290-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Van den Berg
Evaluated 15 May 2007

Plasma phytoestrogens and subsequent breast cancer risk.
Verheus M, van Gils CH, …, Bingham SA, Peeters PH
J Clin Oncol 2007 Feb 20 25(6):648-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 3 May 2007

Estrogens and antiestrogens activate hPXR.
Mnif W, Pascussi JM, …, Duchesne MJ, Balaguer P
Toxicol Lett 2007 Apr 5 170(1):19-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 3 May 2007

The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators.
Pacyniak EK, Cheng X, …, Klaassen CD, Guo GL
Toxicol Sci 2007 May 97(1):94-102 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 28 Mar 2007

Interacting influence of potassium and polychlorinated biphenyl on cortisol and aldosterone biosynthesis.
Li LA, Lin TC
Toxicol Appl Pharmacol 2007 May 1 220(3):252-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 16 Mar 2007

Genistein accumulates in body depots and is mobilized during fasting, reaching estrogenic levels in serum that counter the hormonal actions of estradiol and organochlorines.
Penza M, Montani C, …, Caimi L, Di Lorenzo D
Toxicol Sci 2007 Jun 97(2):299-307 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 7 Mar 2007

Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase.
Hong Y, Yu B, …, Zhou D, Chen S
Mol Endocrinol 2007 Feb 21(2):401-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 23 Feb 2007

Degradation pathways of decabromodiphenyl ether during hydrothermal treatment.
Nose K, Hashimoto S, …, Noma Y, Sakai S
Chemosphere 2007 May 68(1):120-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 14 Feb 2007

Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population.
Dhooge W, van Larebeke N, …, Comhaire F, Flemish Environment and Health Study Group
Environ Health Perspect 2006 Nov 114(11):1670-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Van den Berg
Evaluated 31 Jan 2007

The combination of green tea and tamoxifen is effective against breast cancer.
Sartippour MR, Pietras R, …, Rao JY, Brooks MN
Carcinogenesis 2006 Dec 27(12):2424-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Van den Berg
Evaluated 11 Jan 2007

Naturally occurring estrogens in processed milk and in raw milk (from gestated cows).
Malekinejad H, Scherpenisse P, Bergwerff AA
J Agric Food Chem 2006 Dec 27 54(26):9785-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Van den Berg
Evaluated 8 Jan 2007

Apigenin suppresses cancer cell growth through ERbeta.
Mak P, Leung YK, …, Harwood C, Ho SM
Neoplasia 2006 Nov 8(11):896-904 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Van den Berg
Evaluated 8 Dec 2006

Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Albuquerque EX, Pereira EF, …, Romano JA, Adler M
Proc Natl Acad Sci U S A 2006 Aug 29 103(35):13220-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jerry Buccafusco / Martin Van den Berg
Evaluated 6 Dec 2006

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